메뉴 건너뛰기




Volumn 54, Issue 2, 1998, Pages 291-297

Human immunodeficiency virus type 1 reverse transcriptase expressing the K70E mutation exhibits a decrease in specific activity and processivity

Author keywords

[No Author keywords available]

Indexed keywords

ADEFOVIR DIPIVOXIL; LAMIVUDINE; RNA DIRECTED DNA POLYMERASE;

EID: 0031848831     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.54.2.291     Document Type: Article
Times cited : (28)

References (40)
  • 1
    • 0029786905 scopus 로고    scopus 로고
    • The K65R mutation confers increased DNA polymerase processivity to HIV-1 reverse transcriptase
    • Arion D, Borkow G, Gu Z, Wainberg MA, and Parniak MA (1996) The K65R mutation confers increased DNA polymerase processivity to HIV-1 reverse transcriptase. J Biol Chem 271:19860-19864.
    • (1996) J Biol Chem , vol.271 , pp. 19860-19864
    • Arion, D.1    Borkow, G.2    Gu, Z.3    Wainberg, M.A.4    Parniak, M.A.5
  • 2
    • 0028176053 scopus 로고
    • Comparison of deoxyoligonucleotide and tRNA(Lys-3) as primers in an endogenous human immunodeficiency virus-1 in vitro reverse transcription/template-switching reaction
    • Arts EJ, Li X, Gu Z, Kleiman L, Parniak MA, and Wainberg MA (1994) Comparison of deoxyoligonucleotide and tRNA(Lys-3) as primers in an endogenous human immunodeficiency virus-1 in vitro reverse transcription/template-switching reaction. J Biol Chem 269:14672-14680.
    • (1994) J Biol Chem , vol.269 , pp. 14672-14680
    • Arts, E.J.1    Li, X.2    Gu, Z.3    Kleiman, L.4    Parniak, M.A.5    Wainberg, M.A.6
  • 4
    • 0029566112 scopus 로고
    • Kinetic properties of adenine nucleotide analogues against purified 5-phosphoribosyl-1-pyrophosphate synthetases from E. coli, rat liver, and human erythrocytes
    • Balzarini J, Nave JF, Becker MA, Tatibana M, and De Clercq E (1995) Kinetic properties of adenine nucleotide analogues against purified 5-phosphoribosyl-1-pyrophosphate synthetases from E. coli, rat liver, and human erythrocytes. Nucleosides Nucleotides 14:1861-1871.
    • (1995) Nucleosides Nucleotides , vol.14 , pp. 1861-1871
    • Balzarini, J.1    Nave, J.F.2    Becker, M.A.3    Tatibana, M.4    De Clercq, E.5
  • 5
    • 0029035638 scopus 로고
    • Analysis of mutations at position 184 in reverse transcriptase of HIV-1
    • Boyer PL and Hughes SH (1995) Analysis of mutations at position 184 in reverse transcriptase of HIV-1. Antimicrob Agents Chemother 39:1624-1628.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 1624-1628
    • Boyer, P.L.1    Hughes, S.H.2
  • 6
    • 0029022494 scopus 로고
    • Kinetic interaction of the diphosphates of 9-(2-phosphonylmethoxyethyl) adenine and other anti-HIV active purine congeners with HIV reverse transcriptase and human DNA polymerases a, b and g
    • Cherrington JM, Allen SJW, Bischofberger N, and Chen MS (1995) Kinetic interaction of the diphosphates of 9-(2-phosphonylmethoxyethyl) adenine and other anti-HIV active purine congeners with HIV reverse transcriptase and human DNA polymerases a, b and g. Antivir Chem Chemother 6:217-221.
    • (1995) Antivir Chem Chemother , vol.6 , pp. 217-221
    • Cherrington, J.M.1    Allen, S.J.W.2    Bischofberger, N.3    Chen, M.S.4
  • 8
    • 0029795423 scopus 로고    scopus 로고
    • Novel mutation (K70E) in human immunodeficiency virus type 1 reverse transcriptase confers decreased susceptibility to 9-[2-(phosphonomethoxy)ethyl] adenine in vitro
    • Cherrington JM, Mulato AS, Fuller MD, and Chen MS (1996b) Novel mutation (K70E) in human immunodeficiency virus type 1 reverse transcriptase confers decreased susceptibility to 9-[2-(phosphonomethoxy)ethyl] adenine in vitro. Antimicrob Agents Chemother 40:2212-2216.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 2212-2216
    • Cherrington, J.M.1    Mulato, A.S.2    Fuller, M.D.3    Chen, M.S.4
  • 9
    • 0031281931 scopus 로고    scopus 로고
    • Expression of the catalytic subunit (UL54) and the accessory protein (UL44) of human cytomegalovirus DNa polymerase in a coupled in vitro transcription/translation system
    • Cihlar T, Fuller MD, and Cherrington JM (1997) Expression of the catalytic subunit (UL54) and the accessory protein (UL44) of human cytomegalovirus DNA polymerase in a coupled in vitro transcription/translation system. Protein Expr Purif 11:209-218.
    • (1997) Protein Expr Purif , vol.11 , pp. 209-218
    • Cihlar, T.1    Fuller, M.D.2    Cherrington, J.M.3
  • 14
    • 0028034266 scopus 로고
    • The K65R mutant reverse transcriptase of HIV-1 cross-resistant to ddC, 3TC and ddI shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro
    • Gu Z, Fletcher RS, Arts EJ, Wainberg MA, and Parniak MA (1994a) The K65R mutant reverse transcriptase of HIV-1 cross-resistant to ddC, 3TC and ddI shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro. J Biol Chem 269:28118-28122.
    • (1994) J Biol Chem , vol.269 , pp. 28118-28122
    • Gu, Z.1    Fletcher, R.S.2    Arts, E.J.3    Wainberg, M.A.4    Parniak, M.A.5
  • 15
  • 16
    • 0026465275 scopus 로고
    • Novel mutation in the HIV-1 reverse transcriptase gene that encodes cross-resistance to ddI and ddC
    • Gu Z, Gao Q, Li X, Parniak MA, and Wainberg MA (1992) Novel mutation in the HIV-1 reverse transcriptase gene that encodes cross-resistance to ddI and ddC. J Virol 66:7128-7135.
    • (1992) J Virol , vol.66 , pp. 7128-7135
    • Gu, Z.1    Gao, Q.2    Li, X.3    Parniak, M.A.4    Wainberg, M.A.5
  • 18
    • 0023242380 scopus 로고
    • RNase H activity associated with bacterially expressed reverse transcriptase of human T-cell tropic virus III/ lymphadenopathy-associated virus
    • Hansen J, Schulze T, and Moellin K (1987) RNase H activity associated with bacterially expressed reverse transcriptase of human T-cell tropic virus III/ lymphadenopathy-associated virus. J Biol Chem 262:12393-12396.
    • (1987) J Biol Chem , vol.262 , pp. 12393-12396
    • Hansen, J.1    Schulze, T.2    Moellin, K.3
  • 19
    • 0027238697 scopus 로고
    • Template-driven pausing of DNA synthesis by HIV-1 reverse transcriptase during polymerization of HIV-1 sequences in vitro
    • Klarmann GJ, Schauber CA, and Preston BD (1993) Template-driven pausing of DNA synthesis by HIV-1 reverse transcriptase during polymerization of HIV-1 sequences in vitro. J Biol Chem 268:9793-9802.
    • (1993) J Biol Chem , vol.268 , pp. 9793-9802
    • Klarmann, G.J.1    Schauber, C.A.2    Preston, B.D.3
  • 21
    • 0024508058 scopus 로고
    • HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy
    • Larder BA, Darby AG, and Richman DD (1989) HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy. Science (Washington DC) 243:1731-1734.
    • (1989) Science (Washington DC) , vol.243 , pp. 1731-1734
    • Larder, B.A.1    Darby, A.G.2    Richman, D.D.3
  • 25
    • 0031006111 scopus 로고    scopus 로고
    • Changes in plasma HIV RNA levels and CD4+ lymphocyte counts predict both response to antiretroviral therapy and therapeutic failure: VA Cooperative Study Group on AIDS
    • O'Brien WA, Hartigan PM, Daar ES, Simberkoff MS, and Hamilton JD (1997) Changes in plasma HIV RNA levels and CD4+ lymphocyte counts predict both response to antiretroviral therapy and therapeutic failure: VA Cooperative Study Group on AIDS. Ann Intern Med 126:939-945.
    • (1997) Ann Intern Med , vol.126 , pp. 939-945
    • O'Brien, W.A.1    Hartigan, P.M.2    Daar, E.S.3    Simberkoff, M.S.4    Hamilton, J.D.5
  • 27
    • 9444293982 scopus 로고    scopus 로고
    • Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl) adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines
    • Perno CF, Balestra E, Aquaro S, Panti S, Cenci A, Lazzarino G, Tavazzi B, Di Pierro D, Balzarini J, and Calio R (1996) Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl) adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines. Mol Pharmacol 50:359-366.
    • (1996) Mol Pharmacol , vol.50 , pp. 359-366
    • Perno, C.F.1    Balestra, E.2    Aquaro, S.3    Panti, S.4    Cenci, A.5    Lazzarino, G.6    Tavazzi, B.7    Di Pierro, D.8    Balzarini, J.9    Calio, R.10
  • 28
    • 0029896847 scopus 로고    scopus 로고
    • Endogenous reverse transcription assays reveal high-level resistance to the triphosphate of (-)2′-dideoxy-3′-thiacytidine by mutated M184V HIV-1
    • Quan Y, Gu Z, Li X, Li Z, Morrow CD, and Wainberg MA (1996) Endogenous reverse transcription assays reveal high-level resistance to the triphosphate of (-)2′-dideoxy-3′-thiacytidine by mutated M184V HIV-1. J Virol 70:5642-5645.
    • (1996) J Virol , vol.70 , pp. 5642-5645
    • Quan, Y.1    Gu, Z.2    Li, X.3    Li, Z.4    Morrow, C.D.5    Wainberg, M.A.6
  • 29
    • 0029123494 scopus 로고
    • Metabolic pathways for activation of the antiviral agent 9-(2-phosphonyl-methoxyethyl)adenine in human lymphoid cells
    • Robbins BL, Greenhaw J, Connelly MC, and Fridland A (1995) Metabolic pathways for activation of the antiviral agent 9-(2-phosphonyl-methoxyethyl)adenine in human lymphoid cells. Antimicrob Agents Chemother 39:2304-2308.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 2304-2308
    • Robbins, B.L.1    Greenhaw, J.2    Connelly, M.C.3    Fridland, A.4
  • 32
    • 0030768138 scopus 로고    scopus 로고
    • Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation
    • Sharma PL and Crumpacker CS (1997) Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation. J Virol 71:8846-8851.
    • (1997) J Virol , vol.71 , pp. 8846-8851
    • Sharma, P.L.1    Crumpacker, C.S.2
  • 33
    • 0028823560 scopus 로고
    • Comparative analysis of anti-human immunodeficiency virus type 1 activities of dideoxynucleoside analogs in resting and activated peripheral blood mononuclear cells
    • Shirasaka T, Chokekijchai S, Yamada A, Gosselin G, Imbach JL, and Mitsuya H (1995) Comparative analysis of anti-human immunodeficiency virus type 1 activities of dideoxynucleoside analogs in resting and activated peripheral blood mononuclear cells. Antimicrob Agents Chemother 39:2555-2559.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 2555-2559
    • Shirasaka, T.1    Chokekijchai, S.2    Yamada, A.3    Gosselin, G.4    Imbach, J.L.5    Mitsuya, H.6
  • 35
    • 0031046557 scopus 로고    scopus 로고
    • Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2′,3′-dideoxynucleotide analogs using the single-nucleotide incorporation assay
    • Ueno T and Mitsuya H (1997) Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2′,3′-dideoxynucleotide analogs using the single-nucleotide incorporation assay. Biochemistry 36:1092-1099.
    • (1997) Biochemistry , vol.36 , pp. 1092-1099
    • Ueno, T.1    Mitsuya, H.2
  • 37
    • 0030892246 scopus 로고    scopus 로고
    • HIV-1 reverse transcriptase genotype and drug susceptibility changes in infected individuals receiving dideoxyinosine monotherapy for 1 to 2 years
    • Winters MA, Shafer RW, Jellinger RA, Mamtora G, Gingeras T, and Merigan TC (1997) HIV-1 reverse transcriptase genotype and drug susceptibility changes in infected individuals receiving dideoxyinosine monotherapy for 1 to 2 years. Antimicrob Agents Chemother 41:757-762.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 757-762
    • Winters, M.A.1    Shafer, R.W.2    Jellinger, R.A.3    Mamtora, G.4    Gingeras, T.5    Merigan, T.C.6
  • 38
    • 0028200457 scopus 로고
    • Inhibitory effects of acyclic nucleoside phosphonate analogues in hepatitis B virus DNA synthesis in HB611 cells
    • Yokota T, Konno K, Shigeta S, Holy A, Balzarini J, and De Clercq E (1994) Inhibitory effects of acyclic nucleoside phosphonate analogues in hepatitis B virus DNA synthesis in HB611 cells. Antivir Chem Chemother 5:57-63.
    • (1994) Antivir Chem Chemother , vol.5 , pp. 57-63
    • Yokota, T.1    Konno, K.2    Shigeta, S.3    Holy, A.4    Balzarini, J.5    De Clercq, E.6
  • 39
    • 0030451263 scopus 로고    scopus 로고
    • Zidovudine resistance mutations and human immunodeficiency virus type 1 DNA burden: Longitudinal evaluation of six patients under treatment
    • Zazzi M, Catucci M, De Milito A, Romano L, Venturi G, Almi P, Gonnelli A, Rubino M, and Valensin PE (1996) Zidovudine resistance mutations and human immunodeficiency virus type 1 DNA burden: longitudinal evaluation of six patients under treatment. Infection 24:419-425.
    • (1996) Infection , vol.24 , pp. 419-425
    • Zazzi, M.1    Catucci, M.2    De Milito, A.3    Romano, L.4    Venturi, G.5    Almi, P.6    Gonnelli, A.7    Rubino, M.8    Valensin, P.E.9
  • 40
    • 0028031833 scopus 로고
    • Resistance to 2′,3′-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase
    • Zhang D, Caliendo AM, Eron JJ, De Vore KM, Kaplan JC, Hirsch MS, and D'Aquila RT (1994) Resistance to 2′,3′-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother 38:282-287.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 282-287
    • Zhang, D.1    Caliendo, A.M.2    Eron, J.J.3    De Vore, K.M.4    Kaplan, J.C.5    Hirsch, M.S.6    D'Aquila, R.T.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.