Peptide antibiotics: Holy or heretic grails of innate immunity?

Scandinavian Journal of Immunology

Volumn 43, Issue 5, 1996, Pages 475-482

  Boman, H G ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

POLYPEPTIDE ANTIBIOTIC AGENT;

BACTERIAL INFECTION; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; RNA SEQUENCE; VACCINATION; XENOPUS LAEVIS;

EID: 0029971979     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1996.d01-76.x     Document Type: Review

References (51)

1. Cohn M. The wisdom of hindsight. Annu Rev Immunol 1994;12:1-62.
2. Boman HG. Antibacterial peptides: key components needed in immunity. Cell 1991;65:205-7.
3. Sahl H-G, Jack RW, Bierbaum G. Biosynthesis and biological activities of lantibiotics with unique post-translational modifications. Eur J Biochem 1995;230:827-53.
4. Boman HG, March J, Goode J, eds. Antimicrobial Peptides. Ciba Symposium no. 186. Chichester: John Wiley & Sons Ltd, 1994.
5. Hoffmann J, Natori S, Janeway C, eds. Phylogenetic Perspectives in Immunity: The Insect-Host Defense. Austin, Texas: R. G. Landes Biomedical Publisher, 1994.
6. Boman HG. Peptide antibiotics and their role in innate immunity. Annu Rev Immun 1995;13:61-92.
7. Martin E, Ganz T, Lehrer RI. Defensins and other endagenous peptide antibiotics of vertebrates. J Leukocyte Biol 1995;58:128-36.
8. Maloy WL, Kari UP. Structure-activity studies on magainins and other host defense paptides. Biopolymers 1995;37:105-22.
9. Liu L, Ganz T. The pro region of human neutrophil defensin contain a motif that is essential for normal subcellular sorting. Blood 1995;85:1095-103.
10. Couto MA, Liu L, Lehrer RI, Ganz T. Inhibition of intracellular Histoplasma capsulatum replication by murine macrophages that produce human defensin. Infect Immun 1994;62:2375-8.
11. Petersen UM, Björklund G, Ip YT, Engström Y. The dorsal-related immunity factor, dif, is a sequence-specifc transactivator of Drosophila cecropin gene expresssion. EMBO J 1995;14: 3146-58.
12. Lemaitre B, Kromermetzger E, Michaut L et al. A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense. Proc Natl Acad Sci USA 1995;92:9465-9.
13. Bevins CL, Jones DE, Dutra A, Schaffzin J, Muenke M. Human enteric defensin genes: chromosomal map position and a model for possible evolutionary relationships. Genomics 1996;31:95-106.
14. Gudmundsson GH, Magnusson KP, Chowdhary BP, Johansson M, Andersson L, Boman HG. Structure of the gene for porcine peptide antibiotic PR-39, a cathelin gene family member: comparative mapping of the locus for the human peptide antibiotic FALL-39. Proc Natl Acad Sci USA 1995;92:7085-9.
15. Epand RM, Shai YC, Segrest JP, Anantharamaiah GM. Mechanisms for the modulation of membrane bilayer properties by amyphipathic helical peptides. Biopolymers 1995;37:319-38.
16. Shai Y. Molecular recognition between membrane-spanning polypeptides. TIBS 1995;20:460-4.
17. Wade D, Boman A, Wåhlin B et al. All D-amino acid-containing channel-forming antibiotic peptides. Proc Natl Acad Sci USA 1990;87:4761-5.
18. Merrifield RB, Juvvadi P, Andreu D, Ubach J, Boman A, Boman HG. Retro and retroenantio analogs of cecropin melittin hybrids. Proc Natl Acad Sci USA 1995;92:3449-53.
19. Gazit E, Boman A, Boman HG, Shai Y. Interaction of the mammalian antibacterial peptide cecropin P1 with phospholipid vesicles. Biochemistry 1995;34:11479-88.
20. Groisman EA. How bacteria resist killing by host-defense peptides. Trends Microbiol 1994; 2:444-9.
21. Mallow EB, Harris A, Salzman N et al. Human enteric defensins, gene structure and developmental expression. J Biol Chem 1996;271:4038-45.
22. Herwig S, Su Q, Zhang W, Ma Y, Tempst P. Distinct temporal patterns of defensin mRNA regulation during drug-induced differentiation of human myeloid leukemia cells. Blood 1996;87:350-64.
23. Lehrer RI, Harwig SSL, Ganz T. Defensins and protegrins. Vertebrate analogs of arthropod antimicrobial peptides. In: Hoffmann J, Natori S, Janeway C, eds. Phylogenetic Perspectives in Immunity: The Insect-Host Defense. Austin, Texas:RG Landes Biomedical Publisher, 1994:19-29.
24. Schonwetter BS, Stolzenberg ED, Zasloff MA. Epithelial antibiotics induced at sites of inflammation. Science 1995;267:1645 8.
25. Russell JP, Diamond G, Tarver AP, Scanlin TF, Bevins CL. Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor-α. Infect Immun 1996;64: 565-8.
26. Diamond G, Russel JP, Bevins CL. Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged trcheal epithelial cells. Proc Natl Acad Sci USA 1996;93: in press.
27. Selsted ME, Ouellette AJ. Defensins in granules and non-phagocytic cells. Trends Cell Biol 1995; 5:114-19.
28. Jones DE, Bevins CL. Defensin-6 messenger RNA in human Paneth cells. Implications for antimicrobial peptides in host defense of the human bowel. FEBS Lett 1993;315:187-92.
29. Ward DM, Bateson MM, Weller R, Ruff-Roberts AL. Ribosomal RNA analysis of microrganisms as they occur in mature. Adv Microbial Ecol 1992;12:219-85.
30. Boman HG, Agerberth B, Boman A. Mechanisms of action on Escherichia coli of Cecropin-P1 and PR-39. Two antibacterial peptides from pig intestine. Infect Immun 1993;61:2978-84.
31. Gallo RL, Ono M, Povsic T et al. Syndecans, cell surface heparin sulfate proteoglycans, are induced by a prolin-rich antimicrobial peptide from wounds. Proc Natl Acad Sci USA 1994;91:11035-9.
32. Barra D, Simmaco, M. Amphibian skin: a promising resource for antimicrobial peptides. TIBTECH 1995;13:205-9.
33. Zasloff MA. Antibacterial molecules from frogs, sharks and man. In: Hoffmann J, Natori S, Janeway C, eds). Phylogenetic Perspectives in Immunity: The Insect-Host Defense. Austin, Texas: RG Landes Biomedical Publisher, 1994:31-41.
34. Del Sal G, Storici P, Schneider C, Romeo D, Zanetti M. cDNA cloning of the neutrophil bactericidal peptide indolocidin. Biochem Biophys Res Com 1992;187:467-72.
35. Levy O, Weiss J, Zarember K, Ooi CE, Elsbach P. Antibacterial 15-kDa protein isoforms (p15s) are members of a novel family of leukocyte proteins. J Biol Chem 1993;268:6058-63.
36. Zanetti M, Gennaro R, Romeo D. Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain. FEBS Lett 1995;374:1-5.
37. Mahoney MM, Lee AY, Brezinskicaliguri DJ, Huttner KM. Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide. FEBS Lett 1995;377:519-22.
38. Strukelj B, Pungercar J, Kopitar G et al. Molecular cloning and identification of a novel porcine cathelin-like antibacterial peptide precursor. Biol Chem Hoppe Seyler 1995;376:507-10.
39. Hirata M, Shimomura Y, Yoshida M et al. Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharid-inhibitory activity. Infect Immun 1994;62:1421-6.
40. Qu XD, Harwig SSL, Oren A, Shafer WM, Lehrer RI. Susceptibility of Neisseria gonorrhoeae to protegrins. Infect Immun 1996;64:1210-15.
41. Waring AJ, Harwig SSL, Lehrer RI. Structure and activity of protegrin PG-1 in model lipid membranes. PROT Peptide Lett 1996; in press.
42. Zhao CQ, Ganz T, Lehrer RI. The structure of porcine protegrin genes. FEBS Lett 1995;368:197-202.
43. Zhao C, Ganz T, Lehrer RI. Structures of genes for two cathelin-associated antimicrobial peptides: prophenin-2 and PR-39. FEBS Lett 1995;376:130-4.
44. Gudmundsson GH, Agerberth B, Odeberg J, Bergman T, Olsson B, Cedo R. The human gene FALL39 and the processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. Eur J Biochem 1996; in press.
45. Andersson M, Gunne H, Agerberth B et al. NK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity. EMBO J 1995;14:1615-625.
46. Leippe M. Ancient weapons: NK-lysin is a mammalian homolog to pore-forming peptides of a protozoan parasite. Cell 1995;83:17-18.
47. Leippe M, Andra J, Mullereberhard HJ. Cytolytic and antibacterial activity of synthetic peptides derived from amoebapore, the pore-forming peptide of Entamoeba histolytica. Proc Natl Acad Sci USA 1994;91:2602-6.
48. Andersson M, Holmgren A, Spyrou G. NK-lysin, A disulfide containing effector peptide of T-lymphocytes is reduced and inactivated by human thioredoxin reductase. Implications for a protective mechanism agaisnt NK-lysin cytotoxicity. J Biol Chem 1996; in press.
49. Frohm M, Gunne H, Agerberth B et al. Biochemical and antibacterial analysis of human wound and blister fluid. Eur J Biochem 1996;237:86-92.
50. Jerne N. The Generative Grammar of the Immune System. In: Nobel Lectures. Physiology and Medicine 1981-90. London: World Scientific, 1984:157-71.
51. Cowland JB, Johnsen AH, Borregaard N. hCAP-18, a cathelin/ pro-bactenecin-like protein of human neutrophil specific granules. FEBS Lett 1995;368:173-6.