Targeting DNA methyltransferase in cancer

Cancer and Metastasis Reviews

Volumn 17, Issue 2, 1998, Pages 219-231

  Szyf, Moshe ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Anticancer drugs; DNA demethylase; DNA methyltransferase; Methylation; Oncogenesis; Ras signaling pathway

Indexed keywords

ANTINEOPLASTIC AGENT; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE INHIBITOR; PROTEIN P21; PROTEIN P53; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; CANCER CELL; CARCINOGENESIS; COLON POLYPOSIS; CONTROLLED STUDY; DNA METHYLATION; DRUG TARGETING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LUNG CARCINOMA; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; REVIEW;

ANIMALS; CELL DIVISION; DNA METHYLATION; DNA MODIFICATION METHYLASES; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; NEOPLASMS, EXPERIMENTAL;

EID: 0031817856     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006023023787     Document Type: Review

References (72)

1. Szyf M: DNA methylation properties: consequences for pharmacology. Trends Pharmacol Sci 7: 233-238, 1994
2. Szyf M: The DNA methylation machinery as a target for anticancer therapy. Pharmacol Ther 70: 1-37, 1996
3. Adams RL, McKay EL, Craig LM, Burdon RH: Mouse DNA mathylase: methylation of native DNA. Biochim Biophys Acta 561: 345-357, 1979
4. Yisraeli J, Szyf M: The pattern of methylation of eukaryotic genes. In: Razin A, Cedar H, Riggs AD (eds) DNA Methylation: Biochemistry & Biological Significance, pp 353-378. Springer-Verlag, New York, 1984.
5. Yoder JA, Somans NS, Verdine GL, Bestor TH: DNA (cytosine-5)-methyltransferases in mouse cells and tissues. J Mol Biol 270: 385-395, 1997
6. Becker PB, Ruppert S, Schutz G: Genomic footprinting reveals cell type-specific DNA binding of ubiquitous factors. Cell 51: 435-443, 1987
7. Nan X, Campoy FJ, Bird A: MeCP2 is a transcriptional repressor with abundant binding site in genomic chromatin. Cell 88: 471-481, 1997
8. Kass SU, Landsberger N, Wolffe AP: DNA methylation direct a time-dependent repression ot transcription initiation. Curr Biol 7: 157-165, 1997
9. Zuccotti M, Monk M: Methylation of the mouse Xist gene in sperm and eggs correlates with imprinted Xist expression and paternal X-inactivation. Nature Genet 9: 316-320, 1995
10. Sapienza C, Peterson AC, Rossant J, Balling R: Degree of methylation of transgenes is dependent on gamete of origin. Nature 328: 251-254, 1987
11. Razin A, Cedar H: DNA methylation and gene expression. Microbiol Rev 55: 451-458, 1991
12. Baylin SB, Makos M, Wu JJ, Yen RW, de Bustros A, Vertino P, Nelkin BD: Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression. Cancer Cells 3: 383-390, 1991
13. Feinberg AP, Vogelstein B: Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301: 89-92, 1983
14. Ohtani-Fujita N, Fujita T, Aoike A, Osifchin NE, Robbins PD, Sakai T: CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. Oncogene 8: 1063-1067, 1993
15. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger P, Baylin SB, Sidransky D: 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers. Nature Med 1: 686-692, 1995
16. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB: Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 93: 9821-9826, 1996
17. Herman JG, Latif F, Weng Y, Lerman MI, Zbar B, Liu S, Samid D, Duan DS, Gnarra JR, Linehan WM, Baylin SB: Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 91: 9700-9704, 1994
18. Yoshiura K, Kanai Y, Ochiai A, Shimoyama Y, Sugimura T, Hirohashi S: Silencing of the E-cadherin invasion suppresor gene by CpG methylation in human carcinomas. Proc Natl Acad Sci USA 92: 7416-7419, 1995
19. Ahuja N, Mohan AL, Li Q, Stolker JM, Herman JG, Hamilton SR, Baylin SB, Issa JP: Association between CpG island methylation and microsatellite instability in colorectal cancer. Cancer Res 57: 3370-3374, 1997
20. Angel P, Karin M: The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1072: 129-157, 1991
21. Binetruy B, Smeal T, Karin M: Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature 351:122-127, 1991
22. Lowy D, Wilumsen BM: Function and regulation of Ras. Annu Rev Biochem 62: 851-891, 1993
23. Kautiainen TL, Jones PA: DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture. J Biol Chem 261: 1594-1598, 1986
24. el-Deiry WS, Nelkin BD, Celano P, Yen RW, Falco JP, Hamilton SR, Baylin SB: High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer. Proc Natl Acad Sci USA 88: 3470-3474, 1991
25. Lee PJ, Washer LL, Law DJ, Boland CR, Horon IL, Feinberg AP: Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation. Proc Natl Acad Sci USA 93: 10366-10370, 1996
26. Belinsky SA, Nikula KJ, Baylin SB, Issa J-P: Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer. Proc Natl Acad Sci USA 93: 4045-4050, 1996
27. Rouleau J, Tanigawa G, Szyf M: The mouse DNA methyltransferase 5′-region. A unique housekeeping gene promoter. J Biol Chem 267: 7368-7377, 1992
28. Rouleau J, MacLeod AR, Szyf M: Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway. J Biol Chem 270: 1595-1601, 1995
29. MacLeod AR, Rouleau J, Szyf M: Regulation of DNA methylation by the Ras signaling pathway. J Biol Chem 270: 11327-11337, 1995
30. Yang J, Deng C, Hemati N, Hanash SM, Richardson BC: Effect of mitogenic stimulation and DNA methylation on human T cell methyltransferase expression and activity. J Immunol 159: 1303-1309, 1997
31. Johnson R, Spiegelman B, Hanahan D, Wisdon R: Cellular transformation and malignancy induced by ras require c-jun. Mol Cell Biol 16: 4504-4511, 1996
32. Johnson R, van Lingen B, Papaioannou VE, Spiegelman BM: A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev 7: 1309-1317, 1993
33. MacLeod AR, Szyf M: Expression of an antisense to the DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis. J Biol Chem 270: 8037-8043, 1995
34. Ramchandani S, MacLeod AR, Pinard M, von Hofe E, Szyf M: Inhibition of tumorigenesis by a cytosine-DNA methyltransferase antisense oligodeoxynucleotide. Proc Natl Acad Sci USA 94: 684-689, 1997
35. Brinster RL, Chen HY, Messing A, van Dyke T, Levine AJ, Palmiter RD: Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell 37: 367-379, 1984
36. De Caprio JA, Ludlow JW, Figge J, Shew JY, Huang CM, Lee WH, Marsilio E, Paucha E, Livingston D: SV40 large T antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54: 275-283, 1988
37. Land H, Parada LF, Weinberg RA: Tumorigenic conversion of primary embryo fibroblasts requires al least two cooperating oncogenes. Nature 304: 596-602, 1983
38. wat1. Science 277: 1996-2000, 1997
39. Kopp MU, Winterhalter KH, Trueb B: DNA methylation accounts for the inhibition of collagen VI expression in transformed fibroblasts. Eur J Biochem 249: 489-496, 1997
40. Laird PW, Jackson-Grusby L, Fazeli A, Dickinson SL, Jung WE, Li E, Weinberg RA, Jaenisch R: Suppression of intestinal neoplasia by DNA hypomethylation. Cell 81: 197-205, 1995
41. Jackson-Grusby L, Laird PW, Magge SN, Moeller BJ, Jaenisch R: Mutagenicity of 5-aza-2′-deoxycytidine is mediated by the mammalian DNA methyltransferase. Proc Natl Acad Sci USA 94: 4681-4685, 1997
42. Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B, Clevers H: Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma. Science 275: 1784-1787, 1997
43. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP: Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 72: 141-196, 1998
44. Graff JR, Herman JG, Myohanen S, Baylin SB, Vertino PM: Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation. J Biol Chem 272: 22322-22329, 1997
45. Szyf M, Schimmer BP, Seidman JG: Nucleotide-sequence-specific de novo methylation in a somatic murine cell line. Proc Natl Acad Sci USA 86: 6853-6857, 1989
46. Vertino PM, Yen RW, Gao J, Baylin SB: De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-melhyltransferase. Mol Cell Biol 16: 4555-4565, 1996
47. Szyf M: DNA methylation patterns, an additional level of information? Biochem Cell Biol 69: 764-767, 1991
48. Martin RG, Oppenheim A: Initiation points for DNA replication in nontransformed and simian virus 40-transformed Chinese hamster lung cells. Cell 11: 859-869, 1977
49. Rein T, Zorbas H, DePamphilis M: Active mammalian replication origins are associated with a high-density cluster of mCpG dinucleotides. Mol Cell Biol 17: 416-426, 1997
50. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D: p21 is a universal inhibitor of cyclin kinases. Nature 366: 701-704, 1993
51. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM et al.: WAF1 a potential mediator of p53 tumor suppression. Cell 75: 817-825, 1993
52. Datto MB, Li Y, Panus JF, Howe DJ, Xiong Y, Wang X: Transforming growth factor β induces the cyclin-dependent kinase inhibitor of p21 through a p53-independent mechanism. Proc Natl Acad Sci USA 92: 5545-5549, 1995
53. Waga S, Hannon GJ, Beach D, Stilman B: The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369: 574-578, 1994
54. Xiong Y, Zhang H, Beach D: Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev 7: 1572-1583, 1993
55. Dimri GB, Nakanishi M, Desprez PY, Smith JR, Campisi J: Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein. Mol Cell Biol 16: 2987-2997, 1996
56. Freedman VH, Shin S: Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium. Cell 3: 355-359, 1974
57. Wu RC, Schontal AH: Activation of P53-P21(WAF1) pathway in response to disruption ol cell-matrix interactions. J Biol Chem 272: 29091-29098, 1997
58. Yang ZY, Perkins ND, Ohno T, Nabel EG, Nabel GJ: The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo. Nat Med 1: 1052-1056, 1995
59. Li R, Hannon GJ, Beach D, Stillman B: Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage. Curr Biol 6: 189-199, 1996
60. Halevy O, Novitch BG, Spicer DB, Skapek SX, Rhee J, Hannon GJ et al.: Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 267: 1018-1021, 1995
61. Shiohara M, Koike K, Komiyama A, Koeffler HP: p21WAF1 mutations and human malignancies. Leukemia Lymphoma 26: 35-41, 1997
62. Gruenbaum Y, Cedar H, Razin A: Substrate and sequence specificity of an eukaryotic DNA methylase. Nature 295: 620-622, 1982
63. Wainfan E, Dizik M, Stender M, Christman JK: Rapid appearance of hypomethylated DNA in livers of rats fed cancer-promoting, methyl-deficient diets. Cancer Res 49: 4094-4097, 1989
64. Christman JK, Sheikhnejad G, Dizik M, Abileah S, Wainfan E: Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency. Carcinogenesis 14: 551-557, 1993
65. Szyf M, Bozovic V, Tanigawa G: Growth regulation of mouse DNA methyltransferase gene expression. J Biol Chem 266: 10027-10030, 1991
66. Szyf M, Theberge J, Bozovic V: Ras induces a general DNA demethylation activity in mouse embryonal P19 cells. J Biol Chem 270: 12690-12696, 1995
67. Tucker KL, Talbot D, Lee MA, Leonhardt H, Jaenisch R: Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene. Proc Natl Acad Sci USA 93: 12920-12925, 1996
68. Jones PA: Altering gene expression with 5-azacytidine. Cell 40: 485-486, 1985
69. Wu JC, Santi DV: On the mechanism and inhibition of DNA cytosine methyltransferases. Prog Clinic Biol Res 198: 119-129, 1985
70. Jutterman R, Li E, Jaenisch R: Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci USA 91: 11797-11801, 1994
71. Akhtar S, Agrawal S: In vivo studies with antisense oligonucleotides. Trends Pharmacol Sci 18: 12-18, 1997
72. Szyf M, Rouleau J, Theberge J, Bozovic V: Induction of myogenic differentiation by an expression vector encoding the DNA methyltransferase cDNA sequence in the antisense orientation. J Biol Chem 267: 12831-12836, 1992