메뉴 건너뛰기




Volumn 76, Issue 7, 1998, Pages 512-524

Recent developments in molecular action of antihormones

Author keywords

Antiandrogen; Antiestrogen; Antihormone withdrawal syndrome; Antiprogesterone; Mutant receptors

Indexed keywords

11 [4 (2 DIMETHYLAMINOETHOXY)PHENYL]ESTRADIOL; ANDROGEN RECEPTOR; ANTIANDROGEN; ANTIESTROGEN; ANTIGESTAGEN; CYCLIN D1; ESTROGEN RECEPTOR; FULVESTRANT; GONADORELIN; LILOPRISTONE; MIFEPRISTONE; MUTANT PROTEIN; ONAPRISTONE; PROGESTERONE; PROGESTERONE RECEPTOR; RETINOIC ACID RECEPTOR; SEX HORMONE; STEROID RECEPTOR; TAMOXIFEN;

EID: 0031812663     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090050245     Document Type: Review
Times cited : (16)

References (166)
  • 1
    • 0023913120 scopus 로고
    • The steroid and thyroid hormone receptor superfamily
    • Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240:889-895
    • (1988) Science , vol.240 , pp. 889-895
    • Evans, R.M.1
  • 2
    • 0024545638 scopus 로고
    • Gene regulation by steroid hormones
    • Beato M (1989) Gene regulation by steroid hormones. Cell 56: 335-344
    • (1989) Cell , vol.56 , pp. 335-344
    • Beato, M.1
  • 3
    • 0029618368 scopus 로고
    • Steroid hormone receptor: Many actors in search of a plot
    • Beato M, Herrlich P, Schütz, G (1995) Steroid hormone receptor: many actors in search of a plot. Cell 83:851-857
    • (1995) Cell , vol.83 , pp. 851-857
    • Beato, M.1    Herrlich, P.2    Schütz, G.3
  • 4
    • 0028283503 scopus 로고
    • Molecular mechanisms of action of steroid/thyroid hormone receptor superfamily members
    • Tsui M-J, O'Malley BW (1994) Molecular mechanisms of action of steroid/thyroid hormone receptor superfamily members. Ann Rev Biochem 63:451-486
    • (1994) Ann Rev Biochem , vol.63 , pp. 451-486
    • Tsui, M.-J.1    O'Malley, B.W.2
  • 6
    • 0019993591 scopus 로고
    • Effect d'un steroid antiprogesterone chez, la femme interruption du cycle menstruel de la grosseese au debut
    • Herrman W, Wyss R, Rinodel A, Philibert D, Teutsch G, Sakiz E, Baulieu E (1982) Effect d'un steroid antiprogesterone chez, la femme interruption du cycle menstruel de la grosseese au debut. CR Acad Sci 294:933-938
    • (1982) CR Acad Sci , vol.294 , pp. 933-938
    • Herrman, W.1    Wyss, R.2    Rinodel, A.3    Philibert, D.4    Teutsch, G.5    Sakiz, E.6    Baulieu, E.7
  • 7
    • 0024470651 scopus 로고
    • Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor
    • Baulieu E (1989) Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor. Science 245: 1351-1357
    • (1989) Science , vol.245 , pp. 1351-1357
    • Baulieu, E.1
  • 9
    • 0027296395 scopus 로고
    • Mifepristone (RU 486) - A modulator of progestin and glucocorticoid action
    • Spitz IM, Bardin CW (1993) Mifepristone (RU 486) - a modulator of progestin and glucocorticoid action. N Engl J Med 329:404-412
    • (1993) N Engl J Med , vol.329 , pp. 404-412
    • Spitz, I.M.1    Bardin, C.W.2
  • 10
    • 0027525305 scopus 로고
    • Clinical pharmacology of RU 486 - An antiprogestin and antiglucocorticoid
    • Spitz IM, Bardin CW (1993) Clinical pharmacology of RU 486 - an antiprogestin and antiglucocorticoid. Contraception 48:403-144
    • (1993) Contraception , vol.48 , pp. 403-1144
    • Spitz, I.M.1    Bardin, C.W.2
  • 13
    • 0028040033 scopus 로고
    • Termination of early pregnancy with ZK 98,734:pharmacokinetic behavior and clinical effect
    • Swahn M-L, Kovacs E, Cekan SZ, Aedo A-A, Westlund P (1994) Termination of early pregnancy with ZK 98,734:pharmacokinetic behavior and clinical effect. Hum Reprod 9:57-63
    • (1994) Hum Reprod , vol.9 , pp. 57-63
    • Swahn, M.-L.1    Kovacs, E.2    Cekan, S.Z.3    Aedo, A.-A.4    Westlund, P.5
  • 14
    • 0023571530 scopus 로고
    • Disruption of follicular maturation and delay of ovulation after administration of the antiprogesterone RU 486
    • Liu JH, Garzo G, Morris S, Stuenkel CA, Ulman A, Yen SSC (1987) Disruption of follicular maturation and delay of ovulation after administration of the antiprogesterone RU 486. J Clin Endocrinol Metab 65:1135-1140
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 1135-1140
    • Liu, J.H.1    Garzo, G.2    Morris, S.3    Stuenkel, C.A.4    Ulman, A.5    Yen, S.S.C.6
  • 15
    • 0023579662 scopus 로고
    • Effects of the antiprogesterone RU 486 in normal women. II. Administration in the late follicular phase
    • Shoupe D, Mishell DJ, Page MA, Madkour H, Spitz IM, Lobo RA (1987) Effects of the antiprogesterone RU 486 in normal women. II. Administration in the late follicular phase. Am J Obstet Gynecol 157:1421-1426
    • (1987) Am J Obstet Gynecol , vol.157 , pp. 1421-1426
    • Shoupe, D.1    Mishell, D.J.2    Page, M.A.3    Madkour, H.4    Spitz, I.M.5    Lobo, R.A.6
  • 16
    • 0023914163 scopus 로고
    • Inhibition of folliculogenesis and ovulation by the antiprogesterone RU 486
    • Luukkainen T, Heikinheimo O (1988) Inhibition of folliculogenesis and ovulation by the antiprogesterone RU 486. Fertil Steril 49:961-963
    • (1988) Fertil Steril , vol.49 , pp. 961-963
    • Luukkainen, T.1    Heikinheimo, O.2
  • 17
    • 0026717896 scopus 로고
    • Interruption of endometrial maturation without hormonal changes by an antiprogesterone during the first half of the luteal phase of the menstrual cycle: A contraceptive potential
    • Greene KE, Kettel EM, Yen SSC (1992) Interruption of endometrial maturation without hormonal changes by an antiprogesterone during the first half of the luteal phase of the menstrual cycle: a contraceptive potential. Fertil Steril 58:338-343
    • (1992) Fertil Steril , vol.58 , pp. 338-343
    • Greene, K.E.1    Kettel, E.M.2    Yen, S.S.C.3
  • 18
    • 0027481262 scopus 로고
    • Effects of continuous treatment with low dose mifepristone throughout one menstrual cycle
    • Croxatto H, Salvatierra AM, Fuentealba B (1993) Effects of continuous treatment with low dose mifepristone throughout one menstrual cycle. Hum Reprod 8:201-207
    • (1993) Hum Reprod , vol.8 , pp. 201-207
    • Croxatto, H.1    Salvatierra, A.M.2    Fuentealba, B.3
  • 19
    • 0026695314 scopus 로고
    • Delayed endometrial maturation induced by daily administration of the antiprogestin RU486: A potential new contraceptive strategy
    • Batista M, Cartledge T, Zellnier A, Merino M, Axiotis C, Loriaux E, Nieman E (1992) Delayed endometrial maturation induced by daily administration of the antiprogestin RU486: a potential new contraceptive strategy. Am J Obstet Gynecol 167:60-65
    • (1992) Am J Obstet Gynecol , vol.167 , pp. 60-65
    • Batista, M.1    Cartledge, T.2    Zellnier, A.3    Merino, M.4    Axiotis, C.5    Loriaux, E.6    Nieman, E.7
  • 20
    • 0027200597 scopus 로고
    • Treatment with a progesterone antagonist ZK 98,299 delays endometrial development without blocking ovulation in bonnet monkeys
    • Ishward P, Katkam R, Hinduja I, Chwalisz K, Elger W, Puri C (1993) Treatment with a progesterone antagonist ZK 98,299 delays endometrial development without blocking ovulation in bonnet monkeys. Contraception 48:57-70
    • (1993) Contraception , vol.48 , pp. 57-70
    • Ishward, P.1    Katkam, R.2    Hinduja, I.3    Chwalisz, K.4    Elger, W.5    Puri, C.6
  • 21
    • 0024791247 scopus 로고
    • Noneompetitive antiestrogenic effect of RU 486 in blocking the estrogen-stimulated luteinizing hormone surge and the proliferative action of estradiol on endometrium in castrated monkeys
    • Wolf JP, Hsiu J, Anderson T, Ulmann A, Baulieu EE, Hodgen G (1989) Noneompetitive antiestrogenic effect of RU 486 in blocking the estrogen-stimulated luteinizing hormone surge and the proliferative action of estradiol on endometrium in castrated monkeys. Fertil Steril 52:1055-1060
    • (1989) Fertil Steril , vol.52 , pp. 1055-1060
    • Wolf, J.P.1    Hsiu, J.2    Anderson, T.3    Ulmann, A.4    Baulieu, E.E.5    Hodgen, G.6
  • 22
    • 0025917499 scopus 로고
    • Inhibition of the estradiol-mediated endometrial gland formation by the antigestagen onapristone in rabbits: Relationship to uterine estroszen receptors
    • Chwalisz K, Hegele-Hartung C, Fritzemeier K-H, Beier HM, Elger W (1991) Inhibition of the estradiol-mediated endometrial gland formation by the antigestagen onapristone in rabbits: relationship to uterine estroszen receptors. Endocrinology 129:312-322
    • (1991) Endocrinology , vol.129 , pp. 312-322
    • Chwalisz, K.1    Hegele-Hartung, C.2    Fritzemeier, K.-H.3    Beier, H.M.4    Elger, W.5
  • 24
    • 0027467445 scopus 로고
    • Regression of uterine leiomyomata in response to the anti-progesterone RU486
    • Murphy A, Kettel M, Morales A, Roberts V, Yen S (1993) Regression of uterine leiomyomata in response to the anti-progesterone RU486. J Clin Endocr Metab 76:513-517
    • (1993) J Clin Endocr Metab , vol.76 , pp. 513-517
    • Murphy, A.1    Kettel, M.2    Morales, A.3    Roberts, V.4    Yen, S.5
  • 27
    • 7144238535 scopus 로고    scopus 로고
    • Onapristone, a progesterone receptor antagonist, as first line endocrine therapy in primary breast cancer
    • poster 515
    • Robertson, JFR, Wilhser P, Blamey RW (1996) Onapristone, a progesterone receptor antagonist, as first line endocrine therapy in primary breast cancer (poster 515). In: 19th Annual San Antonio Breast Cancer Symposium
    • (1996) 19th Annual San Antonio Breast Cancer Symposium
    • Robertson, J.F.R.1    Wilhser, P.2    Blamey, R.W.3
  • 29
    • 0025239785 scopus 로고
    • Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B
    • Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H, Chambon P (1990) Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J 9:1603-1614
    • (1990) EMBO J , vol.9 , pp. 1603-1614
    • Kastner, P.1    Krust, A.2    Turcotte, B.3    Stropp, U.4    Tora, L.5    Gronemeyer, H.6    Chambon, P.7
  • 30
    • 0023545241 scopus 로고
    • The A and B forms of the chicken progesterone receptor arise by alternate initiation of translation of a unique mRNA
    • Conneely OM, Maxwell BE, Toft DO, Schrader WT, O'Malley BW (1987) The A and B forms of the chicken progesterone receptor arise by alternate initiation of translation of a unique mRNA. Biochem Biophys Res Commun 149:493-501
    • (1987) Biochem Biophys Res Commun , vol.149 , pp. 493-501
    • Conneely, O.M.1    Maxwell, B.E.2    Toft, D.O.3    Schrader, W.T.4    O'Malley, B.W.5
  • 31
    • 0027494065 scopus 로고
    • Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors
    • Tung L, Mohamed MK, Hoeffler JP, Takimoto GS, Horwitz KB (1993) Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors. Mol Endocrinol 7:1256-1265
    • (1993) Mol Endocrinol , vol.7 , pp. 1256-1265
    • Tung, L.1    Mohamed, M.K.2    Hoeffler, J.P.3    Takimoto, G.S.4    Horwitz, K.B.5
  • 32
    • 0027427216 scopus 로고
    • Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function
    • Vegeto E, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP (1993) Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Mol Endoerinol 7:1244-55
    • (1993) Mol Endoerinol , vol.7 , pp. 1244-1255
    • Vegeto, E.1    Shahbaz, M.M.2    Wen, D.X.3    Goldman, M.E.4    O'Malley, B.W.5    McDonnell, D.P.6
  • 33
    • 0027081043 scopus 로고
    • Ligand-dependent conformational changes in the progesterone receptor are necessary for events that follow DNA binding
    • Allan GE, Tsai SY, Tsai M-J, O'Malley BW (1992) Ligand-dependent conformational changes in the progesterone receptor are necessary for events that follow DNA binding. Proc Natl Acad Sci USA 89:11750-11754
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11750-11754
    • Allan, G.E.1    Tsai, S.Y.2    Tsai, M.-J.3    O'Malley, B.W.4
  • 34
    • 0026653659 scopus 로고
    • The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor
    • Vegeto E, Allan GF, Schrader WT, Tsai M-J, McDonnell DP, O'Malley BW (1992) The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. Cell 69:703-713
    • (1992) Cell , vol.69 , pp. 703-713
    • Vegeto, E.1    Allan, G.F.2    Schrader, W.T.3    Tsai, M.-J.4    McDonnell, D.P.5    O'Malley, B.W.6
  • 35
    • 0026786105 scopus 로고
    • Ligands induce conformational changes in the carboxyl-terminus of progesterone receptors which are detected by a site-directed antipeptide monoclonal antibody
    • Weigel NL, Beck CA, Estes PA, Prendergast P, Altmann M, Christensen K, Edwards DP (1992) Ligands induce conformational changes in the carboxyl-terminus of progesterone receptors which are detected by a site-directed antipeptide monoclonal antibody. Mol Endocrinol 6:1585-1597
    • (1992) Mol Endocrinol , vol.6 , pp. 1585-1597
    • Weigel, N.L.1    Beck, C.A.2    Estes, P.A.3    Prendergast, P.4    Altmann, M.5    Christensen, K.6    Edwards, D.P.7
  • 36
    • 0029026914 scopus 로고
    • Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor
    • Clemm DL, Macy BL, Santiso-Mere D, McDonnell DP (1995) Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor. J Steroid Biochem Mol Biol 53:487-495
    • (1995) J Steroid Biochem Mol Biol , vol.53 , pp. 487-495
    • Clemm, D.L.1    Macy, B.L.2    Santiso-Mere, D.3    McDonnell, D.P.4
  • 38
    • 0029757966 scopus 로고    scopus 로고
    • 16 Alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity
    • Wagner BL, Pollio G, Leonhardt S, Wani MC, Lee DY, Imhof MO, Edwards DP, Cook CE, McDonnell DP (1996) 16 Alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity. Proc Natl Acad Sci USA 93: 8739-8744
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8739-8744
    • Wagner, B.L.1    Pollio, G.2    Leonhardt, S.3    Wani, M.C.4    Lee, D.Y.5    Imhof, M.O.6    Edwards, D.P.7    Cook, C.E.8    McDonnell, D.P.9
  • 41
    • 0021610642 scopus 로고
    • New steroids with antiprogestational and antiglucocorticoid activities
    • Neef G, Beier S, Elger W, Henderson D; Wiechert R (1984) New steroids with antiprogestational and antiglucocorticoid activities. Steroids 44:349-372
    • (1984) Steroids , vol.44 , pp. 349-372
    • Neef, G.1    Beier, S.2    Elger, W.3    Henderson, D.4    Wiechert, R.5
  • 42
    • 0026096890 scopus 로고
    • Two types of antiprogestines identified by their differential action in transcriptionally active extracts from T47D cells
    • Klein-Hitpass L, Cato ACB, Henderson D, Ryffel GU (1991) Two types of antiprogestines identified by their differential action in transcriptionally active extracts from T47D cells. Nucleic Acids Res 19:1227-1233
    • (1991) Nucleic Acids Res , vol.19 , pp. 1227-1233
    • Klein-Hitpass, L.1    Cato, A.C.B.2    Henderson, D.3    Ryffel, G.U.4
  • 46
    • 0024434594 scopus 로고
    • Human progesterone receptor complexed with the antagonist RU 486 binds to hormone response elements in a structurally altered form
    • El-Ashry D, Onate SA, Nordeen SK, Edwards DP (1990) Human progesterone receptor complexed with the antagonist RU 486 binds to hormone response elements in a structurally altered form. Mol Endocrinol 3:1545-1558
    • (1990) Mol Endocrinol , vol.3 , pp. 1545-1558
    • El-Ashry, D.1    Onate, S.A.2    Nordeen, S.K.3    Edwards, D.P.4
  • 47
    • 0027195589 scopus 로고
    • In vivo evidence against the existence of antiprogestines disrupting receptor binding to DNA
    • Delabre K, Guichon-Mantel A, Milgrom E (1993) In vivo evidence against the existence of antiprogestines disrupting receptor binding to DNA. Proc Natl Acad Sci USA 90:4421-4425
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4421-4425
    • Delabre, K.1    Guichon-Mantel, A.2    Milgrom, E.3
  • 48
    • 0028052137 scopus 로고
    • Antiprogestines prevent progesterone receptor binding to hormone responsive elements in vivo
    • Truss M, Bartsch J, Beato M (1994) Antiprogestines prevent progesterone receptor binding to hormone responsive elements in vivo. Proc Natl Acad Sci USA 91:11333-11337
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11333-11337
    • Truss, M.1    Bartsch, J.2    Beato, M.3
  • 49
    • 0029168036 scopus 로고
    • Identification of a group of Ser-Pro motif hormone-inducible phosphorylation sites in the human progesterone receptor
    • Zhang Y, Beck CA, Poletti A, Edwards DP, Weigel NL (1995) Identification of a group of Ser-Pro motif hormone-inducible phosphorylation sites in the human progesterone receptor. Mol Endocrinol 9:1029-1040
    • (1995) Mol Endocrinol , vol.9 , pp. 1029-1040
    • Zhang, Y.1    Beck, C.A.2    Poletti, A.3    Edwards, D.P.4    Weigel, N.L.5
  • 50
    • 0024508880 scopus 로고
    • Phosphotryptic peptide analysis of human progesterone receptors
    • Sheridan PL, Evans RM, Horwitz KB (1989) Phosphotryptic peptide analysis of human progesterone receptors. J Biol Chem 264:6520-6528
    • (1989) J Biol Chem , vol.264 , pp. 6520-6528
    • Sheridan, P.L.1    Evans, R.M.2    Horwitz, K.B.3
  • 51
    • 0028305348 scopus 로고
    • Multiple signaling pathways activate the chicken progesterone receptor
    • Zhang Y, Bai W, Allgood VE, Weigel NL (1994) Multiple signaling pathways activate the chicken progesterone receptor. Mol Endocrinol 8:577-584
    • (1994) Mol Endocrinol , vol.8 , pp. 577-584
    • Zhang, Y.1    Bai, W.2    Allgood, V.E.3    Weigel, N.L.4
  • 52
    • 0026559680 scopus 로고
    • Hormone-induced progesterone receptor phosphorylation consists of sequential DNA-independent and DNA-dependent stages: Analysis with zinc finger mutants and the progesterone antagonist ZK98299
    • Takimoto GS, Tasset DM, Eppert AC, Horwitz KB (1992) Hormone-induced progesterone receptor phosphorylation consists of sequential DNA-independent and DNA-dependent stages: analysis with zinc finger mutants and the progesterone antagonist ZK98299. Proc Natl Acad Sci USA 89: 3050-3054
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3050-3054
    • Takimoto, G.S.1    Tasset, D.M.2    Eppert, A.C.3    Horwitz, K.B.4
  • 53
    • 0030052297 scopus 로고    scopus 로고
    • Two types of anti-progestins have distinct effects on site-specific phosphorylation of human progesterone receptor
    • Beck CA, Zhang Y, Weigel NL, Edwards DP (1996) Two types of anti-progestins have distinct effects on site-specific phosphorylation of human progesterone receptor. J Biol Chem 271:1209-1217
    • (1996) J Biol Chem , vol.271 , pp. 1209-1217
    • Beck, C.A.1    Zhang, Y.2    Weigel, N.L.3    Edwards, D.P.4
  • 54
    • 0027191140 scopus 로고
    • The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways Proc
    • Beck CA, Weigel NL, Mover ML, Nordeen SK, Edwards DP (1992) The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways Proc Natl Acad Sci USA 90:4441-4445
    • (1992) Natl Acad Sci USA , vol.90 , pp. 4441-4445
    • Beck, C.A.1    Weigel, N.L.2    Mover, M.L.3    Nordeen, S.K.4    Edwards, D.P.5
  • 55
    • 0027156480 scopus 로고
    • Antagonist-occupied human progesterone receptors hound to DNA are functionally switched to transcriptional agonists by cAMP
    • Sartorius CA, Tung L, Takimoto GS, Horwitz KB (1993) Antagonist-occupied human progesterone receptors hound to DNA are functionally switched to transcriptional agonists by cAMP. J Biol Chem 268:9262-9266
    • (1993) J Biol Chem , vol.268 , pp. 9262-9266
    • Sartorius, C.A.1    Tung, L.2    Takimoto, G.S.3    Horwitz, K.B.4
  • 56
    • 0028026693 scopus 로고
    • New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: Only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cAMP
    • Sartorius CA, Groshong SD, Miller LA, Powell RL, Tung L, Takimoto GS, Horwitz KB (1994) New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cAMP. Cancer Res 54:3868-3877
    • (1994) Cancer Res , vol.54 , pp. 3868-3877
    • Sartorius, C.A.1    Groshong, S.D.2    Miller, L.A.3    Powell, R.L.4    Tung, L.5    Takimoto, G.S.6    Horwitz, K.B.7
  • 57
    • 0021931574 scopus 로고
    • Endometrial and pituitary responses to the steroidal antiprogestin RU486 in postmenopausal women
    • Gravanis A, Schaison G, George M (1985) Endometrial and pituitary responses to the steroidal antiprogestin RU486 in postmenopausal women. J. Clin Endocr Metab 60:156-163
    • (1985) J. Clin Endocr Metab , vol.60 , pp. 156-163
    • Gravanis, A.1    Schaison, G.2    George, M.3
  • 58
    • 0024811660 scopus 로고
    • The antitumor mechanism of progesterone antagonists is a receptor mediated antiproliferative effect by induction of terminal cell death
    • Michna H, Schneider MR, Nishino Y, El Etreby MF (1989) The antitumor mechanism of progesterone antagonists is a receptor mediated antiproliferative effect by induction of terminal cell death. J Steroid Biochem 34:447-453
    • (1989) J Steroid Biochem , vol.34 , pp. 447-453
    • Michna, H.1    Schneider, M.R.2    Nishino, Y.3    El Etreby, M.F.4
  • 59
    • 7144233948 scopus 로고
    • Antitumor activity and mechanism of action of the progesterone antagonist in experimental breast cancer
    • Masobrio M, Menato G, Cassoni P, Simonetta M (eds) Moduzzi, Bologna
    • Schneider MR, Michna H, Nishino Y, Henderson D (1991) Antitumor activity and mechanism of action of the progesterone antagonist in experimental breast cancer In: Masobrio M, Menato G, Cassoni P, Simonetta M (eds) Attualita endocrine in oncologia ginecologica e in medicina del riproduzione. Moduzzi, Bologna, pp 90-105
    • (1991) Attualita Endocrine in Oncologia Ginecologica e in Medicina del Riproduzione , pp. 90-105
    • Schneider, M.R.1    Michna, H.2    Nishino, Y.3    Henderson, D.4
  • 60
    • 0026636999 scopus 로고
    • The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer?
    • Horwitz KB (1992) The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer? Endocr Rev 13:146-163
    • (1992) Endocr Rev , vol.13 , pp. 146-163
    • Horwitz, K.B.1
  • 62
    • 0027527240 scopus 로고
    • Effects of the progestin antagonist RU 486 on T-47D cell cycle kinetics and cell cycle regulatory genes
    • Musgrove EA, Sutherland RL (1993) Effects of the progestin antagonist RU 486 on T-47D cell cycle kinetics and cell cycle regulatory genes. Biochem Biophys Res Commun 195: 1184-1190
    • (1993) Biochem Biophys Res Commun , vol.195 , pp. 1184-1190
    • Musgrove, E.A.1    Sutherland, R.L.2
  • 63
    • 0027299883 scopus 로고
    • Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression
    • Musgrove E, Hamilton J, Lee C, Sweeny K, Watts C, Sutherland R (1993) Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression. Mol Cel Biol 13:3577-3587
    • (1993) Mol Cel Biol , vol.13 , pp. 3577-3587
    • Musgrove, E.1    Hamilton, J.2    Lee, C.3    Sweeny, K.4    Watts, C.5    Sutherland, R.6
  • 64
    • 0031032142 scopus 로고    scopus 로고
    • Antiprogestin inhibition of cell cycle progression in T-47D breast cancer cells is accompanied by induction of the cyclin-dependent kinase inhibitor p21
    • Musgrove, EA, Lee CSL, Cornish AL, Swarbrick A, Sutherland RL (1997) Antiprogestin inhibition of cell cycle progression in T-47D breast cancer cells is accompanied by induction of the cyclin-dependent kinase inhibitor p21. Mol Endocrinol 11:54-66
    • (1997) Mol Endocrinol , vol.11 , pp. 54-66
    • Musgrove, E.A.1    Lee, C.S.L.2    Cornish, A.L.3    Swarbrick, A.4    Sutherland, R.L.5
  • 66
    • 0025062215 scopus 로고
    • Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen
    • Berry M, Metzger D, Chambon P (1990) Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen. EMBO J 9:2811-2818
    • (1990) EMBO J , vol.9 , pp. 2811-2818
    • Berry, M.1    Metzger, D.2    Chambon, P.3
  • 68
    • 0003193675 scopus 로고
    • Systemic treatment of early breast cancer by hormonal, cytotoxic or immune therapy
    • Early Breast Cancer Trialists' Collaborative Group (1992) Systemic treatment of early breast cancer by hormonal, cytotoxic or immune therapy. Lancet 339:1-15
    • (1992) Lancet , vol.339 , pp. 1-15
  • 69
    • 0019478633 scopus 로고
    • Clinical aspects and development of anti-estrogen therapy: A review of the endocrine effects of tamoxifen in animals and man
    • Patterson JS (1981) Clinical aspects and development of anti-estrogen therapy: a review of the endocrine effects of tamoxifen in animals and man. J Endocrinol 89:323-329
    • (1981) J Endocrinol , vol.89 , pp. 323-329
    • Patterson, J.S.1
  • 70
    • 0027412216 scopus 로고
    • High grade endometrial carcinoma in tamoxifen treated breast cancer patients
    • Magriples A, Naftolin F, Scharz PE (1993) High grade endometrial carcinoma in tamoxifen treated breast cancer patients. J Clin Oncol 11:485-490
    • (1993) J Clin Oncol , vol.11 , pp. 485-490
    • Magriples, A.1    Naftolin, F.2    Scharz, P.E.3
  • 72
    • 0026395885 scopus 로고
    • A potent specific pure antiestrogen with clinical potential
    • Wakeling AE, Dukes M, Bowler J (1991) A potent specific pure antiestrogen with clinical potential. Cancer Res 51:3867-3873
    • (1991) Cancer Res , vol.51 , pp. 3867-3873
    • Wakeling, A.E.1    Dukes, M.2    Bowler, J.3
  • 77
    • 0029877913 scopus 로고    scopus 로고
    • Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
    • Bunone G, Briand P-A, Miksicek J, Picard D (1996) Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J 15:2174-2183
    • (1996) EMBO J , vol.15 , pp. 2174-2183
    • Bunone, G.1    Briand, P.-A.2    Miksicek, J.3    Picard, D.4
  • 79
    • 0026410042 scopus 로고
    • Differential DNA-binding abilities of estrogen receptor occupied with two classes of antiestrogens: Studies using human estrogen recpeptor overexpressed in mammalian cells
    • Reese JC, Katzenellenbogen B (1991) Differential DNA-binding abilities of estrogen receptor occupied with two classes of antiestrogens: studies using human estrogen recpeptor overexpressed in mammalian cells. Nucleic Acids Res 19:6595-6602
    • (1991) Nucleic Acids Res , vol.19 , pp. 6595-6602
    • Reese, J.C.1    Katzenellenbogen, B.2
  • 80
    • 0029044210 scopus 로고
    • Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo
    • Metzger D, Berry M, Ali S, Chambon P (1995) Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo. Mol Endocrinol 9:579-590
    • (1995) Mol Endocrinol , vol.9 , pp. 579-590
    • Metzger, D.1    Berry, M.2    Ali, S.3    Chambon, P.4
  • 81
    • 0029883292 scopus 로고    scopus 로고
    • Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines
    • Pink JJ, Jordan VC (1996) Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines. Cancer Res 56:2321-2330
    • (1996) Cancer Res , vol.56 , pp. 2321-2330
    • Pink, J.J.1    Jordan, V.C.2
  • 82
    • 0025084510 scopus 로고
    • Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization
    • Fawell SE, White R, Hoare S, Sydenham M, Page M, Parker MG (1990) Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization. Proc Natl Acad Sci 87: 6883-6887
    • (1990) Proc Natl Acad Sci , vol.87 , pp. 6883-6887
    • Fawell, S.E.1    White, R.2    Hoare, S.3    Sydenham, M.4    Page, M.5    Parker, M.G.6
  • 83
    • 0026341234 scopus 로고
    • Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers
    • Pham TA, Elusion JF, Nawaz Z, McDonell D, Tsai M-J, O'Malley BW (1991) Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers. Proc Natl Acad Sci 88:3125-3129
    • (1991) Proc Natl Acad Sci , vol.88 , pp. 3125-3129
    • Pham, T.A.1    Elusion, J.F.2    Nawaz, Z.3    McDonell, D.4    Tsai, M.-J.5    O'Malley, B.W.6
  • 84
    • 0026410042 scopus 로고
    • Differential DNA-binding abilities of estrogen receptor occupied with two classes of antiestrogens: Studies using human estrogen receptor overexpressed in mammalian cells
    • Reese JC, Katzenellenbogen BS (1991) Differential DNA-binding abilities of estrogen receptor occupied with two classes of antiestrogens: studies using human estrogen receptor overexpressed in mammalian cells. Nucleic Acids Res 19: 6595-6602
    • (1991) Nucleic Acids Res , vol.19 , pp. 6595-6602
    • Reese, J.C.1    Katzenellenbogen, B.S.2
  • 85
    • 0026784736 scopus 로고
    • Effects of antioestrogens in the DNA binding activity of estrogen receptors in vitro
    • Arbuckle ND, Dauvois S, Parker MG (1992) Effects of antioestrogens in the DNA binding activity of estrogen receptors in vitro. Nucleic Acids Res 20:3839-3844
    • (1992) Nucleic Acids Res , vol.20 , pp. 3839-3844
    • Arbuckle, N.D.1    Dauvois, S.2    Parker, M.G.3
  • 86
    • 0026560435 scopus 로고
    • Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover
    • Dauvois S, Danielian PS, White R, Parker MG (1992) Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover. Proc Natl Acad Sci 89:4037-4041
    • (1992) Proc Natl Acad Sci , vol.89 , pp. 4037-4041
    • Dauvois, S.1    Danielian, P.S.2    White, R.3    Parker, M.G.4
  • 87
    • 0029916220 scopus 로고    scopus 로고
    • Short-term effects of pure anti-estrogen ICI 182780 treatment on oestrogen receptor, epidermal growth factor receptor and transforming growth factor-alpha protein expression in human breast cancer
    • McClelland RA, Gee JMW, Francis AB, Robertson JFR, Blamey RW, Wakeling AE, Nicholson RI (1996) Short-term effects of pure anti-estrogen ICI 182780 treatment on oestrogen receptor, epidermal growth factor receptor and transforming growth factor-alpha protein expression in human breast cancer. Eur J Cancer 32A:413-416
    • (1996) Eur J Cancer , vol.32 A , pp. 413-416
    • McClelland, R.A.1    Gee, J.M.W.2    Francis, A.B.3    Robertson, J.F.R.4    Blamey, R.W.5    Wakeling, A.E.6    Nicholson, R.I.7
  • 88
    • 0024464667 scopus 로고
    • Upregulation of estrogen receptors by nonsteroidal antiestrogens in human breast cancer
    • Kiang DT, Kollander RE, Thomas T, Kennedy BJ (1989) Upregulation of estrogen receptors by nonsteroidal antiestrogens in human breast cancer. Cancer Res 49:5312-5316
    • (1989) Cancer Res , vol.49 , pp. 5312-5316
    • Kiang, D.T.1    Kollander, R.E.2    Thomas, T.3    Kennedy, B.J.4
  • 89
    • 0027475326 scopus 로고
    • Upregulation of estrogen receptor by tamoxifen in human breast cancer
    • Noguchi S, Motomura K, Inaji H, Imaoka S, Koyama H (1993) Upregulation of estrogen receptor by tamoxifen in human breast cancer. Cancer 71:1266-1276
    • (1993) Cancer , vol.71 , pp. 1266-1276
    • Noguchi, S.1    Motomura, K.2    Inaji, H.3    Imaoka, S.4    Koyama, H.5
  • 90
    • 0028977917 scopus 로고
    • Antiestrogenic activity of two 11-estradiol derivatives on MCF-7 breast cancer cells
    • Jin L, Borrás M, Lacroix M, Legros N, Leclercq G (1995) Antiestrogenic activity of two 11-estradiol derivatives on MCF-7 breast cancer cells. Steroids 60:512-518
    • (1995) Steroids , vol.60 , pp. 512-518
    • Jin, L.1    Borrás, M.2    Lacroix, M.3    Legros, N.4    Leclercq, G.5
  • 92
    • 0027768899 scopus 로고
    • The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling
    • Dauvois S, White R, Parker MG (1993) The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling. J Cell Sci 106:1377-1388
    • (1993) J Cell Sci , vol.106 , pp. 1377-1388
    • Dauvois, S.1    White, R.2    Parker, M.G.3
  • 93
    • 0029147741 scopus 로고
    • Repression of the interleukin-6 promoter by estroizen receptor is mediated by NF-κB and C/EBP
    • Stein B, Yang MX (1995) Repression of the interleukin-6 promoter by estroizen receptor is mediated by NF-κB and C/EBP. Mol Cell Biol 15:4971-4979
    • (1995) Mol Cell Biol , vol.15 , pp. 4971-4979
    • Stein, B.1    Yang, M.X.2
  • 94
    • 0029889675 scopus 로고    scopus 로고
    • Involvement of CCA-AT/Enhancer-binding protein and nuclear factor-κB binding sites in interleukin-6 promoter inhibition by estroens
    • Galien R, Evans HF, Garcia T (1996) Involvement of CCA-AT/Enhancer-binding protein and nuclear factor-κB binding sites in interleukin-6 promoter inhibition by estroens. Mol Endocrinol 10:713-722
    • (1996) Mol Endocrinol , vol.10 , pp. 713-722
    • Galien, R.1    Evans, H.F.2    Garcia, T.3
  • 95
    • 0028901194 scopus 로고
    • Tamoxifen activation of the estrogen receptor/AP-1 pathway: Potential origin for the cell specific estrogen like effects of antiestrogens
    • Webb P, Lopez GN, Uht RM, Kushner PJ (1995) Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell specific estrogen like effects of antiestrogens. Mol Endocrinol 9:443-456
    • (1995) Mol Endocrinol , vol.9 , pp. 443-456
    • Webb, P.1    Lopez, G.N.2    Uht, R.M.3    Kushner, P.J.4
  • 96
    • 0029841146 scopus 로고    scopus 로고
    • Identification of an estrogen response element activated by metabolites of 17β-estradiol and raloxifen
    • Yang NN, Venugopalan M, Hardikar S, Glasebrook A (1996) Identification of an estrogen response element activated by metabolites of 17β-estradiol and raloxifen. Science 273: 1222-1225
    • (1996) Science , vol.273 , pp. 1222-1225
    • Yang, N.N.1    Venugopalan, M.2    Hardikar, S.3    Glasebrook, A.4
  • 97
    • 0029075872 scopus 로고
    • Comparison of the effects of a steroidal antiestrogen with those of tamoxifen in a model of human breast cancer
    • Osborne CK, Coronado-Heinsohn EB, McCue BL, Wakeling A, Nicholson RI ( 1995) Comparison of the effects of a steroidal antiestrogen with those of tamoxifen in a model of human breast cancer. J Natl Cancer Inst 87:746-750
    • (1995) J Natl Cancer Inst , vol.87 , pp. 746-750
    • Osborne, C.K.1    Coronado-Heinsohn, E.B.2    McCue, B.L.3    Wakeling, A.4    Nicholson, R.I.5
  • 98
    • 0030017581 scopus 로고    scopus 로고
    • Properties and mode of action of pure antiestrogens in breast cancer in vitro
    • Nicholson RI, Francis AB, Kyne S, Gee JMW (1996) Properties and mode of action of pure antiestrogens in breast cancer in vitro. Breast 5:175-180
    • (1996) Breast , vol.5 , pp. 175-180
    • Nicholson, R.I.1    Francis, A.B.2    Kyne, S.3    Gee, J.M.W.4
  • 100
    • 0028919074 scopus 로고
    • Cross-resitance and molecular mechanisms in antiestrogen resistance
    • Clarke R, Brünner N (1995) Cross-resitance and molecular mechanisms in antiestrogen resistance. Endocr Rel Cancer 2: 59-72
    • (1995) Endocr Rel Cancer , vol.2 , pp. 59-72
    • Clarke, R.1    Brünner, N.2
  • 103
    • 84928580276 scopus 로고
    • Studies on prostatic cancer: The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate
    • Huggins C, Hodges CV (1941) Studies on prostatic cancer: the effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res 1:293-297
    • (1941) Cancer Res , vol.1 , pp. 293-297
    • Huggins, C.1    Hodges, C.V.2
  • 104
    • 0014088849 scopus 로고
    • Treatment and survival of patients with cancer of the prostate
    • Veterans Administration Co-operative Urological Research Group (1967) Treatment and survival of patients with cancer of the prostate. Surg Gynecol Obstet 124:1010-1017
    • (1967) Surg Gynecol Obstet , vol.124 , pp. 1010-1017
  • 105
    • 0021721387 scopus 로고
    • Leuprolide versus diethylstilbesterol for metastatic prostate cancer
    • The Leuprolide Study Group (1984) Leuprolide versus diethylstilbesterol for metastatic prostate cancer. N Engl J Med 311:1281-1286
    • (1984) N Engl J Med , vol.311 , pp. 1281-1286
  • 106
    • 0019977879 scopus 로고
    • From contraception to cancer: A review of the therapeutic applications of LHRH analogs as antitumor agents
    • Corbin A (1982) From contraception to cancer: a review of the therapeutic applications of LHRH analogs as antitumor agents. Yale J Biol Med 55:27-47
    • (1982) Yale J Biol Med , vol.55 , pp. 27-47
    • Corbin, A.1
  • 107
    • 0023681542 scopus 로고
    • Androgenic activity of dehydroepiandrosterone and androstenedione in the rat ventral prostate
    • Labrie C, Belanger A, Labrie F (1988) Androgenic activity of dehydroepiandrosterone and androstenedione in the rat ventral prostate. Endocrinology, 123:1412-1417
    • (1988) Endocrinology , vol.123 , pp. 1412-1417
    • Labrie, C.1    Belanger, A.2    Labrie, F.3
  • 108
    • 0024401194 scopus 로고
    • Stimulation of androgen-dependent gene expression by the adrenal precursors dehydroepiandrosterone and androstenedione in the rat ventral prostate
    • Labrie C, Simard J, Zhao HF, Belanyer A, Pelletier G, Labrie F (1989) Stimulation of androgen-dependent gene expression by the adrenal precursors dehydroepiandrosterone and androstenedione in the rat ventral prostate. Endocr Soc 124:2745-2754
    • (1989) Endocr Soc , vol.124 , pp. 2745-2754
    • Labrie, C.1    Simard, J.2    Zhao, H.F.3    Belanyer, A.4    Pelletier, G.5    Labrie, F.6
  • 110
    • 0027523389 scopus 로고
    • Combination therapy for prostate cancer. Endocrine and biologic basis of its choice as new standard first-line therapy
    • Labrie F, Belanger A, Simard J, Labrie C, Dupont A (1993) Combination therapy for prostate cancer. Endocrine and biologic basis of its choice as new standard first-line therapy. Cancer 71:1059-1067
    • (1993) Cancer , vol.71 , pp. 1059-1067
    • Labrie, F.1    Belanger, A.2    Simard, J.3    Labrie, C.4    Dupont, A.5
  • 112
    • 0022405204 scopus 로고
    • Combination therapy with flutumide and castration (LHRH agonist or orchiectomy) in advanced prostate cancer: A marked improvement in response and survival
    • Labrie F, Dupont A, Belanger A, Giguere M, Lacoursiere Y, Emond J, Monfette G, Bergeron V (1985) Combination therapy with flutumide and castration (LHRH agonist or orchiectomy) in advanced prostate cancer: a marked improvement in response and survival. J Steroid Biochem 23:833-841
    • (1985) J Steroid Biochem , vol.23 , pp. 833-841
    • Labrie, F.1    Dupont, A.2    Belanger, A.3    Giguere, M.4    Lacoursiere, Y.5    Emond, J.6    Monfette, G.7    Bergeron, V.8
  • 113
    • 0021803140 scopus 로고
    • Long term treatment with luteinising hormone releasing hormone agonists and maintenance of serum testosterone to castration concentrations
    • Labrie F, Dupont A, Belanger A, Lachance R, Giguere M (1985) Long term treatment with luteinising hormone releasing hormone agonists and maintenance of serum testosterone to castration concentrations. BMJ 291:369-370
    • (1985) BMJ , vol.291 , pp. 369-370
    • Labrie, F.1    Dupont, A.2    Belanger, A.3    Lachance, R.4    Giguere, M.5
  • 115
    • 0025667031 scopus 로고
    • Combination studies with leuprolide
    • Crawford ED (1990) Combination studies with leuprolide. Eur Urol 3:30-33
    • (1990) Eur Urol , vol.3 , pp. 30-33
    • Crawford, E.D.1
  • 116
    • 0029103141 scopus 로고
    • Maximum androgen blockade in advanced prostate cancer: An overview of 22 randomised trials with 3283 deaths in 5710 patients
    • Prostate Cancer Trialists' Group (1995) Maximum androgen blockade in advanced prostate cancer: an overview of 22 randomised trials with 3283 deaths in 5710 patients. Lancet 346:265-269
    • (1995) Lancet , vol.346 , pp. 265-269
  • 118
    • 0025819482 scopus 로고
    • Immunohistochemical study of androgen receptors in metastatic prostate cancer - Comparison of receptor content and response to hormonal therapy
    • Sadi MV, Walsh PC, Barrack ER (1991) Immunohistochemical study of androgen receptors in metastatic prostate cancer - comparison of receptor content and response to hormonal therapy. Cancer 67:3057-3064
    • (1991) Cancer , vol.67 , pp. 3057-3064
    • Sadi, M.V.1    Walsh, P.C.2    Barrack, E.R.3
  • 119
    • 0027536495 scopus 로고
    • Image analysis of androgen receptor immunostaining in metastatic prostate cancer: Heterogeneity as a predictor of response to hormonal therapy
    • Sadi MV, Barrack ER (1992) Image analysis of androgen receptor immunostaining in metastatic prostate cancer: heterogeneity as a predictor of response to hormonal therapy. Cancer 71:2574-2580
    • (1992) Cancer , vol.71 , pp. 2574-2580
    • Sadi, M.V.1    Barrack, E.R.2
  • 121
  • 122
  • 123
    • 0028823124 scopus 로고
    • Analysis of genetic changes underlying local recurrence of prostate carcinoma during androgen deprivation therapy
    • Koivisto P, Hyytinen E, Palmberg C, Tammela T, Visakorpi T, Isola J, Kallioniemi OP (1995) Analysis of genetic changes underlying local recurrence of prostate carcinoma during androgen deprivation therapy. Am J Pathol 147:1608-1614
    • (1995) Am J Pathol , vol.147 , pp. 1608-1614
    • Koivisto, P.1    Hyytinen, E.2    Palmberg, C.3    Tammela, T.4    Visakorpi, T.5    Isola, J.6    Kallioniemi, O.P.7
  • 125
    • 0028220323 scopus 로고
    • Increased androgen receptor activity and altered c-myc expression in prostate cancer cells alter long-term androgen deprivation
    • Kokontis J, Takakura K, Hay N, Liao S (1994) Increased androgen receptor activity and altered c-myc expression in prostate cancer cells alter long-term androgen deprivation. Cancer Res 54:1566-1573
    • (1994) Cancer Res , vol.54 , pp. 1566-1573
    • Kokontis, J.1    Takakura, K.2    Hay, N.3    Liao, S.4
  • 129
    • 0029915052 scopus 로고    scopus 로고
    • Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence
    • Tilley WD, Buchanan G, Hickey TE, Bentel JM (1996) Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence. Clin Cancer Res 2:277-285
    • (1996) Clin Cancer Res , vol.2 , pp. 277-285
    • Tilley, W.D.1    Buchanan, G.2    Hickey, T.E.3    Bentel, J.M.4
  • 134
    • 0027427321 scopus 로고
    • Threonine on amino acid position 868 in the human androgen receptor is essential for androgen binding specificity and functional activity
    • Ris-Stalpers C, Verleun-Mooijman MCT, Trapman J, Brinkmann AO (1993) Threonine on amino acid position 868 in the human androgen receptor is essential for androgen binding specificity and functional activity. Bioxhem Biophys Res Commun 196:173-180
    • (1993) Bioxhem Biophys Res Commun , vol.196 , pp. 173-180
    • Ris-Stalpers, C.1    Verleun-Mooijman, M.C.T.2    Trapman, J.3    Brinkmann, A.O.4
  • 135
    • 0028804247 scopus 로고
    • Mutant androgen receptors in prostatic tumours distinguish between amino acid-sequence requirements for transactivation and ligand binding
    • Peterziel H, Culig Z, Stober J, Hobisch A, Radmayr C, Bartsch G, Klocker H, Cato ACB (1995) Mutant androgen receptors in prostatic tumours distinguish between amino acid-sequence requirements for transactivation and ligand binding. Int J Cancer 63:544-550
    • (1995) Int J Cancer , vol.63 , pp. 544-550
    • Peterziel, H.1    Culig, Z.2    Stober, J.3    Hobisch, A.4    Radmayr, C.5    Bartsch, G.6    Klocker, H.7    Cato, A.C.B.8
  • 136
    • 0029643780 scopus 로고
    • Crystal structure of the RARγ-ligand binding domain bound to all-trans retinoic acid
    • Renaud J-P, Rochel N, Ruff M, Vivat V, Chambon P, Gronemeyer H, Moras, D (1995) Crystal structure of the RARγ-ligand binding domain bound to all-trans retinoic acid. Nature 378:681-689
    • (1995) Nature , vol.378 , pp. 681-689
    • Renaud, J.-P.1    Rochel, N.2    Ruff, M.3    Vivat, V.4    Chambon, P.5    Gronemeyer, H.6    Moras, D.7
  • 138
    • 0029012163 scopus 로고
    • Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
    • Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras, D (1995) Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α. Nature 375:377-382
    • (1995) Nature , vol.375 , pp. 377-382
    • Bourguet, W.1    Ruff, M.2    Chambon, P.3    Gronemeyer, H.4    Moras, D.5
  • 140
    • 0027477695 scopus 로고
    • Prostate specific antigen decline after antiandrogen withdrawal: The flutamide withdrawal syndrome
    • Kelly WK, Scher HI (1993) Prostate specific antigen decline after antiandrogen withdrawal: the flutamide withdrawal syndrome. J Urol 149:607-609
    • (1993) J Urol , vol.149 , pp. 607-609
    • Kelly, W.K.1    Scher, H.I.2
  • 141
    • 0027203411 scopus 로고
    • Flutamide withdrawal syndrome: Its impact on clinical trials in hormone-refractory prostate cancer
    • Scher HI, Kelly WK (1993) Flutamide withdrawal syndrome: its impact on clinical trials in hormone-refractory prostate cancer. J Clin Oncol 11:1566-1572
    • (1993) J Clin Oncol , vol.11 , pp. 1566-1572
    • Scher, H.I.1    Kelly, W.K.2
  • 142
    • 0028089068 scopus 로고
    • Surprising activity of flutamide withdrawal, when combined with aminoglutethimide, in treatment of "hormone-refractory" prostate cancer
    • published erratum appears in J Natl Cancer Inst 86:463
    • Sartor O, Cooper M, Weinberger M, Headlee D, Thibault A, Tompkins A, Steinberg S, Figg WD, Linehan WM, Myers CE (1994) Surprising activity of flutamide withdrawal, when combined with aminoglutethimide, in treatment of "hormone-refractory" prostate cancer. J Natl Cancer Inst 86:222-227 (published erratum appears in J Natl Cancer Inst 86:463)
    • (1994) J Natl Cancer Inst , vol.86 , pp. 222-227
    • Sartor, O.1    Cooper, M.2    Weinberger, M.3    Headlee, D.4    Thibault, A.5    Tompkins, A.6    Steinberg, S.7    Figg, W.D.8    Linehan, W.M.9    Myers, C.E.10
  • 143
    • 0028907804 scopus 로고
    • Prostate specific antigen decline following the discontinuation of flutamide in patients with stage D2 prostate cancer
    • Figg WD, Sartor O, Cooper MR, Thibault A, Bergan RC, Dawson N, Reed E, Myers CE (1995) Prostate specific antigen decline following the discontinuation of flutamide in patients with stage D2 prostate cancer. Am J Med 98:412-114
    • (1995) Am J Med , vol.98 , pp. 412-1114
    • Figg, W.D.1    Sartor, O.2    Cooper, M.R.3    Thibault, A.4    Bergan, R.C.5    Dawson, N.6    Reed, E.7    Myers, C.E.8
  • 144
    • 0027249588 scopus 로고
    • Response to flutamide withdrawal in advanced prostate cancer in progression under combination therapy
    • Dupont A, Gomez JL, Cusan L, Koutsilieris M, Labrie F (1993) Response to flutamide withdrawal in advanced prostate cancer in progression under combination therapy. J Urol 150:908-913
    • (1993) J Urol , vol.150 , pp. 908-913
    • Dupont, A.1    Gomez, J.L.2    Cusan, L.3    Koutsilieris, M.4    Labrie, F.5
  • 145
    • 0028998340 scopus 로고
    • Molecular implications of the antiandrogen withdrawal syndrome
    • Moul JW, Srivastava S, McLeod DG (1995) Molecular implications of the antiandrogen withdrawal syndrome. Semin Urol 13:157-163
    • (1995) Semin Urol , vol.13 , pp. 157-163
    • Moul, J.W.1    Srivastava, S.2    McLeod, D.G.3
  • 146
    • 0028256111 scopus 로고
    • Prostate-specific antigen decline after casodex withdrawal: Evidence for an antiandrogen withdrawal syndrome
    • Small EJ, Carroll PR (1994) Prostate-specific antigen decline after casodex withdrawal: evidence for an antiandrogen withdrawal syndrome. Urology 43:408-410
    • (1994) Urology , vol.43 , pp. 408-410
    • Small, E.J.1    Carroll, P.R.2
  • 147
    • 0028858232 scopus 로고
    • Antiandrogen withdrawal syndrome in prostate cancer after treatment with steroidal antiandrogen chlormadinone acetate
    • Akakura K, Akimoto S, Ohki T, Shimazaki J (1995) Antiandrogen withdrawal syndrome in prostate cancer after treatment with steroidal antiandrogen chlormadinone acetate. Urology 45:700-704
    • (1995) Urology , vol.45 , pp. 700-704
    • Akakura, K.1    Akimoto, S.2    Ohki, T.3    Shimazaki, J.4
  • 148
    • 0029007052 scopus 로고
    • Dramatic prostate specific antigen decrease in response to discontinuation of megestrol acetate in advanced prostate cancer: Expansion of the antiandrogen withdrawal syndrome
    • Dawson NA, McLeod DG (1995) Dramatic prostate specific antigen decrease in response to discontinuation of megestrol acetate in advanced prostate cancer: expansion of the antiandrogen withdrawal syndrome. J Urol 153:1946-1947
    • (1995) J Urol , vol.153 , pp. 1946-1947
    • Dawson, N.A.1    McLeod, D.G.2
  • 149
    • 0028609997 scopus 로고
    • Tamoxifen withdrawal responses-chance observations or clinical clues to antioestrogen resistance
    • DeFriend DJ, Howell A (1994) Tamoxifen withdrawal responses-chance observations or clinical clues to antioestrogen resistance. Breast 3:199-201
    • (1994) Breast , vol.3 , pp. 199-201
    • DeFriend, D.J.1    Howell, A.2
  • 150
    • 0027416692 scopus 로고
    • Effects of intermittent androgen suppression on androgen-dependent tumors. Apoptosis and serum prostate-specific antigen
    • Akakura K, Bruchovsky N, Goldenberg SL, Rennie PS, Buckley AR, Sullivan LD (1993) Effects of intermittent androgen suppression on androgen-dependent tumors. Apoptosis and serum prostate-specific antigen. Cancer 71:2782-2790
    • (1993) Cancer , vol.71 , pp. 2782-2790
    • Akakura, K.1    Bruchovsky, N.2    Goldenberg, S.L.3    Rennie, P.S.4    Buckley, A.R.5    Sullivan, L.D.6
  • 152
    • 0029050259 scopus 로고
    • Theoretical considerations and initial clinical results of intermittent hormone treatment of patients with advanced prostatic carcinoma
    • Bruchovsky N, Goldenberg SL, Rennie PS, Gleave M (1995) Theoretical considerations and initial clinical results of intermittent hormone treatment of patients with advanced prostatic carcinoma. Urologe A34:389-392
    • (1995) Urologe , vol.A34 , pp. 389-392
    • Bruchovsky, N.1    Goldenberg, S.L.2    Rennie, P.S.3    Gleave, M.4
  • 153
    • 0029068688 scopus 로고
    • Recent multicenter study protocols in the USA for patients with metastatic prostatic carcinoma
    • DeAntoni E, Crawford ED (1995) Recent multicenter study protocols in the USA for patients with metastatic prostatic carcinoma. Urologe A34:382-388
    • (1995) Urologe , vol.A34 , pp. 382-388
    • DeAntoni, E.1    Crawford, E.D.2
  • 154
    • 0029591491 scopus 로고    scopus 로고
    • Defining the role of antiandrogens in the treatment of prostate cancer
    • McLeod DG, Kolvenbag GJ (1996) Defining the role of antiandrogens in the treatment of prostate cancer. Urology 47:85-89
    • (1996) Urology , vol.47 , pp. 85-89
    • McLeod, D.G.1    Kolvenbag, G.J.2
  • 156
    • 0021931574 scopus 로고
    • Endometrial and pituiary responses to the sterodal antiprogestin R7486 in postmeriopansal women
    • Gravanis A, Schaison G, George M (1985) Endometrial and pituiary responses to the sterodal antiprogestin R7486 in postmeriopansal women. J Clin Endocr Metab 60:156-63
    • (1985) J Clin Endocr Metab , vol.60 , pp. 156-163
    • Gravanis, A.1    Schaison, G.2    George, M.3
  • 157
    • 0030272097 scopus 로고    scopus 로고
    • Acquired estrogen independence and antiestrogen resistance in breast cancer. Estrogen receptor driven phenotypes?
    • Clarke R, Brünner N (1996) Acquired estrogen independence and antiestrogen resistance in breast cancer. Estrogen receptor driven phenotypes? Trends Endocrinol Metab 7:291-301
    • (1996) Trends Endocrinol Metab , vol.7 , pp. 291-301
    • Clarke, R.1    Brünner, N.2
  • 161
    • 0030593681 scopus 로고    scopus 로고
    • ERβ: Identification and characterization of a novel estrogen receptor
    • Mosselman S, Polman J, Dijkema R (1996) ERβ: identification and characterization of a novel estrogen receptor. FEBS Lett 392:49-53
    • (1996) FEBS Lett , vol.392 , pp. 49-53
    • Mosselman, S.1    Polman, J.2    Dijkema, R.3
  • 162
    • 0028264276 scopus 로고
    • 1-Carbamoylalkyl-2-phenylindoles: Relationship between side chain structure and estrogen antagonism
    • Von Angerer E, Biberger C, Holler E, Koop R, Leichtl S (1994) 1-Carbamoylalkyl-2-phenylindoles: relationship between side chain structure and estrogen antagonism. J Steroid Biochem Mol Biol 49:51-62
    • (1994) J Steroid Biochem Mol Biol , vol.49 , pp. 51-62
    • Von Angerer, E.1    Biberger, C.2    Holler, E.3    Koop, R.4    Leichtl, S.5
  • 165
    • 0030946198 scopus 로고    scopus 로고
    • Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen. 4-hydroxytamoxifen
    • Smith CL, Nawaz Z, O'Malley BW (1997) Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen. 4-hydroxytamoxifen. Mol Endocrinol 11:657-666
    • (1997) Mol Endocrinol , vol.11 , pp. 657-666
    • Smith, C.L.1    Nawaz, Z.2    O'Malley, B.W.3
  • 166
    • 0030998328 scopus 로고    scopus 로고
    • The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coaetivalor L7/SPA and the compressors N-CoR and SMRT
    • Jackson TA, Richer JK, Bain DL, Takimoto GS, Tung L, Horwitz, KB (1997) The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coaetivalor L7/SPA and the compressors N-CoR and SMRT. Mol Endocrinol 11:693-705
    • (1997) Mol Endocrinol , vol.11 , pp. 693-705
    • Jackson, T.A.1    Richer, J.K.2    Bain, D.L.3    Takimoto, G.S.4    Tung, L.5    Horwitz, K.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.