16α-Substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 16, 1996, Pages 8739-8744

  Wagner, Brandee L ^a   Pollio, Giuseppe ^a,d   Leonhardt, Susan ^b   Wani, Mansukh C ^c   Lee, David Y W ^c   Imhof, Markus O ^a   Edwards, Dean P ^b   Cook, C Edgar ^c   McDonnell, Donald P ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c RTI INTERNATIONAL   (United States)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGESTAGEN; MIFEPRISTONE; MIFEPRISTONE DERIVATIVE; PROGESTERONE RECEPTOR; UNCLASSIFIED DRUG;

AGONIST; ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CONFORMATIONAL TRANSITION; HORMONE RECEPTOR INTERACTION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TARGET CELL;

ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; GENE EXPRESSION; HORMONE ANTAGONISTS; HUMANS; LIGANDS; MIFEPRISTONE; PROTEIN CONFORMATION; RECEPTORS, PROGESTERONE; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0029757966     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.16.8739     Document Type: Article

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