Human follicle-stimulating hormone structure-activity relationships

Biology of Reproduction

Volumn 58, Issue 6, 1998, Pages 1331-1336

  Dias, James A ^a   Lindau Shepard, Barbara ^a   Hauer, Charles ^a   Auger, Ivan ^a  

^a WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; CHORIONIC GONADOTROPIN; CONTRACEPTIVE VACCINE; FOLLITROPIN; FOLLITROPIN RECEPTOR; GLYCOPROTEIN; GONADOTROPIN RECEPTOR; GROWTH FACTOR; HYPOPHYSIS HORMONE; MONOCLONAL ANTIBODY; THYROTROPIN RECEPTOR;

ENZYME LINKED IMMUNOSORBENT ASSAY; GENE MUTATION; HUMAN; IMMUNOCHEMISTRY; INFERTILITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OVARY INSUFFICIENCY; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; FOLLICLE STIMULATING HORMONE; GENE EXPRESSION; HUMANS; INSECTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031811584     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod58.6.1331     Document Type: Short Survey

References (47)

1. Kumar TR, Wang Y, Lu N, Matzuk MM. Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat Genet 1997; 15:201-204.
2. Tapanainen JS, Aittomaki K, Min J, Vaskivuo T, Huhtaniemi IT. Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility. Nat Genet 1997; 15:205-206.
3. Aittomaki K, Lucena JL, Pakarinen P, Sistonen P, Tapanainen J, Gromoll J, Kaskikari R, Sankila EM, Lehvaslaiho H, Engel AR. Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure. Cell 1995; 82:959-968.
4. Matthews CH, Borgato S, Beck-Peccoz P, Adams M, Tone Y, Gambino G, Casagrande S, Tedeschini G, Benedetti A, Chatterjee VK. Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone. Nat Genet 1993; 5:83-86.
5. Moudgal NR, Murthy GS, Kumar KMP, Martin F, Suresh R, Medhamurthy RX, Patil S, Sehgal S, Saxena BN. Responsiveness of human male volunteers to immunization with ovine follicle stimulating hormone vaccine - results of a pilot study. Hum Reprod 1997; 12:457-463.
6. Moudgal NR, Sairam MR, Krishnamurthy HN, Sridhar S, Krishnamurthy H, Khan H. Immunization of male bonnet monkeys (M. radiata) with a recombinant FSH receptor preparation affects testicular function and fertility. Endocrinology 1997; 138:3065-3068.
7. Sun PD, Davies DR. The cystine-knot growth-factor super-family. Annu Rev Biophys Biomol Struct 1995; 24:269-291.
8. Lapthorn AP, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machlin KJ, Morgan FJ, Isaacs NW. Crystal structure of human chorionic gonadotropin. Nature 1994; 369:455-461.
9. Wu H, Lustbader JW, Liu Y, Canfield RE, Hendrickson WA. Structure of human chorionic gonadotropin at 2.6 angstrom resolution from MAD analysis of the selenomethionyl protein. Structure 1994; 15:545-558.
10. Dias JA. Progress and approaches in mapping the surfaces of human follicle stimulating hormone: comparison with the other human pituitary glycoprotein hormones. Trends Endocrinol Metab 1992; 3:24-29.
11. Cunningham BC, Wells JA. High resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis. Science 1989; 244:1081-1085.
12. Bass SH, Mulkerrin MG, Wells JA. A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor. Proc Natl Acad Sci USA 1991; 88:4498-4502.
13. Liu CL, Bowers LD. Mass spectrometric characterization of the beta subunit of human chorionic gonadotropin. J Mass Spectrometry 1997; 32:33-42.
14. Roth KE, Dias JA. Follitropin conformational stability mediated by loop 2β effects follitropin-receptor interaction. Biochemistry 1996; 35:7928-7935.
15. Dias JA. Human follitropin heterodimerization and receptor binding structural motifs: identification and analysis by a combination of synthetic peptide and mutagenesis approaches. Mol Cell Endocrinol 1996; 125:45-54.
16. Hu SB, Johnson L, Roche PC, Keutmann HT. A functional determinant in human luteinizing hormone and chorionic gonadotropin: differential effect of mutations about beta-GLN-54. Endocrinology 1997; 138:1627-1633.
17. van Zuylen CW, Kamerling JP, Vliegenthart JF. Glycosylation beyond the Asn78-linked GIcNAc residue has a significant enhancing effect on the stability of the alpha subunit of human chorionic gonadotropin. Biochem Biophys Research Commun 1997; 232:117-120.
18. Liu C, Dias JA. Long loop residues 33-58 in the human glycoprotein hormone common alpha subunit contain structural components for subunit heterodimerization and human follitropin-receptor binding. Arch Biochem Biophys 1996; 329:127-135.
19. De Beer T, Van Zuylen CWEM, Leeflang BR, Hard K, Boelens R, Kaptein R, Kamerling JP. Vliegenthart JFG. NMR studies of the free alpha subunit of human chorionic gonadotropin: structural influences of N-glycosylation and the beta subunit on the conformation of the alpha subunit. Eur J Biochem 1996; 241:229-242.
20. Dias JA, Zhang Y, Liu X. Receptor binding and functional properties of chimeric human follitropin prepared by an exchange between a small hydrophilic intercysteine loop of human follitropin and human lutropin. J Biol Chem 1994; 269:25289-25294.
21. Grossmann M, Szkudlinski MW Wong R, Dias JA, Ji T, Weintraub BD. Substitution of the seat-belt region of the thyroid-stimulating hormone (TSH) beta-subunit with the corresponding regions of choriogonadotropin or follitropin confers luteotropic but not follitropic activity to chimeric TSH. J Biol Chem 1997; 272:15532-15540.
22. Campbell RK, Dean-Emig DM, Moyle WR. Conversion of human choriogonadotropin into a follitropin by protein engineering. Proc Natl Acad Sci USA 1991; 88:760-764.
23. Liu C, Roth KE, Shepard BA, Shaffer JB, Dias JA. Site-directed alanine mutagenesis of Phe33, Arg35, and Arg42-Ser43-Lys44 in the human gonadotropin alpha-subunit. J Biol Chem 1993; 268:21613-21617.
24. Grossmann M, Szkudlinski MW, Dias JA, Xia H, Wong R, Puett D, Weintraub BD. Site-directed mutagenesis of amino acids 33-44 of the common alpha-subunit reveals different structural requirements for heterodimer expression among the glycoprotein hormones and suggests that cyclic adenosine 3′,5′-monophosphate production and growth promotion are potentially dissociable functions of human thyrotropin. Mol Endocrinol 1996; 10:769-779.
25. Chen F, Wang Y, Puett D. Role of the invariant aspartic acid 99 of human choriogonadotropin β in receptor binding activity. J Biol Chem 1991; 266:19357-19361.
26. Lindau-Shepard B, Roth KE, Dias JA. Identification of amino acids in the C-terminal region of human follicle-stimulating hormone (FSH) β-subunit involved in binding to human FSH receptor. Endocrinology 1994; 135:1235-1240.
27. Heikoop JC, van den Boogaart P, Mulders JW, Grootenhuis PD. Structure-based design and protein engineering of intersubunit disulfide bonds in gonadotropins. Nat Biotechnol 1997; 15:658-662.
28. Yoo J, Ji I, Ji TH. Conversion of lysine 91 to methionine or glutamic acid in human choriogonadotropin α results in the loss of cAMP inducibility. J Biol Chem 1991; 266:17741-17743.
29. Grossman M, Szkudlinski MW, Zeng H, Kraiem Z, Ji I, Tropea JE, Ji TH, Weintraub BD. Role of the carboxy-terminal residues of the alpha subunit in the expression and bioactivity of human thyroid-stimulating hormone. Mol Endocrinol 1995; 9:948-958.
30. Zeng H, Ji I, Ji TH. Lys-91 and His-90 of the alpha subunit are crucial for receptor binding and hormone action of follicle stimulating hormone and play hormone-specific roles in FSH and human chorionic gonadotropin. Endocrinology 1995; 138:2498-2953.
31. Arnold CJ, Liu C, Lindau-Shepard B, Losavio ML, Patrascu MT, Dias JA. Human follitropin alpha-subunit C-terminus collaborates with a beta-subunit cystine noose and alpha-subunit loop to assemble a receptor-binding domain competent for signal transduction. Biochemistry 1998; 37:1762-1768.
32. Keene JL, Nishimori K, Galway AB, Matzuk MM, Hsueh AJW, Boime I. Recombinant deglycosylated human FSH is an antagonist of human FSH action in cultured rat granulosa cells. Endocrinology 1994; 2:175-179.
33. Feng W, Matzuk MM, Mountjoy K, Bedows E, Ruddon RW, Boime I. The asparagine-linked oligosaccharides of the human chorionic gonadotropin beta subunit facilitate correct disulfide bond pairing. J Biol Chem 1995; 270:11851-11859.
34. Bishop L, Robertson DM, Cahir N, Schofield PR. Specific roles for the asparagine-linked carbohydrate residues of recombinant human follicle stimulating hormone in receptor binding and signal transduction. Mol Endocrinol 1994; 8:722-731.
35. Flack MR, Froehlich J, Bennet AP, Anasti J, Nisula B. Site-directed mutagenesis defines the individual roles of the glycosylation sites on follicle-stimulating hormone. J Biol Chem 1994; 269:14015-14020.
36. Butnev VY, Gotschall RR, Butnev VY, Baker VL, Moore WT, Bousfield GR. Hormone-specific inhibitory influence of alpha subunit asn56 oligosaccharide on in vitro subunit association and FSH receptor binding of equine gonadotropins. Biol Reprod 1998; 58:458-469.
37. Kajava AV, Vassart G, Wodak SJ. Modelling of the three-dimensional structure of proteins with the typical leucine-rich repeats. Structure 1995; 15:867-877.
38. Jiang X, Dreano M, Buckler DR, Cheng S, Ythier A, Wu H, Hendrickson WA, Tayar NE. Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions. Structure 1995; 15:1341-1353.
39. Wells JA, Cunningham BC, Fuh G, Lowman HB, Bass SH, Mulkerrin MG, Ultsch M, Devos AM. The molecular basis for growth hormone-receptor interactions. [Review]. Recent Prog Horm Res 1993; 48:253-275.
40. 15N-enriched recombinant human chorionic gonadotropin. Biochemistry 1996; 35:8815-8823.
41. Dunkel L, Jia XC, Nishimori K, Boime I, Hsueh AJ, Deglycosylated human chorionic gonadotropin (hCG) antagonizes hCG stimulation of 3′,5′-cyclic adenosine monophosphate accumulation through a non-competitive interaction with recombinant human luteinizing hormone receptors. Endocrinology 1993; 132:763-769.
42. Freidman S, Gurevich M, Shemesh M. Bovine cyclic endometrium contains high-affinity luteinizing hormone/human chorionic gonadotropin binding sites. Biol Reprod 1995; 52:1020-1026.
43. Kornyei JL, Li X, Lei ZM, Rao CV. Restoration of human chorionic gonadotropin response in human myometrial smooth muscle cells by treatment with follicle-stimulating hormone (FSH): evidence for the presence of FSH receptors in human myometrium. Eur J Endocrinol 1996; 134:225-231.
44. AL-Hader AA, Lei ZM, Rao CV. Novel expression of functional luteinizing hormone/chorionic gonadotropin receptors in cultured glial cells from neonatal rat brains. Biol Reprod 1997; 56:501-507.
45. Tao YX, Bao S, Ackermann DM, Lei ZM, Rao CV. Expression of luteinizing hormone/human chorionic gonadotropin receptor gene in benign prostatic hyperplasia and in prostate carcinoma in humans. Biol Reprod 1997; 56:67-72.
46. Thotakura NR, Blithe DL. Glycoprotein hormones: glycobiology of gonadotropins, thyrotropin and free alpha subunit. Glycobiology 1995; 5:3-10.
47. Krichevsky A, Campbell-Acevedo EA, Tong JY, Acevedo H. Immunological detection of membrane-associated human luteinizing hormone correlates with gene expression in cultured human cancer and fetal cells. Endocrinology 1995; 136:1034-1039.