Responsiveness of human male volunteers to immunization with ovine follicle stimulating hormone vaccine: Results of a pilot study

Human Reproduction

Volumn 12, Issue 3, 1997, Pages 457-463

  Moudgal, N R ^a   Murthy, G S ^a   Prasanna Kumar, K M ^b   Martin, Flora ^a   Suresh, R ^a   Medhamurthy, R ^a   Patil, S ^a   Sehgal, S ^c   Saxena, B N ^d  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b M S RAMAIAH MEDICAL COLLEGE   (India)

^c POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^d INDIAN COUNCIL OF MEDICAL RESEARCH   (India)

Author keywords

FSH antibody in man; FSH vaccine; Seminal transferrin; Sertoli cell

Indexed keywords

CONTRACEPTIVE VACCINE; FOLLITROPIN; HYDROCORTISONE; LIOTHYRONINE; LUTEINIZING HORMONE; MALE CONTRACEPTIVE AGENT; PROLACTIN; TESTOSTERONE; THYROTROPIN; THYROXINE; TRANSFERRIN;

ADULT; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BLOOD CHEMISTRY; CELL FUNCTION; CLINICAL TRIAL; ENDOCRINE FUNCTION; FOLLITROPIN BLOOD LEVEL; HEMATOLOGY; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; INTRADERMAL DRUG ADMINISTRATION; LIOTHYRONINE BLOOD LEVEL; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NORMAL HUMAN; PROLACTIN BLOOD LEVEL; SEMINAL PLASMA; SEMINIFEROUS TUBULE; SERTOLI CELL; TESTOSTERONE BLOOD LEVEL; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

OVIS;

EID: 0030978050     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/12.3.457     Document Type: Article

References (35)

1. Aravindan, G.R., Ravindranath, N., Krishnamurthy, H. and Moudgal, N.R. (1991) FSH deprivation in bonnet monkeys (M. radiata) affects ability of sperm DNA to bind acridine orange and undergo decondensation in vitro flow cytometric analysis. Proceedings of the 24th Annual Meeting of the Society for the Study of Reproduction, USA, Abstr. no. 514, p. 181.
2. Aravindan, G.R., Gopalakrishnan, K., Ravindranath, N. and Moudgal, N.R. (1993) Effect of altering endogenous gonadotropin concentrations on the kinetics of testicular germ cell turnover in the bonnet monkey (Macaca radiata). J. Endocrinol., 137, 485-495.
3. Ballachey, B.E., Saacke, R.G. and Evenson, D.P. (1988) The sperm chromatin structure assay: relationship with alternate tests of sperm quality and heterospermic performance of bulls. J. Androl., 9, 109-115.
4. Deshmukh, U.S. and Talwar, G.P. (1995) The hCG birth control vaccine. In Talwar, G.P. and Raghupathy, R. (eds), Birth Control Vaccines. R.G. Landes Company, Austin, TX, p. 75.
5. Dym, M., Raj, H.G.M., Liu, Y.C. et al. (1979) Is FSH required for maintenance of spermatogenesis in adult rats? Indian J. Biochem. Biophys., 28, 513-520.
6. Evenson, D.P. (1989) Flow cytometry evaluation of male germ cells. In Yen, A. (ed.), Flow Cytometry: Advanced Research and Clinical Applications. CRC Press, Boca Raton, FL, p. 217.
7. Gramoll, J., Simoni, M. and Nieschlag, E. (1996) An activating mutation of the follicle stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man. J. Clin. Endocrinol. Metab., 81, 1367-1370.
8. Holmes, S.D., Lipshultz, L.I. and Smith, R.G. (1982) Transferrin and gonadal dysfunction in man. Fertil. Steril., 38, 600-604.
9. Keene, J.L., Matzuk, M.M., Otani, T. et al. (1989) Expression of biologically active human follitropin in Chinese hamster ovary cells. J. Biol. Chem., 264, 4769-4775.
10. Lerchl, A., Sotiviadon, S., Behre, H.M. et al. (1993) Restoration of spermatogenesis by follicle stimulating hormone despite low intratesticular testosterone in photoinhibited hypogonadotropic Djungarian hamster (P. surgorus). Biol. Reprod., 49, 1108-1117.
11. Matsumoto, A.M., Karpas, A.E. and Bremner, W.J. (1986) Chronic human chorionic gonadotropin administration in normal men: evidence that follicle stimulating hormone is necessary for the maintenance of quantitative normal spermatogenesis in men. J. Clin. Endocrinol. Metab., 62, 1184-1190.
12. Moudgal, N.R. (1981) A need for FSH in maintaining fertility of adult male subhuman primates. Arch. Androl., 7, 117-125.
13. Moudgal, N.R. and Aravindan, G.R. (1993) Induction of infertility in the male by blocking follicle stimulating hormone action. In Naz, R.K. (ed.), Immunology of Reproduction. CRC Press, Boca Raton, USA, p. 251.
14. Moudgal, N.R., Ravindranath, N., Muithy, G.S. et al. (1992) Long term contraceptive efficacy of vaccine of ovine follicle stimulating hormone in male bonnet monkeys (Macaca radiata). J. Reprod. Fertil., 96, 91-102.
15. Murthy, G.S.R.C., Sheela Rani, C.S., Moudgal, N.R. and Prasad, M.R.N. (1979) Effect of passive immunization with specific antiserum to FSH on the spermatogenic process and fertility of adult male bonnet monkeys (Macaca radiata). J. Reprod. Fertil., 26 (Suppl.), 147-163.
16. Nieschlag, E. (1985) Reasons for abandoning immunization against FSH as an approach to male fertility regulation. In Zatuchni, G.I., Goldsmith, A., Spieler, J.M. and Sciarra, J.J. (eds), Advances and Future Prospects in Male Contraception. Parfr Series on Fertility Regulation. Harper and Row, Philadelphia, pp. 395-400.
17. Orlando, C., Caldini, A.L., Barni, T. et al. (1985) Ceruloplasmin and transferrin in human seminal plasma: are they an index of seminiferous tubular function? Fertil. Steril., 43, 290-293.
18. Raj, H.G.M., Murty, G.S.R.C., Sairam, M.R. and Talbert, L.M. (1982) Effect of active immunization against FSH in the monkey. Int. J. Androl., 5 (Suppl.), 27-33.
19. Raj, H.G.M., Kotagi, S.G., Letellier, R. et al. (1991) Active immunization with gonadotropins in the crab eating monkey (M. fascicularis): evaluation for male contraception. In Moudgal, N.R., Yoshinaga, K., Rao, A.J. and Adiga, P.R. (eds), Perspective in Primate Reproductive Biology. Wiley Eastern, New Delhi, pp. 307-316.
20. Rudback, J.A., Jhonson, D.A. and Ulrich, J.J. (1995) Ribi adjuvants: chemistry, biology and utility in vaccines for human and veterinary medicine. In Stewart-Tull (ed.), The Theory and Practical Application of Adjuvants. Wiley, New York, pp. 287-313.
21. Samaddar, M., Sengupta, C., Catterall, J.F. and Dighe, R.R. (1996) Recombinant expression of glycoprotein hormones in the methylotrophic yeast, Pichia pastoris. Proceedings of the 10th International Congress of Endocrinology. Vol. 1, Abstr. no. OR21-5, p. 84.
22. Sehgal, S., Ravindranath, N. and Moudgal, N.R. (1991) Lack of immunotoxicological effects in bonnet monkeys immunized with ovine follicle stimulating hormone. In Moudgal, N.R., Yoshinaga, K., Rao, A.J. and Adiga, P.R. (eds), Perspective in Primate Reproductive Biology. Wiley Eastern, New Delhi, pp. 317-324.
23. Sharma, R.K. and Das, R.P. (1992) Effect of fertility regulating agents on motility and zona free hamster egg penetration by spermatozoa of bonnet monkeys. Indian J. Exp. Biol., 30, 976-1981.
24. Sheela Rani, C.S., Murty, G.S.R.C. and Moudgal, N.R. (1978) Effect of chronic neutralization of endogenous FSH on testicular function in the adult male bonnet monkey: assessment using biochemical parameters. Int. J. Androl., 1, 489-500.
25. Shetty, J., Marathe, G. and Dighe, R.R. (1996) Specific immunoneutralization of FSH leads to apoptotic cell death of pachytene spermatocytes and spermatogonial cells in the rat. Endocrinology, 137, 2179-2182.
26. Singh, J., O'Neill, C. and Handelsman, D.J. (1995) Induction of spermatogenesis by androgens in gonadotropin deficient (hpg) mice. Endocrinology, 136, 5311-5321.
27. Skinner, M.K. and Griswald, M.D. (1982) Secretion of testicular transferrin by cultured Sertoli cells is regulated by follicle stimulating hormone and retinoids. Biol. Reprod., 27, 211-221.
28. Srinath, B.R., Wickings, E.J., Witting, C. and Nieschlag, E. (1983) Active immunization with follicle stimulating hormone for fertility control: a 41 year study in male rhesus monkeys. Fertil. Steril., 40, 110-117.
29. Srivatsava, A. and Das, R.P. (1992) Sperm production and fertility of bonnet monkeys (M. radiata) following immunization with oFSH. Indian J. Exp. Biol, 30, 574-577.
30. Vaishnav, M. and Moudgal, N.R. (1991) Effect of specific FSH or LH deprivation on testicular function of the adult rat. Indian J. Biochem. Biophys., 28, 513-520.
31. Vaishnav, M. and Moudgal, N.R. (1994) Role of FSH in regulating testicular germ cell transformation in the rat: a study using DNA flow cytometry. Andrologia, 26, 111-117.
32. Ward, D.N. and Bousfield, G.R. (1990) FSH structure and their relationships to the other glycoprotein hormones. In Chin, W.W. and Boime, I. (eds), Glycoprotein Hormones Structure, Synthesis and Biological Function. Serono Symposia, USA, Norwell, MA, pp. 81-95.
33. World Health Organization Technical Report Series No. 771 (1988) Requirement for Measles Vaccine (Live) Requirements for Biological Substance No. 12. Published by WHO, pp. 93-132.
34. World Health Organization (1992) WHO Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction. Cambridge University Press, Cambridge.
35. Wickings, E.J., Usadel, K.H., Dathe, G. and Nieschlag, E. (1980) The role of follicle-stimulating hormone in testicular function of the mature rhesus monkey. Acta Endocrinol., 95, 117.