Persistence of serum and salivary antibody responses after oral immunization with a bacterial protein antigen genetically linked to the A2/B subunits of cholera toxin

Infection and Immunity

Volumn 64, Issue 2, 1996, Pages 665-667

  Hajishengallis, George ^a   Michalek, Suzanne M ^a   Russell, Michael W ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; CHOLERA TOXIN; IMMUNOGLOBULIN G ANTIBODY; SECRETORY IMMUNOGLOBULIN;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNIZATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SALIVA; SERUM;

EID: 0030052078     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.2.665-667.1996     Document Type: Article

References (16)

1. Crowley, P. J., L. J. Brady, D. A. Piacentini, and A. S. Bleiweis. 1993. Identification of a salivary agglutinin-binding domain within cell surface adhesin P1 of Streptococcus mutans. Infect. Immun. 61:1547-1552.
2. Gray, D., and H. Skarvall. 1988. B cell memory is short-lived in the absence of antigen. Nature (London) 336:70-73.
3. Hajishengallis, G., S. K. Hollingshead, T. Koga, and M. W. Russell. 1995. Mucosal immunization with a bacterial protein antigen genetically coupled to cholera toxin A2/B subunits. J. Immunol. 154:4322-4332.
4. Hajishengallis, G., T. Koga, and M. W. Russell. 1994. Affinity and specificity of the interactions between Streptococcus mutans, antigen I/II and salivary components. J. Dent. Res 73:1493-1502.
5. Hajishengallis, G., E. Nikolova, and M. W. Russell. 1992. Inhibition of Streptococcus mutans adherence to saliva-coated hydroxyapatite by human secretory immunoglobulin A (S-IgA) antibodies to cell surface protein antigen I/II: reversal by IgA1 protease cleavage. Infect. Immun. 60:5057-5064.
6. Holmgren, J. 1991. Mucosal immunity and vaccination. FEMS Microbiol. Immunol. 89:1-10.
7. Katz, J., C. C. Harmon, G. P. Buckner, G. J. Richardson, M. W. Russell, and S. M. Michalek. 1993. Protective salivary immunoglobulin A responses against Streptococcus mutans infection after intranasal immunization with S. mutans antigen I/II coupled to the B subunit of cholera toxin. Infect. Immun. 61:1964-1971.
8. Lett, E., C. Klopfenstein, J.-P. Klein, M. Schöller, and D. Wachsmann. 1995. Mucosal immunogenicity of polysaccharides conjugated to a peptide or multiple-antigen peptide containing T- and B-cell epitopes. Infect. Immun. 63:2645-2651.
9. Michalek, S. M., and N. K. Childers. 1990. Development and outlook for a canes vaccine. Crit. Rev. Oral Biol Med. 1:37-54.
10. Pierce, N. F., and W. C. Cray. 1982 Determinants of the localization magnitude, and duration of a specific mucosal IgA plasma cell response in enterically immunized rats. J. Immunol 128:1311-1315.
11. Quiding, M., I. Nordström, A. Kilander, G. Anderson, L. Å. Hanson, J. Holmgren, and C. Czerkinsky. 1991. Intestinal immune responses in humans Oral cholera vaccination induces strong intestinal antibody responses, gamma-interferon production and evokes local immunological memory. J. Clin Invest. 88:143-148.
12. Russell, M. W. 1992. Immunization against dental caries Curr. Opin. Dent. 2:72-80
13. Russell, M. W., and H.-Y. Wu. 1991. Distribution, persistence, and recall of serum and salivary antibody responses to peroral immunization with protein antigen I/II of Streptococcus mutans coupled to the cholera toxin B subunit. Infect. Immun. 59:4061-4070.
14. 13a.Russell, M. W., and H.-Y. Wu. Unpublished data.
15. Tew, J. G., R. P. Phipps, and T. E. Mandel. 1980. The maintenance and regulation of the humoral immune response: persisting antigen-binding dendritic cells as accessory cells. Immunol. Rev. 53:175-201
16. Vajdy, M., and N. Y. Lycke. 1992. Cholera toxin adjuvant promotes long-term immunological memory in the gut mucosa to unrelated immunogens after oral immunization. Immunology 75:488-492