메뉴 건너뛰기




Volumn 3, Issue 3, 1998, Pages 192-195

Transgenic models and subcellular pathology - Do they tell us what goes wrong in Huntington's disease?

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; HUNTINGTON CHOREA; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; TRANSGENIC MOUSE; TRINUCLEOTIDE REPEAT;

EID: 0031802550     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000374     Document Type: Short Survey
Times cited : (2)

References (25)
  • 1
    • 0028077894 scopus 로고
    • Neurochemistry and toxin models in Huntington's disease
    • Beal MF. Neurochemistry and toxin models in Huntington's disease. Curr Opin Neurol 1994; 7: 542-547.
    • (1994) Curr Opin Neurol , vol.7 , pp. 542-547
    • Beal, M.F.1
  • 2
    • 0030919567 scopus 로고    scopus 로고
    • Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia
    • Browne SE, Bowling AC, MacGarvey U, Baik MJ, Berger SC, Muqit MM et al. Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia. Ann Neurol 1997; 41: 646-653.
    • (1997) Ann Neurol , vol.41 , pp. 646-653
    • Browne, S.E.1    Bowling, A.C.2    MacGarvey, U.3    Baik, M.J.4    Berger, S.C.5    Muqit, M.M.6
  • 4
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993; 72: 971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 6
    • 0029034511 scopus 로고
    • Widespread expression of Huntington's disease gene (IT15) protein product
    • Sharp AH, Loev SJ, Schilling G, Li S-H, Li X-J, Bao J et al. Widespread expression of Huntington's disease gene (IT15) protein product. Neuron 1995; 14: 1065-1074.
    • (1995) Neuron , vol.14 , pp. 1065-1074
    • Sharp, A.H.1    Loev, S.J.2    Schilling, G.3    Li, S.-H.4    Li, X.-J.5    Bao, J.6
  • 7
    • 0028891145 scopus 로고
    • Huntington's disease gene: Regional and cellular expression in brain of normal and affected individuals
    • Landwehrmeyer GB, McNeil SM, Dure LS, Ge P, Alzawa H, Huang Q et al. Huntington's disease gene: regional and cellular expression in brain of normal and affected individuals. Ann Neurol 1995; 37: 218-230.
    • (1995) Ann Neurol , vol.37 , pp. 218-230
    • Landwehrmeyer, G.B.1    McNeil, S.M.2    Dure, L.S.3    Ge, P.4    Alzawa, H.5    Huang, Q.6
  • 8
    • 0029055601 scopus 로고
    • Cellular localisation of the Huntington's disease protein and discrimination of the normal and mutated form
    • Trottier Y, Devys D, Imbert G, Saudou F, An I, Lutz Y et al. Cellular localisation of the Huntington's disease protein and discrimination of the normal and mutated form. Nature Genet 1995; 10: 104-110.
    • (1995) Nature Genet , vol.10 , pp. 104-110
    • Trottier, Y.1    Devys, D.2    Imbert, G.3    Saudou, F.4    An, I.5    Lutz, Y.6
  • 9
    • 0028989602 scopus 로고
    • Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons
    • DiFiglia M, Sapp E, Chase K, Schwarz C, Meloni A, Young C et al. Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron 1995; 14: 1075-1081.
    • (1995) Neuron , vol.14 , pp. 1075-1081
    • DiFiglia, M.1    Sapp, E.2    Chase, K.3    Schwarz, C.4    Meloni, A.5    Young, C.6
  • 12
    • 0030001072 scopus 로고    scopus 로고
    • Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin
    • Bao J, Sharp AH, Wagster MV, Becher M, Schilling G, Ross CA et al. Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin. Proc Natl Acad Sci USA 1996; 93: 3037-5042.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3037-5042
    • Bao, J.1    Sharp, A.H.2    Wagster, M.V.3    Becher, M.4    Schilling, G.5    Ross, C.A.6
  • 13
    • 0028803757 scopus 로고
    • A huntingtin-associated protein enriched in brain with implications for pathology
    • Li XJ, Li SH, Sharp AH, Nucifora Jr FC, Schilling G, Lanahan A et al. A huntingtin-associated protein enriched in brain with implications for pathology. Nature 1995; 378: 398-402.
    • (1995) Nature , vol.378 , pp. 398-402
    • Li, X.J.1    Li, S.H.2    Sharp, A.H.3    Nucifora Jr., F.C.4    Schilling, G.5    Lanahan, A.6
  • 14
    • 0030986659 scopus 로고    scopus 로고
    • HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain
    • Kalchman MA, Koide HB, McCutcheon K, Graham RK, Nichol K, Nishiyama K et al. HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain. Nature Genet 1997; 16: 44-53.
    • (1997) Nature Genet , vol.16 , pp. 44-53
    • Kalchman, M.A.1    Koide, H.B.2    McCutcheon, K.3    Graham, R.K.4    Nichol, K.5    Nishiyama, K.6
  • 15
    • 16044373842 scopus 로고    scopus 로고
    • Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
    • Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C et al. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 1996; 87: 493-506.
    • (1996) Cell , vol.87 , pp. 493-506
    • Mangiarini, L.1    Sathasivam, K.2    Seller, M.3    Cozens, B.4    Harper, A.5    Hetherington, C.6
  • 16
    • 18544410106 scopus 로고    scopus 로고
    • Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
    • Davies SW, Turmaine M, Cozens BA, DiFiglia M, Sharp AH, Ross CA et al. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 1997; 90: 537-548.
    • (1997) Cell , vol.90 , pp. 537-548
    • Davies, S.W.1    Turmaine, M.2    Cozens, B.A.3    DiFiglia, M.4    Sharp, A.H.5    Ross, C.A.6
  • 17
    • 0030752709 scopus 로고    scopus 로고
    • Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neuntes in brain
    • DiFiglia M, Sapp E, Chase KO, Davies SW, Bates GP, Vonsattel JP et al. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neuntes in brain. Science 1997; 277: 1990-1993.
    • (1997) Science , vol.277 , pp. 1990-1993
    • DiFiglia, M.1    Sapp, E.2    Chase, K.O.3    Davies, S.W.4    Bates, G.P.5    Vonsattel, J.P.6
  • 18
    • 0017183963 scopus 로고
    • Morphometric studies of the neuropathological changes in choreatic diseases
    • Lange H, Thörner G, Hopf A, Schröder KF. Morphometric studies of the neuropathological changes in choreatic diseases. J Neurol Sci 1976; 28: 401-425.
    • (1976) J Neurol Sci , vol.28 , pp. 401-425
    • Lange, H.1    Thörner, G.2    Hopf, A.3    Schröder, K.F.4
  • 19
    • 0021139033 scopus 로고
    • Reduced Purkinje cell density in Huntington's disease
    • Jeste DV, Barban L, Parisi J. Reduced Purkinje cell density in Huntington's disease. Exp Neurol 1984; 85: 78-86.
    • (1984) Exp Neurol , vol.85 , pp. 78-86
    • Jeste, D.V.1    Barban, L.2    Parisi, J.3
  • 20
    • 0030850412 scopus 로고    scopus 로고
    • Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3
    • Paulson HL, Perez MK, Trottier Y, Trojanowski JQ, Subramony SH, Das SS et al. Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3. Neuron 1997; 19: 333-344.
    • (1997) Neuron , vol.19 , pp. 333-344
    • Paulson, H.L.1    Perez, M.K.2    Trottier, Y.3    Trojanowski, J.Q.4    Subramony, S.H.5    Das, S.S.6
  • 21
    • 0030666001 scopus 로고    scopus 로고
    • Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures
    • Skinner PJ, Koshy BT, Cummings CJ, Klement IA, Helin K, Servadio A et al. Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures. Nature 1997; 389: 971-974.
    • (1997) Nature , vol.389 , pp. 971-974
    • Skinner, P.J.1    Koshy, B.T.2    Cummings, C.J.3    Klement, I.A.4    Helin, K.5    Servadio, A.6
  • 22
    • 9344227302 scopus 로고    scopus 로고
    • Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
    • Goldberg YP, Nicholson DW, Rasper DM, Kalchman MA, Koide HB, Graham RK et al. Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nature Genet 1996; 13: 442-449.
    • (1996) Nature Genet , vol.13 , pp. 442-449
    • Goldberg, Y.P.1    Nicholson, D.W.2    Rasper, D.M.3    Kalchman, M.A.4    Koide, H.B.5    Graham, R.K.6
  • 23


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.