Deaggregated homologous immunoglobulin-peptide conjugates induce peptide-specific T cell nonresponsiveness in vivo

European Journal of Immunology

Volumn 28, Issue 12, 1998, Pages 4313-4324

  Seddon, Benedict ^a   Mason, Don ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Anergy; T cell; Tolerance

Indexed keywords

CYTOKINE; FREUND ADJUVANT; IMMUNOGLOBULIN G; MYELIN BASIC PROTEIN; PEPTIDE;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CELL PROTECTION; CONJUGATE; CONTROLLED STUDY; COVALENT BOND; CYTOKINE RELEASE; DISEASE COURSE; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE;

EID: 0031791942     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199812)28:12<4313::AID-IMMU4313>3.0.CO;2-6     Document Type: Article

References (38)

1. Wekerle, H., Linnington, C., Lassmann, H. and Meyermann, R., Cellular immune reactivity within the CNS. Trends Neurosci. 1986. 9: 271-277.
2. Sedgwick, J., Brostoff, S. and Mason, D., Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system. J. Exp. Med. 1987. 165: 1058-1075.
3. Ben-Nun, A., Wekerle, H. and Cohen, I. R., The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol. 1981. 11: 195-199.
4. Zamvil, S. S. and Steinman, L., The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 1990. 8: 579-621.
5. Miller, A., Lider, O., Roberts, A. B., Sporn, M. B. and Weiner, H. L., Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc. Natl. Acad. Sci. USA 1992. 89: 421-425.
6. Khoury, S. J., Hancock, W. W. and Weiner, H. L., Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin-4, and prostaglandin E expression in the brain. J. Exp. Med. 1992. 176: 1355-1364.
7. Santos, L. M., al-Sabbagh, A., Londono, A. and Weiner, H. L., Oral tolerance to myelin basic protein induces regulatory TGF-beta-secreting T cells in Peyer's patches of SJL mice. Cell. Immunol. 1994. 157: 439-447.
8. Chen, Y., Inobe, J., Kuchroo, V. K., Baron, J. L., Janeway, C., Jr. and Weiner, H. L., Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. Proc. Natl. Acad. Sci. USA 1996. 93: 388-391.
9. Metzler, B. and Wraith, D. C., Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity. Int. Immunol. 1993. 5: 1159-1165.
10. Anderton, S. M. and Wraith, D. C., Hierarchy in the ability of T cell epitopes to induce peripheral tolerance to antigens from myelin. Eur. J. Immunol. 1998. 28: 1251-1261.
11. Gaur, A., Wiers, B., Liu, A., Rothbard, J. and Fathman, C. G., Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy. Science 1992. 258: 1491-1494.
12. Marusic, S. and Tonegawa, S., Tolerance induction and autoimmune encephalomyelitis amelioration after administration of Myelin Basic Protein-derived peptide. J. Exp. Med. 1997. 186: 507-515.
13. Tian, J., Clare-Salzler, M., Herschenfeld, A., Middleton, B., Newman, D., Mueller, R., Arita, S., Evans, C., Atkinson, M. A., Mullen, Y., Sarvetnick, N., Tobin, A. J., Lehmann, P. V. and Kaufman, D. L., Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice [see comments]. Nat. Med. 1996. 2: 1348-1353.
14. Ramiya, V. K., Shang, X. Z., Pharis, P. G., Wasserfall, C. H., Stabler, T. V., Muir, A. B., Schatz, D. A. and Maclaren, N. K., Antigen based therapies to prevent diabetes in NOD mice. J. Autoimmun. 1996. 9: 349-356.
15. Ramiya, V. K., Lan, M. S., Wasserfall, C. H., Notkins, A. L. and Maclaren, N. K., Immunization therapies in the prevention of diabetes. J. Autoimmun. 1997. 10: 287-292.
16. Chiller, J. M., Habicht, G. S. and Weigle, W. O., Kinetic differences in unresponsiveness of thymus and bone marrow cells. Science 1971. 171: 813-815.
17. Romball, C. G. and Weigle, W. O., In vivo induction of tolerance in murine CD4+ cell subsets. J. Exp. Med. 1993. 178: 1637-1644.
18. Phillips, J. A., Romball, C. G., Hobbs, M. V., Ernst, D. N., Shultz, L. and Weigle, W. O., CD4+ T cell activation and tolerance induction in B cell knockout mice. J. Exp. Med. 1996. 183: 1339-1344.
19. Finkelman, F. D., Lees, A., Birnbaum, R., Gause, W. C. and Morris, S. C., Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion. J. Immunol. 1996. 157: 1406-1414.
20. Morris, S. C., Lees, A., Holmes, J. M., Jeffries, R. D. and Finkelman, F. D., Induction of B cell and T cell tolerance in vivo by anti-CD23 mAb. J. Immunol. 1994. 152: 3768-3776.
21. Day, M. J., Tse, A. G., Puklavec, M., Simmonds, S. J. and Mason, D. W., Targeting autoantigen to B cells prevents the induction of a cell-mediated autoimmune disease in rats. J. Exp. Med. 1992. 175: 655-659.
22. Levine, S. and Sowinski, R., Treatment of experimental allergic encephalomyelitis with myelin basic protein: which route is best? Neurochem. Res. 1984. 9: 1417-1421.
23. Devaux, B., Enderlin, F., Wallner, B. and Smilek, D. E., Induction of EAE in mice with recombinant human MOG, and treatment of EAE with a MOG peptide. J. Neuroimmunol. 1997. 75: 169-173.
24. Degermann, S., Pria, E. and Adorini, L., Soluble protein but not peptide administration diverts the immune response of a clonal CD4+ T cell population to the T helper 2 cell pathways. J. Immunol. 1996. 157: 3260-3269.
25. Borel, H. and Borel, Y., A novel technique to link either proteins or peptides to gammaglobulin to construct tolerogens. J. Immunol. Methods 1990. 126: 159-168.
26. Saoudi, A., Simmonds, S., Huitinga, I. and Mason, D., Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of the autoantigen-specific T cells [see comments]. J. Exp. Med. 1995. 182: 335-344.
27. Saoudi, A., Kuhn, J., Huygen, K., de-Kozak, Y., Velu, T., Goldman, M., Druet, P. and Bellon, B., TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1-dependent autoimmune disease. Eur. J. Immunol. 1993. 23: 3096-3103.
28. Gracie, J. A. and Bradley, J. A., Interleukin-12 induces interferon-gamma-dependent switching of IgG alloantibody subclass. Eur. J. Immunol. 1996. 26: 1217-1221.
29. Liu, J., Bai, X., Shi, F., Xiao, B., Li, H., Levi, M., Mustafa, M., Wahren, B. and Link, H., Inhibition of experimental autoimmune encephalomyelitis in Lewis rats by nasal administration of encephalitogenic MBP peptides: synergistic effects of MBP 68-86 and 87-99. Int. Immunol. 1998. 10: 1139-1148.
30. Gajewski, T. F., Lancki, D. W., Stack, R. and Fitch, F. W., "Anergy" of THO helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype. J. Exp. Med. 1994. 179: 481-491.
31. Lafaille, J. J., Keerre, F. V., Hsu, A. L., Baron, J. L., Haas, W., Raine, C. S. and Tonegawa, S., Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J. Exp. Med. 1997. 186: 307-312.
32. Williams, A. F., Galfre, G. and Milstein, C., Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: differentiation antigens of rat lymphocytes. Cell 1977. 12: 663-673.
33. Brideau, R. J., Carter, P. B., McMaster, W. R., Mason, D. W. and Williams, A. F., Two subsets of rat T lymphocytes defined with monoclonal antibodies. Eur. J. Immunol. 1980. 10: 609-615.
34. Hsiung, L. M., Barclay, A. N., Brandon, M. R., Sim, E. and Porter, R. R., Purification of human C3b inactivator by monoclonal-antibody affinity chromatography. Biochem. J. 1982. 203: 293-298.
35. Woollett, G. R., Barclay, A. N., Puklavec, M. and Williams, A. F., Molecular and antigenic heterogeneity of the rat leukocyte-common antigen from thymocytes and T and B lymphocytes. Eur. J. Immunol. 1985. 15: 168-173.
36. Robinson, A. P., White, T. M. and Mason, D. W., Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3. Immunology 1986. 57: 239-247.
37. Brenan, M. and Puklavec, M., The MRC OX-62 antigen: a useful marker in the purification of rat veiled cells with the biochemical properties of an integrin. J. Exp. Med. 1992. 175: 1457-1465.
38. van-der-Meide, P. H., Dubbeld, M., Vijverberg, K., Kos, T. and Schellekens, H., The purification and characterization of rat gamma interferon by use of two monoclonal antibodies. J. Gen. Virol. 1986. 67: 1059-1071.