Developmental hematopoiesis

Critical Reviews in Immunology

Volumn 18, Issue 6, 1998, Pages 485-501

  Morales Alcelay, S ^a   Copin S G ^b   Martinez J A ^a   Morales, P ^b   Minguet, S ^b   Gaspar, M L ^a   Marcos, Miguel A R ^a,b  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Angiogenesis; Embryonic lymphohemopoiesis; Gene targeting; Gene therapy; Hematopoietic stem cells

Indexed keywords

ANGIOGENESIS; ARTICLE; EMBRYO; GASTRULATION; GENE TARGETING; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LYMPHOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031788724     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: 10.1615/critrevimmunol.v18.i6.10     Document Type: Article

References (160)

1. Buss, L., The Evolution of Individuality, Princeton University Press, New Jersey, 1987, 69-118.
2. Müller, A. M., Medvinsky, A. L., Strouboulis, J., Grosveld, F., and Dzierzak, E., Development of hematopoietic stem cell activity in the mouse embryo, Immunity, 1, 291-301, 1994.
3. Ogawa, M., Nishikawa, S. I., Yoshinaga, K., Hayashi, S. I., Kunisada, T., Nakao, J., Kina, T., Sudo, T., Kodama, H., and Nishikawa, S. I., Expression and function of c-kit in fetal hemopoietic progenitor cells: transition from the early c-kit-independent to the late c-kit-dependent wave of hemopoiesis in the murine embryo. Development, 117, 1089-1098, 1993.
4. Pardanaud, L., Luon, D., Prigent, M., Bourcheix, L.-M., Catala, M., and Dieterlen-Lièvre, F., Two distinct endothelial lineages in ontogeny, one of them related to hemopoiesis, Development, 122, 1363-1371, 1996.
5. Palis, J., McGrath, K. E., and Kingsley, P. D., Initiation of hematopoiesis and vasculogenesis in murine yolk sac explants, Blood, 86, 156-163, 1995.
6. Russel, E. S. and Bernstein, S. E., Blood and blood formation, in Biology of the Laboratory Mouse, 2nd ed., Green, E. L., Ed., McGraw-Hill, New York, 351-372.
7. Moore, M. A. S. and Metcalf, D., Ontogeny of the hematopoietic system: yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo, Br. J. Haematol., 18, 279-296, 1970.
8. Moore, M. A. S. and Owen, J. J. T., Stem-cell migration in developing myeloid and lymphoid systems, Lancet, II, 658-659, 1967.
9. Dieterlen-Lièvre, F., On the origin of hematopoietic stem cells in the avian embryo: an experimental approach, J. Embryol. Exp. Morphol., 33, 607-619, 1975.
10. Lassila, O., Eskola, J., Toivanen, P., Martin, C., and Dieterlen-Lièvre, F., The origin of lymphoid stem cells studied in chick yolk sac-embryo chimeras, Nature, 272, 353-354, 1978.
11. Dieterlen-Lièvre, F. and Martin, C., Diffuse intraembryonic hemopoiesis in normal and chimeric avian development, Dev. Biol., 88, 180-191, 1981.
12. Smith, R. A. and Glomski, C. A., "Hemogenic endothelium" of the embryonic aorta: Does it exist? Dev. Comp. Immunol., 6, 359-368, 1982.
13. Cormier, F. and Dieterlen-Lièvre, F., The wall of the chick embryo aorta harbors M-CSF, G-CFC, GM-CFC and BFU-E, Development, 102, 279-285, 1988.
14. Godin, I. E., García-Porrero, J. A., Coutinho, A., Dieterlen-Lièvre, F., and Marcos, M. A. R., Para-aortic splanchopleura from early mouse embryos contains B la cell progenitors, Nature, 364, 67-69, 1993.
15. Marcos, M. A. R., Godin, I., Cumano, A., Morales, S., García-Porrero, J. A., Dieterlen-Lièvre, F., and Gaspar, M. L., Developmental events from hemopoietic stem cells to B-cell populations and Ig repertoires, Immunol. Rev., 137, 155-171, 1994.
16. Medvinsky, A., Samoylina, N. L., Müller, A. M., and Dzierzak, E. A., An early pre-liver intraembryonic source of CFU-S in the developing mouse, Nature. 364, 64-66, 1993.
17. Godin, I., Dieterlen-Lièvre, F., and Cumano, A., Emergence of multipotent hematopoietic stem cells in the yolk sac and para-aortic splanchnopleura in mouse embryos, beginning at 8.5 days postcoitus, Proc. Natl. Acad. Sci. U.S.A., 92, 773-777, 1995.
18. Cumano, A., Dieterlen-Lièvre, F., and Godin, I., Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura, Cell, 86, 907-916, 1996.
19. Medvinsky, A. and Dzierzak, E., Definitive hematopoiesis is autonomously initiated by the AGM region, Cell, 86, 897-906, 1996.
20. García-Porrero, J. A., Godin, I. E., and Dieterlen-Lièvre, F., Potential intraembryonic hemogenic sites at preliver stages in the mouse, Anat. Embryol. (Berl.), 192, 425-435, 1995.
21. Kau, C. L. and Turpen, J. B., Dual contribution of embryonic ventral blood island and dorsal lateral plate mesoderm during ontogeny of hematopoietic cells in Xenopus laevis, J. Immunol., 131, 2262-2266, 1983.
22. Turpen, J. B. and Smith, P. B., Location of hemopoietic stem cells influences frequency of lymphoid engraftment in Xenopus embryos, J. Immunol., 143, 3455-3460, 1989.
23. Bechtold, T. E., Smith, P. B., and Turpen, J. B., Differential stem cell contributions to thymocyte succession during development of Xenopus laevis, J. Immunol., 148, 2975-2982, 1992.
24. Turpen, J. B., Kelley, C. M., Mead, P. E., and Zon, L. I., Bipotential primitive-defnitive hematopoietic progenitors in the vertebrate embryo, Immunity, 7, 325-334, 1997.
25. Detrich H. W., III, Kieran, M. W., Chan, F. Y., Barone, L. M., Yee, K., Rundstadler, J. A., Pratt, S., Ransom, D., and Zon, L. I., Intraembryonic hemato-poietic cell migration during vertebrate development, Proc. Natl. Acad. Sci. U.S.A., 92, 10713-10717, 1995.
26. Zon, L. I., Developmental biology of hematopoiesis, Blood, 86, 2876-2891, 1995.
27. Tavian, M., Coulombel, L., Luton, D., San Clemente, H., Dieterlen-Lièvre, F., and Péault, B., Aorta-associated CD34+ hematopoietic cells in early human embryo, Blood, 87, 67-72, 1996.
28. Chen, X. D. and Turpen, J. B., Intraembryonic origin of hepatic hematopoiesis in Xenopus laevis, J. Immunol., 154, 2557-2567, 1995.
29. Beaupain, D., Martin, C., and Dieterlen-Lièvre, F., Are developmental hemoglobin changes related to the origin of stem cells and site of erythropoiesis? Blood, 53, 212-225, 1979.
30. Delassus, S. and Cumano, A., Circulation of hematopoietic progenitors in the mouse embryo, Immunity, 4, 97-106, 1996.
31. Martin, C., Beaupain, D., and Dieterlen-Lièvre, F., A study of the development of the hemopoietic system using quail-chick chimeras obtained by blastoderm recombination, Dev. Biol., 75, 303-314, 1980.
32. Le Douarin, N. M., Dieterlen-Lièvre, F., and Oliver, P. D., Ontogeny of primary lymphoid organs and lymphoid stem cells, Am. J. Anat., 170, 261-299, 1984.
33. Johnson, G. R. and Moore, M. A. S., Role of stem cell migration in initiation of mouse fetal liver hematopoiesis, Nature, 258, 726-728, 1975.
34. Johnson, G. R. and Jones, R. O., Differentiation of the mammalian hepatic primordium in vitro. I. Morphogenesis and the onset of hematopoiesis, J. Embryol. Exp. Morphol., 30, 83-96, 1973.
35. Marcos, M. A. R., Morales-Alcelay, S., Godin, I. E., Dieterlen-Lièvre, F., Copín, S. G., and Gaspar, M. L., Antigenic phenotype and gene expression pattern of lymphohemopoietic progenitors during early mouse ontogeny, J. Immunol., 158, 2627-2637, 1997.
36. Okuda, T., Deursen, J. V., Hiebert, S. W., Grosveld, G., and Downing, J. R., AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis, Cell, 84, 321-330, 1996.
37. Coltey, M., Bucy, R. P., Chen, C. H., Cihak, J., Lösch, U., Char, D., Le Douarin, N. M., and Cooper, M. D., Analysis of the first two waves of thymus homing stem cells and their T cell progeny in chickquail chimeras, J. Exp. Med., 170, 543-557, 1989.
38. Dunon, D., Courtois, D., Vainio, O., Six, A., Chen, C. H., Cooper, M. D., Dangy, J. P., and Imhof, B. A., Ontogeny of the immune system: γ/δ and α/β T cells migrate from thymus to the periphery in alternating waves, J. Exp. Med., 186, 977-988, 1997.
39. Fontaine-Pérus, J., Caiman, F. M., Kaplan, C., and Le Douarin, N., Seeding of the 10-day mouse embryo thymic rudiment by lymphocyte precursors in vitro, J. Immunol., 126, 2310-2316, 1981.
40. Jotereau, F., Heuze, F., Salomon-Vie, V., and Gascan, H., Cell kinetics in the mouse fetal thymus: precursor cell input, proliferation, and migration, J. Immunol., 138, 1026-1030, 1987.
41. Haas, W. and Tonegawa, S., Development and selection of γδ T cells, Curr. Opin. Immunol., 4, 147-155, 1992.
42. Carding, S. R., Kyes, S., Jenkinson, E. J., Kingston, R., Bottomly, K., Owen, J. J., and Hayday, A. C., Developmentally regulated fetal thymic and extrathymic T-cell receptor gamma delta gene expression, Genes Dev., 4, 1304-1315, 1990.
43. Aurrand-Lions, M., Galland, F., Bazin, H., Zakharyev, V. M., Imhof, B. A., and Naquet, P., Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing, Immunity, 5, 391-405, 1996.
44. Ruiz, P., Wiles, M. W., and Imhof, B. A., α6 integrins participate in pro-T cell homing to the thymus, Eur. J. Immunol., 25, 2034-2041, 1995.
45. Hirsch, E., Iglesias, A., Potocnick, A. J., Hartmann, U., and Fassler, R., Impaired migration but not differentiation of hematopoietic stem cells in the absence of beta-1 integrins, Nature, 380, 171-175, 1996.
46. Arroyo, A., Yang, J. T., Rayburn, H., and Hynes, R. O., Differential requirements for alpha-4 integrins during fetal and adult hematopoiesis, Cell, 85, 997-1008, 1996.
47. Aguila, H. L., Akashi, K., Domen, J., Gandy, K. L., Lagasse, E., Mebius, R. E., Morrison, S. J., Shiznrn, J., Strober, S., Uchida, N., Wright, D. E., and Weissmann, I. L., From stem cells to lymphocytes: biology and transplantation, Immunol. Rev., 157, 13-40, 1997.
48. Hedrick, J. and Zlotnik, A., Chemokines and lymphocyte biology, Curr. Opin. Immunol., 8, 343-347, 1996.
49. Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S.-I., Kitamura, Y., Yoshida, N., Kikutani, H., and Kishimoto, T., Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1, Nature, 382, 635-638, 1996.
50. Rocha, B., Vassalli, P., and Guy-Grand, D., Thymic and extrathymic origins of gut intraepithelial lymphocyte populations in mice, J. Exp. Med., 180, 681-686, 1994.
51. + lymphohemopoietic progenitors develop, J. Exp. Med., 184, 1449-1459, 1996.
52. Kubai, L. and Auerbach, R., A new source of embryonic lymphocytes in the mouse, Nature, 301, 154-156, 1983.
53. Solvason, N., Lehuen, A., and Kearney, F. J., An embryonic source of Lyl but not conventional B cells, Int. Immunol., 3, 543-550, 1991.
54. Velardi, A. and Cooper, M. D., An immunofluorescence analysis of the ontogeny of myeloid, T and B lineage cells in mouse hemopoietic tissues, J. Immunol., 133, 672-677, 1984.
55. Yoder, M. C. and Hyatt, K., Engraftment of embryonic hematopoietic cells in conditioned newborn recipients, Blood, 89, 2176-2183, 1997.
56. Yoder, M. C., Hiatt, K., and Mukherjee, P., In vivo repopulating hematopoietic stem cells are present in the murine yolk sac at day 9.0 postcoitus, Proc. Natl. Acad. Sci. U.S.A., 94, 6776-6780, 1997.
57. Yoder, M. C., Hiatt, K., Dutt, P., Mukherjee, P., Bodine, D. M., and Orlic, D., Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac, Immunity, 7, 335-344, 1997.
58. Zanjani, E., Ascensao, J., and Tavassoli, M., Liver-derived fetal hematopoietic stem cells selectively and preferentially home to the fetal bone marrow, Blood, 81, 399-404, 1993.
59. Rebel, V. I., Miller, C. L., Thornbury, G. R., Dragowska, W. H., Eaves, C. J., and Lansdorp, P. M., A comparison of long-term repopulating hematopoietic stem cells in fetal liver and in adult bone marrow of the mouse, Exp. Hematol., 24, 638-648, 1996.
60. Rebel, V. I., Miller, C. L., Eaves, C. J., and Lansdorp, P. M., The repopulation potential of fetal , liver hematopoietic stem cells in mice exceeds that of their adult bone marrow counterparts, Blood, 87, 3500-3507, 1996.
61. Harrison, D. E., Zhong, R. K., Jordan, C. T., Lemischka, I. R., and Astle, C. M., Relative to adult bone marrow, fetal liver repopulates nearly five times more effectively long-term than short-term, Exp. Hematol., 25, 293-297, 1997.
62. Harrison, D. E. and Astle, C. M., Short- and longterm multilineage repopulating hematopoietic stem cells in late fetal and newborn mice: Models for human umbilical cord blood, Blood, 90, 174-181, 1997.
63. Houssaint, E. and Hallet, M., Inability of adult circulating haematopoietic stem cells to sustain hemopoiesis in mouse fetal liver microenvironment, Immunology, 64,463-467, 1988.
64. Carmeliet, P., Ferreira, V., Breier, G., Pollefeist, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoek, A., Harpol, K., Eberhardt, C., Declercq, C., Pawling, J., Moons, L., Collen, D., Risau, W., and Nagy, A., Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele, Nature, 380, 435-439, 1996.
65. Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O'Shea, K. S., Powell-Braxton, L., Hillan, K. J., and Moore, M. W., Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene, Nature, 380, 439-4142, 1996.
66. Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X. F., Breitman, M. L., and Schuh, A. C., Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice, Nature, 376, 62-66, 1995.
67. Shalaby, F., Ho, J., Stanford, A. C., Schwartz, L., Bernstein, A., and Rossant, J., A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis, Cell, 89, 981-990, 1997.
68. Kabrun, N., Bühring, H.-J., Choi, K., Ullrich, A., Risau, W., and Keller, G., Flk-1 expression defines a population of early embryonic hematopoietic precursors, Development 124, 2039-2048, 1997.
69. Liao, W., Bisgrove, B. W., Sawyer, H., Hug, B., Bell, B., Peters, K., Grunwald, D. J., and Stainier, D. Y., The zebrafish gene cloche acts upstream of a flk-1 homologue to regulate endothelial cell differentiation, Development, 124, 381-389, 1997.
70. Stainier, D. Y., Weinstein, B. M., Detrich, H. W., Zon, L. I., and Fishman, M. C., Cloche, an early acting zebrafish gene, is required by both the endothe liai and hematopoietic lineages, Development, 121, 3141-3150, 1995.
71. Liao, E. C., Paw, B. H., Oates, A. C., Pratt, S. J., Postlethwait, J. H., and Zon, L. I., SCL/Tal-l transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish, Genes Dev., 12, 621-626, 1998.
72. Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S., and Akhurst, R. J., Defective hematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice, Development, 121, 1845-1854, 1995.
73. Fong, G. H., Rossant, J., Gertsenstein, M., and Breitman, M. L., Role of the Flt-1 receptor tyrosine kinase in regulating assembly of vascular endothelium, Nature, 376, 66-70, 1995.
74. Sato, T. N., Tozawa, Y., Deutsch, U., Wolburg-Buchholz, K., Fujiwara, Y., Gendron-Maguire, M., Gridley, T., Wolburg, H., Risau, W., and Qin, Y., Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation, Nature, 376, 70-74, 1995.
75. Puri, M. C., Rossant, J., Alitalo, K., Bernstein, A., and Partanen, J., The receptor tyrosine kinase TIE is required for the integrity and survival of vascular endothelial cells, EMBO J., 14, 5884-5891, 1995.
76. Suri, C., Jones, P. F., Patan, S., Bartunkoba, S., Maisonpierre, P. C., Davies, S., Sato, T. N., and Yancopoulos, G. D., Requisite role of angiopoietin-1, a ligand for the TIE-2 receptor, during embryonic angiogenesis, Cell 87, 1171-1180, 1996.
77. Partanen, J., Puri, M. C., Schwartz, L., Fischer, K.-D., Bernstein, A., and Rossant, J., Cell autonomous functions of the receptor tyrosine kinase TIE in a late phase of angiogenic capillary growth and endothelial cell survival during murine development, Development, 122, 3013-3021, 1996.
78. Dumont, D. J., Gradwolh, G., Fong, G. H., Puri, M. C., Gertsenstein, M., Auerbach, A., and Breitman, M. L., Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo, Genes Dev., 8, 1897-1909, 1994.
79. Carmeliet, P., Mackman. N., Moons, L., Luther, T. T., Gressens, P., van Vlaenderen, I., Demunek, H., Kasper, M., Breier, G., Evrard, P., Müller, M., Risau, W., Edgington, T., and Cullen, D., Role of tissue factor in embryonic blood vessel development, Nature, 383, 73-75, 1996.
80. Henkemeyer, M., Rossi, D. J., Holmyard, D. P., Puri, M. C., Mbamalu, G., Harpal, K., Shih, T. S., Jacks, T., and Pawson, T., Vascular system defects and neuronal apoptosis in mice lacking Ras GTPaseactivating protein, Nature, 377, 695-701, 1995.
81. Wang, L. C., Kuo, F., Fujiwara, Y., Giililand, D. G., Golub, T. R., and Orkin, S. H., Yolk sac angiogenic defect and infra-embryonic apoptosis in mice lacking the Ets-related factor TEL, EMBO J., 16, 4374-4383, 1997.
82. Offermanns, S., Mancino, V., Revel, J. P., and Simon, M., Vascular system defects and impaired cell chemokinesis as a result of Gα deficiency, Science, 275, 533-536, 1997.
83. Maltepe, E., Schmidt, J. V., Baunoch, D., Bradfleld, C. A., and Celeste Simon, M., Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT, Nature, 386, 403-407, 1997.
84. Orkin, S. H., Hematopoiesis: how does it happen? Curr. Opin. Cell Biol., 7, 870-877, 1995.
85. Maeno, M., Mead, P. E., Kelley, C., Xu, R., Kung, H., Suzuki, A., Ueno, N., and Zon, L. I., The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis, Blood, 88, 1965-1972, 1996.
86. Bertwistle, D., Walmsley, M. E., Read, E. M., Pizzey, J. A., and Patient, R. K., GATA factors and the origins of adult and embryonic blood in Xenopus: responses to retinoic acid, Mech. Dev., 57, 199-214, 1996.
87. Ting, C.-N., Olson, M. C., Barton, K. B., and Leiden, J. M., Transcription factor GATA-3 is required for development of the T-cell lineage, Nature, 384, 474-478, 1996. _ ,
88. Soudais, C., Bielinska, M., Heikinheimo, M., MacArthur, C. A., Narita, N., Saffitz, J. E., Simon, M. C., Leiden, J. M., and Wilson, D. B., Targeted mutagenesis of the transcription factor GATA-4 in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro, Development, 121, 3877-3888, 1995.
89. Tsai, F. Y., Keller, G., Kuo, F. C., Weiss, M., Chen, J., Rosenblatt, M., Alt, F. W., and Orkin, S. H., An early hematopoietic defect in mice lacking the transcription factor GATA-2, Nature, 371, 221-226, 1994.
90. Shivdasani, R., Mayer, E., and Orkin, S. H., Absence of blood formation in mice lacking the T-cell leukemia oncoprotein tal-1/SCL, Nature, 373, 432-434, 1995.
91. Robb, L., Elwood, N. J., Elefanty, A. G., Königen, F., Li, R., Barnett, D., and Begley, C. G., The scl product is required for the generation of all hematopoietic lineages in the adult mouse, EMBO J., 15, 412-4129, 1996.
92. Robb, L., Lyons, I., Li, R., Hartley, L., Königen, F., Harvey, R., Metcalf, D., and Begley, C., Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene, Proc. Natl. Acad. Sci. U.S.A., 92, 7075-7079, 1995.
93. Porcher, C., Swat, W., Rockwell, K., Fujiwara, Y., Alt, F. W., and Orkin, S. H., The T cell leukemia oncoprotein SCL/Tal-1 is essential for development of all hematopoietic lineages, Cell, 86, 47-57, 1996.
94. Warren, A. J., Colledge, W. H., Carlton, M. B. L., Evans, M. J., Smith, A. J. H., and Rabbitts, T. H., The oncogenic cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development, Cell, 78, 45-57, 1994.
95. Elefanty, A. G., Robb, L., Birner, R., and Begley, C. G-, Hematopoietic-specific genes are not induced during in vitro differentiation of scl-null embryonic stem cells, Blood, 90, 1435-1447, 1997.
96. Visvader, J. E., Fujiwara, Y., and Orkin, S. H., Unsuspected role for the T-cell leukemia protein SCL/ tal-1 in vascular development, Genes Dev., 12, 473-479, 1998.
97. Wang, Q., Stacy, T., Binder, M., Marin-Padilla, M., Sharpe, A. H., and Speck, N. A., Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis, Proc. Natl. Acad. Sci. U.S.A., 93, 3444-3449, 1996.
98. Wang, Q., Stacy, T., Miller, J. D., Lewis, A. F., Gu, T. L., Huang, X., Bushweller, J. H., Bones, J. C., Alt, F. W., Ryan, G., Liu, P. P., Wynshaw-Boris, A., Binder, M., Marin-Padilla, M., Sharpe, A. H., and Speck, N. A., The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo, Cell, 87, 697-708, 1996.
99. Sasaki, K., Yagi, H., Bronson, R. T., Tominaga, K., Matsunashi, T., Deguchi, K., Tani, Y., Kishimoto, T., and Komori, T., Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor β, Proc. Natl. Acad. Sci. U.S.A., 93, 12359-12363, 1996.
100. Castilla, L. H., Wijmenga, C., Wang, Q., Stacy, T., Speck, N. A., Eckhaus, M., Marin-Padilla, M., Collins, F. S., Wynshaw-Boris, A., and Liu, P. P., Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11, Cell, 87, 687-696, 1996.
101. Niki, M., Okada, H., Takano, H., Kuno, J., Tani, K., Hibino, H., Asano, S., Tto, Y., Satake, M., and Noda, T., Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor, Proc. Natl. Acad. Sci. U.S.A., 94, 5697-5702, 1997.
102. Mucenski, M. L., McLain, K., Kier, A. B., Swerdlow, S- H., Schreiner, C. M., Miller, T. A., Pietriga, D. W., Scott, W. J., and Potter, S. S., A functional c-myb is required for normal murine fetal liver hematopoiesis, Cell, 65, 677-689, 1991.
103. Clarke, A. R., Robanus Maandag, E., van Roon, M., van der Lugt, N. M. T., van der Valk, M., Hooper, M. L., Berns, A., and te Riele, H., Requirement for a functional Rb-1 gene in murine development, Nature, 359, 328-330, 1992.
104. Jacks, T., Fazeli, A., Schmitt, E. M., Bronson, R. T., Goodell, M. A., and Weinberg, R. A., Effects of an Rb mutation in the mouse, Nature, 359, 295-300, 1992.
105. Lee, E. Y. H. P., Chang, C. Y., Hu, N., Wang, Y. C. J., Lai, C. C., Herrup, K. Lee, W. H., and Bradley, A., Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis, Nature, 359, 288-294, 1992.
106. Clevers, H. C. and Grosschedl, R., Transcriptional control of lymphoid development: lessons from gene targeting, Immunol. Today, 17, 336-343, 1996.
107. Pevny, L., Celeste Simon, M., Robertson, E., Klein, W. H., Tsai, S. F., D'Agati, V., Orkin, S. H., and Constantini, F., Erythroid differentiation in chimeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1, Nature, 349, 257-260, 1991.
108. Tsang, A. P., Visvader, J. E., Turner, C. A., Fujiwara, Y., Yu, C., Weiss, M. J., Crossley, M., and Orkin, S. H., FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation, Cell, 90, 109-119, 1997.
109. Weiss, M. J., Keller, G., and Orkin, S. H., Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells, Genes Dev., 8, 1184-1197, 1994.
110. Pandolfi, P. P., Roth, M. E., Karis, A., Leonard, M. W., Dzierzak, E., Grosveld, F. G., Engel, J. D., and Lindenbaum, M. H., Targeted disruption of the GATA-3 gene causes severe abnormalities in the nervous system and in fetal liver hematopoiesis, Nature Genet., 11, 40-44, 1995.
111. Ting, C.-N., Olson, M. C., Barton, K. P., and Leiden, J. M., Transcription factor GATA-3 is required for development of the T-cell lineage, Nature, 384, 474-478, 1996.
112. Nuez, B., Michalovich, D., Bygrave, A., Ploemacher, R., and Grosveld, F., Defective hematopoiesis in fetal liver resulting from inactivation of the EKLF gene, Nature, 375, 316-318, 1995.
113. Perkins, C. P., Mar, V., Shutter, J. R., del Castillo, J., Danilenko, D. M., Medlock, E. S., Ponting, I. L., Graham, M., Stark, K. L., Zuo, Y., Cunningham, J. M., and Bosselman, R. A., Anemia and perinatal death result from loss of the murine ecotropic retrovirus receptor mCAT-1, Genes Dev., 11, 914-925, 1997.
114. Scott, E., Simon, M., Anastasi, J., and Singh, H., Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages, Science, 265, 1573-1577, 1994.
115. Scott, E. W., Fisher, R. C., Olson, M. C., Kehrli, E. W., Celeste Simon, M., and Singh, H., PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors, Immunity, 6, 437-447, 1997.
116. McKercher, S. R., Torbett, B. E., Anderson, K. L., Henkel, G. W., Vestal, D. J., Baribault, H., Klemsz, M., Feeney, A. J., Wu, G. E., Paige, C. J., and Maki, R. A., Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities, EMBO J., 15, 5647-5658, 1996.
117. Georgopoulos, K., Winandy, S., and Avitahl, N., The role of the Ikaros gene in lymphocyte development and homeostasis, Annu. Rev. Immunol., 15, 155-176, 1997.
118. Yu, B. D., Hess, J. L., Horning, S. E., Brown, G. A. J., and Korsmeyer, S. J., Altered Hox expression and segmental identity in Mll-mutant mice, Nature, 378, 505-508, 1995.
119. Hess, J. L., Yu, B. D., Li, B., Hanson, R., and Korsmeyer, S. J., Defects in yolk sac hematopoiesis in Mll-null embryos, Blood, 90, 1799-1806, 1997.
120. Lawrence, H. J., Helgason, C. D., Sauvageau, G., Fong, S., Izon, D. J., Humphries, R. K., and Largman, C., Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis, Blood, 89, 1922-1930, 1997.
121. Kennedy, M., Firpo, M., Choi, K., Wall, C., Robertson, S., Kabrun, N., and Keller, G., A common precursor for primitive erythropole sis and definitive hematopoiesis, Nature, 386, 488-493, 1997.
122. Nakano, T., Kodama, H., and Honjo, T., In vitro development of primitive and definitive erythrocytes from different precursors, Science, 272, 722-724, 1996.
123. Potten, C. S. and Loeffler, M., Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the Crypt, Development, 110, 1001-1020, 1990.
124. Abramson, S., Miller, R. G., and Phillips, R. A., The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems, J. Exp. Med., 145, 1567-1579, 1977.
125. Morrison, S. J., Shah, N. M., and Anderson, D. J., Regulatory mechanisms in stem cell biology, Cell, 88, 287-298, 1997.
126. Morrison, S. J., Uchida, N., and Weissman, I. L., The biology of hematopoietic stem cells, Annu. Rev. Cell Dev. Biol., 11, 35-71, 1995.
127. Bradford, G. B., Williams, B., Rossi, R., and Bertoncello, I., Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment, Exp. Hematol, 25, 445-453, 1997.
128. Suda, T., Suda, J., and Ogawa, M., Single-cell origin of mouse hemopoietic colonies expressing multiple lineages in variable combinations, Proc. Natl. Acad. Sci. U.S.A., 80, 6689-6693, 1983.
129. Brady, G., Billia, F., Knox, J., Hoang, T., Kirsch, I. R., Voura, E. B., Hawley, R. G., Cumming, R., Buchwald, M., Siminovitch, K., Miyamoto, N., Boehmelt, G., and Iscove N. N., Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells, Curr. Biol., 5, 909-922, 1995.
130. Hu, M., Krause, D., Greaves, M., Sharkis, S., Dexter, M., Heyworth, C., and Enver, T., Multilineage gene expression precedes commitment in the hemopoietic system, Genes Dev., 11, 774-785, 1997.
131. Fairbairn, L. J., Cowling, G. J., Reipert, B. M., and Dexter, T. M., Suppression of apoptosis allows differentiation and development of a multipotent hematopoietic cell line in the absence of added growth factors, Cell, 74, 823-832, 1993.
132. Mayani, H., Dragowska, W., and Lansdorp, P. M., Lineage commitment in human hemopoiesis involves asymmetric cell division of multipotent progenitors and does not appear to be influenced by cytokines, J. Cell Physiol., 157, 579-586, 1993.
133. Li, C. L. and Johnson, G. R., Stem cell factor enhances the survival but not the self-renewal of murine hematopoietic long-term repopulating cells, Blood, 84, 408-414, 1994.
134. Kee, B. L. and Paige, C. J., In vivo tracking of IL-7 responsiveness and gene expression during commitment of bipotent B-cell/macrophage progenitors, Curr. Biol., 6, 1159-1169, 1996.
135. van Zant, G., Eldridge, P. W., Behringer, R. R., and Dewey, M. J., Genetic control of hematopoietic kinetics revealed by analyses of allophenic mice and stem cell suicide, Cell, 35, 639-646, 1983.
136. de Haan, G., Nijhof, W., and van Zant, G., Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cell during aging: correlation between lifespan and cycling activity, Blood, 89, 1543-1550, 1997.
137. de Haan, G. and van Zant, G., Intrinsic and extrinsic control of hemopoietic stem cell numbers: mapping of a stem cell gene, J. Exp. Med., 186, 529-536, 1997.
138. Spangrude, G. J., Heimfeld, S., and Weissman, I. L., Purification and characterization of mouse hematopoietic stem cells, Science, 241, 58-62, 1988.
139. Uchida, N. and Weissman, I. L., Searching for hematopoietic stem cells: Evidence that Thy-1.11o Lin-Sca-1+ cells are the only stem cells in C57BL/ Ka-Thy-1.1 bone marrow, J. Exp. Med., 175, 175-184, 1992.
140. Morrison, S. J., Hemmati, H. D., Wandycz, A. M., and Weissman, I. L., The purification and characterization of fetal liver hematopoietic stem cells, Proc. Natl. Acad. Sci. U.S.A., 92, 10302-10306, 1995.
141. Jordan, C. T., McKearn, J. P., and Lemischka, I. R., Cellular and developmental properties of fetal hemopoietic stem cells, Cell. 61, 953-963, 1990.
142. Cumano, A., Furlonger, C., and Paige, C. J., Differentiation and characterization of B-cell precursors detected in the yolk sac and embryo body of embryos beginning at the 10- to 12-somite stage, Proc. Natl. Acad. Sci. U.S.A., 90, 6429-6433, 1993.
143. Huang, H. and Auerbach, R., Identification and characterization of hematopoietic stem cells from the yolk sac of the early mouse embryo, Proc. Natl. Acad. Sci. U.S.A., 90, 10110-10114, 1993.
144. Sanchez, M.-J., Holmes, A., Miles, C., and Dzierzak, E., Characterization of the first definitive hematopoietic stem cells in the AGM and liver of the mouse embryo, Immunity, 5, 513-525, 1996.
145. Kodama, H., Nose, M., Niida, S., Nishikawa, S., and Nishikawa, S. I., Involvement of the c-kit receptor in the adhesion of hematopoietic stem cells to stromal cells, Exp. Hematol., 22, 979-984, 1994.
146. Satoh, M., Mioh, H., Shiotsu, Y., Ogawa, Y., and Tamaoki, T., Mouse bone marrow stromal cell line MC3T3-G2/PA6 with hematopoietic-supporting activity expresses high levels of stem cell antigen Sca-1, Exp. Hematol., 25, 972-979, 1997.
147. Fleischman, R. A., Guster, R. P., and Mintz, B., Totipotent hematopoietic stem cells: normal self-renewal and differentiation after transplantation between mouse fetuses, Cell, 30, 351-359, 1982.
148. Lansdorp, P. M., Dragowska, W., and Mayani, H., Ontogeny-related changes in proliferative potential of human hematopoietic cells, J. Exp. Med., 178, 787-791, 1993.
149. Fleming, W. H., Alpern, E. J., Uchida, N., Ikuta, K., Spangrude, G. J., and Weissman, I. L., Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells, J. Cell Biol., 122, 897-902, 1993.
150. Ogawa, M., Nishikawa, S., Ikuta, K., Yamamura, F., Naito, M., Takahashi, K., and Nishikawa, S. I., B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac, EMBO J., 7, 1337-1343, 1988.
151. Hansen, J. D., Characterization of rainbow trout terminal deoxynucleotidyl transferase structure and expression. TdT and RAG1 co-expression define the trout primary lymphoid tissues, Immunogenetics, 46, 367-375, 1997.
152. Matsuzaki, Y., Nakayama, K.-I., Nakayama, K., Tomita, T., Isoda, M., Loh, D. Y., and Nakauchi, H., Role of bc 1-2 in the development of lymphoid cells from the hematopoietic stem cell, Blood, 89, 853-862, 1997.
153. Faust, N., Huber, M. C., Sippel, A. E., and Bonifer, C., Different macrophage populations develop from embryonic/fetal and adult hematopoietic tissues, Exp. Hematol., 25, 432-444, 1997.
154. Ikuta, K., Kina, T., MacNeil, I., Uchida, N., Péault, B., Chien, Y., and Weissman, I. L., A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells, Cell, 62, 863-874, 1990.
155. Kantor, A. B., Stall, A. M., Adams, S., Herzenberg, L. A., and Herzenberg, L. A., Differential development of progenitor activity for three B-cell lineages, Proc. Natl. Acad. Sci. U.S.A., 89, 3320-3324, 1992.
156. Komori, T., Okada, A., Stewart, V., and Alt, F. W., Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes, Science, 261, 1171-1175, 1993.
157. Gilfillan, S., Dierich, A., Lemeur, M., Benoist, C., and Mathis, D., Mice lacking TdT: Mature animals with an immature lymphocyte repertoire, Science, 261, 1175-1178, 1993.
158. Gregoire, K. E., Goldschneider, I., Barton, R. W., and Bollum, F. J., Ontogeny of terminal deoxynucleotidyl transferase-positive cells in lymphohemopoietic tissues of rat and mouse, J. Immunol., 123, 1347-1352, 1979.
159. Li, Y.-S., Hayakawa, K., and Hardy, R. R., The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver, J. Exp. Med., 178, 951-960, 1993.
160. Nutt, S. L., Urbanek, P., Rolink, A., and Busslinger, M., Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus, Genes Dev., 11, 476-491, 1997.