Differential regulation of hippocampal AMPA and kainate receptor subunit expression by haloperidol and clozapine

Molecular Psychiatry

Volumn 1, Issue 1, 1996, Pages 41-53

  Meador Woodruff, J H ^a   King, R E ^a   Damask, S P ^a   Bovenkerk, K A ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Antipsychotics; Dopamine; Entorhinal cortex; Glutamate receptors; Hippocampus; In situ hybridization; Messenger RNA; Rat

Indexed keywords

AMPA RECEPTOR; CLOZAPINE; HALOPERIDOL; KAINIC ACID RECEPTOR; MESSENGER RNA; NEUROLEPTIC AGENT;

ANIMAL; ARTICLE; CHEMISTRY; DRUG EFFECT; ENTORHINAL CORTEX; GENE EXPRESSION REGULATION; GENETICS; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIPSYCHOTIC AGENTS; CLOZAPINE; ENTORHINAL CORTEX; GENE EXPRESSION REGULATION; HALOPERIDOL; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; RNA, MESSENGER;

EID: 0030090886     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Creese I, Burt IR, Snyder SH. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science 1976; 192: 481-483.
2. Seeman P, Lee T, Chau-Wong M, Wong K. Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature 1976; 261: 717-719.
3. Snyder S. The dopamine hypothesis in schizophrenia: focus on the dopamine receptor. Am J Psychiatry 1976; 113: 197-202.
4. Davis KL, Kahn RS, Ko G, Davidson M. Dopamine in schizophrenia: a review and reconceptualization. Am J Psychiatry 1991; 148: 1474-1486.
5. Daniel DG et al. The effect of 1-DOPA on negative symptoms: cognitive performance and regional cerebral blood flow in schizophrenia. Biol Psychiatry 1990; 27: 118A.
6. Ogura C, Kishimoto A, Nakao T. Clinical effects of 1-dopa on schizophrenia. Curr Ther Res 1976; 20: 308-318.
7. Bannon MJ, Roth RH. Pharmacology of mesocortical dopamine neurons. Pharmacol Rev 1983; 35: 53-68.
8. Meador-Woodruff JH, Damask SP, Watson SJ Jr. Differential expression of autoreceptors in the ascending dopamine systems of the human brain. Proc Natl Acad Sci USA 1994; 91: 8297-8301.
9. Domino E, Luby ED. Abnormal mental states induced by phencyclidine as a model of schizophrenia. In: Cole J, Freedman A, Freidhoff A (eds). Psychopathology and Psychopharmacology. Johns Hopkins University Press: Baltimore, 1973, pp 37-50.
10. Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 1991; 148: 1301-1308.
11. Krystal JH et al. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive and neuroendocrine responses. Arch Gen Psychiatry 1994; 51: 199-214.
12. Luby ED et al. Model psychoses and schizophrenia. Am J Psychiatry 1962; 119: 61-67.
13. Kim JS et al. Glutamic acid and the dopamine hypothesis of schizophrenia. In: Shagass C (ed). Biological Psychiatry. Elsevier: Amsterdam-New York, 1985, pp 1109-1111.
14. Carlsson M, Carlsson A. Interactions between glutamatergic and monoaminergic systems within the basal ganglia - implications for schizophrenia and Parkinson's disease. Trends Neurosci 1990; 13: 272-276.
15. Carlsson M, Carlsson A. Schizophrenia: a subcortical neurotransmitter imbalance syndrom? Schizophr Bull 1990; 16: 425-432.
16. Johnson KM. Phencyclidine: behavioral and biochemical evidence supporting a role for dopamine. Fed Proc 1983; 42: 2579-2583.
17. Conrad AJ, Scheibel AB. Schizophrenia and the hippocampus: the embryological hypothesis extended. Schizophr Bull 1987; 13: 577-587.
18. Isaacson RL. The Limbic System, 2nd edn. Plenum Press: New York, 1982, 327 pp.
19. Gruzelier J et al. Impairments on neuropsychologic tests of temporohippocampal and frontohippocampal functions and word fluency in remitting schizophrenia and affective disorders. Arch Gen Psychiatry 1988; 45: 623-629.
20. Altshuler LL, Casanova MF, Coldberg TE, Kleinmann JE. The hippocampus and parahippocampus in schizophrenic, suicide, and control brains. Arch Gen Psychiatry 1990; 47: 1029-1034.
21. Arnold SE, Hyman BT, Van Hoesen GW, Damasio AR. Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Arch Gen Psychiatry 1991; 48: 625-632.
22. Eison MS. A common neurobiologic substrate in anxiety and depression. J Clin Psychopharmacol 1989; 9: 10S-26S.
23. Falkai P, Bogerts B, Rozumek M. Limbic pathology in schizophrenia: the entorhinal region - a morphometric study. Biol Psychiatry 1988; 24: 515-521.
24. Heckers S, Heinsen H, Heinsen YC, Beckmann H. Limbic structures and lateral ventricle in schizophrenia. Arch Gen Psychiatry 1990; 47: 1016-1022.
25. Krieckhaus EE, Donahoe JW, Morgan MA. Paranoid schizophrenia may be caused by dopamine hyperactivity of CA1 hippocampus. Biol Psychiatry 1992; 31: 560-570.
26. 2 receptor expression in hippocampus and parahippocampal cortex of rat, cat, and human in relation to tyrosine hydroxylase-immunoreactive fibers. Hippocampus 1994; 4: 354-373.
27. Gaspar P et al. Catecholamine innervation of the human cerebral cortex as revealed by comparative immunohistochemistry of tyrosine hydroxylase and dopamine-beta-hydroxylase. J Comp Neurol 1989; 279: 249-271.
28. Samson Y, Wu JJ, Friedman AH, Davis JN. Catecholaminorgic innervation of the hippocampus in the cynomolgus monkey. J Comp Neurol 1990; 298: 250-263.
29. Torack RM, Morris JC. Tyrosine hydroxylase-like (TH) immunoreactivity in human mesolimbic system. Neurosci Lett 1990; 116: 75-80.
30. Akil M, Lewis DA. The dopaminergic: innervation of monkey entorhinal cortex. Cereb Cortex 1993; 3: 533-550.
31. Fallon JH, Koziell DA, Moore RY. Catecholamine innervation of the basal forebrain. II. Amygdala, suprarhinal cortex and entorhinal cortex. J Comp Neurol 1978; 180: 509-532.
32. Meador-Woodruff JH et al. Dopamine receptor gene expression in the human medial temporal lobe. Neuropsychopharmacology 1994; 10: 239-247.
33. 2 receptors in the rat hippocampal region. Neurosci Lett 1991a; 126: 107-109.
34. 125I-NCQ 298. Neurosci Lett 1991b; 125: 12-14.
35. 1 dopamine receptors in the rat brain: a quantitative autoradiographic analysis. J Neurosci 1986; 6: 2352-2365.
36. 2 receptors are unevenly distributed in the rat hippocampus and are modulated differently than in striatum. Eur J Pharmacol - Mol 1993; 245: 157-164.
37. 2 receptors in basal ganglia and cortex of human brain. J Pharmacol Exp Ther 1991; 257: 1253-1263.
38. 2 receptors in the brain of several mammalian species. J Neural Transm [Gen Sect] 1990; 80: 105-127.
39. 1 sites. Neuroscience 1989; 28: 263-273.
40. 3H]YM-09151-2 in the rat hippocampus: characterization and autoradiographic distribution. Brain Res 1995; 681: 153-159.
41. Hollmann M, Heinemann S. Cloned glutamate receptors. In: Cowan WM (ed). Annual Review of Neuroscience. Annual Reviews: Palo Alto, 1994, pp 31-108.
42. Bennett JA, Dingledine R. Topology profile for a glutamate receptor: three transmembrane domains and a channel-lining reentrant membrane loop. Neuron 1995; 14: 373-384.
43. Hollman M, Maron C, Heinemann S. N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor CluR1. Neuron 1994; 13: 1331-1343.
44. 2 dopamine receptor mRNA in rat brain. Proc Natl Acad Sci USA 1989; 86: 7625-7628.
45. 2 dopamine receptor mRNAs in rat brain. Neuropsychopharmacology 1991; 5: 231-242.
46. Boulter J et al. Molecular cloning and functional expression of glutamate receptor subunit genes. Science 1990; 249: 1033-1037.
47. Hollman M, O'Shea-Greenfield A, Rogers SW, Heinemann S. Cloning by functional expression of a member of the glutamate receptor family. Nature 1989; 342: 643-648.
48. Keinänen K et al. A family of AMPA-selective glutamate receptors. Science 1990; 249: 556-560.
49. Nakanishi N, Shneider NA, Axel R. A family of glutamate receptor genes - evidence for the formation of heteromultimeric receptors with distinct channel properties. Neuron 1990; 5: 569-581.
50. Bettler B et al. Cloning of a novel glutamate receptor subunit, GluRS: expression in the nervous system during development. Neuron 1990; 5: 583-595.
51. Egebjerg J, Bettler B, Hermans-Borgmeyer I, Heinemann S. Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA. Nature 1991; 351: 745-748.
52. Lomeli H et al. The rat delta-1 and delta-2 subunits extend the excitatory amino acid receptor family. FEBS Lett 1993; 315: 318-322.
53. Bettler B et al. Cloning of a novel glutamate receptor subunit, GluR5 - a low affinity kainate-binding subunit. Neuron 1992; 8: 257-265.
54. Werner P et al. Cloning of a putative high-affinity kainate receptor expression predominantly in hippocampal CA3 cells. Nature 1991; 351: 742-744.
55. Herb A et al. The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits. Neuron 1992; 8: 775-785.
56. Meador-Woodruff JH et al. Effects of cocaine on dopamine receptor gene expression: a study in the postmortem human brain. Biol Psychiatry 1993; 34: 348-355.
57. Eastwood SL et al. Differential changes in glutamate receptor subunit messenger RNAs in rat brain after haloperidol treatment. J Psychopharmacol 1994; 8: 196-203.
58. Fitzgerald LW et al. Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs. J Neurosci 1995; 15: 2453-2461.
59. Oretti RG, Spurlock G, Buckland PR, McGuffin P. Lack of effect of antipsychotic and antidepressant drugs on glutamate receptor mRNA levels in rat brains. Neurosci Lett 1994; 177: 39-43.
60. Deakin JF et al. Frontal cortical and left temporal glutamatergic dysfunction in schizophrenia. J Neurochem 1989; 52: 1781-1786.
61. Ishimaru M, Kurumaji A, Toru M. Increases in strychnine-insensitive glycine binding sites in cerebral cortex of chronic schizophrenics: evidence for glutamate hypothesis. Biol Psychiatry 1994; 35: 84-95.
62. 3H]kainic acid binding in the prefrontal cortex in schizophrenia. Neurosci Lett 1983; 40: 245-250.
63. Kerwin R, Patel S, Meldrum B. Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem. Neuroscience 1990; 39: 25-32.
64. Eastwood SL et al. Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia. Brain Res Mol Brain Res 1995; 29: 211-223.
65. Harrison PJ, McLaughlin D, Kerwin RW. Decreased hippocampal expression of a glutamate receptor gene in schizophrenia. Lancet 1991; 337: 450-452.
66. Breese CR, Freedman R, Leonard SS. Glutamate receptor subtype expression in human postmortem brain tissue from schizophrenia and alcohol abusers. Brain Res 1995; 674: 82-90.
67. Morris BJ. Control of receptor sensitivity at the mRNA level. Mol Neurobiol 1993; 7: 189-205.