Increased density of glutamate/N-methyl-D-aspartate receptors in putamen from schizophrenic patients

Neuroscience Letters

Volumn 241, Issue 2-3, 1998, Pages 143-146

  Iraide Aparicio Legarza, M ^a   Davis, Ben ^c   Hutson, Peter H ^b   Reynolds, Gavin P ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^c NONE

Author keywords

3H L 689,560; Human brain; N Methyl D aspartate receptor; Putamen; Rat brain; Schizophrenia

Indexed keywords

5,7 DICHLORO 1,2,3,4 TETRAHYDRO 4 (3 PHENYLUREIDO) 2 QUINOLINECARBOXYLIC ACID; GLUTAMATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CAUDATE NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PUTAMEN; RAT; RECEPTOR DENSITY; RECEPTOR UPREGULATION; SCHIZOPHRENIA;

ANIMALS; ANTIPSYCHOTIC AGENTS; BINDING SITES; CASE-CONTROL STUDIES; CAUDATE NUCLEUS; HALOPERIDOL; HUMANS; MALE; NUCLEUS ACCUMBENS; PUTAMEN; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SCHIZOPHRENIA;

EID: 0344404408     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00017-2     Document Type: Article

References (25)

1. 3H]D-aspartate binding to glutamate uptake sites in striatal and accumbens tissue in patients with schizophrenia. Neurosci. Lett. 232:1997;13-16.
2. Deakin J.F.W., Slater P., Simpson M.D.C., Gilchrist A.C., Skon W.J., Royston M.C., Reynolds G.P., Cross C.J. Frontal cortical and left temporal glutamatergic dysfunction in schizophrenia. J. Neurochem. 52:1989;1781-1786.
3. Eastwood S.L., Story P., Burnet P., Heath P., Harrison P.J. Differential changes in glutamate receptor subunit messenger-RNAs in rat brain after haloperidol treatment. J. Psychopharmacol. 8:1994;196-203.
4. Ellison G. The N-methyl-D-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioural and anatomical models of the dementias. Brain Res. Rev. 20:1995;250-367.
5. Foster A.C., Kemp J.A., Leeson P.D., Grimwood S., Donald A.E., Marshall G.R., Priestley T., Smith J.D., Carling R.W. Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain. Mol. Pharmacol. 41:1992;914-922.
6. 3H]L-689,560, an antagonist for the glycine site on the N-methyl-D-aspartate receptor, to rat brain membranes. Mol. Pharmacol. 41:1992;923-930.
7. Harrison P.J., McLaughlin D., Kerwin R.W. Decrease hippocampal expression of a glutamate receptor gene in schizophrenia. Lancet. 337:1991;450-452.
8. Ishimaru M., Kurumaji A., Toru M. Increases in strychnine insensitive glycine binding sites in cerebral cortex of chronic schizophrenics: evidence for glutamate hypothesis. Biol. Psychiatry. 35:1994;84-95.
9. Javitt D.C., Zukin S.R. Recent advances in the phencyclidine model of schizophrenia. Am. J. Psychiatry. 148:1991;1301-1308.
10. Kim J.S., Kornhuber H.H., Schmid-Burgk W., Holzmuller B. Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci. Lett. 20:1980;379-382.
11. Kerwin, R.W., Patel, S., Meldrum, B.S., Czudek, C. and Reynolds, G.P., Asymmetric loss of glutamate receptor subtype in left hippocampus in schizophrenia, Lancet, i (1988) 583-584.
12. Kerwin R., Patel S., Meldrum B. Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem. Neuroscience. 39:1990;25-32.
13. 3H]MK-801 binding sites in post mortem brain regions of schizophrenic patients. J. Neural Transm. 77:1989;231-236.
14. 3H]Amino-3-hydroxy-5-methylisoxazole-4-propionic acid binding to human cerebral cortical membranes: minimal changes in postmortem brains of chronic schizophrenics. J. Neurochem. 59:1992;829-837.
15. Meshul C.K., Bunker G.L., Mason J.N., Allen C., Janowsky A. Effects of subchronic clozapine and haloperidol on striatal glutamergic synapses. J. Neurochem. 67:1996;1965-1973.
16. 3H]kainic acid binding in the prefrontal cortex in schizophrenia. Neurosci. Lett. 40:1983;245-250.
17. Ossowska K., Pietraszek M., Wardas J. Further evidence for the subsensitivity of striatal AMPA receptor induced by chronic haloperidol administration: an autoradiographic study. Arch. Pharmacol. 354:1996;384-388.
18. Perry T.L. Normal cerebrospinal fluid and brain glutamate levels in schizophrenics do not support the hypothesis of glutamatergic neuronal dysfunction. Neurosci. Lett. 28:1982;81-85.
19. 3H]L-689,560 binding to the glycine site of the glutamate/NMDA receptor in the brain in Huntington's disease. J. Neurol. Sci. 41:1994;46-49.
20. Simpson M.D.C., Slater P., Royston M.C., Deakin R.W. Alterations in phencyclidine and sigma binding sites in schizophrenic brains - effects of disease process and neuroleptic medication. Schizophr. Res. 6:1991;41-48.
21. Toru M., Watanabe S., Shibuya H., Nishikawa T., Noda K., Mitsushio H., Ichikawa H., Kurumaji A., Takashima M., Mataga N. Neurotransmitters, receptors and neuropeptides in post-mortem brains of chronic schizophrenic patients. Acta Psychiatr. Scand. 78:1988;121-137.
22. Ulas J., Monaghan D.T., Cotman C.W. Kainate receptors in the rat hippocampus: a distribution and time course of changes in response to unilateral lesions of the entorhinal cortex. J. Neurosci. 10:1990;2352-2362.
23. Ulas J., Nguyen L., Cotman C.W. Chronic haloperidol treatment enhances binding to NMDA receptors in rat cortex. NeuroReport. 4:1993;1049-1051.
24. Ulas J., Weihmuller F.B., Brunner L.C., Joyce J.N., Marshall J.F., Colman C.W. Selective increase of NMDA-sensitive glutamate binding in the striatum of Parkinson's disease, Alzheimer's disease, and mixed Parkinson's disease Alzheimer's disease patients - an autoradiographic study. J. Neurosci. 14:1994;6317-6324.
25. Weihmuller F.B., Ulas J., Nguyen L., Cotman C.W., Marshall J.F. Elevated NMDA receptors in Parkinsonian striatum. NeuroReport. 3:1992;977-980.