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0027158083
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GFP tagging of budding yeast chromosomes reveals that protein - Protein interactions can mediate sister chromatid cohesion
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Straight, A.F.1
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Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast
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Funabiki H, Hagan I, Uzawa S, Yanagida M. Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast. J Cell Biol. 121:1993;961-976.
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Funabiki, H.1
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Yanagida, M.4
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0001503931
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Isolation and characterization of Schizosaccharomyces pombe cut mutants that block nuclear division but not cytokinesis
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Hirano T, Funahashi S, Uemura T, Yanagida M. Isolation and characterization of Schizosaccharomyces pombe cut mutants that block nuclear division but not cytokinesis. EMBO J. 5:1986;2973-2979.
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Hirano, T.1
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Structure and function of chromosomes in mitosis of budding yeast
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Guacci V, Yamamoto A, Strunnikov A, Kingsbury J, Hogan E, Meluh P, Koshland D. Structure and function of chromosomes in mitosis of budding yeast. Cold Spring Harb Symp Quant Biol. 58:1993;677-685.
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Guacci, V.1
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Meluh, P.6
Koshland, D.7
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17
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0030885925
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Cohesins: Chromosomal proteins that prevent premature separation of sister chromatids
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of outstanding interest. This paper describes a Saccharomyces cerevisiae genetic screen that isolated the 'cohesins', the SCC1, SCC2, SMC1 and SMC3 genes. The Scc1 protein (or Mcd1p, see [18]) binds to chromatin and dissociates at the metaphase to anaphase transition. Scc1p association with chromatin depends on functional Smc1p.
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Michaelis C, Ciosk R, Nasmyth K. Cohesins: chromosomal proteins that prevent premature separation of sister chromatids. of outstanding interest Cell. 91:1997;35-45 This paper describes a Saccharomyces cerevisiae genetic screen that isolated the 'cohesins', the SCC1, SCC2, SMC1 and SMC3 genes. The Scc1 protein (or Mcd1p, see [18]) binds to chromatin and dissociates at the metaphase to anaphase transition. Scc1p association with chromatin depends on functional Smc1p.
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Cell
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Michaelis, C.1
Ciosk, R.2
Nasmyth, K.3
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18
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0030886602
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A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae
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of outstanding interest. The MCD1 gene (or SCC1 gene, see [17]) was identified in two genetic screens and is required for the establishment and maintenance of sister chromatid cohesion. Mcd1p binds to Smc1p, and mcd1 mutants display condensation defects in addition to cohesion defects. This paper provides the first demonstration that the processes of condensation and cohesion are linked in budding yeast.
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Guacci V, Koshland D, Strunnikov A. A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. of outstanding interest Cell. 91:1997;47-57 The MCD1 gene (or SCC1 gene, see [17]) was identified in two genetic screens and is required for the establishment and maintenance of sister chromatid cohesion. Mcd1p binds to Smc1p, and mcd1 mutants display condensation defects in addition to cohesion defects. This paper provides the first demonstration that the processes of condensation and cohesion are linked in budding yeast.
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Cell
, vol.91
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Guacci, V.1
Koshland, D.2
Strunnikov, A.3
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0027059030
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Cloning and characterization of rad21 an essential gene of Schizosaccharomyces pombe involved in DNA double-strand-break repair
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Birkenbihl RP, Subramani S. Cloning and characterization of rad21 an essential gene of Schizosaccharomyces pombe involved in DNA double-strand-break repair. Nucleic Acids Res. 20:1992;6605-6611.
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Birkenbihl, R.P.1
Subramani, S.2
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20
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0031931420
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Isolation of a Schizosaccharomyces pombe rad21ts mutant that is aberrant in chromosome segregation, microtubule function, DNA repair and sensitive to hydroxyurea: Possible involvement of Rad21 in ubiquitin-mediated proteolysis
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Tatebayashi K, Kato J, Ikeda H. Isolation of a Schizosaccharomyces pombe rad21ts mutant that is aberrant in chromosome segregation, microtubule function, DNA repair and sensitive to hydroxyurea: possible involvement of Rad21 in ubiquitin-mediated proteolysis. Genetics. 148:1998;49-57.
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Genetics
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Tatebayashi, K.1
Kato, J.2
Ikeda, H.3
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21
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0027759461
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SMC1: An essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family
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Strunnikov AV, Larionov VL, Koshland D. SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family. J Cell Biol. 123:1993;1635-1648.
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Strunnikov, A.V.1
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Koshland, D.3
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0032559293
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MIX-1: An essential component of the C. elegans mitotic machinery executes X chromosome dosage compensation
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Lieb JD, Albrecht MR, Chuang PT, Meyer BJ. MIX-1: an essential component of the C. elegans mitotic machinery executes X chromosome dosage compensation. Cell. 92:1998;265-277.
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Lieb, J.D.1
Albrecht, M.R.2
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Meyer, B.J.4
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0028942904
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SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family
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Strunnikov AV, Hogan E, Koshland D. SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family. Genes Dev. 9:1995;587-599.
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Strunnikov, A.V.1
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Koshland, D.3
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24
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0028081446
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Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis
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Saka Y, Sutani T, Yamashita Y, Saitoh S, Takeuchi M, Nakaseko Y, Yanagida M. Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis. EMBO J. 13:1994;4938-4952.
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Saka, Y.1
Sutani, T.2
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Saitoh, S.4
Takeuchi, M.5
Nakaseko, Y.6
Yanagida, M.7
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25
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0028104856
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DPY-27: A chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome
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Chuang PT, Albertson DG, Meyer BJ. DPY-27: a chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome. Cell. 79:1994;459-474.
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Chuang, P.T.1
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Meyer, B.J.3
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26
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SMC protein complexes and higher-order chromosome dynamics
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Hirano T. SMC protein complexes and higher-order chromosome dynamics. Curr Opin Cell Biol. 10:1998;317-322.
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Hirano, T.1
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27
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0032127940
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Identification of Xenopus SMC protein complexes required for sister chromatid cohesion
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of outstanding interest. The isolation of the Xenopus cohesin complex is described. The complex contains homologs of the budding yeast Smc1 and Smc3 proteins, as well as the homolog of the Mcd1(Scc1) protein. Although the cohesin complex is required for cohesion, it binds to interphase chromatin but not mitotic chromatin. This behavior differs from that of the budding yeast cohesins.
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Losada A, Hirano M, Hirano T. Identification of Xenopus SMC protein complexes required for sister chromatid cohesion. of outstanding interest Genes Dev. 12:1998;1986-1997 The isolation of the Xenopus cohesin complex is described. The complex contains homologs of the budding yeast Smc1 and Smc3 proteins, as well as the homolog of the Mcd1(Scc1) protein. Although the cohesin complex is required for cohesion, it binds to interphase chromatin but not mitotic chromatin. This behavior differs from that of the budding yeast cohesins.
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Genes Dev
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Losada, A.1
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Hirano, T.3
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Yanagida M. Fission yeast cut mutations revisited: control of anaphase. Trends Cell Biol. 8:1988;144-149.
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0028052205
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Fission yeast minichromosome loss mutants mis cause lethal and replication abnormality
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Takahashi K, Yamada H, Yanagida M. Fission yeast minichromosome loss mutants mis cause lethal and replication abnormality. Mol Biol Cell. 5:1994;1145-1158.
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Takahashi, K.1
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Murphy TD, Karpen GH. Centromeres take flight: alpha satellite and the quest for the centromere. Cell. 93:1998;317-320.
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Murphy, T.D.1
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Wiens GR, Sorger PK. Centromeric chromatin and epigenetic effects in kinetochore. Cell. 93:1998;313-316.
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Wiens, G.R.1
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The Drosophila mei-S332 gene promotes sister-chromatid cohesion in meiosis following kinetochore differentiation
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Kerrebrock AW, Miyazaki WY, Birnby D, Orr-Weaver TL. The Drosophila mei-S332 gene promotes sister-chromatid cohesion in meiosis following kinetochore differentiation. Genetics. 130:1992;827-841.
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Kerrebrock, A.W.1
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Birnby, D.3
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Goldstein, L.S.B.1
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34
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Mei-S332, a Drosophila protein required for sister-chromatid cohesion, can localize to meiotic centromere regions
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Kerrebrock AW, Moore DP, Wu JS, Orr-Weaver TL. Mei-S332, a Drosophila protein required for sister-chromatid cohesion, can localize to meiotic centromere regions. Cell. 83:1995;247-256.
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Kerrebrock, A.W.1
Moore, D.P.2
Wu, J.S.3
Orr-Weaver, T.L.4
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35
-
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0032498796
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The cohesion protein MEI-S332 localizes to condensed meiotic mitotic centromeres until sister chromatids separate
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of special interest. The mei-S322 protein localizes to mitotic centromeres as well as meiotic centromeres. During mitosis, mei-S322 localizes to centromeres when sister chromatids are held together, then dissociates when they separate. Although there has been no mitotic phenotype reported for mei-S322 mutants, this could be due to functional redundancy.
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Moore DP, Page AW, Tang TT, Kerrebrock AW, Orr-Weaver TL. The cohesion protein MEI-S332 localizes to condensed meiotic mitotic centromeres until sister chromatids separate. of special interest J Cell Biol. 140:1998;1003-1012 The mei-S322 protein localizes to mitotic centromeres as well as meiotic centromeres. During mitosis, mei-S322 localizes to centromeres when sister chromatids are held together, then dissociates when they separate. Although there has been no mitotic phenotype reported for mei-S322 mutants, this could be due to functional redundancy.
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Moore, D.P.1
Page, A.W.2
Tang, T.T.3
Kerrebrock, A.W.4
Orr-Weaver, T.L.5
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36
-
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0029098091
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The rec8 gene of Schizosaccharomyces pombe is involved in element formation, chromosome pairing and sister-chromatid during meiosis
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Molnar M, Bahler J, Sipiczki M, Kohli J. The rec8 gene of Schizosaccharomyces pombe is involved in element formation, chromosome pairing and sister-chromatid during meiosis. Genetics. 141:1995;61-73.
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Molnar, M.1
Bahler, J.2
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Kohli, J.4
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37
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0031469851
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Mis6, a fission yeast inner centromere protein, acts during G1/S forms specialized chromatin required for equal segregation
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of special interest. The Mis6 protein is essential for establishing the inner centromere structure, and defects lead to chromosome missegregation. Since the centromeres separate in a metaphase arrest, Mis6 could be involved in maintaining sister chromatid cohesion at the centromere.
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Saitoh S, Takahashi K, Yanagida M. Mis6, a fission yeast inner centromere protein, acts during G1/S forms specialized chromatin required for equal segregation. of special interest Cell. 90:1997;131-143 The Mis6 protein is essential for establishing the inner centromere structure, and defects lead to chromosome missegregation. Since the centromeres separate in a metaphase arrest, Mis6 could be involved in maintaining sister chromatid cohesion at the centromere.
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Cell
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Saitoh, S.1
Takahashi, K.2
Yanagida, M.3
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0027435584
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Mutations in the Drosophila melanogaster gene three rows permit aspects of mitosis to continue in the absence of chromatid segregation
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Philp AV, Axton JM, Saunders RD, Glover DM. Mutations in the Drosophila melanogaster gene three rows permit aspects of mitosis to continue in the absence of chromatid segregation. J Cell Sci. 106:1993;87-98.
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Philp, A.V.1
Axton, J.M.2
Saunders, R.D.3
Glover, D.M.4
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39
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0027142030
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The three rows gene of Drosophila melanogaster encodes a novel protein that is required for chromosome disjunction during mitosis
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D'Andrea RJ, Stratmann R, Lehner CF, John UP, Saint R. The three rows gene of Drosophila melanogaster encodes a novel protein that is required for chromosome disjunction during mitosis. Mol Biol Cell. 4:1993;1161-1174.
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D'Andrea, R.J.1
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Lehner, C.F.3
John, U.P.4
Saint, R.5
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40
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0030071762
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Separation of sister chromatids in mitosis requires the Drosophila pimples product, a protein degraded after the metaphase/anaphase transition
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Stratmann R, Lehner CF. Separation of sister chromatids in mitosis requires the Drosophila pimples product, a protein degraded after the metaphase/anaphase transition. Cell. 84:1996;25-35.
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Cell
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Stratmann, R.1
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Identification of genomic regions required for DNA replication during Drosophila embryogenesis
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Smith AV, King JA, Orr-Weaver TL. Identification of genomic regions required for DNA replication during Drosophila embryogenesis. Genetics. 135:1993;817-829.
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Smith, A.V.1
King, J.A.2
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43
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0029999538
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Mitotic chromosome condensation in the rDNA requires TRF4 and DNA topoisomerase I in Saccharomyces cerevisiae
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Castano IB, Brzoska PM, Sadoff BU, Chen H, Christman MF. Mitotic chromosome condensation in the rDNA requires TRF4 and DNA topoisomerase I in Saccharomyces cerevisiae. Genes Dev. 10:1996;2564-2576.
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Castano, I.B.1
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Chen, H.4
Christman, M.F.5
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44
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0030830639
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Condensins, chromosome condensation protein complexes C, XCAP-E and a Xenopus homolog of the Drosophila Barren
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of outstanding interest. The condensin complex, containing Xenopus homologs of the budding yeast Smc2 and Smc4 proteins, was isolated and is essential for chromosome condensation in vitro. The complex binds to mitotic chromatin but not interphase chromatin. Together with [27], two complexes containing members of the SMC (structural maintenance of chromosomes) protein family have been identified and characterized.
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Hirano T, Kobayashi R, Hirano M. Condensins, chromosome condensation protein complexes C, XCAP-E and a Xenopus homolog of the Drosophila Barren. of outstanding interest Cell. 89:1997;511-521 The condensin complex, containing Xenopus homologs of the budding yeast Smc2 and Smc4 proteins, was isolated and is essential for chromosome condensation in vitro. The complex binds to mitotic chromatin but not interphase chromatin. Together with [27], two complexes containing members of the SMC (structural maintenance of chromosomes) protein family have been identified and characterized.
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(1997)
Cell
, vol.89
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Hirano, T.1
Kobayashi, R.2
Hirano, M.3
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45
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0027943721
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A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro
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Hirano T, Mitchison TJ. A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro. Cell. 79:1994;449-458.
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Cell
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Hirano, T.1
Mitchison, T.J.2
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46
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0030874421
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ATP-dependent positive supercoiling of DNA by 13S condensin: A biochemical implication for chromosome condensation
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of special interest. The first biochemical activity for the condensin complex is reported. The complex can introduce positive supercoils into DNA in the presence of ATP and topl. This suggests potential mechanisms for chromosome condensation.
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Kimura K, Hirano T. ATP-dependent positive supercoiling of DNA by 13S condensin: a biochemical implication for chromosome condensation. of special interest Cell. 90:1997;625-634 The first biochemical activity for the condensin complex is reported. The complex can introduce positive supercoils into DNA in the presence of ATP and topl. This suggests potential mechanisms for chromosome condensation.
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King, R.W.1
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48
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CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic and is essential for the metaphase to anaphase transition
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Tugendreich S, Tomkiel J, Earnshaw W, Hieter P. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic and is essential for the metaphase to anaphase transition. Cell. 81:1995;261-268.
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Cohen-Fix O, Koshland D. The metaphase-to-anaphase transition: avoiding a mid-life crisis. Curr Opin Cell Biol. 9:1997;800-806.
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Funabiki H, Yamano H, Kumada K, Nagao K, Hunt T, Yangida M. Cut2 proteolysis required for sister-chromatid separation in fission yeast. Nature. 381:1996;438-441.
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Funabiki, H.1
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Hunt, T.5
Yangida, M.6
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51
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Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s)
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Yamamoto YA, Guacci V, Koshland D. Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s). J Cell Biol. 133:1996;99-110.
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Yamamoto, Y.A.1
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52
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Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae
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Yamamoto A, Guacci V, Koshland D. Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae. J Cell Biol. 133:1996;85-97.
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Cohen-Fix O, Peters JM, Kirschner MW, Koshland D. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev. 10:1996;3081-3093.
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0032554912
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Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis
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of outstanding interest. This paper shows that the function of Cut1 depends on binding to the Cut2 protein and this complex formation is essential for sister chromatid separation. The complex is required for Cut1 to localize to the spindle.
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Kumada K, Nakamura T, Nagao K, Funabiki H, Nakagawa T, Yanagida M. Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis. of outstanding interest Curr Biol. 8:1998;633-641 This paper shows that the function of Cut1 depends on binding to the Cut2 protein and this complex formation is essential for sister chromatid separation. The complex is required for Cut1 to localize to the spindle.
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Kumada, K.1
Nakamura, T.2
Nagao, K.3
Funabiki, H.4
Nakagawa, T.5
Yanagida, M.6
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55
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0030824368
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Fission yeast Cut2 required for anaphase has two destruction boxes
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of outstanding interest. Two destruction boxes, the sequence recognized by the anaphase promoting complex gene (APC) to target proteins for ubiquitin-mediated proteolysis, are identified in the Cut2 protein. Both destruction boxes are functional, and they mediate the polyubiquitination of the Cut2 protein in Xenopus egg extracts.
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Funabiki H, Yamano H, Nagao K, Tanaka H, Yasuda H, Hunt T, Yanagida M. Fission yeast Cut2 required for anaphase has two destruction boxes. of outstanding interest EMBO J. 16:1997;5977-5987 Two destruction boxes, the sequence recognized by the anaphase promoting complex gene (APC) to target proteins for ubiquitin-mediated proteolysis, are identified in the Cut2 protein. Both destruction boxes are functional, and they mediate the polyubiquitination of the Cut2 protein in Xenopus egg extracts.
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Funabiki, H.1
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Yasuda, H.5
Hunt, T.6
Yanagida, M.7
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56
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0032511150
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An ESP1/PDS1 complex regulates loss of sister chromatid metaphase to anaphase transition in yeast
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of outstanding interest. This paper isolates a Pds1p-binding-protein and shows that Pds1p destruction is probably the sole anaphase promoting complex (APC)-mediated event in Saccharomyces cerevisiae. The Pds1p-binding-protein, Esp1, is required for sister chromatid separation. In esp1 mutants, the cohesin Scc1p does not dissociate from chromosomes (see [17]), suggesting that Esp1p regulates sister separation by mediating Scc1p dissociation. The role of Pds1p appears to be to inhibit Esp1p function until the metaphase to anaphase transition.
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Ciosk R, Zachariae W, Michaelis C, Shevchenko A, Mann M, Nasmyth K. An ESP1/PDS1 complex regulates loss of sister chromatid metaphase to anaphase transition in yeast. of outstanding interest Cell. 93:1998;1067-1076 This paper isolates a Pds1p-binding-protein and shows that Pds1p destruction is probably the sole anaphase promoting complex (APC)-mediated event in Saccharomyces cerevisiae. The Pds1p-binding-protein, Esp1, is required for sister chromatid separation. In esp1 mutants, the cohesin Scc1p does not dissociate from chromosomes (see [17]), suggesting that Esp1p regulates sister separation by mediating Scc1p dissociation. The role of Pds1p appears to be to inhibit Esp1p function until the metaphase to anaphase transition.
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Cell
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Ciosk, R.1
Zachariae, W.2
Michaelis, C.3
Shevchenko, A.4
Mann, M.5
Nasmyth, K.6
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Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes
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Funabiki H, Kumada K, Yanagida M. Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes. EMBO J. 15:1996;6617-6628.
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McGrew JT, Goetsch L, Byers B, Baum P. Requirement for ESP1 in the nuclear division of Saccharomyces cerevisiae. Mol Biol Cell. 3:1992;1443-1454.
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An anaphase calcium signal controls chromosome disjunction in urchin embryos
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of outstanding interest. This paper provides the first demonstration that a calcium transient occurs at anaphase that appears to trigger the separation of sister chromatids.
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Groigno L, Whitaker M. An anaphase calcium signal controls chromosome disjunction in urchin embryos. of outstanding interest Cell. 92:1998;193-204 This paper provides the first demonstration that a calcium transient occurs at anaphase that appears to trigger the separation of sister chromatids.
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Zhang D, Nicklas RB. 'Anaphase' and cytokinesis in the absence of chromosomes. Nature. 382:1996;466-468.
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Bhat MA, Philp AV, Glover DM, Bellen HJ. Chromatid segregation at anaphase requires the barren product, chromosome-associated protein that interacts with Topoisomerase II. Cell. 87:1996;1103-1114.
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Uhlmann F, Nasmyth K. Sister chromatid cohesion formed in S phase. Curr Biol. 8:1998;1095-1101.
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