An endogenously processed self peptide and the corresponding exogenous peptide bound to the same MHC class II molecule could be distinct ligands for TCR with different kinetic stability

European Journal of Immunology

Volumn 28, Issue 12, 1998, Pages 4050-4061

  Gyotoku, Takahiro ^a   Fukui, Yoshinori ^a,b   Sasazuki, Takehiko ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Kinetic stability; MHC class II peptide complex; TCR recognition

Indexed keywords

AUTOANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN ANTIBODY COMPLEX; ANTIGEN RECOGNITION; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; HYBRIDOMA; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; SPLEEN CELL; T LYMPHOCYTE;

EID: 0031769696     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1521-4141(199812)28:12<4050::aid-immu4050>3.0.co;2-y     Document Type: Article

References (45)

1. Brown, J. H., Jardetzky, T. S., Gorga, J. C., Stern, L. J., Urban, R. G., Strominger, J. L. and Wiley, D. C., Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 1993. 364: 33-39.
2. Stern, L. J., Brown, J. H., Jardetzky, T. S., Gorga, J. C., Urban, R. G., Strominger, J. L. and Wiley, D. C., Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 1994. 368: 215-221.
3. Fremont, D. H., Hendrickson, W. A., Marrack, P. and Kappler, J., Structures of an MHC class II molecule with covalently bound single peptides. Science 1996. 272: 1001-1004.
4. k in complex with a dominant epitope of lysozyme. Immunity 1998. 8: 305-317.
5. d-peptide complexes reveal that high affinity can be achieved without large anchor residues. Immunity 1998. 8: 319-329.
6. Rammensee, H.-G., Friede, T. and Stevanovic, S., MHC ligands and peptide motifs: first listing, Immunogenetics 1995. 41: 178-228.
7. Sanui, H., Redmond, T. M., Kotake, S., Wiggert, B., Hu, L.-H., Margalit, H., Berzofsky, J. A., Chader, G. J. and Gery, I., Identification of an immunodominant and highly immunopathogenic determinant in the retinal interphotoreceptor retinoid-binding protein (IRBP). J. Exp. Med. 1989. 169: 1947-1960.
8. Zamvil, S. S. and Steinman, L., The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 1990. 8: 579-621.
9. Shimoda, S., Nakamura, M., Ishibashi, H., Hayashida, K. and Niho, Y., HUV-DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliarry cirrhosis: evidence of molecular mimicry in human autoimmune diseases. J. Exp. Med. 1995. 181: 1835-1845.
10. Theofilopoulos, A. N., The basis of autoimmunity: part I mechanism of aberrant self-recognition, Immunol. Today 1995. 16: 90-98.
11. Gammon, G. and Sercarz, E., How some T cells escape tolerance induction. Nature 1989. 342: 183-185.
12. Cibotti, R., Kanellopoulos, J. M., Cabaniols, J.-P., Halle-Panenko, O., Kosmatopoulos, K., Sercarz, E. and Kourilsky, P., Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinants. Proc. Natl. Acad. Sci. USA 1992. 89: 416-420.
13. Fairchild, P. J., Wildgoose, R., Atherton, E., Webb, S. and Wraith, D. C., An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction. Int. Immunol. 1993. 5: 1151-1158.
14. Bodmer, H., Viville, S., Benoist, C. and Mathis, D., Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain. Science 1994. 263: 1284-1286.
15. Rudensky, A. Y., Preston-Hurlburt, P., Hong, S.-C., Barlow, A. and Janeway, C. A. Jr., Sequence analysis of peptides bound to MHC class II molecules. Nature 1991. 353: 622-627.
16. Murphy, D. B., Lo, D., Rath, S., Brinster, R. L., Flavel, R. A., Slanelz, A. and Janeway, C. A. Jr., A novel MHC class II epitope expressed in thymic medulla but not cortex. Nature 1989. 338: 765-767.
17. Rudensky, A. Y., Rath, S., Preston-Hurlburt, P., Murphy, D. and Janeway, C. A. Jr., On the complexity of self. Nature 1991. 353: 660-662.
18. Surh, C. D., Gao, E.-K., Kosaka, H., Lo, D., Ahn, C., Murphy, D. B., Karlsson, L., Peterson, P. and Sprent, J., Two subsets of epithelial cells in the thymic medulla. J. Exp. Med. 1992. 176: 495-505.
19. Fukui, Y., Esaki, Y., Kimura, A., Hirokawa, K., Nishimura, Y. and Sasazuki, T., T cell repertoire in a strain of transgenic C57BL/6 mice with the HLA-DRA gene on the X chromosome, Immunogenetics 1993. 37: 204-211.
20. d gene in C57BL/6 transgenic mice. Nature 1985. 316: 67-69.
21. Fukui, Y., Yamamoto, K., Yokoyama, N., Iwanaga, T., Kurashima, C., Esaki, Y., Kimura, A., Akashi, T., Hirokawa, K. and Sasazuki, T., Restricted expression of transgenic HLA-DRA gene in thymic epithelial cell and its role in acquisition of T cell tolerance to self-superantigens and processed DRα-derived peptide. Eur. J. Immunol. 1993. 23: 1678-1686.
22. k. Nature 1989. 337: 274-276.
23. Sadegh-Nasseri, S., Stern, L. J., Wiley, D. C. and Germain, R. N., MHC class II function preserved by low-affinity peptide interactions preceding stable binding. Nature 1994. 370: 647-650.
24. Beeson, C. and McCornell, H. M., Kinetic intermediates in the reactions between peptides and proteins of major histocompatibility complex class II. Proc. Natl. Acad. Sci. USA 1994. 91: 8842-8845.
25. Rudensky, A. Y., Preston-Hurlburt, P., AI-Ramadi, B. K., Rothbard, J. and Janeway, C. A. Jr., Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs. Nature 1992. 359: 429-431.
26. Reay, P. A., Kantor, R. M. and Davis, M. M., Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103). J. Immunol. 1994. 152: 3946-3957.
27. Scott, J., A place in the world for RNA editing. Cell 1995. 81: 833-836.
28. Skipper, J. C. A., Hendrickson, R. C., Gulden, P. H., Brichard, V., Pel, A. V., Chen, Y., Shabanowitz, J., Wolfel, T., Slingluff, C. L. Jr., Boon, T., Hunt, D. F. and Engelhard, V. H., An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins. J. Exp. Med. 1996. 183: 527-534.
29. Viner, N. J., Nelson, C. A., Deck, B. and Unanue, E. R., Complexes generated by the binding of free peptides to class II MHC molecules are antigenically diverse compared with those generated by intracellular processing. J. Immunol. 1996. 156: 2365-2368.
30. Rabinowitz, J. D., Liang, M. N., Tate, K., Lee, C., Beeson, C. and McCornnel, H. M., Specific T cell recognition of kinetic isomers in the binding of peptide to class II major histocompatibility complex. Proc. Natl. Acad. Sci. USA 1997. 94: 8702-8707.
31. Rudensky, A. Y., Maric, M., Eastman, S., Shoemaker, L., DeRoos, P. C. and Blum, J. S., Intracellular assembly and transport of endogenous peptide-MHC class II complexes. Immunity 1994. 1: 585-594.
32. Peters, P. J., Neefjes, J. J., Oorschot, V., Ploegh, H. L. and Geuze, H. J., Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments. Nature 1991. 349: 669-676.
33. Sanderson, F., Kleijmeer, M. J., Kelly, A., Verwoerd, D., Tulp, A., Neefjes, J. J., Geuze, H. J. and Trowsdale, J., Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments. Science 1994. 266: 1566-1569.
34. Karlsson, L., Péléraux, A., Lindstedt, R., Liljedahl, M. and Peterson, P. A., Reconstitution of an operational MHC class II compartment in non antigen-presenting cells. Science 1994. 266: 1569-1573.
35. Kropshofer, H., Vogt, A. B., Moldenhauer, G., Hammer, J., Blum, J. S. and Hämmerling, G. J., Editing of the HLA-DR-peptide repertoire by HLA-DM. EMBO J. 1996. 15: 6144-6154.
36. Weber, D. A., Evavold, B. D. and Jensen, P. E., Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM. Science 1996. 274: 618-620.
37. Katz, J. F., Stebbins, C., Appella, E. and Sant, A. J., Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules. J. Exp. Med. 1996. 184: 1747-1753.
38. van Ham, S. M., Grüneberg, U., Malcherek, G., Bröker, I., Melms, A. and Trosdale, J., Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs. J. Exp. Med. 1996. 184: 2019-2024.
39. Wall, K. A., Hu, J.-Y., Currier, P., Southwood, S., Sette, A. and Infante, A. J., A disease-related epitope of torpedo acetylcholine receptor. J. Immunol. 1994. 152: 4526-4536.
40. Ignatowicz, L., Rees, W., Pacholczyk, R., Ignatowicz, H., Kushnir, E., Kappler, J. and Marrack, P., T cells can be activated by peptides that are unrelated in sequence to their selecting peptide. Immunity 1997. 7: 179-186.
41. d. Science 1992. 256: 1817-1820.
42. Tompkins, S. M., Moore, J. C. and Jensen, P. E., An insulin peptide that binds an alternative site in class II major histocompatibility complex. J. Exp. Med. 1996. 183: 857-866.
43. Janeway, C. A., Conrad, P., Lerner, E., Babich, J., Wettstein, P. and Murphy, D., Monoclonal antibodies specific for la antigens as targets of immunoregulatory T cells. J. Immunol. 1984. 132: 662-669.
44. Ozato, K., Mayer, N. and Sachs, D., Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and la antigens. J. Immunol. 1980. 124: 533-540.
45. Ignatowicz, L., Winslow, G., Bill, J., Kappler, J. and Marrack, P., Cell surface expression of class II MHC proteins bound by a single peptide. J. Immunol. 1995. 154: 3852-3862.