Aging and the biological effects of endocrine mediators: Metabolic and nutritional consequences;Les modifications de la sensibilité aux hormones au cours du vieillissement : Conséquences métaboliques et nutritionnelles

Nutrition Clinique et Metabolisme

Volumn 12, Issue 3, 1998, Pages 161-186

  De Bandt, Jean Pascal ^a,b   Blondé Cynober, Françoise ^a,c   Bories, Phuong Nhi ^a,d   Cassereau, Catherine ^c   Cynober, Luc ^a,e,f,g   Devanlay, Michel ^a,d   Le Boucher, Jacques ^a,e   Minet Quinard, Régine ^g   Pailla, Karine ^a,c   Vasson, Marie Paule ^g   Villié, Françoise ^g  

^a GERBAP   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c Hôpitaux Universitaires Henri Mondor   (France)

^d Hopital Albert Chenevier   (France)

^e HÔPITAL SAINT ANTOINE   (France)

^f HÔTEL DIEU   (France)

^g CRNH AUVERGNE   (France)

Author keywords

Catecholamines; Glucagon; Gtucocorticoids; Insulin; Nutrition; Thyroid hormones

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADRENALIN; ALANINE; CATECHOLAMINE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; DOPA; DOPAMINE; GAMMA INTERFERON; GLUCAGON; GLUCOCORTICOID; GLUCOSE; GLUTAMATE AMMONIA LIGASE; GLUTAMINE; HORMONE RECEPTOR; INSULIN; INSULIN RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 6; LEUCINE; LIPID; MALATE DEHYDROGENASE; NORADRENALIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTEIN; THYROID HORMONE; TRANSCORTIN; TUMOR NECROSIS FACTOR ALPHA;

AGING; BODY COMPOSITION; BODY MASS; CATABOLISM; ENDOCRINE SYSTEM; ENERGY METABOLISM; ENZYME ACTIVITY; GENE; GLUCAGON RELEASE; GLUCOSE INTOLERANCE; HUMAN; IMMUNE SYSTEM; INSULIN RELEASE; LIPID METABOLISM; LIPID PEROXIDATION; METABOLISM; NONHUMAN; NUTRITION; REVIEW;

EID: 0031769356     PISSN: 09850562     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0985-0562(98)80071-x     Document Type: Review

References (193)

1. Oreskovich MR, Howard JD, Copass MK et al. Geriatric trauma: injury patterns and outcome. J Trauma 1984; 24: 565-72.
2. Marx AB, Campbell R, Harder F. Polytrauma in elderly. World J Surg 1986; 10: 330-5.
3. Caruso C, Candore G, Cigna D et al. Cytokine production pathway in the elderly. Immunol Res 1996; 10: 84-90.
4. Lesourd BM. Immunité et nutrition chez les sujets âgés. Âge & Nutrition 1995; 6: 39-43.
5. Poehlman ET. Energy intake and energy expenditure in the elderly. Am J Human Biol 1996; 8: 199-206.
6. Poehlman ET, Toth MJ, Fonong T. Exercise, substrate utilization and energy requirements in the elderly. Int J Obesity 1995; 19 (suppl 4): S93-S96.
7. Horber FF, Kohler K, Lippuner K, Jaeger P. Effect of regular physical training on age-associated alteration of body composition in men. Eur J Clin Invest 1996; 26: 279-85.
8. Roberts SB, Fuss P, Heyman MB, Young VR. Influence of age on energy requirements. Am J Clin Nutr 1995; 62 (suppl): 1035S-58S.
9. Zachwieja JJ, Toffolo G, Cobelli C, Bier DM, Yarasheski KE. Resistance exercice and growth hormone administration in older men: effects on insulin sensitivity and secretion during a stable-label intravenous glucose tolerance test. Metabolism 1996; 45: 254-60.
10. Colman E, Katzel LI, Rogus E, Coon P, Muller D, Goldberg AP. Weight loss reduces abdominal fat and improves insulin action in middle-aged and older men with impaired glucose tolerance. Metabolism 1995; 44: 1502-8.
11. Calles-Escandon J, Arciero PJ, Gardner AW, Bauman C, Poehlman ET. Basal fat oxidation decreases with aging in women. J Appl Physiol 1995; 78: 266-71.
12. Roberts SB, Fuss P, Dallal GE et al. Effects of age on energy expenditure and substrate oxidation during experimental overfeeding in healthy men. J Gerontol 1996; 51A: B148-57.
13. Jeevanandam M, Young DH, Schiller WR. Energy cost of fat-fuel mobilization in geriatric trauma. Metabolism 1990; 39: 144-9.
14. Dudl RJ, Ensinck JW. Insulin and glucagon relationship during aging in man. Metabolism 1977; 26: 33-41.
15. Pagano G, Cassader M, Cavallo-Perin P et al. Insulin resistance in the aged: a quantitative evaluation of in vivo insulin sensitivity and in vitro glucose transport. Metabolism 1984; 33: 976-81.
16. Pacini G, Beccaro F, Valerio A, Nosadini R, Crepaldi G. Reduced beta-cell secretion and insulin hepatic extraction in healthy elderly subjects. J Am Geriatr Soc 1990; 38: 1283-9.
17. Gumbiner B, Thorburn AW, Ditzler TM, Bulacan F, Henry RR. Role of impaired intracellular glucose metabolism in the insulin resistance of aging. Metabolism 1992; 41: 1115-21.
18. Boden G, Chen X, DeSantis RA, Kendrick Z. Effects of age and body fat on insulin resistance in healthy men. Diabetes Care 1993; 16: 728-33.
19. Gumbiner B, Polonsky KS, Beltz W, Wallace P, Brechtel G, Fink RI. Effects of aging on insulin secretion. Diabetes 1989; 38: 1549-56.
20. Davidson MB. The effect of aging on carbohydrate metabolism: a review of the english literature and a practical approach to the diagnosis of diabetes mellitus in the elderly. Metabolism 1979; 28: 688-705.
21. Shimizu M, Kawazu S, Tomono S et al. Age related alteration at pancreatic beta-cell function: increases proinsulin and proinsulin-to-insulin ration in the elderly, but not in obese subjects without glucose intolerance. Diabetes Care 1996; 19: 8-11.
22. Broughton DL, James OWF, Alberti KGMM, Taylor R. Peripheral and hepatic insulin sensitivity in healthy elderly human subjects. Eur J Clin Invest 1991; 21: 13-21.
23. Olefsky J, Bacon VC, Baur S. Insulin receptors of skeletal muscle: specific insulin binding sites and demonstration of decreased number of sites in obese rats. Metabolism 1976; 25: 179-91.
24. Lönnroth P, Smith V. Aging enhances the insulin-resistance in obesity through both receptor and post-receptor alterations. J Clin Endocrinol Metab 1986; 62: 433-7.
25. Olefsky JM, Reaven GM. Effect of age and obesity on insulin binding in isolated adipocytes. Endocrinology 1975; 96: 1486-96.
26. Vidal H, Auboeuf D, Beylot M, Riou JP. Regulation of insulin receptor mRNA splicing in rat tissues. Diabetes 1995; 44: 1196-201.
27. Barnard RJ, Lawani LO, Martin DA, Youngren JF, Singh R, Scheck SH. Effects of maturation and aging on skeletal muscle glucose transport system. Am J Physiol 1992; 262: E619-26.
28. Fink RI, Kolterman OG, Griffin J, Olefsky JM. Mechanisms of insulin resistance in aging. J Clin Invest 1983; 71: 1523-35.
29. Trischitta V, Brunetti A, Chiavetta A, Beuzi L, Papa R, Vigneri R. Defects in insulin receptor internalization and processing in monocytes of obese subjects and obese NIDDM patients. Diabetes 1989; 38: 1579-84.
30. Carvalho CRO, Brenelli SL, Silva AC, Nunes ALB, Velloso LA, Saad MJA. Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats. Endocrinology 1996; 137: 151-9.
31. Rowe JW, Minaker KL, Pallotta JA. Characterization of the insulin resistance of aging. J Clin Invest 1983; 71: 1581-7.
32. Pacini G, Valerio A, Beccaro F, Nosadini R, Cobelli C, Crepaldi G. Insulin sensitivity and beta-cell responsivity are not decreased in elderly subjects with normal OGTT. J Am Geriatr Soc 1988; 36: 317-23.
33. Hollenberg ND, Schneider EL. Receptor for insulin and epidermal growth factor in adult human fibroblasts do not change with donor age. Mech Ageing Dev 1979; 11: 37-43.
34. Kono S, Kuzuya H, Okamoto M et al. Changes in insulin receptor kinase with aging in rat skeletal muscle and liver. Am J Physiol 1990; 259: E27-35.
35. Prinz JB. Food, obesity and non-insulin dependent diabetes: are there molecular links. Proc Nutr Soc 1997; 56: 889-98.
36. DeFronzo RA. Glucose intolerance and aging: evidence for tissus insensitivity to insulin? Diabetes 1979; 28: 1095-101.
37. Robert JJ, Cummins JC, Wolfe RR et al. Quantitative aspects of glucose production and metabolism in healthy elderly subjects. Diabetes 1982; 31: 203-11.
38. Jackson RA, Blix PM, Matthew JA et al Influence of ageing on glucose homeostasis. J Clin Endocrinol Metab 1982; 55: 840-48.
39. Fink RI, Wallace P, Olefsky JM. Effects of aging on glucose-mediated glucose disposal and glucose transport. J Clin Invest 1986; 77: 2034-41.
40. Fransilla-Kallunki A, Schalin-Jäntti C, Groop L. Effect of gender on insulin resistance associated with aging. Am J Physiol 1992; 263: E780-5.
41. Bonadonna RC, Groop LC, Simonson DC, DeFronzo RA. Free fatty acid and glucose metabolism in human aging: evidence for operation of the Randle cycle. Am J Physiol 1994; 266: E501-9.
42. Shimokata H, Muller DC, Fleg JL, Sorkin J, Ziemba AA, Andres R. Age as independent determinant of glucose tolerance. Diabetes 1991; 40: 44-51.
43. Chen M, Bergman RN, Porte D. Insulin resistance and β-cell dysfunction in aging: the importance of dietary carbohydrate. J Clin Endocrinol Metab 1988; 67: 951-60.
44. Khan SE, Larson WG, Schwartz RS et al. Exercise training delineates the importance of β-cell disfunction to the glucose intolerance of human aging. J Clin Endocrinol Metab 1992; 74: 1336-42.
45. Kohrt WM, Kirwan JP, Staten MA, Bourey RE, King DS, Holloszy JO. Insulin resistance in aging is related to abdominal obesity. Diabetes 1993; 42: 273-81.
46. Ferrannini E, Vichi S, Beck-Nielsen H et al. Insulin action and age. Diabetes 1996; 45: 947-53.
47. Kimmerling G, Javorski WC, Reaven GM. Aging and insulin resistance in a group of non obese male volunteers. J Am Geriatr Soc 1977; 8: 349-53.
48. Kalant N, Leibovici T, Fukushima N. Effect of age on glucose utilization and responsiveness to insulin in forearm muscle. J Am Geriatr Soc 1980; 7: 304-7.
49. Broughton DL, Alberti KGMM, James OFW, Taylor R. Peripheral insulin sensitivity in healthy elderly subjects. Gerontology 1987; 33: 357-62.
50. Coon PJ, Rogus EM, Drinkwater D, Muller DC, Glodberg AP. Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age. J Clin Endocrinol Metab 1992; 74: 1125-32.
51. O'Shaughnessy IM, Kasdorf GM, Hoffman RG, Kalkhoff RK. Does aging intensify the insulin resistance of human obesity? J Clin Endocrinol Metab 1992; 74: 1075-81:
52. Fukagawa NK, Minaker KL, Young VR, Matthews DE, Bier DM, Rowe JW. Leucine metabolism in aging humans: effect of insulin and substrate availability. Am J Physiol 1989; 256: E288-94.
53. Houmard JA, Weidner MD, Dolan PL et al. Skeletal muscle GLUT4 protein concentration and aging in humans. Diabetes 1995; 44: 555-60.
54. Fukagawa NK, Minaker KL, Rowe JW, Matthews DE, Bier DM, Young VR. Glucose and amino acid metabolism in aging man: differential effects of insulin. Metabolism 1988; 37: 371-7.
55. Cefalu WT, Wang ZQ, Werbel S et al. Contribution of visceral fat mass to the insulin resistance of aging. Metabolism 1995; 44: 954-9.
56. Kohrt WM, Holloszy JO. Loss of skeletal muscle with aging: effect on glucose tolerance. J Gerontol 1995; 50 (suppl): 68-72.
57. Pratley RE, Coon PJ, Rogus EM, Goldberg AP. Effects of weight loss on norepinephrine and insulin levels in obese older men. Metabolism 1995; 44: 438-44.
58. Hollenbeck CB, Haskell W, Rosenthal M, Reaven GM. Effect of habitual physical activity on regulation of insulin-stimulated glucose disposal in older males. J Am Geriatr Soc 1984; 33: 273-7.
59. Kahn SE, Larson VG, Beard JC et al. Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging. Am J Physiol 1990; 258: E937-43.
60. Tonino RP. Effect of physical training on the insulin resistance of aging. Am J Physiol 1989; 256: E352-6.
61. Hughes V, Fiatarone MA, Fielding RA et al. Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. Am J Physiol 1993; 264: E855-62.
62. Houmard JA, Shinebarger MH, Dolan PL et al. Exercise training increases GLUT-4 protein concentration in previously sedentary middle-aged men. Am J Physiol 1993; 264: E896-901.
63. Kern M, Dolan PL, Mazzeo RS, Wells JA, Dohm GL. Effect of aging and exercise on GLUT-4 glucose transporters in muscle. Am J Physiol 1992; 263: E362-7.
64. Hersey WC, Graves JE, Pollock ML et al. Endurance exercise training improves body composition and plasma insulin responses in 70- to 79-year-old men and women. Metabolism 1994; 43: 847-54.
65. NIH consensus statement. Diet and exercise in non-insulin-dependent diabetes mellitus. Nutrition 1997; 13: 89-94.
66. Feuerstein BL, Weinstock RS. Diet and exercise in type 2 diabetes mellitus. Nutrition 1997; 13: 95-9.
67. Yarasheski KE, Zachwieja JJ, Bier DM. Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women. Am J Physiol 1993; 265: E210-4.
68. Broughton DL, Taylor R. Deterioration of glucose tolerance with age: the role of insulin resistance. Age Ageing 1991; 20: 221-5.
69. De Mazancourt P, Giudicelli Y. Régulation hormonale de la lipolyse adipocytaire. Nutr Clin Métabol 1990; 4: 139-49.
70. Shaposhnikov VM. The ultrastructural features of secretory cells of some endocrine glands in aging. Mech Ageing Dev 1985; 30: 123-42.
71. Swenne I. Effects of aging on the regenerative capacity of the pancreatic β-cell of the rat. Diabetes 1983; 32: 14-9.
72. Starnes JW, Cheong E, Matschinsky FM. Hormone secretion by isolated perfused pancreas of aging Fischer 344 rats. Am J Physiol 1991; 260: E59-66.
73. Sartin J, Chaudhuri M, Obrenrader M, Adelman RC. The role of hormones in changing adaptive mechanisms during aging. Fed Proc 1980; 39: 3163-7.
74. Yoshino G, Kazumi T, Kobayashi N, Terashi K, Morita S, Baba S. Insulin and glucagon relationships during aging in rats. Endocrinol Japon 1979; 26: 325-9.
75. Simonson DC, DeFronzo RA. Glucagon physiology and aging: evidence for enhanced hepatic sensitivity. Diabetologia 1983; 25: 1-7.
76. Meneilly GS, Minaker KL, Young JB, Landsberg L, Rowe JW. Counterregulatory responses to insulin-induced glucose reduction in the elderly. J Clin Endocrinol Metab 1985; 61: 178-82.
77. Shima K, Ikegami H, Tahara Y, Hirota M, Tanaka A, Kumahara Y. Pharmacokinetics of insulin and glucagon injected subcutaneously in the elderly. Med J Osaka University 1984; 34: 87-93.
78. 125I]glucagon binding by liver membranes from young and adult rats. Diabetes 1978; 57: 589-91.
79. Dax EM, Partilla JS, Piñeyro MA, Gregerman RI. β-adrenergic receptors, glucagon receptors, and their relationship to adenylate cyclase in rat liver during aging. Endocrinology 1987; 120: 1534-41.
80. Bertrand HA, Anderson WR, Masoro EJ, Yu BP. Action of food restriction on age-related changes in adipocyte lipolysis. J Gerontol 1987; 42: 666-73.
81. Adelman RC. Loss of adaptive mechanisms during aging. Fed Proc 1979; 38: 1968-71.
82. Katz MS, McNair CL, Hymer TK, Boland DR. Emergence of beta-adrenergic-responsive hepatic glycogenolysis during post-maturational aging. Biochem Biophys Res Commun 1987; 147: 724-30.
83. Podolin DA, Gleeson TT, Mazzeo RS. Hormonal regulation of hepatic gluconeogenesis: influence of age and training. Am J Physiol 1996; 270: R365-72.
84. Frayeman N, Van Ermen A. Influence of aging on the β- and glucagon-receptor-mediated glycogenolysis in rat hepatocytes. Mech Ageing Dev 1993; 70: 115-26.
85. Kalish MI, Katz MS, Piñeyro MA, Gregerman RI. Epinephrine- and glucagon-sensitive adenylate cyclases of rat liver during aging: evidence for membrane instability associated with increased enzymatic activity. Biochim Biophys Acta 1977; 483: 452-66.
86. Kirkland JL, Dax EM. Adipocyte hormone responsiveness and aging in the rat: problems in the interpretation of aging research. J Am Geriatr Soc 1984; 32: 219-28.
87. 125I-labeled glucagon binding and lipolytic capacity. J Lipid Res 1974; 15: 26-32.
88. De Santis RA, Gorenstein T, Livingston JN, Lockwood DH. Role of phosphodiesterase in glucagon resistance of large adipocytes. J Lipid Res 1974; 15: 33-8.
89. Mangianello V, Vaughan M. Selective loss of adipose cell responsiveness to glucagon with growth in the rat. J Lipid Res 1972; 13: 12-6.
90. Ward WF. Food restriction enhances the proteolytic capacity of the aging rat liver. J Gerontol 1988; 43: B121-4.
91. Ward W, Richardson A. Effect of age on liver protein synthesis and degradation. Hepatology 1991; 14: 935-48.
92. Ward WF. Enhancement by food restriction of liver protein synthesis in the aging Fischer 344 rat. J Gerontol 1988; 43: B50-3.
93. Sapolsky RM, Krey LC, Mc Ewen BS. The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocrinol Rev 1986; 7: 284-301.
94. Touitou Y. Effects of ageing on endocrine and neuroendocrine rhythms in humans. Horm Res 1995; 43: 12-9.
95. Carnes M, Goodman BM, Lent SJ, Vo H, Jaeckels R. Coincident plasma ACTH and corticosterone time series: comparisons between young and old rats. Exp Gerontol 1994; 29: 625-43.
96. Matthews DE, Battezzati A. Substrate kinetics and catabolic hormones. In: Kinney JM, Tucker HN ed. Organ metabolism and nutrition. New York: Raven Press, 1994: 1-22.
97. Cynober L. Métabolisme protéique chez le sujet âgé. In: Albarede JL, Vellas P, Rouzaud D ed. L'Année Gérontologique. Paris: Maloine, 1990: 31-5.
98. Sapolsky RM. The adrenocortical axis. In: Schneider EL, Rowe JW ed. Handbook of the biology of aging. San Diego: Academic Press, 1990: 330-46.
99. Scaccianoce S, Nicolai R, Cigliana G, Angelucci L. Reduced glucocorticoid response to corticotropin secretagogues in the aged Sprague-Dawley rat. Neuroendocrinology 1995; 62: 32-8.
100. Brudieux R, Ait Chaoui A, Rakotondrazafy J. Age-related decreases in plasma adrenocorticotropic hormone, corticosterone, and aldosterone responses to exogenous corticotropin-releasing hormone in the rat. Gerontology 1995; 41: 308-14.
101. Van Eackelen JA, Oitzl MS, De Kloet ER. Adrenocortical hyporesponsiveness and glucocorticoid feedback resistance in old male brown Norway rats. J Gerontol A Biol Sci Med Sci 1995; 50: B83-9.
102. Sabatino F, Masoro EJ, Mahan CA et al. Assessment of the role of the glucocorticoid cascade hypothesis. Endocrinol Rev 1986; 7: 284-301.
103. Sapolsky RM, Krey LC, Mc Ewen BS. The adrenocortical stress-response in the aged male rat: impairment of recovery from stress. Exp Gerontol 1983; 18: 55-64.
104. Armanini D, Scali M, Vittadello G et al. Corticosteroid receptors and aging. J Steroid Biochem Mol 1993; 45: 191-4.
105. Zovato S, Simoncini M, Gottardo C et al. Dexamethasone suppression test: corticosteroid receptors regulation in mononuclear leukocytes of young and aged subjects. Aging 1996; 8: 360-4.
106. Touitou Y, Sulon J, Bogdan A, Reinberg A, Sodoyez JC, Demey-Ponsart E. Adrenocortical hormones, ageing, and mental condition: seasonal and circadian rhythms of plasma 18-hydroxy-11-deoxycorticosterone, total and free cortisol, and urinary corticosteroids. J Endocrinol 1983; 96: 53-64
107. Rosner W. Plasma steroid-binding proteins. Endocrinol Metab Clin North Am 1991; 20: 697-721.
108. Siiteri PK, Murai JT, Hammond GL, Nisker JA, Raymoure WJ, Kuhn RW. The serum transport of steroid hormones. Recent Prog Horm Res 1982; 38: 457-510.
109. Guazzo EP, Kirkpatrick PJ, Goodyer IM, Shiers HM, Herert J. Cortisol, dehydroepiandrosterone (DHEA), and DHEA sulfate in the cerebrospinal fluid of man: relation to blood levels and the effects of age. J Clin Endocrinol Metab 1996; 81: 3951-60.
110. Wilkinson CW, Peskind ER, Raskind MA. Decreased hypothalamic-pituitary-adrenal axis sensitivity to cortisol feedback inhibition in human aging. Neuroendocrinology 1997; 65: 79-90.
111. Levy FO, Ree AH, Eikvar L, Govindan MV, Jahnsen T, Hansson V. Glucocorticoid receptors and glucocorticoid effects in rat Sertoli cells. Endocrinology 1989; 124: 430-36.
112. Debra C, Dubois C, Almon RR. Glucocorticoid sites in skeletal muscle: adrenalectomy, maturation, fiber type, and sex. Am J Physiol 1984; 247: E118-25.
113. Grasso G, Lodi L, Lupo C, Muscettola M. Glucocorticoid receptors in human peripheral blood mononuclear cells in relation to age and to sport activity. Life Sci 1997; 61: 301-8.
114. Muhlbacher F, Kapadia CR, Colpoys FM et al. Effect of glucocorticoids on glutamine metabolism in skeletal muscle. Am J Physiol 1984; 247: E75-83.
115. Dardevet D, Sornet C, Taillandier D et al. Sensitivity and protein turnover response to glucocorticoids are different in skeletal muscle from adult and old rats. J Clin Invest 1995; 96: 2113-9.
116. Savary I, Debras E, Dardevet D et al. Effect of glucocorticoid excess on skeletal muscle and heart protein synthesis in adult and old rats. Br J Nutr 1998; sous presse.
117. Mc Grath JA, Goldspink DF. Glucocorticoid action on protein synthesis and protein breakdown in isolated skeletal muscles. Biochem J 1983; 214: 605-15.
118. Rannels SR, Jefferson LS. Effects of glucocorticoids on muscle protein turnover in perfused rat hemicorpus. Am J Physiol 1980; 238: E564-72.
119. Ardawi MSM, Jamal YS. Glutamine metabolism in skeletal muscle of glucocorticoids treated rats. Clin Sci 1990; 79: 139-47.
120. Jepson MM, Millward DJ. Impact of glutamine infusions on muscle protein synthesis in fasted and endotoxin treated rats. Clin Nutr 1991; 10 (suppl 1): 43-6.
121. Meynial-Denis D, Mignon M, Miri A et al. Glutamine synthetase induction by glucocorticoids is preserved in skeletal muscle of aged rats. Am J Physiol 1996; 271: E1061-6.
122. Moinard C, Minet R, Walrand S et al Muscle glutamine metabolism in dexamethasone-treated rats: effects of aging. Clin Nutr 1996; 15 (suppl 1): 35 (résumé).
123. Simpson JR, Hoffman-Goetz L. Monokines et malnutrition protéinoénergétique. Nutr Clin Métabol 1990; 4: 31-7.
124. Buckingham JC, Loxley HD, Christian HC, Philip JG. Activation of the HPA axis by immune insults: roles and interactions of cytokines, eicosanoids, and glucocorticoids. Pharmacol Biochem Behav 1996; 54: 285-98.
125. Mooradian AD, Reed RL, Souder P. Serum levels of tumor necrosis factor alpha, interleukin-1 alpha and bêta in healthy elderly subjects. Age 1991; 14: 61-4.
126. DeFronzo RA. Glucose intolerance and aging. Diabetes Care 1981; 4: 493-501.
127. Leighton B, Parry-Billings M, Dimitriadis G et al. Physiological glucocorticoid levels regulate glutamine and insulin-mediated glucose metabolism in skeletal muscle of the rat. Biochem J 1991; 274: 187-92.
128. Linares OA, Halter JB. Sympathochromaffin system activity in the elderly. J Am Geriatr Soc 1987; 35: 448-53.
129. Blandini F, Martignoni E, Melzi d'Eril GV et al. Free plasma catecholamine levels in healthy subjects: a basal and dynamic study. The influence of age. Scand J Lab Invest 1992, 52: 9-17.
130. Young JB, Rowe JW, Pallotta JA, Sparrow D, Landsberg L. Enhanced plasma norepinephrine response to upright posture and oral glucose administration in elderly human subjects. Metabolism 1980; 29: 532-9.
131. Esler M, Skews H, Leonard P, Jackman G, Bobik A, Korner P. Age-dependence of noradrenaline kinetics in normal subjects. Clin Sci 1981; 60: 217-9.
132. Rubin PC, Scott PJW, McLean K, Reid J. Noradrenaline release and clearance in relation to age and blood pressure in man. Eur J Clin Invest 1982; 12: 121-5.
133. Minaker KL, Rowe JW, Young JB, Pallotta JA, Landsberg L. Effect of age on insulin stimulation of sympathetic nervous system activity in man. Metabolism 1982; 31: 1181-4.
134. Sowers JR, Rubenstein LZ, Stern N. Plasma norepinephrine responses to posture and isometric exercise increase with age in the absence of obesity. J Gerontol 1983; 38: 315-7.
135. Prinz PN, Vitiello MV, Smallwood RG, Schocne RB, Halter JB. Plasma norepinephrine in normal young and aged men: relationship with sleep. J Gerontol 1984; 39: 561-7.
136. Fleg JL, Tzankoff SP, Lakatta EG. Age-related augmentation of plasma catecholamines during exercise in healthy males. J Appl Physiol 1985; 59: 1033-9.
137. Morrow LA, Linares OA, Hill TJ et al. Age differences in the plasma clearance mechanisms for epinephrine and norepinephrine in humans. J Clin Endocrinol Metab 1987; 65: 508-11.
138. Schwartz RS, Jaeger LF, Veith RC. The importance of body composition to the increase in plasma norepinephrine appearance rate in elderly men. J Gerontol 1987; 42: 546-51.
139. Featherstone JA, Veith RC, Flatness D, Murburg MM, Villacres EC, Halter JB. Age and alpha-2 adrenergic regulation of plasma norepinephrine kinetics in humans. J Gerontol 1987; 42: 271-6.
140. Poehlman ET, McAuliffe T, Danforth E. Effects of age and level of physical activity on plasma norepinephrine kinetics. Am J Physiol 1990; 258: E256-62.
141. Schwartz RS, Jaeger LF, Veith RC. The thermic effect of feeding in older men: the importance of the sympathetic nervous system. Metabolism 1990; 39: 733-7.
142. Klein CE, Nies A, Gerber J. The effect of age on the β-adrenergic lipolytic response in healthy humans. Clin Pharmacol Ther 1994; 56: 210-6.
143. Poehlman ET, Toth MJ, Ades PA, Calles-Escandon J. Gender differences in resting metabolic rate and noradrenaline kinetics in older individuals. Eur J Clin Invest 1997; 27: 23-8.
144. Young JB, Troisi RJ, Weiss ST, Parker DR, Sparrow D, Landsberg L. Relationship of catecholamine excretion to body size, obesity, and nutrient intake in middle-aged and elderly men. Am J Clin Nutr 1992; 56: 827-34.
145. Poehlman ET, Danforth E. Endurance training increases metabolic rate and norepinephrine appearance rate in older individuals. Am J Physiol 1991; 261: E233-9.
146. Poehlman ET, Gardner AW, Goran MI. Influence of endurance training on energy intake, norepinephrine kinetics, and metabolic rate in older individuals. Metabolism 1992; 41: 941-8.
147. Feldman RD. Physiological and molecular correlates of age-related changes in the human β-adrenergic receptor system. Fed Proc 1986; 45: 48-50.
148. Scarpace PJ. Decreased β-adrenergic responsiveness during senescence. Fed Proc 1986; 45: 51-4.
149. James RC, Burns TW, Chase GR. Lipolysis of human adipose tissue cells: influence of donor factors. J Lab Clin Med 1971; 77: 254-66.
150. Lönnqvist F, Nyberg B, Wahrenberg H, Arner P. Catecholamine-induced lipolysis in adipose tissue of the elderly. J Clin Invest 1990; 85: 1614-21.
151. Carey DGP. Abdominal obesity. Curr Opin Lipidol 1998; 9: 35-40.
152. Landsberg L, Young JB. The role of the sympathetic nervous system and catecholamines in the regulation of energy matabolism. Am J Clin Nutr 1983; 38: 1018-24.
153. Welle S. Sympathetic nervous system response to intake. Am J Clin Nutr 1995; 62 (suppl): 1118S-22S.
154. Reymond F, Denereaz N, Lemarchand-Beraud T. Thyrotropin action is impaired in the thyroid gland of old rats. Acta Endocrinol 1992; 126: 55-63.
155. Donda A, Reymond MJ, Lemarchand-Beraud T. Influence of age on the control of thyrotropin secretion by thyrotropin-releasing hormone in the male rat. Neuroendocrinology 1989; 49: 389-94.
156. Donda A, Lemarchand-Beraud T. Aging alters the activity of 5′-deiodinase in the adenohypophysis, thyroid gland, and liver of the male rat. Endocrinology 1989; 124: 1305-9.
157. Cizza G, Brady LS, Calogero AE et al. Central hypothyroidism is associated with advanced age in male Fischer 344/N rats: in vivo and in vitro studies. Endocrinology 1992; 131: 2672-80.
158. Forciea MA, Schwartz HL, Towle HC, Mariash CN, Kaiser FE, Oppenheimer JH. Thyroid hormone-carbohydrate interaction in the rat. J Clin Invest 1981; 67: 1739-47.
159. Sawin CT, Chopra D, Azizi F, Mannix JE, Bacharach P. The aging thyroid. Increased prevalence of elevated serum thyrotropin levels in the elderly. JAMA 1979; 242: 247-50.
160. Harman SM, Wehmann RE, Blackman MR. Pituitary-thyroid hormone economy in healthy aging men: basal indices of thyroid function and thyrotropin responses to constant infusions of thyrotropin releasing hormone. J Clin Endocrinol Metab 1984; 58: 320-6.
161. Herrmann J, Heinen E, Kroll HJ, Rudorff KH, Kruskemper HL. Thyroid function and thyroid hormone metabolism in elderly people Low T3-syndrome in old age? Klin Wochenschr 1981; 59: 315-23.
162. Bermudez F, Surks MI, Oppenheimer JH. High incidence of decreased serum triiodothyronine concentration in patients with nonthyrpidal disease. J Clin Endocrinol Metab 1975; 41: 27-40.
163. Van Coevorden A, Laurent E, Decoster C et al. Decreased basal and stimulated thyrotropin secretion in healthy elderly men. J Clin Endocrinol Metab 1989; 69: 177-85.
164. Greenspan SL, Klibanski A, Rowe JW, Elahi D. Age-related alterations in pulsatile secretion of TSH: role of dopaminergic regulation. Am J Physiol 1991; 260: E486-91.
165. Mariotti S, Barbesino G, Caturegli P et al. Complex alteration of thyroid function in healthy centenarians. J Clin Endocrinol Metab 1993; 77: 1130-4.
166. Goichot B, Schlienger JL, Grunenberger F, Pradignac A, Sapin R. Thyroid hormone status and nutrient intake in the free-living elderly. Interest of reverse triiodothyronine assessment. Eur J Endocrinol 1994; 130: 244-52.
167. Monzani F, Del Guerra P, Caraccio N et al. Age-related modifications in the regulation of the hypothalamic-pituitary-thyroid axis. Horm Res 1996; 46: 107-12.
168. Mariotti S, Franceschi C, Cossarizza A, Pinchera A. The aging thyroid. Endocrinol Rev 1995; 16: 686-715.
169. Tunbridge WMG, Evered DC, Hall R et al. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol 1977; 7: 481-93.
170. Blum CJ, Lafont C, Ducasse M et al. Thyroid function tests in ageing and their relation to associated non-thyroidal disease. J Endocrinol Invest 1989; 12: 307-12.
171. Barreca T, Franceschini R, Messina V, Bottaro L, Rolandi E. 24-hour thyroid-stimulating hormone secretory pattern in elderly men. Gerontology 1985; 31: 119-23.
172. Katzeff HL. Increasing age impairs the thyroid hormone response to overfeeding. Proc Soc Exp Biol Med 1990; 194: 198-203.
173. Pekary AE, Hershman JM, Sugawara M et al. Preferential release of triiodothyronine: an intrathyroidal adaptation to reduced serum thyroxine in aging rats. J Gerontol 1983; 38: 653-9.
174. Yu BP. Aging and oxidative stress: modulation by dietary restriction. Free Rad Biol Med 1996; 21: 651-68.
175. Gregerman RI, Gaffhey GW, Shock NW. Thyroxine turnover in euthyroid man with special reference to changes with age. J Clin Invest 1962; 41: 2065-74.
176. Lewis GF, Alessi CA, Imperial JG, Refetoff S. Low serum free thyroxine index in ambulating elderly is due to a resetting of the threshold of thyrotropin feedback suppression. J Clin Endocrinol Metab 1991; 73: 843-9.
177. Froklis VV, Valueva GV. Metabolism of thyroid hormones during aging. Gerontology 1978; 24: 81-94.
178. 131I-labeled L-thyroxine. J Clin Endocrinol 1964; 24: 775-84.
179. Poehlman ET, Berke EM, Joseph JR, Gardner AW, Katzman-Rooks SM, Goran ML Influence of aerobic capacity, body composition, and thyroid hormones on the age-related decline in resting metabolic rate. Metabolism 1992; 41: 915-21.
180. 2max. J Appl Physiol 1988; 65: 1147-51.
181. Mooradian AD, Wong NCW. Age-related changes in thyroid hormone action. Eur J Endocrinol 1994; 131: 451-61.
182. Poehlman ET, McAuliffe TL, Van Houten DR, Danforth E. Influence of age and endurance training on metabolic rate and hormones in healthy men. Am J Physiol 1990; 259: E66-72.
183. Tzankoff SP, Norris AH. Effect of muscle mass decrease on age-related BMR changes. J Appl Physiol 1977; 43: 1001-6.
184. 2 consumption with age. J Clin Invest 1976; 53: 572-81.
185. + ATPase in rat renal cortex and liver. Endocrinology 1981; 108: 27-30.
186. 2+-ATPase activity in specific pathogen-free Fischer 344 rats. Metabolism 1991; 40: 819-24.
187. Mooradian AD, Habib MP, Dickerson F, Yetskievych T. Effect of age on L-3,5,3′-triiodothyronine- induced ethane exhalation. J Appl Physiol 1994; 77: 160-4.
188. Oppenheimer JH, Schwartz HL, Mariash CN, Kinlaw WB, Wong NCW, Freake HC. Advances in our understanding of thyroid hormone action at the cellular level. Endocrinol Rev 1987; 8: 288-308.
189. Mooradian AD, Deebaj L, Wong NCW. Age-related alterations in the response of hepatic lipogenic enzymes to altered thyroid states in the rat. J Endocrinol 1991; 128: 79-84.
190. Mariash CN, Kaiser FE, Schwartz HL, Towle HC, Oppenheimer JH. Synergism of thyroid hormone and high carbohydrate diet in the induction of lipogenic enzymes in the rat. J Clin Invest 1980; 65: 1126-34.
191. Mariash CN, Seelig S, Schwartz HL, Oppenheimer JH. Rapid synergistic interaction between thyroid hormone and carbohydrate in mRNA-S14 induction. J Biol Chem 1986; 261: 9583-6.
192. Wong NCW, Schwartz HL, Strait K, Oppenheimer JH. Thyroid hormone-, carbohydrate- and age-dependent regulation of a methylation site in the hepatic S14 gene. Mol Endocrinol 1989; 3: 645-50.
193. Mooradian AD, Fox-Robichaud A, Meijer ME, Wong NCW. Relationship between transcription factors and S14 gene expression in response to thyroid hormone and age. Proc Soc Exp Biol Med 1994; 207: 97-101.