Anti-T cell receptor antibody prolongs transgene expression and reduces lung inflammation after adenovirus-mediated gene transfer

Human Gene Therapy

Volumn 8, Issue 8, 1997, Pages 935-941

  Zsengellér, Zsuzsanna K ^a   Boivin, Gregory P ^b   Sawchuk, Steven S ^a   Trapnell, Bruce C ^c   Whitsett, Jeffrey A ^a   Hirsch, Raphael ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE ANTIBODY;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE TRANSFER; HISTOPATHOLOGY; INFLAMMATORY INFILTRATE; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PNEUMONIA; TRANSGENE;

EID: 0030910938     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.8-935     Document Type: Article

References (30)

1. CARBONE, A., HARBECK, R., DALLAS, A., NEMAZEE, D., FINKEL, T., O'BRIEN, R., KUBO, R., and BORN, W. (1991). Alpha beta T-lymphocyte depleted mice, a model for γδ T-lymphocyte functional studies. Immunol. Rev. 120, 35-50.
2. DAI, Y., SCHWARZ, E.M., GU, D., ZHANG, W., SARVETNICK, N., and VERMA, I.M. (1995). Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression. Proc. Natl. Acad. Sci. USA. 92, 1401-1405.
3. DEMATTEO, R.P., MARKMANN, J.F., KOZARSKY, K.F., BARKER, C.F., and RAPER, S.E. (1996). Prolongation of adenoviral transgene expression in mouse liver by T lymphocyte subset depletion. Gene Ther. 3, 4-12.
4. ENGELHARDT, J.F., SIMON, R.H., YANG, Y., ZEPEDA, M., WEBER-PENDELTON, S., DORANZ, B., GROSSMAN, M., and WILSON, J.M. (1993). Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: Biological efficacy study. Hum. Gene Ther. 4, 759-769.
5. ENGELHARDT, J.F., YE, X., DORANZ, B., and WILSON, J.M. (1994). Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory responses in mouse liver. Proc. Natl. Acad. Sci. USA 91, 6196-6200.
6. GINSBERG, H.S., MOLDAWER, L.L., SEHGAL, P.B., REDINGTON, M., KILIAN, P.L., CHANOCK, R.M., and PRINCE, G.A. (1991). A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia. Proc. Natl. Acad. Sci. USA 88, 1651-1655.
7. GOLDSTEIN, G. (1987). Overview of the development of orthoclone OKT3: Monoclonal antibody for therapeutic use in transplantation. Transpl. Proc. XIX, No. 2, Suppl. 1, 1-6.
8. GORZIGLIA, M.I., KADAN, M.J., YEI, S., LIM, J., LEE, G.M., LUTHRA, R., AND TRAPNELL, B.C. (1996). Elimination of both E1 and E2a from adenovirus vectors further improves prospects for in vivo human gene therapy. J. Virol. 70, 4173-4178.
9. GRAHAM, F., and VAN DER EB, A. (1973). A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52, 446-467.
10. GRAHAM, F.L., SMILEY, J., RUSSELL, W.C., and NAIRN, R. (1977). Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36, 59-72.
11. HENRICKSON, M., REID, J., BELLET, J., SAWCHUK, S.J., and HIRSCH, R. (1995). Comparison of in vivo efficacy and mechanism of action of anti-murine monoclonal antibodies directed against TCR ab (H57-597) or CD3 (145-2C11). Transplantation 60, 828-835.
12. HIRSCH, R., ECKHAUS, M., AUCHINCLOSS, H., JR., SACHS, D.H., and BLUESTONE, J.A. (1988). Effects of in vivo administration of anti-T3 monoclonal antibody on T cell function in mice. I: Immunosuppression of transplantation responses. J. Immunol. 140, 3766-3772.
13. HIRSCH, R., GRESS, R.E., PLUZNIK, D.H., ECKHAUS, M., and BLUESTONE, J.A. (1989). Effects of in vivo administration of anti-CD3 monoclonal antibody on T cell function in mice. II. In vivo activation of T cells. J. Immunol. 142, 737-743.
14. HIRSCH, R., BLUESTONE, J.A., DENENNO, L., and GRESS, R.E. (1990). Anti-CD3 F(ab′)2 fragments are immunosuppressive in vivo without evoking either the strong humoral response or morbidity associated with whole mAb. Transplantation 49, 1117-1123.
15. 2 fragments induce a selective T helper dysfunction. J. Immunol. 147, 2088-2093.
16. KAY, M.A., HOLTERMAN, A., MEUSE, L., GOWN, A., OCHS, H.D., LINSLEY, P.S., and WILSON, C.B. (1995). Long-term hepatic adenovirus-mediated gene expression in mice following CLTA4Ig administration. Nature Genet. 11, 191-197.
17. KOLLS, J.K., LEI, D., ODOM, G., NELSON, S., SUMMER, W.R., GERBER, M.A., and SHELLITO, J.E. (1996). Use of transient CD4 lymphocyte depletion to prolong transgene expression of E1-deleted adenoviral vectors. Hum Gene Ther 7, 489-497.
18. LEO, O., FOO, M., SACHS, D.H., SAMELSON, L.E., and BLUESTONE, J.A. (1987). Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84, 1374-1378.
19. LOWRY, O.H., ROSEBROUGH, N.J., FARR, A.L., and RANDALL, R.J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
20. SAWCHUK, S.J., BOIVIN, G.P., DUWEL, L., BALL, W., TRAPNELL, B., BOVE, K., and HIRSCH, R. (1996). Anti-T cell receptor monoclonal antibody prolongs transgene expression following adenoviral-mediated in vivo gene transfer to mouse synovium. Hum. Gene Ther. 7, 499-506.
21. SIMON, R.H., ENGELHARDT, J.F., YANG, Y., ZEPEDA, M., WEBER-PENDLETON, S., GROSSMAN, M., and WILSON, J.M. (1993). Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: Toxicity study. Hum. Gene Ther. 4, 771-780.
22. THISTLETHWAITE JR, J.R., COSIMI, A.B., DELMONICO, F.L., RUBIN, R.H., TALKOFF-RUBIN, N., NELSON, P.W., FANG, L., and RUSSELL, P.S. (1984). Evolving use of OKT3 monoclonal antibody for treatment of renal allograft rejection. Transplantation. 38, 695-701.
23. VIGERAL P., CHKOFF, N., CHATENOUD, L., CAMPOS, H., LACOMBE, M., DROZ, D., GOLDSTEIN, G., BACH, J.F., and KREIS, H. (1986). Prophylactic use of OKT3 monoclonal antibody in cadaver kidney recipients. Utilization of OKT3 as the sole immunosuppressive agent. Transplantation 41, 730-733.
24. VILQUIN, J., GUERETTE, B., KINOSHITA, I., ROY, B., GOULET, M., GRAVEL, C., ROY, R., and TREMBLAY, J.P. (1995). FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer. Hum. Gene Ther. 6, 1391-1401.
25. WILMOTT, R.W., AMIN, R.S., PEREZ, C.R., WERT, S.E., KELLER, G., BOIVIN, G., HIRSCH, R., DE INOCENCIO, J., LU, P., YEI, S., WHITSETT, J.A., and TRAPNELL, B. (1996). Safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lungs of non-human primates. Hum. Gene Ther. 7, 301-318.
26. YANG, Y., HILDEGUND, C., ERTL, C.J., and WILSON, J.M. (1994a). MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatochtes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1, 433-442.
27. YANG, Y., NUNES, F.A., BERENCSI, K., FURTH, E.E., GÖNCZÖL, E., and WILSON, J.M. (1994b). Cellular immunity to viral antigens limits E1-deleted adenovirus for gene therapy. Proc. Natl. Acad. Sci. USA. 91, 4407-4411.
28. + CTLs in vivo. J. Immunol. 155, 2564-2570.
29. YEI, S., MITTEREDER, N., TANG, K., O'SULLIVAN, C., and TRAPNELL, B.C. (1994). Adenovirus-mediated gene transfer for cystic fibrosis: Quantitative evaluation of repeated in vivo vector administration to the lung. Gene Ther. 1, 192-200.
30. ZSENGELLER, Z.K., WERT, S.E., HULL, W.M., HU, X., YEI, S., TRAPNELL, B.C., and WHITSETT, J.A. (1995). Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice. Hum. Gene Ther. 6, 457-467.