메뉴 건너뛰기




Volumn 76, Issue 6, 1998, Pages 451-458

The level of erbB2 expression predicts sensitivity to the cytotoxic effects of an intracellular anti-erbB2 sFv

Author keywords

Apoptosis; erbB2; Her2 Neu; Single chain antibody; Tumor cells

Indexed keywords

CELL ANTIBODY; PROTEIN SFV; UNCLASSIFIED DRUG;

EID: 0031979392     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090050237     Document Type: Article
Times cited : (13)

References (36)
  • 1
    • 0028290891 scopus 로고
    • The neu-oncogene: Signal transduction pathways, transformation mechanisms and evolving therapies
    • Dougall WC, Qian X, Peterson NC, Miller MJ, Samanta A, Greene MI (1994) The neu-oncogene: signal transduction pathways, transformation mechanisms and evolving therapies. Oncogene 9:2109-2123
    • (1994) Oncogene , vol.9 , pp. 2109-2123
    • Dougall, W.C.1    Qian, X.2    Peterson, N.C.3    Miller, M.J.4    Samanta, A.5    Greene, M.I.6
  • 3
    • 0023430930 scopus 로고
    • Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells
    • Hudziak RM, Schlessinger J, Ullrich A (1987) Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells. Proc Natl Acad Sci USA 84:7159-7163
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7159-7163
    • Hudziak, R.M.1    Schlessinger, J.2    Ullrich, A.3
  • 4
    • 0030031576 scopus 로고    scopus 로고
    • Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations, cell proliferation characteristics in non-small cell lung cancer cells lines
    • Tsai CM, Chang KT, Wu LH, Chen JY, Gazdar AF, Mitsudomi T, Chen MH, Perng RP (1996) Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations, cell proliferation characteristics in non-small cell lung cancer cells lines. Cancer Res 56:206-209
    • (1996) Cancer Res , vol.56 , pp. 206-209
    • Tsai, C.M.1    Chang, K.T.2    Wu, L.H.3    Chen, J.Y.4    Gazdar, A.F.5    Mitsudomi, T.6    Chen, M.H.7    Perng, R.P.8
  • 5
    • 0029930643 scopus 로고    scopus 로고
    • Concomitant overexpression of the EGFR and erbB-2 genes in renal cell carcinoma (RCC) is correlated with dedifferentiation and metastasis
    • Stumm G, Eberwein S, Rostock-Wolf S, Stein H, Pomer S, Schlegel J, Waldherr R (1996) Concomitant overexpression of the EGFR and erbB-2 genes in renal cell carcinoma (RCC) is correlated with dedifferentiation and metastasis. Int J Cancer 69:17-22
    • (1996) Int J Cancer , vol.69 , pp. 17-22
    • Stumm, G.1    Eberwein, S.2    Rostock-Wolf, S.3    Stein, H.4    Pomer, S.5    Schlegel, J.6    Waldherr, R.7
  • 7
    • 0028670125 scopus 로고
    • The biology of erbB-2/neu/HER-2 and its role in cancer
    • Hynes NE, Stern DF (1994) The biology of erbB-2/neu/HER-2 and its role in cancer. Biochim Biophys Acta 1198:165-184
    • (1994) Biochim Biophys Acta , vol.1198 , pp. 165-184
    • Hynes, N.E.1    Stern, D.F.2
  • 9
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235:177-82
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 10
    • 18844476205 scopus 로고
    • Biological studies and potential therapeutic applications of monoclonal antibodies and small molecules reactive with the neu/c-erbB-2 protein
    • Dougall WC, Greene MI (1994) Biological studies and potential therapeutic applications of monoclonal antibodies and small molecules reactive with the neu/c-erbB-2 protein. Cell Biophysics 25:209-218
    • (1994) Cell Biophysics , vol.25 , pp. 209-218
    • Dougall, W.C.1    Greene, M.I.2
  • 12
    • 0028172880 scopus 로고
    • Inhibition of transcription factor binding to the HER2 promoter by triplex-forming oligodeoxyribonucleotides
    • Noonberg SB, Scott GK, Hunt CA, Hogan ME, Benz CC (1994) Inhibition of transcription factor binding to the HER2 promoter by triplex-forming oligodeoxyribonucleotides. Gene 149: 123-126
    • (1994) Gene , vol.149 , pp. 123-126
    • Noonberg, S.B.1    Scott, G.K.2    Hunt, C.A.3    Hogan, M.E.4    Benz, C.C.5
  • 13
    • 0028823229 scopus 로고
    • c-erbB-2 anti-sense phosphorothioate oligodeoxyribonucleotides inhibit growth and serum-induced cell spreading P185c-erbB-2-overexpressing ovarian carcinoma cells
    • Wiechen K, Dietel M (1995) c-erbB-2 anti-sense phosphorothioate oligodeoxyribonucleotides inhibit growth and serum-induced cell spreading P185c-erbB-2-overexpressing ovarian carcinoma cells. Int J Cancer 63:604-608
    • (1995) Int J Cancer , vol.63 , pp. 604-608
    • Wiechen, K.1    Dietel, M.2
  • 14
    • 0028238218 scopus 로고
    • Reduction of erbB2 gene product in mamma carcinoma cell lines by erbB2 mRNA-specific and tyrosine kinase consensus phosphorothioate antisense oligonucleotides
    • Bertram J, Killian M, Brysch W, Schlingensiepen K H, Kneba M (1994) Reduction of erbB2 gene product in mamma carcinoma cell lines by erbB2 mRNA-specific and tyrosine kinase consensus phosphorothioate antisense oligonucleotides. Biochem Biophys Res Comm 200:661-667
    • (1994) Biochem Biophys Res Comm , vol.200 , pp. 661-667
    • Bertram, J.1    Killian, M.2    Brysch, W.3    Schlingensiepen, K.H.4    Kneba, M.5
  • 15
    • 0028139425 scopus 로고
    • erbB-2 antisense oligonucleotides inhibit the proliferation of breast carcinoma cells with erbB-2 oncogene amplification
    • Colomer R, Lupu R, Bacus SS, Gelmann EP (1994) erbB-2 antisense oligonucleotides inhibit the proliferation of breast carcinoma cells with erbB-2 oncogene amplification. Br J Canc 70: 819-825
    • (1994) Br J Canc , vol.70 , pp. 819-825
    • Colomer, R.1    Lupu, R.2    Bacus, S.S.3    Gelmann, E.P.4
  • 16
    • 0029993609 scopus 로고    scopus 로고
    • Novel genetic immunotoxins and intracellular antibodies for cancer therapy
    • Chen SY, Marasco WA (1996) Novel genetic immunotoxins and intracellular antibodies for cancer therapy. Semin Oncol 23:148-153
    • (1996) Semin Oncol , vol.23 , pp. 148-153
    • Chen, S.Y.1    Marasco, W.A.2
  • 17
    • 0028148050 scopus 로고
    • Intracellular expression of single chain antibodies reverts erbB-2 transformation
    • Beerli RR, Wels W, Hynes NE (1994) Intracellular expression of single chain antibodies reverts erbB-2 transformation. J Biol Chem 269:23931-23936
    • (1994) J Biol Chem , vol.269 , pp. 23931-23936
    • Beerli, R.R.1    Wels, W.2    Hynes, N.E.3
  • 18
    • 0028500163 scopus 로고
    • Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines
    • Deshane J, Loechel F, Conry RM, Siegal GP, King CR, Curiel DT (1994) Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines. Gene Ther 1:332-337
    • (1994) Gene Ther , vol.1 , pp. 332-337
    • Deshane, J.1    Loechel, F.2    Conry, R.M.3    Siegal, G.P.4    King, C.R.5    Curiel, D.T.6
  • 21
    • 0028579733 scopus 로고
    • Oncogenes and the strategy of growth factors
    • Baserga R (1994) Oncogenes and the strategy of growth factors. Cell 79:927-930
    • (1994) Cell , vol.79 , pp. 927-930
    • Baserga, R.1
  • 22
    • 0025328284 scopus 로고
    • The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity
    • Di Fiore PP, Segatto O, Lonardo F, Fazioli F, Pierce JH, Aaronson SA (1990) The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity Mol Cell Biol 10:2749-2756
    • (1990) Mol Cell Biol , vol.10 , pp. 2749-2756
    • Di Fiore, P.P.1    Segatto, O.2    Lonardo, F.3    Fazioli, F.4    Pierce, J.H.5    Aaronson, S.A.6
  • 23
    • 0028324325 scopus 로고
    • High-efficiency gene transfer employing adenovirus-polylysine-DNA complexes
    • Curiel DT (1994) High-efficiency gene transfer employing adenovirus-polylysine-DNA complexes. Nat Immun 13:141-164
    • (1994) Nat Immun , vol.13 , pp. 141-164
    • Curiel, D.T.1
  • 25
    • 0030236157 scopus 로고    scopus 로고
    • ErbB-2 knockout employing an intracellular single chain antibody (sFv) accomplishes specific toxicity in erbB-2 expressing lung cancer cells
    • Grim J, Deshane J, Feng M, Lieber A, Kay M, Curiel DT (1996) ErbB-2 knockout employing an intracellular single chain antibody (sFv) accomplishes specific toxicity in erbB-2 expressing lung cancer cells. Am J Resp Cell Mol Bio 15:348-354
    • (1996) Am J Resp Cell Mol Bio , vol.15 , pp. 348-354
    • Grim, J.1    Deshane, J.2    Feng, M.3    Lieber, A.4    Kay, M.5    Curiel, D.T.6
  • 27
    • 0030935529 scopus 로고    scopus 로고
    • An intracellular anti-erbB-2 single-chain antibody is specifically cytotoxic to human breast cancer cells overexpressing erbB-2
    • Wright M, Grim J, Deshane J, Kim M, Strong TV, Siegal GP, Curiel DT (1997) An intracellular anti-erbB-2 single-chain antibody is specifically cytotoxic to human breast cancer cells overexpressing erbB-2. Gene Ther 4:317-322
    • (1997) Gene Ther , vol.4 , pp. 317-322
    • Wright, M.1    Grim, J.2    Deshane, J.3    Kim, M.4    Strong, T.V.5    Siegal, G.P.6    Curiel, D.T.7
  • 29
    • 0026659222 scopus 로고
    • erbB-2 autophosphorylation is required for mitogenic action and high-affinity substrate coupling
    • Segatto O, Lonardo F, Helin K, Wexler D, Fazioli F, Rhee SG, Di Fiore PP (1992) erbB-2 autophosphorylation is required for mitogenic action and high-affinity substrate coupling. Oncogene 7:1339-1346
    • (1992) Oncogene , vol.7 , pp. 1339-1346
    • Segatto, O.1    Lonardo, F.2    Helin, K.3    Wexler, D.4    Fazioli, F.5    Rhee, S.G.6    Di Fiore, P.P.7
  • 30
    • 0029893166 scopus 로고    scopus 로고
    • Novel gene therapy strategy to accomplish growth factor modulation induces enhanced tumor cell sensitivity
    • Barnes MN, Deshane JS, Siegal GP, Alvarez RD, Curiel DT (1996) Novel gene therapy strategy to accomplish growth factor modulation induces enhanced tumor cell sensitivity. Clin Canter Res 2:1089-1095
    • (1996) Clin Canter Res , vol.2 , pp. 1089-1095
    • Barnes, M.N.1    Deshane, J.S.2    Siegal, G.P.3    Alvarez, R.D.4    Curiel, D.T.5
  • 31
    • 0028955535 scopus 로고
    • Phenotypic knockout of the high affinity human interleukin 2 receptor by intracellular single-chain antibodies against the alpha subunit of the receptor
    • Richardson JH, Sodroski JG, Waldmann TA, Marasco WA (1995) Phenotypic knockout of the high affinity human interleukin 2 receptor by intracellular single-chain antibodies against the alpha subunit of the receptor. Proc Natl Acad Sci USA 92:3137-3141
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3137-3141
    • Richardson, J.H.1    Sodroski, J.G.2    Waldmann, T.A.3    Marasco, W.A.4
  • 32
    • 0028893444 scopus 로고
    • Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling
    • Graus-Porta D, Beerli RR, Hynes NE (1995) Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling. Mol Cell Biol 15:1182-1191
    • (1995) Mol Cell Biol , vol.15 , pp. 1182-1191
    • Graus-Porta, D.1    Beerli, R.R.2    Hynes, N.E.3
  • 33
    • 0028176477 scopus 로고
    • A neu acquaintance for erbB3 and erbB4: A role for receptor heterodimerization in growth signaling
    • Carraway KR, Cantley LC (1994) A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. Cell 78:5-8
    • (1994) Cell , vol.78 , pp. 5-8
    • Carraway, K.R.1    Cantley, L.C.2
  • 34
    • 0025687686 scopus 로고
    • The normal erbB-2 product is an atypical receptor-like tyrosine kinase with constitutive activity in the absence of ligand
    • Lonardo F, Di Marco E, King CR, Pierce JH, Segatto O, Aaronson SA, Di Fiore PP (1990) The normal erbB-2 product is an atypical receptor-like tyrosine kinase with constitutive activity in the absence of ligand. New Biol 2:992-1003
    • (1990) New Biol , vol.2 , pp. 992-1003
    • Lonardo, F.1    Di Marco, E.2    King, C.R.3    Pierce, J.H.4    Segatto, O.5    Aaronson, S.A.6    Di Fiore, P.P.7
  • 35
    • 0028030096 scopus 로고
    • Autocrine inhibition of the epidermal growth factor receptor by intracellular expression of a single-chain antibody
    • Beerli RR, Wels W, Hynes NE (1994) Autocrine inhibition of the epidermal growth factor receptor by intracellular expression of a single-chain antibody. Biochem Biophys Res Comm 204:666-672
    • (1994) Biochem Biophys Res Comm , vol.204 , pp. 666-672
    • Beerli, R.R.1    Wels, W.2    Hynes, N.E.3
  • 36
    • 0029812091 scopus 로고    scopus 로고
    • Intracellular expression of a single-chain antibody directed to the EGFR leads to growth inhibition of tumor cells
    • Jannot CB, Beerli RR, Mason S, Gullick WJ, Hynes NE (1996) Intracellular expression of a single-chain antibody directed to the EGFR leads to growth inhibition of tumor cells. Oncogene 13: 275-282
    • (1996) Oncogene , vol.13 , pp. 275-282
    • Jannot, C.B.1    Beerli, R.R.2    Mason, S.3    Gullick, W.J.4    Hynes, N.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.