Role of caspases 1 and 3 and Bcl-2-related molecules in endothelial cell apoptosis associated with thrombotic microangiopathies

American Journal of Hematology

Volumn 59, Issue 4, 1998, Pages 279-287

  Mitra, Debashis ^a,c   Kim, Jiyun ^a   MacLow, Clarinda ^a   Karsan, Aly ^b   Laurence, Jeffrey ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

Caspase; Cell death, programmed; Hemolytic uremic syndrome; Human immunodeficiency virus; Protease inhibitors; Purpura, thrombotic thrombocytopenic

Indexed keywords

AURINTRICARBOXYLIC ACID; COMPLEMENTARY DNA; CYSTEINE PROTEINASE INHIBITOR; INTERLEUKIN 1BETA CONVERTING ENZYME; OKADAIC ACID; PROTEIN BCL 2; PROTEINASE INHIBITOR; TETRAPEPTIDE; TUMOR NECROSIS FACTOR ALPHA; VINCRISTINE;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE OVEREXPRESSION; GENE TRANSFER; HEMOLYTIC UREMIC SYNDROME; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; MICROANGIOPATHY; PRIORITY JOURNAL; THROMBOSIS; THROMBOTIC THROMBOCYTOPENIC PURPURA;

APOPTOSIS; AUTOIMMUNE DISEASES; BCL-X PROTEIN; CASPASE 1; CASPASE 3; CASPASES; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HEMOLYTIC-UREMIC SYNDROME; HIV INFECTIONS; HUMANS; PROTEASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-BCL-2; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RECOMBINANT FUSION PROTEINS;

EID: 0031756049     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8652(199812)59:4<279::AID-AJH3>3.0.CO;2-J     Document Type: Article

References (44)

1. Hobson B, Denekamp J: Endothelial proliferation in tumours and normal tissues: Continuous labelling studies. Br J Cancer 49:405-413. 1984.
2. Karsan A, Yee E, Kaushansky K, Harlan JM: Cloning of a human Bcl-2 homologue: Inflammatory cytokines induce human A1 in cultured endothelial cells. Blood 87:3089-3096, 1996.
3. Laurence J, Mitra D, Steiner M, Staiano-Coico L, Jaffe E: Plasma from patients with idiopathic and human immunodeficiency virus-associated thrombotic thrombocytopenic purpura induces apoptosis in microvascular endothelial cells. Blood 87:3245-3254, 1996.
4. Mitra D, Jaffe EA, Weksler B, Hajjar KA, Soderland C, Laurence J: Thrombotic thrombocytopenic purpura and sporadic hemolytic-uremic syndrome plasmas induce apoptosis in restricted lineages of human microvascular endothelial cells. Blood 89:1224-1234, 1997.
5. Laurence J, Mitra D: Apoptosis of microvascular endothelial cells in the pathophysiology of thrombotic thrombocytopenic purpura/sporadic hemolytic uremic syndrome. Semin Hematol 34:98-105, 1997.
6. Ruggenenti P, Remuzzi G: The pathophysiology and management of thrombotic thrombocytopenic purpura. Eur J Hematol 56:191-207, 1996.
7. Lian EC-Y, Wu X-W, Li O-Z: Platelet aggregation and endothelial cell apoptosis induced by LMW substance(s) in the plasma from a patient with TTP. Blood 90:85b(abst.), 1997.
8. Arends MJ, Harrison DJ: Novel histopathologic findings in a surviving case of hemolytic uremic syndrome after bone marrow transplantation. Hum Pathol 20:89-91, 1989.
9. Kroemer G: The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nature Med 3:614-629, 1997.
10. Susin SA, Zamzami N, Castedo M, Daugas D, Wong H-G, Geley S, Fassy F, Reed JC, Kroemer G: The central executioner of apoptosis: Multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramid-induced apoptosis. J Exp Med 186:25-37, 1997.
11. Villa P, Kaufman SH, Earnshaw WC: Caspases and caspase inhibitors. Trends Biochem Sci 22:123, 1997.
12. Takahashi A, Hirata H, Yonehara S, Imu Y, Lee K-K, Moyer RW, Turner PC, Mesner PW, Okazaki T, Sawai H, Kishi S, Yamamoto K, Okura M, Sasada M: Affinity labeling displays the stepwise activation of ICE-related proteases by Fas, staurosporine, and CrmA-sensitive caspase-8. Oncogene 14:2741-2752, 1997.
13. Henkart PA: ICE family proteases: Mediators of all apoptotic cell death? Immunity 4:195-201, 1996.
14. Kelton JG, Warkentin TE, Hayward CPM, Murphy WG, Moore JC: Calpain activity in patients with thrombotic thrombocytopenic purpura is associated with platelet microparticles. Blood 80:2246-2251, 1992.
15. Mitra D, Steiner M, Lynch DH, Staiano-Coico L, Laurence J: HIV-1 upregulates Fas ligand expression in CD4+ T cell in vitro and in vivo: Association with Fas-mediated apoptosis and modulation by aurintricarboxylic acid. Immunology 87:581-585, 1996.
16. Stanger BZ: Looking beneath the surface: The cell death pathway of Fas/APO-1 (CD95). Mol Med 2:7-20, 1996.
17. Mitra D, Laurence J: Quantitative RT-PCR for human Fas (CD95) expression. Biotechniques 22:442-446, 1997.
18. Nagata S: Apoptosis by death factor. Cell 88:355-365, 1997.
19. Wang L, Miura M, Bergeron L, Zhu H, Yuan J: IcH-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78:739-750, 1994.
20. Fernandes-Alnemri T, Litwark G, Alnemri ES: CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein ced-3 and mammalian interleukin-1β-converting enzyme. J Biol Chem 269:30761-30764, 1994.
21. Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindstein T, Turka LA, Mao X, Nunez G, Thompson CB: Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597, 1993.
22. Livingston DJ: In vitro and in vivo studies of ICE inhibitors. J Cell Biochem 64:19-26, 1997.
23. Enari M, Hug H, Nagata S: Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 375:78-81, 1995.
24. Cohen P, Holmes CFB, Tsukitani Y: Okadaic acid: A new probe for the study of cellular regulation. Trends Biochem Sci 15:98-102, 1990.
25. Chow SC, Weis M, Kass GEN, Holmstrom TH, Eriksson JE, Orrenius S: Involvement of multiple proteases during Fas-mediated apoptosis in T lymphocytes. Fed Eur Biochem Soc Lett 364:134, 1995.
26. Hara H, Friedlander RM, Gagliardini V, Ayata C, Fink K, Huang Z, Shimizu-Sasamata M, Yuan J, Moskowitz MA: Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc Natl Acad Sci USA 94:2007-2012, 1997.
27. Karsan A, Yee E, Harlan JM: Endothelial cell death induced by tumor necrosis factor-α is inhibited by the Bcl-2 family member, A1. J Biol Chem 271:27201-27204, 1996.
28. Huang S, Jiang Y, Li Z, Nishida E, Mathias P, Lin S, Ulvevitch RJ, Nemerow GR, Han J: Apoptosis signaling pathway in T cells is composed of ICE/ced-3 family proteases and MAP kinase kinase 6b. Immunity 6:739-749, 1997.
29. Enari M, Talanian RV, Wong WW, Nagata S: Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380:723-726, 1996.
30. Friedlander RM, Gagliardini V, Rotello RJ, Yuan J: Functional role of interleukin 1β (IL-1β) in IL-1β-converting enzyme-mediated apoptosis. J Exp Med 184:717-724, 1996.
31. Richardson BC, Lalwani ND, Johnson KJ, Marks RM: Fas ligation triggers apoptosis in macrophages but not endothelial cells. Eur J Immunol 24:2642-2645, 1994.
32. Consonni R, Falanga A, Barbui T: Further characterization of platelet-aggregating cysteine protease activity in thrombotic thrombocytopenic purpura. Br J Hematol 87:321-324, 1994.
33. Pavord S, Kelton JG, Warner MN, Moore JC, Warkentin TE, Hayward CPM: Proteolytic degradation of high molecular weight kininogen in acute thrombotic thrombocytopenic purpura. Br J Hematol 97:762-767, 1997.
34. Moake JL: Studies on the pathophysiology of thrombotic thrombocytopenic purpura. Semin Hematol 34:83-89, 1997.
35. Lafrenie RM, Wahl LM, Epstein JS, Hewlett IK, Yamada KM, Dhawan S: HIV-1 Tat modulates the function of monocytes and alters their interaction with microvessel endothelial cells: A mechanism of pathogenesis: J Immunol 156:1638-1645, 1996.
36. Kroemer G: The pharmacology of T cell apoptosis. Adv Immunol 58:211-296, 1995.
37. Knudson CM, Korsmeyer SJ: Bcl-2 and bax function independently to regulate cell death. Nat Gen 16:358-365, 1997.
38. Reed JC: Double identity for proteins of the Bcl-2 family. Nature 387:773-776, 1997.
39. Susin SA, Zamzami N, Castedo M, Hirsch T, Marchetti P, Macho A, Daugas E, Geuskens M, Kroemer G: Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J Exp Med 184:1331-1341, 1996.
40. Perry DK, Smyth MJ, Wang H-G, Reed JC, Dariez P, Poirier GG, Obeid LM, Hannun YA: Bcl-2 acts upstream of the PARP protease and prevents its activation. Cell Death Differ 4:29-33, 1997.
41. L as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. Proc Natl Acad Sci USA 94:6939-6942, 1997.
42. L through caspase interaction. Proc Natl Acad Sci USA 95:554-559, 1998.
43. Simonian PL, Grillot DAM, Nunez G: Bcl-2 and Bcl-XL can differentially block chemotherapy-induced cell death. Blood 90:1208-1216, 1997.
44. Ruggenenti P, Remuzzi G: Malignant vascular disease of the kidney: Nature of the lesions, mediators of disease progression, and the case for bilateral nephrectomy. Am J Kidney Dis 27:459-475, 1996.