Proteolytic degradation of high molecular weight kininogen in acute thrombotic thrombocytopenic purpura

British Journal of Haematology

Volumn 97, Issue 4, 1997, Pages 762-767

  Pavord, Susannah ^a   Kelton, John G ^a,b   Warner, Margaret N ^a   Moore, Jane C ^a   Warkentin, Theodore E ^a   Hayward, Catherine P M ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Calpain; HK; Proteolysis; TTP

Indexed keywords

CALPAIN; HIGH MOLECULAR WEIGHT KININOGEN; PROTEINASE;

ARTICLE; ENZYME ACTIVITY; ENZYME CHEMISTRY; HEMOSTASIS; HUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTEIN DEGRADATION; THROMBOTIC THROMBOCYTOPENIC PURPURA;

EID: 0030812273     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.1282947.x     Document Type: Article

References (21)

1. Amorosi, E.L. & Ultman, J.E. (1966) TTP: report of 16 cases and review of the literature. Medicine, 45, 139-157.
2. Bradford, H.N., Schmaier, A.H. & Colman, R.W. (1990) Kinetics of inhibition of platelet calpain II by human kininogens. Biochemical Journal, 270, 83-90.
3. DeLa Cadena, R.A. & Colman, R.W. (1991) Structure and functions of human kininogens. TiPS, 12, 272-275.
4. Falanga, A., Consonni, R., Ruggenenti, P. & Barbui, S. (1991) A cathepsin-like proteinase activity in thrombotic thrombocytopenic purpura. British Journal of Haematology, 79, 474-480.
5. Higashiyama, S., Ohkubo, I., Ishiguro, H., Kunimatsu, M., Sawaki, K. & Sasaki, M. (1986) Human high molecular weight kininogen as a thiol protease inhibitor: presence of the entire inhibition capacity in the native form of heavy chain. Biochemistry, 25, 1669-1675.
6. Kelton, J.G., Moore, J.C. & Murphy, W.G. (1987) Studies investigating platelet aggregation and release initiated by sera from patients with thrombotic thombocytopenic purpura. Blood, 69, 924-928.
7. Kelton, J.G., Moore, J.C., Santos, A. & Sheridan, D. (1984) Detection of a platelet-aggregating factor in thrombotic thrombocytopenic purpura. Annals of Internal Medicine, 101, 589-593.
8. Kelton, J.G., Warkentin, T.E., Hayward, C.P.M., Murphy, W.G. & Moore, J.C. (1992) Calpain activity in patients with thrombotic thrombocytopenic purpura is associated with platelet microparticles. Blood, 80, 2246-2251.
9. Kerbiriou, D.M. & Griffin, J.H. (1979) Human high molecular weight kininogen: studies of structure-function relationships and of proteolysis of the molecule occurring during contact activation of plasma. Journal of Biological Chemistry, 254, 12020-12027.
10. Lian, E.C.-Y., Harkness, D.R., Byrnes, J.J., Wallach, H. & Nunez, R. (1979) The presence of a platelet aggregating factor in the plasma of patients with thrombotic thrombocytopenia purpura and its inhibition by normal plasma. Bloood, 53, 333-338.
11. Moake, J.L., Rudy, C.K., Troll, J.H., Weinstein, M.J., Colannino, N.M., Azocar, J., Seder, R.H., Hong, S.L. & Deykin, D. (1982) Unusually large plasma factor VIII: von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura. New England Journal of Medicine, 307, 1432-1435.
12. Moore, J.C., Murphy, W.G. & Keltom, J.G. (1990) Calpain proteolysis of von Willebrand factor enhances its binding to platelet membrane glycoproteins IIb/IIIa: an explanation for platelet aggregation in thrombotic thrombocytopenic purpura. British Journal of Haematology, 74, 457-464.
13. Muller-Esterl, W., Fritz, H., Machleidt, W., Ritonja, A., Brzin, J., Kotnik, M., Turk, V., Kellerman, J. & Lottspeich, F. (1985) Human plasma kininogens are identical with α-cysteine proteinase inhibitors. FEBS Letters, 182, 310-314.
14. Murachi, T. (1984) Calpain and calpastatin. Trends in Biochemistry, 8, 167-169.
15. Murphy, W.G., Moore, J.C. & Kelton, J.G. (1987) Calcium-dependent cysteine protease activity in the sera of patients with thrombotic thrombocytopenic purpura. Blood, 70, 1683-1687.
16. Saito, H., Goldsmith, G. & Waldmann, R. (1976) Fitzgerald factor (high molecular weight kininogen) clotting activity in human plasma in health and disease in various animal plasmas. Blood, 48, 941-947.
17. Salvesen, G., Parkes, C., Abrahamson, M., Grubb, A. & Barrett, A.J. (1986) Human low-Mr kininogen contains three copies of a cystatin sequence that are divergent in structure and in inhibitory activity for cysteine proteases. Biochemical Journal, 234, 424-434.
18. Schmaier, A.H., Bradford, H., Silver, L.D., Farber, A., Scott, C.F., Schutsky, D. & Colman, R.W. (1986a) High molecular weight kininogen is an inhibitor of platelet calpain. Journal of Clinical Investigation, 77, 1565-1573.
19. Schmaier, A.H., Smith, P.M., Purdon, A.D., White, J.G. & Colman, R.W. (1986b) High molecular weight kininogen: localization in the unstimulated and activated platelet and activation by a platelet calpain(s). Blood, 67, 119-130.
20. Thompson, R.E., Mandle, R., Jr & Kaplan, A.P. (1978) Characterization of human high molecular weight kininogen. Journal of Experimental Medicine, 147, 488-499.
21. Van Iwaarden, F. & Bouma, B.N. (1987) Role of high molecular weight kininogen in contact activation. Seminars in Thrombosis and Haemostasis, 13, 15-24.