Rapid retroviral infection of human haemopoietic cells of different lineages: Efficient transfer in fresh T cells

British Journal of Haematology

Volumn 103, Issue 2, 1998, Pages 449-461

  Introna, Martino ^a,d   Barbui, Anna Maria ^a   Golay, Josée ^a   Bambacioni, Federica ^a   Schirò, Raffaella ^b   Bernasconi, Sergio ^a   Breviario, Ferruccio ^a   Erba, Eugenio ^a   Borleri, Gianmaria ^c   Barbui, Tiziano ^c   Biondi, Andrea ^b   Rambaldi, Alessandro ^c  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c OSPEDALI RIUNITI   (Italy)

^d Laboratory of Molecular Biology   (Italy)

Author keywords

Gene transfer; Retroviruses; T lymphocytes

Indexed keywords

GREEN FLUORESCENT PROTEIN;

ARTICLE; CELL CULTURE; CELL LINEAGE; GENE TRANSFER; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HEMATOPOIETIC CELL; IMMUNOFLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; T LYMPHOCYTE; VIRUS EXPRESSION; VIRUS INFECTION;

ANTIGENS, CD34; B-LYMPHOCYTES; BLOTTING, NORTHERN; ENDOTHELIUM; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOPHENOTYPING; LUMINESCENT PROTEINS; MOLONEY MURINE LEUKEMIA VIRUS; RETROVIRIDAE INFECTIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTE SUBSETS; TUMOR CELLS, CULTURED;

EID: 0031754314     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.01020.x     Document Type: Article

References (65)

1. Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G. & Isner, J.M. (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science, 275, 964-967.
2. Baisch, H., Gohde, W. & Linden, W.A. (1975) Analysis of PCP: data to determine the fraction of cells in the various phases of the cell cycle. Radiation and Environmental Biophysics, 12, 31-41.
3. Bauen, T. & Miller, A.D. (1996) Improved transfer of the leukocyte integrin CD18 subunit into hematopoietic cell lines by using retroviral vectors having a gibbon ape leukemia virus envelope. Blood, 86, 2379-2387.
4. Bierhuizen, M.F.A., Westerman, Y., Visser, T.P. Dimjati, W., Wognum, A.W. & Wagemaker, G. (1997) Enhanced green fluorescent protein as selectable marker of retroviral mediated gene transfer in immature hematopoietic bone marrow cells. Blood, 90, 3304-3315.
5. Blease, R.M., Culver, K.W., Miller, A.D., Carter, C.S., Fleisher, T., Clerici, M., Shearer, G., Chang, L., Chiang, Y., Tolstoshev, P., Greenblatt, J.J., Rosenberg, S.A., Klein, H., Berger, M., Mullen, C.A., Ramsey, W.J., Muul, L., Morgan, R. & Anderson, W.F. (1995) T-lymphocytes-directed gene therapy for ADA-SCID: initial trial results after 4 years. Science, 270, 475-480.
6. Bonini, C., Ferrari, G., Verzeletti, S., Servida, P., Zappone, E., Ruggieri, L., Ponzoni, M., Rossini, S., Mavilio, F., Travesari, C. & Bordignon, C. (1997) HSV-TK gene transfer into donor lymphocytes for control of allogenic graft-versus-leukemia. Science, 276, 1719-1724.
7. Bordignon, C., Notarangelo, L.D., Nobili, N., Ferrari, G., Casorati, G., Panina, P., Mazzolari, E., Maggioni, D., Rossi, C., Servida, P., Ugazio, A.G. & Mavilio, F. (1995) Gene therapy in peripheral blood lymphocytes and bone marrow for ADA-immunodeficient patients. Science, 270, 470-475.
8. Bordignon, C., Yu, S.F., Smith, C.A., Hantzopoulos, P., Ungers, G.E., Keever, C.A.. O'Reilly, R. & Gilboa, E. (1989) Retroviral vector mediated high efficiency expression of adenosine deaminase (ADA) in hematopoietic long-term cultures of ADA-deficient marrow cells. Proceedings of the National Academy of Sciences of the United States of America, 86, 6748-6752.
9. Bregni, M., Magni, M., Siena, S., Di Nicola, M., Bonadonna, G. & Massimo Gi, A. (1992) Human peripheral blood hematopoietic progenitors are optimal targets of retroviral mediated gene transfer. Blood, 80, 1418-1422.
10. Brenner, M.K., Rill, D.R., Holladay, M.S., Heslop, H.E., Moen, R.C., Buschle, M., Krance, R.A., Santana, V.M., Anderson, W.F. & Ihle, J.N. (1993) Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients. Lancet, 342, 1134-1137.
11. Candotti, F., Johnston, J.A., Puck, J.M., Sugamura, K., O'Shea, J.J. & Blease, R.M. (1996) Retroviral mediated gene correction for X-linked severe combined immunodeficiency. Blood, 87, 3097-3102.
12. Caslini, C., Spinelli, O., Cazzaniga, G., Golay, J., De Gioia, L., Pedretti, A., Brevlario, F., Amaru, R., Barbui, T., Blondi, A., Introna, M. & Rambaldi, A. (1997) Identification of two novel isoforms of the ZNF162 gene: a growing family of signal transduction and activation of RNA proteins. Genomics, 42, 268-277.
13. + cord blood cells is expressed by their T-cell progeny in the SCID-hu thymus. Blood, 88, 107-113.
14. Claret, E.J., Alyea, E.P., Orsini, E., Pickett, C.C., Collins, H., Wang, Y., Neuberg, D., Soiffer, R.J. & Ritz, J. (1997) Characterization of T cell repertoire in patients with graft versus leukemia after donor lymphocytes infusion. Journal of Clinical Investigation. 100. 855-866.
15. Conneally, E., Bardy, P., Eaves, C.J., Thomas, T., Chappel, S., Shpall, K.J. & Humphries, R.K. (1996) Rapid and efficient selection of human hematopoietic cells expressing murine heat-stable antigen as an indicator of retroviral-mediated gene transfer. Blood, 87, 456-464.
16. Cormack, B.P., Valdivia, R.H. & Falkow, S. (1946) FACS-optimized mutants of the green fluorescent protein (GFP). Gene. 173, 33-38.
17. + bone marrow progenitor cells. Blood, 82, 3290-3297.
18. Danos, O. & Mulligan, H.C. (1988) Safe and efficient generation of recombinant retroviruses with amphotrophic and ecotropic host ranges, proceedings of the National Academy of Sciences of the United States of America, 85, 6460-6464.
19. + cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML. Blood, 83, 3068-3076.
20. Dimitrov, D.S. (1997) How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity. Cell, 91, 721-730.
21. Dranoff, G., Jaffee, E., Lazenby, A., GolumbeK, P., Levitsky, H., Brose, K., Jackson, V., Hamada, H., Pardoll, D. & Mulligan, R.C. (1993) Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proceedings of the National Academy of Sciences of the United States of America, 90, 3539-3543.
22. Dunbar, C.E., Cottler-Fox, M., O'Shaughnessy, J.A., Doren, S., Carter, C., Berenson, R., Brown, S., Moen, R.C., Greenblatt, J., Stewart, F.M., Leitman, S.F., Wilson, W.H., Cowan, K., Young, N.S. & Nienhuis, A.W. (1995) Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation. Blood, 85, 3048- 3057.
23. Elwood, N.J., Zogos, H., Willson, T. & Begley, C.G. (1996) Retroviral transduction of human progenitor cells: use of granulocyte colony stimulating factor plus stem cell factor to mobilize progenitor cells in vivo and stimulation by Flt3/Flt2 ligand in vitro. Blood, 88, 4452-4462.
24. + cells for six hours without growth factors or no autologous stroma does not improve marking efficiency assessed in vivo. Blood, 89, 4040-4046.
25. Gallardo, U.F., Tan, C., Ory, D. & Sadelain, M. (1997) Recombinant retroviruses pseudotyped with vesicular stomatitis virus G glycoprotein mediate both stable gene transfer and pseudotransduction in human peripheral blood lymphocytes. Blood, 90, 952-957.
26. Garcia-Hernandez, B., Castellanos, A., Lopez, A., Orfao, A. & Sanchez-Garcia, I. (1997) Murine hematopoietic reconstitution after tagging and selection of retrovirally transduced bone marrow cells. Proceedings of the National Academy of Sciences of the United States of America, 94, 13239-13244.
27. Golay, J., Capucci, A., Arsura, M., Castellano, M., Rizzo, V. & Introna, M. (1991) Expression of c-myb and B-myb, but not A-myb. correlates with proliferation in human hematopoietic cells. Blood, 77, 149-158.
28. +, CD39 , and sIgM-B lymphocytes an in Burkitts lymphoma cell lines. Journal of Immunology, 153, 543-553.
29. Grignani, F., Kinsella, T., Mencarelli, A., Valtieri, M., Riganelli, D., Lanfrancone, L., Peschle, C., Nolan, G.P. & Pelicci. P.G. (1998) High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein. Cancer Research, 58, 14-19.
30. Hacein-Bey, S., Cavazzana-Calvo, M., LeDeist, F., Dautry-Varsat, A., Hivroz, C., Riviere, I., Danos, O., Heard, J.M., Sugamura, K., Fisher, A. & DeSaintBasile, G. (1996) γc gene transfer into SCID XI patients' B-cell lines restores normal high affinity interleukin 2 receptor expression and function. Blood, 87, 3108-3116.
31. Heslop, H.E., Ng, C.Y.C., Li, C., Smith, C.A., Loftin, S.K., Krance, R.A., Brenner, M.K. & Rooney, C.M. (1996) Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes. future Medicine, 2, 551-555.
32. Introna, M., Breviario, F., D'Aniello, E.M., Golay, J., Dejana, E. & Mantovani, A. (1995) IL-1 inducible genes in human umbilical vein endothelial cells. European Heart Journal, 14, 78-81.
33. Kiem, H.P., Heyward, S., Winkler, A., Potter, J., Allen, J.M. Miller, D. & Andrews, R.G. (1997) Gene transfer into marrow repopulating cells: comparison between amphotropic and gibbon ape leukemia virus pseudotyped retroviral vectors in a competitive repopulation assay in baboons. Blood, 90, 4658-4645.
34. Kinsella, T.M. & Nolan, G.P. (1996) Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Human Gene Therapy, 7, 1405-1413.
35. Kohn, D.B., Weinberg, K.I., Nolta, J.A., Heiss, L.N., Lenarsky, C., Crooks, G.M., Hanley, M.E., Annett, G., Brooks, J.S., El-Khoureiy, A., Lawrence, K., Wells, S., Moen, R.C., Bastian, J., Williams-Herman, D.E., Elder, M., Wara, D., Bowen, T., Hershtield, M.S., Mullen, C.A., Blease, R.M. & Parkman. R. (1995) Engraftment of gene modified umbilical cord blood cells in neonates with adenosine deaminase deficiency. Nature Madicine, 1, 1017-1023.
36. Kolb, H.J., Mittermuller, J., Clemm, C., Holler, E., Ledderose, G., Brehm, G., Heim, M. & Wilmanns, W. (1990) Donor leukocyte transfusion for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood, 76. 2462-2465.
37. Limon, A., Briones, J., Puig, T., Carmona, M., Fornas, O., Cancelas, J.A., Nadal, M., Garcia, J., Rueda, F. & Barquinero, J. (1997) High titer retroviral vectors containing the enhanced green fluorescent protein gene for the efficient expression in hematopoietic cells. Blood, 90, 3316-3321.
38. Magni, M., Shammah, S., Schiro, R., Mellado, W., DallaFavera, R. & Massimo Gianni, A. (1996) Induction of cyclophosphamide resistance by aldehyde dehydrogenase gene transfer. Blood, 87, 1097-1103.
39. Mavilio, F., Ferrari, G., Rossini, S., Nobili, N., Bonini, C., Casorati, G., Traversari, C. & Bordignon, C. (1994) Peripheral blood lymphocytes as a target cells of retroviral vector-mediated gene transfer. Blood, 83, 1988-1997.
40. + cells and corrects the enzyme deficiency in cells from Gaucher patients. Blood, 87, 1754-1762.
41. Merrouche, Y., Negrier, S., Bain, C., Combaret, V., Mercatello, A. Coronel, B., Moskovtchenko, J., Tolstoshev, P., Moen, R., Philip, T. & Favrot, M.C. (1995) Clinical application of retroviral gene transfer in oncology: results of a french study with tumor-infiltrating lymphocytes transduced with the gene of resistance to neomycin. Journal Clinical Oncology, 13, 410-418.
42. Miller, A.D. (1990) Retrovirus packaging cells. Human Gene Therapy, 1, 5-14.
43. Miller, A.D. (1996) Cell-surface receptors for retroviruses and implication for gene transfer. proceedings of the National Academy of Sciences of the United States of America, 93, 11407-11413.
44. Miller, D.G., Edwards, R.H. & Miller, A.D. (1994) Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus. Proceedings of the National Academy of Sciences of the United States of America, 91, 78-82.
45. Moritz, T., Patel, V. & Williams, D.A. (1944) Bone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors. Journal of Clinical Investigation, 91, 1451-1457.
46. Munshi, N.C., Govindarajan, R., Drake, R., Ding, L.M., Iyer, R., Saylors, R., Kornbluth, J., Marcus, S., Chiang, Y., Ennist, D., Kwak, L., Reynolds, C., Tricot, G. & Barlogie, B. (1997) Thymidine kinase (TK) gene-transduced human lymphocytes can be highly purified. remain fully functional. and are killed efficiently with gancyclovir. Blood, 89, 1334-1340.
47. Onodera, M., Ariga, T., Kawamura, N., Kobayashi, I., Ohtsu, M., Yamada, M., Tame, A., Furuta, H., Okano, M., Shuzo, M., Kotani, H., McGarrity, G.J., Blease, R.M. & Sakiyama, Y. (1998) Successful peripheral T-lymphocyte-directed transfer for a patient with severe combined immune deficiency caused by adenosine deaminase deficiency. Blood, 91, 30-36.
48. Orlic, D., Girard, L., Jordan, C., Anderson, S.M., Cline, A. & Bodine, D.M. (1996) The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction. Proceedings of the National Academy of Sciences of the United States of America, 93, 11097-11092.
49. Persons, D.A., Allay, J.A., Smeyne, R.J., Ashmun, R.A., Sorrentino, B.P. & Nienhuis, A.W. (1997) Retroviral mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro and identification of genetically modified cells in vivo. Blood, 90, 1777-1786.
50. Phillips, K., Gentry, T., McCowage, G., Gilboa, E. & Smith, C. (1996) Cell-surface markers for assessing gene transfer into human haematopoietic cells. Nature Medicine, 2, 1154-1557.
51. Premack, B.A. & Schall, T.J. (1996) Chemokine receptors: gateways to Inflammation and infection. Nature Medicine, 2, 1174-1178.
52. Rambaldi, A., Bettoni, S., Tosi, S., Giudici, G., Schiro, R., Borleri, G.M., Abbate, M., Chiaffarino, F., Colotta, F., Barbui, T. & Biondi, A. (1993) Establishent and characterization of a new granulocyte-macrophage colony-stimulating factor dependent and interleukin- 5 dependent human acute myeloid leukemia cell line (GF-D8). Blood, 81, 1376-1383.
53. Rambaldi, A., Borleri, G., Dotti, G., Bellavita, P., Amaru, R., Biondi, A. & Barbui, T. (1998) Innovative two step negative selection of granulocyte colony-stimulating factor mobilized circulating progenitor cells: adequacy for autologous and allogeneic transplantation. Blood, 91, 2189-2896.
54. Riddell, S.R., Elliott, M. Lewinsohn, D.A., Gilbert, M.J., Wilson, L., Manley, S.A., Lupton, S.D., Overell, R.W., Reynolds, T., Corey, L. & Greenberg, P.D. (1996) T-cell mediated rejection of gene modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nature Medicine, 2, 216-223.
55. Rooney, C.M., Smith, C.A., Ng, C.Y.C., Loftin, S., Li, C., Krance, R.A., Brenner, M.K. & Heslop, H.E. (1995) Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation. Lancet, 345, 9-13.
56. Rosenberg, S.A., Aebersolod. P., Cornetta, K., Kasid, A., Morgan, R.A., Moen, R., Karson, E.M., Lotze, M.T., Yang, J.C., Topalian, S.L., Merino, M.J., Culver, K., Miller, A.D., Blaese, R.M. & Anderson. W.F. (1990) Gene transfer into humans: immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. New England Journal of Medicine, 323, 570-578.
57. Russel, S.J. (1997) Gene therapy. British Medical Journal, 315. 1289-1292.
58. Soiffer, R.J. (1997) Donor lymphocyte infusions: the door is open. Journal of Clinical Oncology, 15, 416-417.
59. Su, L., Lee, R., Bonyhadi, M., Matsuzaki, H., Forestell, S., Escaich, S., Bohnlein, E. & Kaneshima, H. (1997) Hematopoietic stem cell based gene therapy for aquired immunodeficiency syndrome: efficient transduction and expression of RevM10 in myeloid cells in vivo and in vitro. Blood, 89, 2283-2290.
60. Tiberghien, P., Reynolds, C.W., Keller, J., Spence, S., Deschaseaux, M., Certoux, J., Contassot, E., Murphy, W.J., Lyons, R., Chiang, Y., Hervé, P., Longo, D.L. & Ruscetti, F.W. (1994) Gancyclovir treatment of herpes simplex thymidine kinase-transduced primary T lymphocytes: an approach for specific in vivo donor T-cell depletion after hone marrow transplantation. Blood, 84, 1333-1341.
61. ++ human cord blood cells generated T cells expressing high levels of the retroviral encoded green fluorescent protein marker in vitro. Blood, 91, 431-440.
62. Verma, I.M. & Somia, N. (1997) Gene therapy: promises. problems and prospects. Nature, 389, 239-242.
63. Weiss, R.A. & Tailor, C.S. (1995) Retrovirus receptor. Cell, 82, 531-533.
64. Zhang, G., Gurtu, V. & Kain, S.R. (1998) An enhanced green fluorescence protein allows sensitive detection of gene transfer in mammalian cells. Biochemical and Biophysical Research Communications. 227, 707-711.
65. Zon, L.I. (1995) Developmental biology of hematopoiesis. Blood, 86, 2876-2891.