Retroviral transduction of human progenitor cells: Use of granulocyte colony-stimulating factor plus stem cell factor to mobilize progenitor cells in vivo and stimulation by Flt3/Flk-2 ligand in vitro

Blood

Volumn 88, Issue 12, 1996, Pages 4452-4462

  Elwood, Ngaire J ^a   Zogos, Helen ^a   Willson, Tracy ^a   Begley, C Glenn ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; STEM CELL FACTOR; VIRUS VECTOR;

ARTICLE; EXPRESSION VECTOR; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RETROVIRUS; STEM CELL;

EID: 0029959591     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.12.4452.bloodjournal88124452     Document Type: Article

References (51)

1. Duhrsen U, Villeval JL, Boyd J, Kannourakis G, Morstyn G, Metcalf D: Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients. Blood 72:2074, 1988
2. DeLuca E, Sheridan WP, Watson D, Szer J, Begley CG: Prior chemotherapy does not prevent effective mobilisation by G-CSF of peripheral blood progenitor cells. Br J Cancer 66:893, 1992
3. Sheridan WP, Begley CG, Juttner CA, Szer J, To LB, Maher D, McGrath KM, Morstyn G, Fox RM: Hemopoietic recovery following infusion of autologous bone marrow and G-CSF mobilized peripheral blood progenitor cells after high dose chemotherapy. Lancet 1:640, 1992
4. Galli SJ, Zsebo KM, Geissler EN: The kit ligand, stem cell factor. Adv Immunol 55:1, 1994
5. Cicuttini FM, Begley CG, Boyd AW: The effect of recombinant stem cell factor (SCF) on purified CD34-positive human umbilical cord blood progenitor cells. Growth Factors 6:31, 1992
6. Fleming WH, Alpern EJ, Uchida N, Ikuta K, Weissman IL: Steel factor influences the distribution and activity of murine hematopoietic stem cells in vivo. Proc Natl Acad Sci USA 90:3760, 1993
7. Andrews RG, Bensigner WI, Knitter GH, Bartelmez SH, Longin K, Bernstein ID, Appelbaum FR, Zsebo KM: The ligand for c-kit, stem cell factor, stimulates the circulation of cells that engraft lethally irradiated baboons. Blood 80:2715, 1992
8. Briddell RA, Hartley CA, Smith KA, McNiece IK: Recombinant rat stem cell factor synergizes with recombinant human granulo-cyte colony-stimulating factor in vivo in mice to mobilize peripheral blood progenitor cells that have enhanced repopulating potential. Blood 82:1720, 1993
9. Yan X-Q, Briddell R, Hartley C, Stoney G, Samal B, McNiece I: Mobilization of long-term hematopoietic reconstituting cells in mice by the combination of stem cell factor plus granulocyte colony-stimulating factor. Blood 84:795, 1994
10. Yan X-Q, Hartley C, McElroy P, Chang A, McCrea C, McNiece I: Peripheral blood progenitor cells mobilized by recombinant human granulocyte colony-stimulating factor plus recombinant rat stem cell factor contain long-term engrafting cells capable of cellular proliferation for more than two years as shown by serial transplantation in mice. Blood 85:2303, 1995
11. Andrews RG, Briddell RA, Knitter GH, Opie T, Bronsden M, Myerson D, Appelbaum FR, McNiece IK: In vivo synergy between recombinant human stem cell factor and recombinant human granu-locyte colony-stimulating factor in baboons: Enhanced circulation of progenitor cells. Blood 84:800, 1994
12. McNiece I, Glaspy J. LeMaistre F, Briddell R, Menchaca D, Shpall EJ: Effects of recombinant methyionyl human stem cell factor (rhSCF) and Filgrastim (rhG-CSF) on mobilization of peripheral blood progenitor cells: Preliminary laboratory results from a phase I/II study. Blood 82:84, 1993 (abstr, suppl 1)
13. Begley CG, Basser R, Mansfield R, Maher D, To B, Juttner C, Fox R, Cebon J, Grigg A, Szer J, McGrath K, Thomson B, Sheridan W, Menchaca D, Collins J, Russell I, Green M: Randomized prospective study demonstrating a prolonged effect of SCF with G-CSF (filgrastim) on PBPC in untreated patients: Early results. Blood 84:25, 1994 (abstr, suppl 1)
14. Bregni M, Magni M, Siena S, Di Nicola M, Bonadonna G, Gianni AM: Human peripheral blood hematopoietic progenitors are optimal targets of retroviral-mediated gene transfer. Blood 80:1418, 1992
15. Cassel A, Cottler-Fox M, Doren S, Dunbar CE: Retroviral-mediated gene transfer into CD34-enriched human peripheral blood stem cells. Exp Hematol 21:585, 1993
16. Nimgaonkar MT, Bahnson AB, Boggs SS, Ball ED, Barranger JA: Transduction of mobilized peripheral blood CD34+ cells with the glucocerebrosidase cDNA. Gene Ther 1:201, 1994
17. Lu M, Maruyama M, Zhang N, Levine F, Friedmann T, Ho AD: High efficiency retroviral-mediated gene transduction into CD34+ cells purified from peripheral blood of breast cancer patients primed with chemotherapy and granulocyte-macrophage colony-stimulating factor. Hum Gene Ther 5:203, 1994
18. Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan JF, Kastelein R, Hudak S, Wagner J, Mattson J, Luh J, Duda G, Martina N, Peterson D, Menon S, Shanafelt M, Muench M, Kelner G, Namikawa R, Rennick D: Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. Nature 368:643, 1994
19. Lyman SD, James L, Johnson L, Brasel K, de Vries P, Escobar SS, Downey H, Splett RR, Beckmann MP, McKenna HJ: Cloning of the human homologue of the murine flt3 ligand: A growth factor for early hematopoietic progenitor cells. Blood 83:2795, 1994
20. Muench MO, Roncarolo MG, Menon S, Xu Y, Kastelein R, Zurawski S, Hannum CH, Culpepper J, Lee F, Namikawa R: FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver. Blood 85:963, 1995
21. Hudak S, Hunte B, Culpepper J, Menon S, Hannum C, Thompson-Snipes L, Rennick D: FLT3/FLK2 ligand promotes the growth of murine stem cells and the expansion of colony-forming cells and spleen colony-forming units. Blood 85:2747, 1995
22. Jacobsen SEW, Okkenhaug C, Myklebust J, Veiby OP, Lyman SD: The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: Synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors. J Exp Med 181:1357, 1995
23. Hirayama F, Lyman SD, Clark SC, Ogawa M: The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors. Blood 85:1762, 1995
24. Lyman SD, James L, Vanden Bos T, de Vries P, Brasel K, Gliniak B, Hollingsworth LT, Picha KS, McKenna HJ, Splett RR, Fletcher FA, Maraskovsky E, Farrah T, Foxworthe D, Williams DE, Beckmann MP: Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells. Cell 75:1157, 1993
25. Matthews W, Jordan CT, Wiegand GW, Pardoll D, Lemischka IR: A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell 65:1143, 1991
26. Small D, Levenstein M, Kim E, Carow C, Amin S, Rockwell P, Witte L, Burrow C, Ratajczak MZ, Gewirtz AM, Civin CI: STK-1 the human homolog of FLK2/FLT3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci USA 91:459, 1994
27. Rasko JEJ, Metcalf D, Rossner MT, Begley CG, Nicola NA: The flt3/flk-2 ligand: receptor distribution and action on murine hematopoietic cell survival and proliferation. Leukemia 9:2058, 1995
28. Basser R, To LB, Begley CG, Juttner CA, Maher DW, Szer J, Cebon J, Collins JP, Russell I, Olver I, Gill PG, Fox RM, Sheridan WP, Green MD: Adjuvant treatment of high risk breast cancer using multi-cycle high-dose chemotherapy and filgrastim-mobilized peripheral blood progenitor cells. Clin Cancer Res 1:715, 1995
29. Miller AD, Buttimore C: Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol 6:2895, 1986
30. Bender MA, Palmer TD, Gelinas RE, Miller AD: Evidence that the packaging signal of Moloney murine leukemia virus extends into the gag region. J Virol 61:1639, 1987
31. Bowtell DDL, Johnson GR, Kelso A, Cory S: Expression of genes transferred to haemopoietic stem cells by recombinant retroviruses. Mol Biol Med 4:229, 1987
32. Begley CG, Rasko JEJ, Curtis D, Takagi K, Metcalf D, Hilton D, Roberts B, Nicola NA, Rossner MT: Murine flt3 ligand protects M1 leukemic cells from LIF-induced differentiation and suppression of self-renewal. Exp Hematol 24:1247, 1996
33. Begley CG:. Human progenitor cell assays, in Morstyn G, Sheridan W (eds): Cell Therapy. Cambridge, UK, Cambridge University, 1996, p 59
34. Nolta JA, Crooks GM, Overell RW, Williams DE, Kohn DB: Retroviral vector-mediated gene transfer into primitive human hematopoietic progenitor cells: Effects of mast cell growth factor (MGF) combined with other cytokines. Exp Hematol 20:1065, 1992
35. Rill DR, Moen RC, Buschle M, Bartholomew C, Foreman NK, Mirro J Jr, Krance RA, Ihle JN, Brenner MK: An approach for the analysis of relapse and marrow reconstitution after autologous marrow transplantation using retrovirus-mediated gene transfer. Blood 79:2694, 1992
36. Dunbar CE, Cottler-Fox M, O'Shaughnessy JA, Doren S, Carter C, Berenson R, Brown S, Moen RC, Greenblatt J, Stewart FM, Leitman SF, Wilson WH, Cowan K, Young NS, Nienhuis AW: Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation. Blood 85:3048, 1995
37. Roberts AW, DeLuca E, Begley CG, Basser R, Grigg AP, Metcalf D: Broad inter-individual variations in circulating progenitor cell numbers induced by granulocyte colony-stimulating factor therapy. Stem Cells 13:512, 1995
38. Carow CE, Hangoc G, Cooper SH, Williams DE, Broxmeyer HE: Mast cell growth factor (c-kit ligand) supports the growth of human multipotential progenitor cells with a high replating efficiency. Blood 78:2216, 1991
39. McNiece IK, Langley KE, Zsebo KM: Recombinant human stem cell factor synergizes with GM-CSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages. Exp Hematol 19:226, 1991
40. Bernstein ID, Andrews RG, Zsebo KM: Recombinant human stem cell factor enhances the formation of colonies by CD34+ and CD34+lin- cells, and the generation of colony-forming cell progeny from CD34+lin- cells cultured with IL-3, G-CSF, or GM-CSF. Blood 77:2316, 1991
41. Andrews RG, Knitter GH, Bartelmez SH, Langely KE, Farrar D, Hendren RW, Appelbaum FR, Bernstein ID, Zsebo KM: Recombinant human stem cell factor, a c-kit ligand, stimulates hematopoiesis in nonhuman primates. Blood 78:1975, 1991
42. Gore SD, Amin S, Weng L-J, Civin CI: Steel factor supports the cycling of isolated human CD34+ cells in the absence of other growth factors. Exp Hematol 23:413, 1995
43. + bone marrow progenitor cells. Blood 82:3290, 1993
44. Bodine DM, Seidel NE, Gale MS, Nienhuis AW, Orlic D: Efficient retrovirus transduction of mouse pluripotent hematopoietic stem cells mobilized into the peripheral blood by treatment with granulocyte colony-stimulating factor and stem cell factor. Blood 84:1482, 1994
45. + hematopoietic progenitor cells. Blood 86:3413, 1995
46. Gabbianelli M, Pelosi E, Montesoro E, Valtieri M, Luchetti L, Samoggia P, Vitelli L, Barberi T, Testa U, Lyman S, Peschle C: Multi-level effects of flt3 ligand on human hematopoiesis: Expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors. Blood 86:1661, 1995
47. Visser JWM, Rozemuller H, Dejong MO, Belyavsky A: The expression of cytokine receptors by purified hemopoietic stem cells. Stem Cells 11:49, 1993 (suppl 2)
48. Zeigler FC, Bennett BD, Jordan CT, Spencer SD, Baumhueter S, Carroll KJ, Hooley J, Bauer K, Matthews W: Cellular and molecular characterization of the role of the flk-2 flt-3 receptor tyrosine kinase in hematopoietic stem cells. Blood 84:2422, 1994
49. Maraskovsky E, Roux E, Tepee M, McKenna HJ, Brasel K, Lyman SD, Williams DE: The effect of Flt3 Ligand and/or c-Kit Ligand on the generation of Dendritic cells from human CD34+ bone marrow. Blood 86:420a, 1995 (abstr, suppl 1)
50. Moore KA, Deisseroth AB, Reading CL, Williams DE, Belmont JW: Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells. Blood 79:1393, 1992
51. Moritz T, Patel VP, Williams DA: Bone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors. J Clin Invest 93:1451, 1994