Gene therapy of neoplastic meningosis

Journal of Neuro-Oncology

Volumn 38, Issue 2-3, 1998, Pages 241-244

  Vrionis, Fotios D ^a,b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS MEDICAL CENTER   (United States)

Author keywords

Brain tumor; Bystander effect; Gene therapy; Meningeal neoplasia

Indexed keywords

THYMIDINE KINASE; VIRUS VECTOR;

ADENOVIRUS; CELL COMMUNICATION; CELL JUNCTION; CONFERENCE PAPER; CYTOTOXICITY; EXPRESSION VECTOR; GENE TARGETING; GENE THERAPY; GENETIC TRANSDUCTION; HERPES VIRUS; HUMAN; MENINGIOMA; NONHUMAN; RETROVIRUS;

GENE THERAPY; HUMANS; MENINGEAL NEOPLASMS;

EID: 0031748394     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005900807890     Document Type: Conference Paper

References (27)

1. Moolten F: Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for prospective cancer control strategy. Cancer Res 46: 5276-5281, 1986
2. Culver K, Ram Z, Wallbridge S, Hiroyuki I, Oldfield E, Blaese R: In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 256: 1550-1552, 1992
3. Freeman S, Abboud C, Whartenby K, Packman C, Koeplin D, Moolten F, Abraham GN: The 'bystander effect': tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 53: 5274-5283, 1993
4. Barba D, Hardin J, Ray J, Gage F: Thymidine kinase-mediated killing of rat brain tumors. J Neurosurg 79: 729-735, 1993
5. Wu J, Cano W, Meylaerts S, Qi P, Vrionis F, Cherington V: Bystander tumoricidal effect in the treatment of experimental brain tumors. Neurosurgery 35: 1094-1103, 1994
6. Ram Z, Walbridge S, Oshiro EM, Viola JJ, Chiang Y, Mueller SN, Blaese RM, Oldfield EH : Intrathecal gene therapy for malignant leptomeningeal neoplasia. Cancer Res 54: 2141-2145, 1994
7. Tapscott S, Miller A, Olson J, Berger M, Groudine M, Spence A: Gene therapy of rat 9L gliosarcoma tumors by transduction with selectable genes does not require drug selection. Proc Natl Acad Sci USA 91: 8185-8189, 1994
8. Kooistra KL, Rodriguez M, Powis G, Yaksh TL, Harty GJ, Hilton JF, Laws ER Jr: Development of experimental models for meningeal neoplasia using intrathecal injection of 9L gliosarcoma and Walker 256 carcinosarcoma in the rat. Cancer Res 46: 317-323, 1986
9. Vrionis FD, Wu J, Qi P, Cano W, Cherington V: Tumor cells expressing the herpes simplex virus thymidine kinase gene in the treatment of Walker 256 meningeal neoplasia in rats. J Neurosurg 84: 250-257, 1996.
10. Vrionis FD, Wu J, Qi P, Cano W, Cherington V: Tumor cells expressing the herpes simplex virus thymidine kinase gene elicit a more potent bystander cytocidal effect than fibroblast virus producer cells in vitro. J Neurosurg 83: 698-704, 1995
11. Moolten FL, Wells JM: Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors. J Natl Cancer Inst 82: 297-300, 1990
12. Vrionis FD, Wu J, Qi P, Cano W, Cherington V: Preservation of the bystander cytocidal effect of irradiated Herpes Simplex Virus thymidine kinase (HSV-tk) modified tumor cells. J Neuroncol, in press, 1996
13. Viola JJ, Ram Z, Walbridge S, Oshiro EM, Trapnell B, TaoCheng JH, Oldfield EH : Adenovirally mediated gene transfer into experimental solid brain tumors and leptomeningeal cancer cells. J Neurosurg 82: 70-76, 1995
14. Vincent A, Esandi M, van Someren G, Noteboom JL, Avezaat CJJ, Veht C, Smitt PAE, van Bekkum DW, Valerio D, Hoogerbrugge PM, Bout A: Treatment of leptomeningeal metastases in a rat model using a recombinant adenovirus containing the HSV-tk gene. J Neurosurg 85: 648-654, 1996
15. Kolberg R: The bystander effect in gene therapy: great, but does it work? J NIH Res 6: 62-64, 1994
16. Bi W, Parysek L, Warnick R, Stambrook P: In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy. Hum Gene Ther 4: 725-731, 1993
17. Vrionis FD, Wu JK, Qi P, Waltzman M, Cherington V, Spray DC: The bystander effect exerted by tumor cells expressing the Herpes Simplex Virus thymidine kinase gene is dependent on connexin expression and cell communication via gap junctions. Gene Ther, in press, 1996
18. Shinoura N, Chen L, Wani MA, Kim YG, Larson JJ, Warnick RE, Simon M, Menon AG, Bi WL, Stambrook PJ: Protein and messenger RNA expression of connexin43 in astrocytomas: implications in brain tumor gene therapy. J Neurosurg 84: 839-846, 1996
19. Caruso M, Panis YSG, Houssin D, Salzmann J, Klatzmann D: Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc Natl Acad Sci USA 90: 7024-7028, 1993
20. Pavlovic J, Nawrath M, Tu R, Heinicke T, Moelling K: Antitumor immunity is involved in the thymidine kinase-mediated killing of tumors induced by activated Ki-ras (G12 V). Gene Ther 3: 635-643, 1996
21. Elshami AA, Kucharczuk JC, Sterman DH, Smythe WR, Hwang HC, Amin KM, Litzky LA, Albelda SM, Kaiser LR: The role of immunosuppression in the efficacy of cancer gene therapy using adenovirus transfer of the Herpes Simplex thymidine kinase gene. Annals Surg 222: 298-310, 1995
22. Vile RG, Nelson JA, Castleden S, Chong H, Hart IR: Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component. Cancer Res 54: 6228-6234, 1994
23. Freeman SM, Ramesh R, Shastri M, Munshi A, Jensen AK, Marrogi AJ: The role of cytokines in mediating the bystander effect using HSV-TK xenogeneic cells. Cancer Lett 92: 167-174, 1995
24. O 'Malley BW Jr, Cope KA, Chen S-H, Li D, Schwartz MR, Woo SLC: Combination gene tharapy for oral cancer in a murine model. Cancer Res 56: 1737-1741, 1996
25. Chen S-H, Kosai K-I, Xu B, Pham-Nguyen K, Contant C, Finegold MJ, Woo SLC: Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: sustained antitumor immunity prolongs animal survival. Cancer Res 56: 3758-3762, 1996
26. Hoganson DK, Batra RK, Olsen JC, Boucher RC:Comparison of the effects of three different toxin genes and their levels of expression on cell growth and bystander effect in lung adenocarcinoma. Cancer Res 56: 1315-1323, 1996
27. Culver KW, Vickers TM, Lamsham JL, Walling HW, Seregina T: Gene therapy for solid tumors. Brit Med Bull 51:192-204, 1995