Tumor cells expressing the herpes simplex virus-thymidine kinase gene in the treatment of Walker 256 meningeal neoplasia in rats

Journal of Neurosurgery

Volumn 84, Issue 2, 1996, Pages 250-257

  Vrionis, Fotios D ^a   Wu, Julian K ^a,b   Qi, Peimin ^a   Cano, William G ^a   Van Cherington, ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS MEDICAL CENTER   (United States)

Author keywords

brain tumor; carcinomatous meningitis; ganciclovir; gene therapy; herpes simplex virus thymidine kinase gene

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE;

ANIMAL CELL; ARTICLE; BRAIN TUMOR; CANCER SURVIVAL; CARCINOMATOUS MENINGITIS; CELL INFILTRATION; DNA SYNTHESIS; GENE THERAPY; HERPES SIMPLEX VIRUS; MENINGIOMA; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL TIME; TARGET CELL; WALKER CARCINOMA;

EID: 0030067907     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.1996.84.2.0250     Document Type: Article

References (25)

1. Barba D, Hardin J, Ray J, et al: Thymidine kinase-mediated killing of rat brain tumors. J Neurosurg 79:729-735, 1993
2. Barba D, Hardin J, Sadelain M, et al: Development of antitumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proc Natl Acad Sci USA 91: 4348-4352, 1994
3. Caruso M, Panis Y, Gagandeep S, et al: Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc Natl Acad Sci USA 90:7024-7028, 1993
4. Cepko C: Detection of helper virus in retrovirus stocks, in Ausubel F, Brent R, Kingston R, et al (eds): Short Protocols in Molecular Biology, ed 2. New York: Greene, 1992, paras. 9.13.1-9.13.5
5. Cepko C: Retrovirus infection of cells in vitro and in vivo, in Ausubel F, Brent R, Kingston R, et al (eds): Short Protocols in Molecular Biology, ed 2. New York: Greene, 1992, paras. 9.14.1-9.14.3
6. Culver KW, Ram Z, Walbridge S, et al: In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 256:1550-1552, 1992
7. Freeman SM, Abboud CN, Whartenby KA, et al: The "by-stander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 53: 5274-5283, 1993
8. Golumbek PT, Hamzeh FM, Jaffec EM, et al: Herpes simplex-1 virus thymidine kinase gene is unable to completely eliminate live, nonimmunogenic tumor cell vaccines. J Immunother 12: 224-230, 1992
9. Kooistra KL, Rodriguez M, Powis G, et al: Development of experimental models for meningeal neoplasia using intrathecal injection of 9L gliosarcoma and Walker 256 carcinosarcoma in the rat. Cancer Res 46:317-323, 1986
10. Levin VA, Vestnys PS, Edwards MS, et al: Improvement in survival produced by sequential therapies in the treatment of recurrent medulloblastoma. Cancer 51:1364-1370, 1983
11. Miller AD, Buttimore C: Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol 6:2895-2902, 1986
12. Miller AD, Rosman G: Improved retroviral vectors for gene transfer and expression. BioTechniques 7:980-990, 1980
13. Moolten FL: Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 46:5276-5281, 1986
14. Moolten FL, Wells JM: Curability of tumors bearing herpes thymidine kinase senes transferred by retroviral vectors. J Natl Cancer Inst 82:297-300, 1990
15. Nakagawa H, Murasawa A, Kubo S, et al: Diagnosis and treatment of patients with meningeal carcinomatosis. J Neurooncol 13:81-89, 1992
16. Oldfield EH, Ram Z, Culver KW, et al: Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum Gene Ther 4:39-69, 1993
17. Olson ME, Chernik NL, Posner JB: Infiltration of the leptomeninses by systemic cancer. A clinical and pathologic study. Arch Neurol 130:122-137, 1974
18. Osaki T, Tanio Y, Tachibana I, et al: Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene. Cancer Res 54:5258-5261, 1994
19. Ram Z, Culver KW, Walbridge S, et al: In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res 53:83-88, 1993
20. Ram Z, Walbridge S, Oshiro EM, et al: Intrathecal gene Therapy for malignant leptomeningeal neoplasia. Cancer Res 54: 2141-2145, 1994
21. Shapiro WR: Meningeal carcinomatosis. West J Med 154: 350-351, 1991 (Editorial)
22. Short MP, Choi BC, Lee JK, et al: Gene delivery to ghoma cells in rat brain by grafting of a retrovirus packagina cell line. J Neurosci Res 27:427-139, 1990
23. Takamiya Y, Short P, Moolten FL, et al: An experimental model of retrovirus gene therapy for malignant brain tumors. J Neurosurg 79:104-110, 1993
24. Vrionis FD, Wu JK, Qi P, et al: A more potent bystander cytocidal effect elicited by tumor cells expressing the herpes simplex virus-thymidine kinase gene than by fibroblast virus-producer cells in vitro. J Neurosurg 83:698-704, 1995
25. Wu JK, Cano WG, Meylaerts SAG, et al: Bystander tumoricidal effect in the treatment of experimental brain tumors. Neurosurgery 35:1094-1103, 1994