In vitro response to all-trans retinoic acid of acute promyelocytic leukemias with nonreciprocal PML/RARA or RARA/PML fusion genes

Genes Chromosomes and Cancer

Volumn 22, Issue 3, 1998, Pages 241-250

  Mozziconacci, Marie Joëlle ^a,b   Liberatore, Concetta ^c   Brunel, Véronique ^a,b   Grignani, Francesco ^c   Arnoulet, Christine ^a   Ferrucci, Pier Francesco ^d   Fernandez, Francisca ^a,b   Sainty, Danielle ^a   Pelicci, Pier Giuseppe ^c,d   Birg, Françoise ^b   Lafage Pochitaloff, Marina ^a,b  

^a INSTITUT PAOLI CALMETTES   (France)

^b INSERM   (France)

^c UNIVERSITY OF PERUGIA   (Italy)

^d EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

RETINAL;

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; CELL DIFFERENTIATION; CHROMOSOME 15; DOSE RESPONSE; GENE INSERTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MULTIGENE FAMILY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TRANSCRIPTION REGULATION; TUMOR GROWTH;

ADULT; CELL DIFFERENTIATION; CHROMOSOMES, HUMAN, PAIR 15; CHROMOSOMES, HUMAN, PAIR 17; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE CONVERSION; GENES, NEOPLASM; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MALE; MIDDLE AGED; NEOPLASM PROTEINS; ONCOGENE PROTEINS, FUSION; TRANSLOCATION, GENETIC; TRETINOIN; TUMOR CELLS, CULTURED;

EID: 0031744518     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199807)22:3<241::AID-GCC10>3.0.CO;2-R     Document Type: Article

References (58)

1. Alcalay M, Zangrilli D, Pandolfi PR Longo L, Mencarelli A, Giacomucci A, Rocchi M, Biondi A, Rambaldi A, Lo Coco F, Diverio D, Donti E, Grignani F, Pelicci PG (1991) Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor a locus. Proc Nad Acad Sci USA 88:1977-1981.
2. Alcalay M, Zangrilli D, Fagioli M, Pandolfi PP, Mencarelli A, Lo Coco F, Blondi A, Grignani F, Pelicci PG (1992) Expression pattern of the RARα-PML fusion gene in acute promyelocytic leukemia. Proc Natl Acad Sci USA 89:4840-4844.
3. Altabef M, Garcia M, Lavau C, Bae SC, Dejean A, Samarut J (1996) A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RARα fusion gene transforms hematopoietic progenitors in vitro and induces acute leukemias. EMBO J 15:2707-2716.
4. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C (1976) Proposals for the classification of the acute leukemias. Br J Haematol 33:451-158.
5. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C (1980) A variant form of hypergranular promyelocytic leukemia (M3). Br J Haematol 44:169-170.
6. Biondi A, Rambaldi, Pandolfi PP, Rossi V, Giudici G, Alcalay M, Lo Coco F, Diverio D, Pogliani EM, Lanzi EM, Mandelli F, Masera G, Barbui T, Pelicci PG (1992) Molecular monitoring of the MYL/ retinoic acid receptor-a fusion gene in acute promyelocytic leukemia by polymerase chain reaction. Blood 80:492-497.
7. Borrow J, Goddard AD, Sheer D, Solomon E (1990) Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 249:1577-1580.
8. Borrow J, Goddard AD, Gibbons B, Katz F, Swirsky D, Fioretos T, Dube I, Winfield DA, Kingston J, Hagemeijer A, Rees JHK, Lister TA, Solomon E (1992) Diagnosis of acute promyelocytic leukemia by RT-PCR: Detection of PML-RARA and RARA-PML fusion transcripts. Br J Haematol 82:529-540.
9. Borrow J, Shipley J, Howe K, Kiely F, Goddard A, Sheer D, Srivastava A, Antony AC, Fioretos T, Mitelman F, Solomon E (1994) Molecular analysis of simple variant translocations in acute promyelocytic leukemia. Genes Chromosomes Cancer 9:234-243.
10. Brown D, Kogan S, Lagasse E, Weissman I, Alcalay M, Pelicci PG, Atwater S, Bishop JM (1997) A PML/RARα transgene initiates murine acute promyelocytic leukemia. Proc Natl Acad Sci USA 94:2551-2556.
11. Brunel V, Sainty D, N Carbuccia N, Arnoulet C, Costello R, Mozziconacci MJ, Simonetti J, Coignet L, Gabert J, Stoppa AM, Birg F, Lafage-Pochitaloff M (1995) Unbalanced translocation t(5;17) in an atypical acute promyelocytic leukemia. Genes Chromosomes Cancer 14:307-312.
12. Brunel V, Lafage-Pochitaloff M, Alcalay M, Pelicci PG, Birg F(1996) Variant and masked translocations in acute promyelocytic leukemia. Leuk Lymphoma 22:221-228.
13. Castaigne S, Chomienne C, Daniel MT, Ballerini P, Berger R, Fenaux P, Degos L (1990) All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood 76:1704-1709.
14. Chang KS, Fan YH, Andreeff M, Liu J, Mu ZM (1995) The PML gene encodes a phosphoprotein associated with the nuclear matrix. Blood 85:3646-3653.
15. Chen Z, Brand NJ, Chen A, Chen SJ, Tong JH, Wang ZY, Waxman S, Zelent A (1993) Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-a locus due to a variant t(11;17) translocation associated with acute promyelocytic leukemia. EMBO J 12:1161-1167.
16. Chen Z, Tong JH, Dong S, Zhu J, Wang ZY, Chen SJ (1996) Retinoic acid regulatory pathways, chromosomal translocations, and acute promyelocytic leukemia. Genes Chromosomes Cancer 15:147-156.
17. Chomienne C, Ballerini P, Balitrand N, Daniel MT, Fenaux P, Castaigne S, Degos L (1990) All-trans retinoic acid in acute promyelocytic leukemia. II. In vitro studies: Structure-function relationship. Blood 76:1710-1717.
18. Collins SJ, Bodner A, Ting R, Gallo RC (1980) Induction of morphological and functional differentiation of human promyelocytic leukemia cells (HL60) by compounds which induce differentiation of murine leukemia cells. Int J Cancer 25:213-218.
19. Collins SJ, Robertson KA, Muller L (1990) Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RARa). Mol Cell Biol 10:2154-2163.
20. Corey SJ, Locker J, Oliver DR, Shekter-Levin S, Redner RL, Penchanski I, Gollin SM (1994) A nonclassical translocation involving 17q12 (retinoic acid receptor a) in acute promyelocytic leukemia (APML) with atypical features. Leukemia 8:1350-1353.
21. de Thé H, Chomienne C, Lanotte C, Degos L, Dejean A (1990) The t(15;17) translocation of acute promyelocytic leukemia fuses the tetinoie acid receptor-a gene to a novel transcribed locus. Nature 347:558-561.
22. Degos L, Dombret H, Chomienne C, Daniel MT, Micléa JM, Chastang C, Castaigne S, Fenaux P (1995) All-trans-retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia. Blood 85:2643-2653.
23. Dyck JA, Maul GG, Miller WH Jr, Chen JD, Kakizuka A, Evans RM (1994) A novel macromolecular structure is a target of the promyelocytic-retinoic acid receptor oncoprotein. Cell 76:333-343.
24. Oyck JA, Warrel RP Jr, Evans RM, Miller WH Jr (1995) Rapid diagnosis of acute promyelocytic leukemia by immunohistochemical localization of PML/RAR alpha protein. Blood 86:862-867.
25. Flenghi L, Fagioli M, Tomassoni L, Pileri S, Gambacorta M, Pacini R, Grignani F, Casini T, Ferrucci PF, Martelli MF, Pelicci PG, Falini B (1995) Characterization of a new monoclonal antibody (PG-M3) directed against the aminoterminal portion of the PML gene product: Immunocytochemical evidence for high expression of PML proteins on activated macrophages, endothelial cells, and epithelia. Blood 85:1871-1880.
26. Frankel SR, Eardley A, Lauwers G, Weiss M, Warrell R (1992) The "retinoic acid syndrome" in acute promyelocytic leukemia. Ann Intern Med 117:292-296.
27. Goddard A, Borrow J, Freemont PS, Solomon E (1991) Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. Science 254:1371-1374.
28. Grignani F, Ferrucci PF, Testa U, Talamo G, Fagioli M, Alcalay M, Mencarelli A, Grignani F, Peschle C, Nicoletti I, Pelicci PG (1993) The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 74:423-431.
29. Grignani F, Pelicci PG (1996) Pathogenetic role of the PML/RARα fusion protein in acute promyelocytic leukemia. Curr Top Microbiol Immunol 211:269-278.
30. Grimwade D, Howe K, Langabeer S, Burnett A, Goldstone A, Solomon E (1996a) Minimal residual disease detection in acute promyelocytic leukemia by reverse transcriptase PCR: Evaluation of PML-RARα and RARα-PML assessment in patients who ultimately relapse. Leukemia 10:61-66.
31. Grimwade D, Howe K, Langabeer S, Davies L, Oliver F, Walker H, Swirsky D, Wheatley K, Goldstone A, Burnett A, Solomon E, on behalf of the M.R.C. Adult Leukemia Working Party (1996b) Establishing the presence of the t(15;17) in suspected acute promyelocytic leukemia: Cytogenetic, molecular and PML immunofluorescence assessment of patients entered into the M.R.C. ATRA trial. Br J Haematol 94:557-573.
32. Grimwade D, Gorman P, Duprez E, Howe K, Langabeer S, Oliver F, Walker H, Culligan D, Waters J, Pomfret M, Goldstone A, Burnett A, Freemont P, Sheer D, Solomon E (1997) Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia. Blood 90:4876-4885.
33. Grisolano JM, Wesselschmidt RL, Pelicci PG, Ley TJ (1997) Altered myeloid development and acute leukemia in transgenic mice expressing PML-RARα under control of cathepsin G regulatory sequences. Blood 89:376-387.
34. Hioms LR, Min T, Swansbury GJ, Zelent A, Dyer MJS, Catovsky D (1994) Interstitial insertion of retinoic acid receptor-alpha gene in acute promyelocytic leukemia with normal chromosomes 15 and 17. Blood 83:2946-2951.
35. Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhoa L, Gu HT, Wang ZY (1988) Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72:567-572.
36. Kakizuka A, Miller WH Jr, Umesono K, Warrel RP Jr, Frankel SR, Murty VVVS, Dmitrovsky E, Evans RM (1991) Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARa with a novel putative transcription factor, PML. Cell 66:663-674.
37. 3 signaling. Nature 355:446-449.
38. Koken MH, Puvion-Dutilleul F, Guillemin MC, Viron A, Linares-Cruz G, Stuurman N, de Jong L, Szostecki C, Calvo F, Chomienne C, Degos L, Puvion E, de Thé H (1994) The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion. EMBO J 13:1073-1083.
39. Lafage M, Pedeutour F, Marchetto S, Simonetti J, Prosperi MT, Gaudray P, Birnbaum D (1992) Fusion and amplification of two originally nonsyntenic chromosomal regions in a mammary carcinoma cell line. Genes Chromosomes Cancer 5:40-49.
40. Lafage-Pochitaloff M, Alcalay M, Brunel V, Longo L, Sainty D, Simonetti J, Birg F, Pelicci PG (1995) Acute promyelocytic leukemia cases with nonreciprocal PML/RARa or RARa/PML fusion genes. Blood 85:1169-1174.
41. Lafage-Pochitaloff-Huvalé M, Sainty D, Adriaanssen HJ, Lopez M, Maraninchi D, Simonetti J, Mannoni P, Carcassone Y, Hagemeijer A (1989) Translocation (3:21) in Philadelphia positive chronic myeloid leukemia. Leukemia 3:554-559.
42. Lanotte M, Martin-Thouvenin V, Najman S, Ballerini P, Valensi F, Berger R (1991) NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyclocytic leukemia (M3). Blood 77:1080-1086.
43. Larson RA, Kondo K, Vardiman JW, Butler AE, Golomb HM, Rowley JD (1984) Evidence for a 15;17 translocation in every patient with acute promyelocytic leukemia. Am J Med 76:827-841.
44. Licht JD, Chomienne C, Goy A, Chen A, Scott AA, Head DR, Michaux JL, Wu Y, DeBlasio A, Miller WH Jr, Zelent AD, Willman CL, Chen Z, Chen SJ, MacIntyre E, Veil A, J Cortes J, Kantarjian H, Waxman S (1995) Clinical and molecular characterization of a rare syndrome of acute promyclocytic leukemia associated with translocation (11:17). Blood 85:1083-1094.
45. Lo Coco F, Diverio D, d'Adamo F, Avvisati G, Alimena G, Nanni M, Alcalay M, Pandolfi P, Pelicci PG (1992) PML-RAR-α rearrangement in acute promyelocytic leukemias apparently lacking the t(15;17) translocation. Eur J Haematol 48:173-176.
46. Maniatis T, Fritsch EF, Sambrook J (1989) Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
47. Mu ZM, Chin KV, Liu JH, Lozano G, Chang KS (1994) PML, a growth suppressor disrupted in acute promyelocytic leukemia. Mol Cell Biol 14:6858-6867.
48. Perez A, Kastner P, Sethi S, Lutz Y, Reibel C, Chambon P (1993) PML-RAR homodimers: Distinct DNA binding properties and heteromeric interactions with RXR. EMBO J 12:3171-3182.
49. Raelson JV, Nervi C, Rosenauer A, Benedetti L, Monczak Y, Pearson M, Pelicci PG, Miller WH Jr (1996) The PML/RARα oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells. Blood 88:2826-2832.
50. Redner RL, Rush EA, Faas S, Rudert WA, Corey SJ (1996) The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin retinoic acid receptor fusion. Blood 87:882-886.
51. Stone RM, Mayer RJ (1990). The unique aspects of acute promyelocytic leukemia. J Clin Oncol 8:1913-1921.
52. Tobal K, Saunders MJ, Grey MR, Yin JAL (1995) Persistence of RARα-PML fusion mRNA detected by reverse trancriptase-polymerase chain reaction in patients in long-term remission of acute promyelocytic leukemia. Br J Haematol 90:615-618.
53. Warrell RP Jr, Frankel SR, Miller WH Jr, Sheinberg DA, Itri LM, Hittelman WN, Vyas R, Andreeff R, Tafuri A, Jakubowski A, Gabrilove J, Gordon MS, Dmitrowski E (1991) Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans retinoic acid). N Engl J Med 324:1385-1393.
54. Weis K, Rambaud S, Lavau C, Jansen J, Carvalho T, Carmo-Fonseca M, Lamond A, Dejean A (1994) Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells. Cell 76:345-356.
55. Wells RA, Hummel JL, de Koven A, Zipursky A, Kirby M, Dube I, Kamel-Reid S (1996) A new variant translocation in acute promyelocytic leukemia: Molecular characterization and clinical correlation. Leukemia 10:735-740.
56. Wells RA, Catzavelos C, Kamel-Reid S (1997) Fusion of retinoic acid receptor α to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukemia. Nat Genet 17:109-113.
57. Yu VC, Delsert C, Andersen B, Holloway JM, Devary OV, Naar AM, Kim SY, Boutin JM, Glass CK, Rosenfeld MG (1991) RXRb: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67:1251-1266.
58. Zhang XK, Hoffmann B, Tran PBV Graupner G, Pfahl M (1992) Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature 355:441-446.