Pathogenetic role of the PML/RARα fusion protein in acute promyelocytic leukemia

Current Topics in Microbiology and Immunology

Volumn 211, Issue , 1996, Pages 269-278

  Grignani, F ^a   Pelicci, P G ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; ZINC FINGER PROTEIN; NUCLEAR PROTEIN; PML PROTEIN, HUMAN; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; TRANSCRIPTION FACTOR; TUMOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ACUTE MYELOBLASTIC LEUKEMIA; CELL DIFFERENTIATION; CELL GROWTH; CHROMOSOME TRANSLOCATION; CONFERENCE PAPER; GENE REARRANGEMENT; HUMAN; PRIORITY JOURNAL; GENETIC RECOMBINATION; GENETICS; PATHOPHYSIOLOGY; PHYSIOLOGY; PROMYELOCYTIC LEUKEMIA; REVIEW;

HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; NEOPLASM PROTEINS; NUCLEAR PROTEINS; RECEPTORS, RETINOIC ACID; RECOMBINATION, GENETIC; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 0029690598     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-85232-9_27     Document Type: Conference Paper

References (47)

1. Bennet, J. M., Catovski, D., Daniel, M. T., Flandrin, G., Galton, D. A. G., Gralnick, H. R., and Sultan, C. (1976). Proposals for the classification of the acute leukemias. British J. of Haematol. 33:451-458
2. Raza A, Yousuf N, Abbas A, Umerani A, Mehdi A, Bokhari SKJ, Sheikh Y, Qadir K, Freeman J, Masterson M, Miller MA, Lampkin B, Browman G, Bennett J, Goldberg J, Grunwald H, Larson R, Vogler R, Preisler HD (1992). High expression of transforming growth factor-β prolonged cell cycle times and a unique clustering of S-phase cells in patients with acute promyelocytic leukemia. Blood 79:1037-1048
3. Huang M, Yu-Chen Y, Shu-Rong C, Chai J, Lin Z, Long J, Wang Z (1988). Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72:567-572
4. Caslaigne S, Chomienne C, Daniel MT, Berger R, Fenaux P, Degos L (1990). All-trans retinoic acid as a differentiating therapy for acute promyelocytic leukemia L Clinical results. Blood 76:1704-1709
5. Warrell RP Jr, Frankel SR, Miller WH Jr, Scheinberg DA, Itri LM, Hittelman WN, Vyas R, Andreeff M, Tafuri A, Jakubowski A, Gabrilove J, Gordon MS, Dmilrovsky E (1991). Differentiation therapy for acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med 324:1385-1392
6. Mitelman F: Catalog of chromosome aberrations in cancer. Third edition. Alan R. Liss, Inc., New York, 1988.
7. Goddard AD, Borrow J, Freemont P, Solomon E (1991). Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. Science 254:1371-1374.
8. de Thè H, Chomienne C, Lanotte M, Degos L, Dejean A. (1990). The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus. Nature 347:558-561,.
9. Borrow J, Goddard AD, Sheer D, Solomon E (1990). Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 249:1577-1580
10. Lemmons RS, Eilender D, Waldmann RA, Rebentisch M, Frej AK, Ledbetter DM, Willmann C, McConnell T, O'Connell P (1990). Cloning and characterization of the t(15;17) translocation breakpoint region in acute promyelocytic leukemia. Genes Chromosom Cancer 2:79-87
11. Longo L, Pandolfi PP, Biondi A, Rambaldi A, Mencarelli A, Lo Coco F, Diverio D, Pegoraro L, Avanzi G, Tabilio A, Zangrilli D, Alcalay M, Donti E, Grignani F, Pelicci PG (1990). Rearrangements and aberrant expression of the retinoic acid receptor a gene in acute promyelocytic leukemia. J Exp Med 172:1571-1575
12. Alcalay M, Zangrilli D, Pandolfi PP, Longo L, Mencarelli A, Giacomucci A, Rocchi M, Biondi A, Rambaldi A, Lo Coco F, Diverio D, Donti E, Grignani F, Pelicci PG (1991). Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor α locus. Proc Natl Acad Sci U S A 88:1977-1981
13. Pandolfi PP, Grignani F, Alcalay M, Mencarelli A, Biondi A, Lo Coco F, Grignani F, Pelicci PG (1991). Structure and origin of the acute promyelocytic leukemia myL/RARα cDNA and characterization of its retinoid-binding and transactivation properties. Oncogene 6:1285-1292
14. de Thè H, Lavau C, Marehio A, Chomienne C, Degos L, Dejean A (1991). The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 66:675-684.
15. Kakizuka A, Miller WH Jr, Umesono K, Warrel RP Jr, Frankel SR, Murty VVVS, Dmitrovsky E, Evans RM (1991). Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML. Cell 66:663-674
16. Kastner P, Perez A, Lutz Y, Rochette-Egly C, Gaub MP, Durand B, Lanotte M, Berger R, Chambon P (1992). Structure, localization and transcriptional properties of two classes of retinoic acid receptor a fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. EMBO J 11:629-642
17. Collins SJ, Robertson K, Mueller (1990). Retinoic acid induced granulocytic differentiation of HL60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-α). Mol Cell Biol 10:2154-2161
18. Robertson KA, Emami B, Collins SJ (1989). Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand binding domain that confers dominant negative activity. Blood 80:1885-1889.
19. Chen Z, Brand NJ, Chen A, Chen SJ, Tong JH, Wang ZY, Waxman S, Zelent A (1993). Fusion between a novel Kruppel-like finger gene and the retinoic acid receptor-α locus due to a variant t(11;17) translocation associated with acute promyelocytic leukemia. EMBO J 12:1161-1167
20. Redner RL, Rush EA, Faas S, Rudert WA, Corey SJ (1994). The t(5;17) translocation in acute promyelocytic leukemia generates a nucleophosmin-RARα fusion transcript Blood 84:1486 Supplement 1, Thirty-Sixth Annual Meeting of the American Society of Hematology
21. Diverio D, LoCoco F, D'Adamo F, Biondi A, Fagioli M, Grignani Fr, Rambaldi A, Rossi V, Avvisati G, Petti MC, Testi AM, Liso V, Specchia G, Fioritoni G, Recchia A, Frassoni F, Ciolli S, Pelicci PG (1992). Identification of DNA rearrangements at the RARα locus in all patients with acute promyelocytic leukemia (APL) and mapping of APL breakpoints within the RARα second intron. Blood 79:3331-3336.
22. Chen SJ, Zhu YJ, Tong JH, Dong S, Huang W, Chen Y, Xiang WM, Zhang L, Song Li X, Qian GQ, Wang ZY, Chen Z, Larsen CJ, Berger R (1991). Rearrangements in the second intron of the RARα gene are present in a large majority of patients with acute promyelocytic leukemia and are used as molecular marker for retinoic acid induced leukemic cell differentiation. Blood 78:2696-2701
23. Evans RM (1988). The steroid and thyroid hormone receptor superfamily. Science 240:889-895
24. Freemont PS, Hanson IM, Trowsdale J (1991). A novel cysteine-rich sequence motif. Cell 64: 483-484.
25. Lovering R, Hanson IM, Borden KLB, Martin S, O'Reilly NJ, Evan GI, Rahman D, Pappin DJC, Trowsdale, Freemont P (1993). Identification and preliminary characterization of a protein motif related to the zinc finger. Proc Natl Acad Sci U.S.A. 90: 2112-2116
26. Forman BM, Samuels HH (1990). Interaction among a subfamily of nuclear hormone receptors: The regulatory Zipper model. Mol Endocr 4:1293-1301.
27. Perez A, Kastner P, Sethi S, Lutz Y, Reibel C, Chambon P (1993). PMLRAR homodimers: distinct DNA binding properties and heterodimeric interaction with RXR. EMBO J 12:3171-3182
28. Alcalay M, Zangrilli D, Fagioli M, Pandolfi PP, Mencarelli A, Lo Coco F, Biondi A, Grignani F, Pelicci PG (1992). Expression pattern of the RARα-PML fusion gene in acute promyelocytice leukemia. Proc Natl Acad Sci USA 89:4840-4844
29. Grignani Fr, Ferrucci PF, Testa U, Talamo G, Fagioli M, Alcalay M, Mencarelli A, Grignani F, Peschle C, Nicoletti I, Pelicci PG (1993). The acute promyelocytic leukaemia specific PML\RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 74: 423-431.
30. Testa U, Masciulli R, Tritarelli E, Pustorino R, Mariani G, Martucci R, Barberi T, Camagna A, Valtieri M, Peschle C (1993). Transforming growth factor-β potentiates vitamin D3 induced terminal monocytic differentiation of human leukemic cell lines. J Immunol 150:2418-2430
31. Grignani Fr, Testa U, Fagioli M, Barberi T, Masciulli R, Mariani G, Peschle C, Pelicci PG (1995). Promyelocytic leukemia-specific PML-retinoic acid α receptor fusion protein interferes with erythroid differentiation of human erythroleukemia K562 cells. Cancer Research, in press.
32. Muindi, J., Frankel, S.R., Miller, W.H., Jakuboski, A., Scheinberg, D.A., Young C.W., Dmitrovsky, E. and Warrel, R.P (1992). Continous treatment with All-trans retinoic acid causes progressive reduction in plasma drug concentrations: implication for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia. Blood 79:299-303
33. Daniel MT, Koken M, Romagne O, Barbey S, Bazarbachi A, Stadler M, Guillemin MC, Degos L, Chomienne C, de Thè H (1993). PML protein expression in hematopoietic and acute promyelocytic leukemia cells. Blood, 82: 1858-1867.
34. Weis K, Rambaud S, Lavau C, Jansen J, Carcalho T, Carmo-Fonseca M, Lamond A, Dejean A (1994). Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells. Cell 76:345-358
35. Dyck JA, Maul GG (1994). A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell 76:333-343
36. Koken MHM, Puvio-Dutilleul F, Guillemin MC, Viron A, Cruz-Linares G, Stuurman N, de Jong L, Szostecki C, Calvo F, Chomienne C, Degos L, Puvion E, de Thè H (1994). The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion. The EMBO J. 13:1073-1083
37. Yu VC, Delsert C, Andersen B, Holloway JM, Devary OV, Naar AM, Kim SY, Boutin JM, Glass CK, Rosenfeld MG (1991). RXRß: a coregualtor that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67:1251-1266
38. 3 signalling. Nature 355:446-449
39. Nervi C, Poindexter CE, Grignani F, Pandolfi PP, Lo Coco F, Avvisati G, Pelicci PG, Jetten AM (1992). Characterization of the PML/RARa chimeric product of the acute promyelocytic leukemia-specific t(15;17) translocation. Cancer research 52:3687-3692
40. Flenghi L, Fagioli M, Tomassoni L, Pileri S, Gambacorta M, Pacini R, Grignani Fr, Casini T, Ferrucci PF, Martelli MF, Pelicci PG, Falini B (1995). Characterization of a new monoclonal antibody (PG-M3) directed against the aminoterminal portion of the PML gene product: immunocytochemical evidence for high expression of PML proteins on activated macrophages, endothelial cells, and epithelia. Blood, in press.
41. Gaub MP, Lutz Y, Ruberte E, Petkovich M, Brand N, Chambon P (1989). Antibodies specific to the retinoic acid human nuclear receptors α and β. Proc Natl Acad Sci USA 86:3089-3094.
42. Reitsma, PH, Rothberg PG, Astrin SM, Trial J, Bar-Shavit Z, Hall A, Teitelbaun SL (1983). Regulation of myc gene expression in HL-60 leukemia cells by a vitamin D metabolite. Nature 306:492-494
43. Nilsson B (1984). Probable in vivo induction of differentiation by retinoic acid of promyelocytes in acute promyelocytic leukaemia. Br J Haematol 57:365-371
44. Chomienne C, Ballerini P, Balitrand N, Daniel MT, Fenaux P, Castaigne S, Degos L (1990). All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship. Blood 76:1710-1717
45. Miller WH Jr, Kakizuka A, Frankel SR, Warrel RP Jr, DeBlasio A, Levine K, Evans RM, Dmitrovsky E (1992). Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor α clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia. Proc Natl Acad Sci USA89:2694-2698
46. Dermime S, Grignani Fr, Clerici M, Nervi C, Sozzi G, Talamo GP, Marchesi E, Formelli F, Panniani G, Pelicci PG, Gambacorti-Passerini C (1993). Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB306 is associated with altered expression of the PML/RARα protein. Blood 82: 1573-1577.
47. Grignani Fr, Fagioli M, Alcalay M, Longo L, Pandolfi PP, Donti E, Biondi A, Lo Coco F, Grignani F, Pelicci PG (1994): Acute promyelocytic leukemia: from genetics to treatment. Blood 83:10-25