The PML/RARα oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells

Blood

Volumn 88, Issue 8, 1996, Pages 2826-2832

  Raelson, John V ^a   Nervi, Clara ^a   Rosenauer, Angelika ^a   Benedetti, Laura ^a   Monczak, Yury ^a   Pearson, Mark ^a   Pelicci, Pier Giuseppe ^a   Miller Jr , Wilson H ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; MESSENGER RNA; ONCOPROTEIN; RETINOIC ACID RECEPTOR;

ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LIGAND BINDING; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN DNA BINDING; PROTEIN EXPRESSION;

EID: 0029919406     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.8.2826.bloodjournal8882826     Document Type: Article

References (40)

1. Rowley JD, Golomb HM, Dougherty C: 15;17 translocation, a consistent chromosomal change in acute promyelocytic leukemia. Lancet 1:549, 1977
2. Grignani F, Fagioli M, Alcalay M, Longo L, Pandolfi PP, Donti E, Biondi A, Lo Coco F, Pelicci PG: Acute promyelocytic leukemia: From genetics to treatment (review). Blood 83:10, 1994
3. Breitman TR, Collins SJ, Keene BR: Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid. Blood 57:1000, 1981
4. Collins SJ, Robertson KA, Mueller L: Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-α). Mol Cell Biol 10:2154, 1990
5. Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM: Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. Nature 355:446, 1992
6. Giguere V, Ong ES, Segui P, Evans RM: Identification of a receptor for the morphogen retinoic acid. Nature 330:624, 1987
7. Kakizuka A, Miller WH Jr, Umesono K, Warrell RP Jr, Frankel SR, Murty VV, Dmitrovsky E, Evans RM: Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell 66:663, 1991
8. Pandolfi PP, Grignani F, Alcalay M, Mencarelli A, Biondi A, Lo Coco F, Pelicci PG: Structure and origin of the acute promyelocytic leukemia myl/RARα cDNA and characterization of its retinoid-binding and transactivation properties. Oncogene 6:1285, 1991
9. de The H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A: The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 66:675, 1991
10. Chang KS, Fan YH, Andreeff M, Liu J, Mu ZM: The PML gene encodes a phosphoprotein associated with the nuclear matrix. Blood 85:3646, 1995
11. Mu ZM, Chin KV, Liu IH, Lozano G, Chang KS: PML, a growth suppressor disrupted in acute promyelocytic leukemia. Mol Cell Biol 14:6858, 1994
12. Lavau C, Marchio A, Fagioli M, Jansen J, Falini B, Lebon P, Grosveld F, Pandolfi PP, Pelicci PG, Dejean A: The acute promyelocytic leukaemia-associated PML gene is induced by interferon. Oncogene 11:871, 1995
13. Chelbialix MK, Pelicano L, Quignon F, Koken MHM, Venturini L, Stadler M, Pavlovic J, Degos L, Dethe H: Induction of the PML protein by interferons in normal and APL cells. Leukemia 9:2027, 1995
14. Stadler M, Chelbialix MK, Koken MHM, Venturini L, Lee C, Saib A, Quignon F, Pelicano L, Guillemin MC, Schindler C, Dethe H: Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element. Oncogene 11:2565, 1995
15. Dyck JA, Maul GG, Miller WH Jr, Chen JD, Kakizuka A, Evans RM: A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell 76:333, 1994
16. Daniel MT, Koken M, Romagne O, Barbely S, Bazarbachi A, Stadler M, Guillemin MC, Degos L, Chomienne C, de The H: PML protein expression in hematopoietic and acute promyelocytic leukemia cells. Blood 82:1858, 1993
17. Testa U, Grignani F, Barberi T, Fagioli M, Masciulli R, Ferrucci PF, Seripa D, Camagna A, Alcalay M, Pelicci PG: PML/RAR α+ U937 mutant and NB4 cell lines: Retinoic acid restores the monocytic differentiation response to vitamin D3. Cancer Res 54:4508, 1994
18. Rousselot P, Hardas B, Patel A, Guidez F, Gaken J, Castaigne S, Dejean A, de The H, Degos L, Farzaneh F: The PML-RAR alpha gene product of the t(15;17) translocation inhibits retinoic acid-induced granulocytic differentiation and mediated transactivation in human myeloid cells. Oncogene 9:545, 1994
19. Perez A, Kastner P, Sethi S, Lutz Y, Reibel C, Chambon P: PML-RAR homodimers: Distinct DNA binding properties and heteromeric interactions with RXR. EMBO J 12:3171, 1993
20. Nervi C, Poindexter EC, Grignani F, Pandolfi PP, Lo Coco F, Avvisati, G, Pelicci PG, Jetten AM: Characterization of the PML-RARα chimeric product of the acute promyelocytic leukemia-specific t(15;17) translocation. Cancer Res 52:3687, 1992
21. Kastner P, Perez A, Lutz Y, Rochette-Egly C, Gaub MP, Durand B, Lanotte M, Berger R, Chambon P: Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): Structural similarities with a new family of oncoproteins. EMBO J 11:629, 1992
22. Jansen JH, Mahfoudi A, Rambaud S, Lavau C, Wahli W, Dejean A: Multimeric complexes of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways. Proc Natl Acad Sci USA 92:7401, 1995
23. Ahn MJ, Nason-Burchenal K, Moasser MM, Dmitrovsky E: Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML. Oncogene 10:2307, 1995
24. Lanotte M, Martin-Thouvenin V, Najman S, Ballerini P, Valensi F, Bergen R: NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood 77:1080, 1991
25. Rosenauer A, Raelson JV, Nervi C, Eydoux P, DeBlasio A, Miller WH Jr: Alterations in expression, binding to ligand and DNA, and transcriptional activity of rearranged and wildtype retinoid receptors in retinoid-resistant acute promyelocytic leukemia cell lines. Blood 88:2671, 1996
26. Grignani F, Ferrucci PF, Testa U, Talamo G, Fagioli M, Alcalay M, Mencarelli A, Peschle C, Nicoletti I, Pelicci PG: The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 74:423, 1993
27. Petkovich M, Brand NJ, Krust A, Chambon P: A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330:444, 1987
28. Miller WH Jr, Moy D, Li A, Grippo JF, Dmitrovsky E: Retinoic acid induces down-regulation of several growth factors and proto-oncogenes in a human embryonal cancer cell line. Oncogene 5:511, 1990
29. Dermime S, Grignani F, Clerici M, Nervi C, Sozzi G, Talamo GP, Marcheis E, Formelli F, Parmiani G, Pelicci PG, Gambacorti-Passerini C: Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the pml/RARα protein. Blood 82:1573, 1993
30. Allegretto EA, McClurg MR, Lazarchik SB, Clemm DL, Kerner SA, Elgort MG, Boehm MF, White SK, Pike JW, Heyman RA: Transactivation properties of retinoic acid and retinoid X receptors in mammalian cells and yeast. Correlation with hormone binding and effects of metabolism. J Biol Chem 268:26625, 1993 (erratum 269:7834, 1994)
31. Andrews NC, Faller DV: A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res 19:2499, 1991
32. Arlinghaus RB, Ascione R: Isolation of mammalian cell polyribosomes, in Last JA, Laskin AI (eds): Protein Biosynthesis in Nonbacterial Systems. New York, NY, Marcel Dekker, 1972, p 29
33. Brannan CI, Dees EC, Ingram RS, Tilghman SM: The product of the H19 gene may function as an RNA. Mol Cell Biol 10:28, 1990
34. Pachnis V, Tilghman SM: The structure and expression of a novel gene activated in early mouse embryogenesis. EMBO J 7:673, 1988
35. Frankel SR, Eardley A, Lauwers G, Weiss M, Warrell RP Jr: The "retinoic acid syndrome" in acute promyelocytic leukemia. Ann Intern Med 117:292, 1992
36. Terris B, Baldin V, Dubois S, Degott C, Flejou JF, Henin D, Dejean A: PML nuclear bodies are general targets for inflammation and cell proliferation. Cancer Res 55:1590, 1995
37. Benedetti L, Grignani F, Scicchitano BM, Jetten AM, Diverio D, Lococo F, Avvisati G, Gambacortipasserini C, Adamo S, Levin AA, Pelicci G, Nervi C: Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARα-mediated increase of type II transglutaminase. Blood 87:1939, 1996
38. Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhoa L, Gu LJ, Wang Z-Y: Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72:567, 1988
39. Castaigne S, Chomienne C, Daniel MT, Berger R, Fenaux P, Degos L: All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood 76:1704, 1990
40. Miller WH Jr, Jakubowski A, Tong WP, Miller VA, Rigas JR, Benedetti F, Gill GM, Truglia JA, Ulm E, Shirley M: 9-cis retinoic acid induces complete remission but does not reverse clinically acquired retinoid resistance in acute promyelocytic leukemia. Blood 85:3021, 1995