Retinoic acid regulatory pathways, chromosomal translocations, and acute promyelocytic leukemia

Genes Chromosomes and Cancer

Volumn 15, Issue 3, 1996, Pages 147-156

  Chen, Zhu ^a   Tong, Jian Hua ^a   Dong, Shuo ^a   Zhu, Jun ^a   Wang, Zhen Yi ^a   Chen, Sai Juan ^a  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR;

ACUTE MYELOBLASTIC LEUKEMIA; CANCER REGRESSION; CARCINOGENESIS; CHROMOSOME TRANSLOCATION; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION 15; CHROMOSOME TRANSLOCATION 5; GENE CONTROL; PRIORITY JOURNAL; REVIEW;

ADULT; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CHIMERA; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 15; CHROMOSOMES, HUMAN, PAIR 17; CLONING, MOLECULAR; CONSENSUS SEQUENCE; EMBRYONIC AND FETAL DEVELOPMENT; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; NEOPLASM PROTEINS; NEOPLASMS; NUCLEAR PROTEINS; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC; TRETINOIN; TUMOR SUPPRESSOR PROTEINS;

ATRA;

EID: 0029881415     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199603)15:3<147::AID-GCC1>3.0.CO;2-2     Document Type: Review

References (123)

1. Bardwell VJ, Tresman R (1994) The POZ domain: A conserved protein-protein interaction motif. Genes Dev 8:1664-1677.
2. Bennette JM, Catovsky D, Daniel D, Frandrin G, Galton DAG, Gralnick HR, Sultan C (1976) Proposals for the classification of the acute leukemias. Br J Haematol 33:451-458.
3. Borrow J, Goddard AD, Sheer D, Solomon E (1990) Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 249:1577-1580.
4. Borrow J, Shipley J, Howe K, Kiely F, Goddard A, Sheer D, Srivastava A, Antony A, Fioretos T, Mitelman F, Solomon E (1994) Molecular analysis of simple variant translocation in acute promyelocytic leukemia. Genes Chromosom Cancer 9:234-243.
5. Breitman TR, Selonick SE, Collins SJ (1980) Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc Natl Acad Sci USA 77:2936-2940.
6. Brockes JP (1990) Reading the retinoid signals. Nature 345:766-768.
7. Burn TC, Petrovick MS, Hohans S, Rollins BJ, Tenen DG (1994) Monocyte chemo-attractant protein-1 gene is expressed in activated neutrophils and retinoic acid-induced human myeloid cell lines. Blood 84:2776-2783.
8. Castaigne S, Chomienne C, Daniel MT, Ballerini P, Berger R, Fenaux P, Degos L (1990) All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood 76:1704-1709.
9. Castaigne S, Balitrand N, de Thé H, Dejean A, Degos L, Chomienne C (1992) A PML/retinoic acid receptor a fusion transcript is constantly detected by RNA-based polymerase chain reaction in acute promyelocytic leukemia. Blood 79:3110-3115.
10. Chambon P, Zelent A, Petkovich M, Mendelsohn C, Leroy P, Krust A, Kastner P, Brand N (1991) The family of retinoic acid nuclear receptors. In Saurat JH (ed): Retinoids: 10 Years On. Basel: Karger, pp 10-17.
11. Chang KS, Trujillo JM, Ogura T, Castiglione CM, Kidd KK, Zhao S, Freireich EJ, Stass SA (1991) Rearrangement of the retinoic acid receptor gene in acute promyelocytic leukemia. Leukemia 5:200-204.
12. Chang KS, Stass SA, Chu DT, Deaven L, Trujillo JM, Freireich EJ (1992) Characterization of a fusion cDNA (RARA/myl) transcribed from the t(15;17) translocation breakpoint in acute promyelocytic leukemia. Mol Cell Biol 12:800-810.
13. Chang KS, Fan YH, Andreeff M, Lin J, Mu ZM (1995) The PML gene encodes a phosphoprotein associated with the nuclear matrix. Blood 85:3646-3653.
14. Chen JY, Penco S, Ostrowski J, Balaguer P, Pons M, Starrett JE, Reczek P, Chambon P, Gronemeyer H (1995) RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation. EMBO J 14:1187-1197.
15. Chen SJ, Zhu YJ, Tong JH, Dong S, Huang W, Chen Y, Xiang WM, Zhang L, Li XS, Qian GQ, Wang ZY, Chen Z, Larsen CJ, Berger R (1991) Rearrangements in the second intron of the RARA gene are present in a large majority of patients with acute promyelocytic leukemia and are used as molecular marker for retinoic acid-induced leukemia cell differentiation. Blood 78:2696-2701.
16. Chen SJ, Chen Z, Chen A, Tong JH, Dong S, Wang ZY, Waxman S, Zelent A (1992) Occurrence of distinct PML-RARα fusion gene isoforms in patients with acute promyelocytic leukemia detected by reverse transcriptase/polymerase chain reaction. Oncogene 7:1223-1232.
17. Chen SJ, Zelent A, Tong JH, Yu HQ, Wang ZY, Derré J, Berger R, Waxman S, Chen Z (1993) Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia. J Clin Invest 91:2260-2267.
18. Chen SJ, Wang ZY, Chen Z (1995) Acute promyelocytic leukemia: From clinic to molecular biology. Stem Cells 13:22-31.
19. Chen Z, Chen SJ, Tong JH, Zhu YJ, Huang ME, Wang WC, Wu Y, Sun GL, Wang ZY, Larsen CJ, Berger R (1991) The retinoic acid alpha receptor gene is frequently disrupted in its 5′ part in Chinese patients with acute promyelocytic leukemia. Leukemia 5:288-292.
20. Chen Z, Brand NJ, Chen A, Chen SJ, Tong JH, Wang ZY, Waxman S, Zelent A (1993) Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-α locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J 12:1161-1167.
21. Chen Z, Guidez F, Rousselot P, Agadir A, Chen SJ, Wang ZY, Degos L, Zelent A, Waxman S, Chomienne C (1994) PLZF-RARα fusion proteins generated from the variant t(11;17)(q23; q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors. Proc Natl Acad Sci USA 91:1178-1182.
22. Chinese National Cooperative Study Group on APL (1994) Report on the results of post remission follow-up study in 481 APL patients treated with ATRA. Chin J Hematol 15:411.
23. Cook M, Gould A, Brand N, Davies J, Strutt R, Shaknovich R, Licht J, Waxman S, Chen Z, Gluecksohn-Waelsch S, Krumlauf R, Zelent A (1995) Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain. Proc Natl Acad Sci USA 92:2249-2253.
24. Daenen S, Vellenga E, van Dobbenburgh OA, Halie MR (1986) Retinoic acid as antileukemic therapy in a patient with acute promyelocytic leukemia and Aspergillus pneumonia. Blood 67: 559-561.
25. de Luca LM (1991) Retinoids and their receptors in differentiation, embryogenesis, and neoplasia. FASEB J 5:2924-2933.
26. Delva L, Cornic M, Balitrand N, Guidez F, Miclea JM, Delmer A, Teillet F, Fenaux P, Castaigne S, Degos L, Chomienne C (1993) Resistance to all-trans retinoic acid (ATRA) therapy in relapsing acute promyelocytic leukemia: Study of in vitro ATRA sensitivity and cellular retinoic acid binding protein in leukemic cells. Blood 82:2175-2181.
27. de Thé H, Chomienne C, Lanotte M, Degos L, Dejean A (1990) The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus. Nature 347:558-561.
28. de Thé H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A (1991) The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 66:675-684.
29. Dermime S, Grignani F, Clerici M, Nervi C, Sozzi G, Talarno GP, Marchesi E, Formelli F, Parmiani G, Pelicci PG, Passerini CG (1993) Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the PML/RARα protein. Blood 82:1573-1577.
30. Dong S, Geng JP, Tong JH, Wu Y, Cai JR, Sun GL, Chen SR, Wang ZY, Larsen CJ, Berger R, Chen SJ, Chen Z (1993) Breakpoint clusters of the PML gene in acute promyelocytic leukemia: Primary structure of the reciprocal products of the PML-RARA gene in a patient with t(15;17). Genes Chromosom Cancer 6:133-139.
31. Douer D, Preston-Martin S, Keung YK, Chang E, Watkins K, Levine AM (1994) High occurrence of FAB M3 subtype among acute myelocytic leukemia (AML) patients of Latino origin. Blood 84(Suppl):51a.
32. Dowson MI, Elstner E, Kizaki M, Chen DL, Pakkala S, Kerner B, Koeffler HP (1994) Myeloid differentiation mediated through retinoic acid receptor/retinoic X receptor (RXR) not RXR/RXR pathway. Blood 84:446-452.
33. Dyck JA, Maul GG, Miller WH, Chen JD, Kakizuka A, Evans RD (1994) A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell 76:333-343.
34. Fenaux P, Castaigne S, Dombret H, Archimbaud E, Durate M, Morel P, Lamy T, Tilly H, Guerci A, Maloisel F, Bordessoule D, Sadoun A, Tiberghien P, Fegueux N, Daniel MT, Chomienne C, Degos L (1992) All-trans retinoic acid followed by intensive chemotherapy gives a high complete remission rate and may prolong remissions in newly diagnosed acute promyelocytic leukemia: A pilot study on 26 cases. Blood 80:2176-2181.
35. Fenaux P, Chastang C, Castaigne S, Archimbaud E, Sanz M, Link H, Guerci A, Fegueux N, Zittoun R, Stoppa AM, Travade P, Lamy T, Maloisel F, Sadoun A, San Miguel J, Veil A, Rayon C, Conde E, Fey M, Bordessoule D, Ganser A, Bowen D, Dryfus F, Huguet F, Tilly H, Guy H, Auzanneau G, Chomienne C, Degos L (1994) Treatment of newly diagnosed acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA) followed by intensive chemotherapy (CT). Updated results of the European group. Blood 84 (Suppl):379a.
36. Flynn PJ, Miller WJ, Weisdorf DJ, Arthur D, Banning R, Branda R (1983) Retinoic acid treatment of acute promyelocytic leukemia: In vitro and in vivo observation. Blood 62:1211-1217.
37. Forman BM, Umesono K, Chen J, Evans RM (1995) Unique response pathways are established by allosteric interaction among nuclear hormone receptors. Cell 81:541-550.
38. Fragioli M, Alcalay M, Pandolfi PP, Venturini L, Mencarelli A, Simeone A, Acampora D, Grignani F, Pelicci PG (1992) Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminal different protein isoforms. Oncogene 7:1083-1091.
39. Fukutani H, Naoe T, Yoshida H, Yamamori S, Ohno R (1993) Molecular heterogeneity of the PML gene rearrangement in acute promyelocytic leukemia: Prevalence and clinical significance. Jpn J Cancer Res 84:257-264.
40. Gallagher RE, Li YP, Rao S, Paietta E, Andersen J, Etkind P, Bennett JM, Tallman MS, Wiernik PH (1995) Characterization of acute promyelocytic leukemia cases with PML-RARα break/fusion sites in PML exon 6: Identification of a subgroup with decreased in vitro responsiveness to all-trans retinoic acid. Blood 86:1540-1547.
41. Geng JP, Tong JH, Dong S, Wang ZY, Chen SJ, Chen Z, Zelent A, Berger R, Larsen CJ (1993a) Localization of the chromosome 15 breakpoints and expression of multiple PML-RARα transcripts in acute promyelocytic leukemia: A study of 28 Chinese patients. Leukemia 7:20-26.
42. Geng JP, Chi ZW, Tong JH, Dong S, WAng ZY, Chen SJ, Chen Z (1993b) Genomic organization of the PML gene and its rearrangement in acute promyelocytic leukemia. Sci China (Series B) 23: 624-631.
43. Goddard AD, Borrow J, Freemont P, Solomon E (1991) Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. Science 254:1371-1374.
44. Grignani F, Farrucci PF, Leste U, Talamo G, Fagioli M, Alcalay M, Mencarelli A, Grignani F, Peschle C, Nicoletti I, Pelicci PG (1993) The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 74:423-431.
45. Grignani F, Fagioli M, Alcalay M, Longo L, Pandolfi PP, Donti E, Biondi A, Lo Coco F, Grignani F, Pelicci PG (1994) Acute promyelocytic leukemia: From genetics to treatment. Blood 83:10-25.
46. Gudas LJ, Sporn MB, Roberts AB (1994) In Sporn MB, Roberts AB, Goodman DS (eds): The Retinoids, 2nd ed. New York: Raven Press, pp 443-520.
47. Guidez F, Huang W, Tong JH, Dubois C, Balitrand N, Waxman S, Michaux JL, Martiat P, Degos L, Chen Z, Chomienne C (1994) Poor response to all-trans retinoic acid therapy in a t(11;17) PLZF/RARα patient. Leukemia 8:312-317.
48. Guigere V (1994) Retinoic acid receptors and cellular retinoic binding proteins: Complete interplay in retinoic signaling. Endocrine Rev 15:61-79.
49. Heim S, Mitelman F (1989) Cancer Cytogenetics. New York: Alan R. Liss, Inc.
50. Heyman RA, Mangelsdorf DJ, Dyck JA, Stein RB, Eichele G, Evans RM, Thaller C (1992) 9-Cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 68:397-406.
51. Hiorns LR, Min T, Swansburg GT, Zelent A, Dyer MJS, Catovsky D (1994) Interstitial insertion of retinoic acid receptor-α gene in acute promyelocytic leukemia with normal chromosomes 15 and 17. Blood 83:2946-2951.
52. Horibe K, Matsushita T, Numata S, Miyajima Y, Katayama I, Kitabayashi T, Yanai M, Sekiguchi N, Egi S (1993) Acute promyelocytic leukemia with t(15;17) abnormality after chemotherapy containing etoposide for Langerhans cell histiocytosis. Cancer 72: 3723-3726.
53. Huang ME, Ye YC, Wang ZY (1987a) Treatment of 4 APL patients with ATRA. Chin J Intern Med 26:330-332.
54. Huang ME, Ye YC, Chen SR (1987b) All-trans retinoic acid with or without low dose cytosine arabinoside in acute promyelocytic leukemia. Chin Med J 100:949-953.
55. Huang ME, Ye YC, Chen SR, Cai JR, Lu JX, Zhao L, Gu RJ, Wang ZY (1988) Use of all trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72:567-572.
56. Huang W, Sun GL, Li XS, Cao Q, Lu Y, Jang GS, Zhang FQ, Cai JR, Wang ZY, Waxman S, Chen Z, Chen SJ (1993) Acute promyelocytic leukemia: Clinical relevance of two major PML-RARα isoforms and detection of minimal residual disease by retrotranscriptase/polymerase chain reaction to predict relapse. Blood 4:1264-1269.
57. Kakizuka A, Miller WH Jr, Umesono K, Warrell RP Jr, Frankel SR, Murty VVVS, Dmitrovsky E, Evans RM (1991) Chromosome translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML. Cell 66:663-674.
58. Kanamaru A, Takemoto Y, Tanimoto M, Murakami H, Asou N, Kobayashi T, Kuriyama K, Ohmoto E, Sakamaki H, Tsubak K, Kiraoka A, Yamada O, Oh H, Saito K, Matsuda S, Minato K, Ueda T, Ohno R (1995) All-trans retinoic acid for the treatment of newly diagnosed acute promyelocytic leukemia. Blood 85:1202-1206.
59. Kastner P, Perez A, Lutz Y, Rochette-Egly C, Gaub MP, Durand B, Lanotte M, Berger R, Chambon P (1992) Structure, localisation and transcriptional properties of two classes of retinoic acid receptor α fusion proteins in acute promyelocytic leukemia (APL): Structural similarities with a new family of oncoproteins. EMBO J 11:629-642.
60. Kizaki M, Ikeda Y, Tanosaki R, Nakajima H, Morikawa M, Sakashita A, Koeffler HP (1993) Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid rcceptor-α and retinoid X receptor-α RNA by HL-60 cells. Blood 82:3592-3599.
61. Kizaki M, Ueno H, Takayama N, Nakajima H, Morikawa M, Yamazoe Y, Koeffler HP, Ikeda Y (1994) Mechanisms of retinoid resistance in leukemic cells: Role of cytochrome P-450 and P-glycoprotein. Blood 84(Suppl):380a.
62. Koken MHM, Puvion-Dutilleul F, Guillemin MC, Viron A, Linares-Cruz G, Stuurman N, de Jong L, Szostecki C, Calvo F, Chomienne C, Degos L, Puvion E, de Thé H (1994) The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion. EMBO J 13:1073-1083.
63. Koken MHM, Linares-Cruz G, Guignon F, Viron A, Chelbi-Alix MK, Sobczak-Thepot J, Juhlin L, Degos L, Calvo F, de The H (1995) The PML growth-suppressor has an altered expression in human oncogenesis. Oncogene 10:1315-1324.
64. Kurokawa R, Direnzo J, Boehm M, Sugarman J, Gloss B, Rosenfeld MG, Heyman RA, Glass CK (1994) Regulation of retinoid signaling by receptor polarity and allosteric control of ligand binding. Nature 371:528-531.
65. Lanotte M, Martin-Thouvenin V, Najman S, Ballerini P, Valensi F, Berger R (1991) NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood 77:1080-1086.
66. Larson RA, Kondo K, Vardiman JW, Butler AE, Golomb HM, Rowley JD (1984) Evidence for a 15;17 translocation in every patient with acute promyelocytic leukemia. Am J Med 76:827-841.
67. Lefebvre P, Thomas G, Goumel B, Agadir A, Castaigne S, Dreux C, Degos L, Chomienne C (1991) Pharmacokinetics of oral all-trans retinoic acid in patients with acute promyelocytic leukemia. Leukemia 5:1054-1058.
68. Leid M, Kastner P, Chambon P (1992a) Multiplicity generates diversity in retinoic acid signalling pathway. Trends Biochem Sci 17:427-433.
69. Leid M, Kastner P, Lyons R, Nakshatri H, Saunder M, Zacharewski T, Chen J-Y, Staub A, Garnier J-M, Mader S, Chambon P (1992b) Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell 68:377-395.
70. Levin AA, Sturzenbecker LJ, Kazmer S, Bosakowski T, Huselton C, Allenby G, Speck J, Kratzeisen C, Rosenberger M, Lovey A, Grippo JF (1992) 9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα. Nature 355:359-361.
71. Li YP, Said F, Gallagher RE (1994) Retinoic acid-resistant HL-60 cells exclusively contain mutant retinoic acid receptor-a. Blood 83:3298-3302.
72. Licht JD, Chen A, Goy A, Wu Y, Scott AA, DeBlasio A, Miller WH, Zelenetz AD, Willman CL, Head DR, Chomienne C, Chen Z, Chen SJ, Zelent A, MacIntyre E, Veil A, Cortes J, Kantarjian H, Waxman S (1995) Clinical and molecular characterization of acute promyelocytic leukemia associated with translocation (11;17). Blood 85:1083-1094.
73. Licht JD, Shaknovich R, English M, Melnick A, Li JY, Reddy JC, Dong S, Chen SJ, Zelent A, Waxman S (1996) Reduced and altered DNA-binding and transcriptional properties of the PLZF-retinoic acid receptor-α chimera generated in t(11;17)-associated acute promyelocytic leukemia. Oncogene (in press).
74. LoCoco F, Diverio D, D'Adamo F, Avvisati G, Alimena G, Nanni M, Alcalay M, Pandolfi PP, Pelicci PG (1992) PML/RAR-α rearrangement in acute promyelocytic leukemias apparently lacking the t(15;17) translocation. Eur J Haematol 48:173-176.
75. Lohnes D, Mark M, Mendelsohn C, Dolle P, Dierich A, Gorry P, Gansmuller A, Chambon P (1994) Function of the retinoic acid receptors (RARs) during development. (I) Craniofacial and skeletal abnormalities in RAR double mutants. Development 120: 2723-2748.
76. Longo L, Pandolfi PP, Biondi A, Rambladi A, Mencarelli A, Lo Coco F, Diverio D, Pegoraro L, Avanzi G, Tabilio A, Zangrilli D, Alcalay M, Donti E, Grignani F, Pelicci PG (1990) Rearrangements and aberrant expression of the RARa gene in acute promyelocytic leukemia. J Exp Med 172:1571-1575.
77. Lopez-Andreu JA, Ferris J, Verdeguer A, Esquembre C, Castel V (1994) Acute promyelocytic leukemia with t(15;17) abnormality after chemotherapy containing etoposide for Langerhans cell histiocytosis. Cancer 74:1650-1652.
78. Mattei MG, Petkovich M, Mattei J, Brand N, Chambon P (1988) Mapping of the human retinoic acid receptor to the q21 of chromosome 17. Hum Genet 80:186-188.
79. Mendelson C, Lohnes D, Decimo D, Lufkin T, LeMeur M, Chambon P, Mark M (1994) Function of the retinoic acid receptors (RARs) during development. (II) Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development 120:2749-2771.
80. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu QY, Cochran C, Bennett LM, Ding W, Bell R, Rosenthal J, Hussey C, Tran T, McClure M, Frye C, Hattier T, Phelps R, Haugen-Strano A, Katcher H, Yakumo K, Gholami Z, Shaffer D, Stone S, Bayer S, Wray C, Bogden R, Dayananth P, Ward J, Tonin P, Narod S, Bristow PK, Norris FH, Helvering L, Morrison P, Rosteck P, Lai M, Barrett JC, Lewis C, Neuhausen S, Cannon-Albright L, Goldgar D, Wiseman R, Kamb A, Skolnick MH (1994) A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266:66-71.
81. Miller WH Jr, Kakizuka A, Frankel SR, Warrell RP Jr, Deblasio A, Levine K, Evans RM, Dmitrovsky E (1992) Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor a clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia. Proc Natl Acad Sci USA 89:2694-2698.
82. Miller WH Jr, Levine K, Deblasio A, Frankel S, Dmitrovsky E, Warrell RP Jr (1993) Detection of minimal residual disease in acute promyelocytic leukemia by reverse transcription polymerase chain reaction assay for the PML/RARα fusion mRNA. Blood 82:1689-1694.
83. Miller WH, Jakubowski JA, Tong WP, Miller VA, Rigas JR, Benedetti F, Gill GM, Truglia JA, Ulm E, Shirley M, Warrell RP (1995) 9-Cis retinoic acid induces complete remission but does not reverse clinically acquired retinoid resistance in acute promyelocytic leukemia. Blood 85:3021-3027.
84. Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, Look AT (1994) Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 263:1281-1284
85. Mu ZM, Chin KV, Liu JH, Lozano G, Chang KS (1994) PML, a growth suppressor disrupted in acute promyelocytic leukemia. Mol Cell Biol 14:6858-6867.
86. Muindi J, Frankel SR, Miller Jr WH, Jakubowski A, Scheinberg DA, Young CW, Dmitrovsky E, Warrell RP Jr (1992) Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentration: Implication for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia. Blood 79:299-303.
87. Nilsson B (1984) Probable in vivo induction of differentiation by retinoic acid of promyelocytes in acute promyelocytic leukemia. Br J Haematol 57:365-371.
88. Ogura T, Evans RM (1995) A retinoic acid-triggered cascade of HOXB1 gene activation. Proc Natl Acad Sci USA 92:387-391.
89. Ohno R, Yoshida H, Fukutani H, Naoe T, Ohshima T, Kyo T, Endoh N, Fujimoto T, Kobayashi T, Hiraoka A, Mizoguchi H, Kodera Y, Suzuki H, Hirano M, Akiyama H, Aoki N, Shinodo H, Yokomaku S (1993) The Leukemia Study Group of the Ministry of Health and Welfare. Multi-institutional study of all-trans-retinoic acid as a differentiation therapy of refractory acute promyelocytic leukemia. Leukemia 7:1722-1727.
90. Pandolfi PP, Gargnani F, Alcalay M, Mencarelli A, Biondi A, LoCoco F, Pelicci PG (1991) Structure and origin of the acute promyelocytic leukemia myl/RARa cDNA and characterization of its retinoid binding and transactivation properties. Oncogene 6:1285-1292.
91. Pandolfi PP, Alcalay M, Fagioli M, Zangrilli D, Mencarelli A, Diverio D, Biondi A, LoCoco F, Rambladi A, Grignani F, Rochette-Egly C, Gaube MP, Chambon P, Pelicci PG (1992) Genomic variability and alternative splicing generate multiple PML/RARa transcripts that encode aberrant PML protein and PML/RARa isoforms in acute promyelocytic leukemia. EMBO J 11:1397-1407.
92. Perez A, Kastner P, Sethi S, Lutz Y, Reibel C, Chambon P (1993) PML-RAR homodimers: Distinct DNA binding properties and heteromeric interactions with RXR. EMBO J 12:3171-3182.
93. Rabbitts TH (1994) Chromosome translocations in human cancer. Nature 372:143-149.
94. Robertson K, Emami B, Collins S (1992) Retinoid acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand-binding domain that confers dominant negative activity. Blood 80:1885-1889.
95. Ruchaud S, Duprez E, Gendron MC, Houge G, Genieser HG, Jastorff B, Doskeland SO, Lanotte M (1994) Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line. Proc Natl Acad Sci USA 91:8428-8432.
96. Runde V, Aul C, Sudhoff T, Heyll A, Schneider W (1992) Retinoic acid in the treatment of acute promyelocytic leukemia: Inefficacy of the 13-cis isomer and induction of complete remission by the all-trans isomer complicated by thromboembolic events. Ann Haematol 64:270-272.
97. Sachs L (1978) Control of normal differentiation and the phenotypic reversion of malignancy in myeloid leukemia cells. Nature 274: 535-539.
98. Sarker A, Yang P, Fan YH, Mu ZM, Hauptmann R, Adolf GR, Stass SA, Chang KS (1994) Regulation of the expression of annexin VIII in acute promyelocytic leukemia. Blood 84:279-286.
99. Smith MA, Parkinson DR, Cheson BD, Freidman MA (1992) Retinoids in cancer therapy. J Clin Oncol 10:839-864.
100. Sommerbell D, Maden M (1990) Retinoic acid, a developmental signaling molecule. Trends Neurosci 13:142-147.
101. Stone RM, Mayer RJ (1990) The unique aspects of acute promyelocytic leukemia. J Clin Oncol 8:1913-1921.
102. Sun GL, Tang XM, Cai JR, Chen SR, Li XS, Sheng ZX, Lu DY, Wang ZY (1986) Studies on inducers of differentiation in leukemia cells. Chin J Hematol 7:479a.
103. Sun GL, Ou Yang RR, Chen SJ, Gu YS, Huang LA, Lu JX, Wang ZY (1993) Treatment of acute promyelocytic leukemia with all-trans retinoic acid - A five-year experience. Chin Med J 106:743-748.
104. Takatsuki H, Umemura T, Yufu Y, Nishimura J, Nawata H (1994) Transformation at the level of pluripotent stem cell in acute promyelocytic leukemia. Blood 84(Suppl):49a.
105. Tashiro S, Kotomura N, Tanaka K, Suzuki K, Kyo T, Oohy H, Niwa O, Kamada N (1994) Identification of illegitimate recombination hot spot of the retinoic acid receptor alpha gene involved in 15;17 chromosomal translocation of acute promyelocytic leukemia. Oncogene 9:1939-1945.
106. Teboul M, Enmark E, Li Q, Wikstrom AC, Pelto-Huikko M, Gustafsson JA (1995) OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor. Proc Natl Acad Sci USA 92:2006-2100.
107. Tong JH, Dong S, Geng JP, Huang W, Wang ZY, Sun GL, Chen SJ, Chen Z, Larsen CJ, Berger R (1992) Molecular rearrangements of the MYL gene in acute promyelocytic leukemia (APL, M3) define a breakpoint cluster region as well as some molecular variants. Oncogene 7:311-316.
108. Tsai S, Collins SJ (1993) A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocytic stage. Proc Natl Acad Sci USA 90:7153-7157.
109. Turhan AG, Lemoin FM, Debert C, Nonnet ML, Baillon C, Picard F, Macintyre EA, Varet B (1995) Highly purified primitive hematopoietic stem cells are PMLRARA negative and generate nonclonal progenitors in acute promyelocytic leukemia. Blood 85: 2154-2161.
110. Vahdat L, Maslak P, Miller WH, Eardley A, Heller G, Scheinberg DA, Warrell RP Jr (1994) Early mortality and the retinoic acid syndrome in acute promyelocytic leukemia: Impact of leukocytosis, low-dose chemotherapy, PML/RARa isoform, and CD13 expression in patients treated with all-trans retinoic acid. Blood 84:3843-3849.
111. Wang YZ, Lu JX, Yan MR, Liu WS, Guo XY (1989) Study on the leukemogenic effect of Bimolane (in Chinese, with abstract in English). Chin J Hematol 10:19-20.
112. Wang ZY, Sun GL, Lu JX, Gu LJ, Huang ME, Chen SR (1990a) Treatment of acute promyelocytic leukemia with all-trans retinoic acid in China. Nouv Rev Fr Hematol 32:34-36.
113. Wang ZY, Sun GL, Ye YC, Gu LJ, Huang ME, Chen SR (1990b) Clinical study on 90 cases of APL treated with all-trans retinoic acid. Chin J Hematol 11:480a.
114. Warrell RP Jr, Frankel SR, Miller WH Jr, Scheinberg DA, Itri LM, Hittelman WN, Vyas R, Andreeff M, Tafuri A, Jakubowski A, Gabrilove J, Gordon MS, Dmitrovsky E (1991) Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans retinoic). N Engl J Med 324:1385-1393.
115. Warrell RP Jr, de The H, Wang ZY, Degos L (1993) Acute promyelocytic leukemia. N Engl J Med 329:177-189.
116. Weis K, Rambaud S, Lavau C, Jansen J, Carvalho T, Carmo-Fonseca M, Lamond A, Dejean A (1994) Retinoic acid regulates aberrant nuclear localization of PML-RARa in acute promyelocytic leukemia cells. Cell 76:345-356.
117. Xue YQ, Lu DR, Guo Y, Lin BJ (1994) Cytogenetic analysis of secondary leukemia due to treatment of psoriasis with Bimolane (in Chinese, with abstract in English). Chin J Hematol 15:12-14.
118. Ye BH, Lista F, LoCoco F, Knowles DM, Offit K, Chaganti RSK, Dalla-Favera R (1993) Alteration of a zinc-finger encoding gene, Bcl6, in diffuse large-cell lymphoma. Science 262:747-750.
119. Yoshida H, Naoe T, Fukutani H, Kubo K, Ohno R (1995) Analysis of the joining sequences of the t(15;17) translocation in human acute promyelocytic leukemia: Sequence non-specific recombination between the PML and RARA genes within identical short stretches. Genes Chromosom Cancer 6:133-139.
120. Yu V, Naar AM, Rosenfeld MG (1992)Transcriptional regulation by the nuclear receptor superfamily. Curr Opin Biotechnol 3:597-602.
121. Zelent A (1994) Translocation of the RARα locus to the PML or PLZF gene in acute promyelocytic leukaemia. Br J Haematol 86:451-460.
122. Zhang XK, Hoffmann B, Tran PBV, Graupner G, Pfahl M (1992) Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature 355:441-446.
123. Zhu J, Shi XG, Chu HY, Tong JH, Wang ZY, Naoe T, Waxman S, Chen SJ, Chen Z (1995) Effect of retinoic acid isomers on proliferation, differentiation and PML relocalization in the APL cell line NB4. Leukemia 9:302-309.