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Volumn 118, Issue 43, 1996, Pages 10408-10411

Elemental fluorine to 8-fluoropurines in one step

Author keywords

[No Author keywords available]

Indexed keywords

ORGANOFLUORINE DERIVATIVE; PURINE DERIVATIVE;

EID: 0029799813     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja961456c     Document Type: Article
Times cited : (31)

References (67)
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    • note
    • With protected purines (1b,d,e,f), about 80% of the starting material was consumed under the conditions described in the Experimental Section. For reaction with purines la,c in EtOH, larger amounts of starting material could be recovered from the reaction mixture. Longer reaction times, however, revealed the formation of side products in detriment of the yield of the C(8)-fluorinated products. Also, solvents such as water and HOAc provided much lower yields than that observed in EtOH medium.
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    • 19F NMR of nucleotides in these series. Specific influences of the phosphate-(s) on the sugar base torsion angle (XCN) have been recognized with purine nucleotides:
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    • 2O, 60:36:4)). Optimum reaction times for product (2a,c) isolation varied from 2 to 5 h.


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