Role of ACE inhibition or AT1 blockade in the remodeling following myocardial infarction

Basic Research in Cardiology

Volumn 93, Issue 2 SUPPL., 1998, Pages 92-100

  Holtz, J ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Cardiac hypertrophy; Coronary reserve; Heart failure; Myocardial apoptosis; Myocardial fibrosis

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN RECEPTOR; BETA ADRENERGIC RECEPTOR; BRADYKININ; CALCIUM ION; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR;

APOPTOSIS; ASSISTED CIRCULATION; CALCIUM HOMEOSTASIS; CONFERENCE PAPER; FIBROSING ALVEOLITIS; GENE EXPRESSION; HEART CELL CULTURE; HEART FAILURE; HEART INFARCTION; HEART MUSCLE; HEART MUSCLE CELL; HEART VENTRICLE REMODELING; HEMODYNAMICS; MEMBRANE; MORTALITY; PHENOTYPE; SIGNAL TRANSDUCTION; SURVIVAL;

ANGIOTENSIN II; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; APOPTOSIS; CARDIOMEGALY; HUMANS; MYOCARDIAL INFARCTION; MYOCARDIUM; RECEPTORS, ANGIOTENSIN; RENIN-ANGIOTENSIN SYSTEM;

EID: 0031736751     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: None     Document Type: Article

References (98)

1. Aikawa R, Komuro I, Yamazaki T, Zou Y, Kudoh S, Tanaka M, Shiojima I, Hiroi Y, Yazaki Y (1997) Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest 100: 1813-1821 (Pubitemid 27431340)
2. Asano K, Dutcher DL, Port JD, Minobe WA, Tremmel KD, Roden RL, Bohlmeyer TJ, Bush EW, Jenkin MJ, Abraham WT, Raynolds MV, Zisman LS, Perryma MB, Bristow MR (1997) Selective downregulation of the angiotensin II AT1-receptor subtype in failing human ventricular myocardium. Circulation 95: 1193-1200 (Pubitemid 27097830)
3. Azizi M, Chatellier G, Guyene TT, Murieta-Geoffroy D, Menard J (1995) Additive effects of combined angiotensinconverting enzyme inhibition and angiotensin II antagonism on blood pressure and renin release in sodium-depleted normotensives. Circulation 92: 825-834
4. Azizi M, Guyene TT, Chatellier G, Wargon M, Menard J (1997) Additive effects of losartan and enalapril on blood pressure and plasma active renin. Hypertension 29: 634-640 (Pubitemid 27074730)
5. Bartling B, Holtz J, Darmer D (1998) Contribution of myocyte apoptosis to myocardial infarction? Basic Res Cardiol 93: 71-84
6. Bartling B, Schumann H, Holtz J, Grapow M, Zerkowski HR, Darmer D (1998) Die myokardiale Expression der mitochondrialen Bcl-Apoptose-Modulatoren ist bei Herzinsuffizienz vermindert und wird durch Therapie mit ACE-Hemmern teilweise normalisiert (Abstr). Z Kardiol 87 (Suppl 1): 192
7. Bartling B, Schumann H, Milting H, El Banayosy A, Körfer R, Darmer D, Holtz J, Zerkowski HR (1998) Veränderungen der Genexpression von Determinanten der Myokardapoptose während Herzentlastung durch ventrikuläre Assistsysteme bei terminaler Herzinsuffizienz (Abstr). Z Kardiol 87 (Suppl 1): 34
8. Beuckelmann DJ, Näbauer M, Erdmann E (1992) Intracellular calcium handling in ventricular myocytes from patients with terminal heart failure. Circulation 85: 1046-1055
9. Böhm M, Zolk O, Flesch M, Schiffer F, Schnabel P, Stasch JP, Knorr A (1998) Effects of angiotensin II type 1 receptor blockade and angiotensin-converting enzyme inhibition on cardiac b-adrenergic signal transduction. Hypertension 31: 747- 754 (Pubitemid 28108572)
10. Booz GW, Baker KM (1996) Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy. Hypertension 28: 635-640 (Pubitemid 26327961)
11. Bristow MR (1993) Changes in myocardial and vascular receptors in heart failure. J Am Coll Cardiol 22: 61A-71A (Pubitemid 23285799)
12. Brodde OE, Michel MC, Zerkowski HR (1995) Signal transduction mechanisms controlling cardiac contractility and their alterations in chronic heart failure. Cardiovasc Res 30: 570-584
13. Campbell DJ, Kladis A, Valentijn AJ (1995) Effects of losartan on angiotensin and bradykinin peptides and angiotensin converting enzyme. J Cardiovasc Pharmacol 26: 233-240
14. Campbell SE, Katwa LC (1997) Angiotensin II stimulated expression of transforming growth factor-b1 in cardiac fibroblasts and myofibroblasts. J Mol Cell Cardiol 29: 1947-1958 (Pubitemid 27303099)
15. Cheng W, Kajstura J, Nitahara JA, Li B, Reiss K, Liu Y, Clark WA, Krajewski S, Reed JC, Olivetti G, Anversa P (1996) Programmed myocyte cell death affects viable myocardium after infarction in rats. Exp Cell Res 226: 316-327 (Pubitemid 26260556)
16. Cheng W, Li B, Kajstura J, Li P, Wolin MS, Sonnenblick EH, Hintze TH, Olivetti G, Anversa P (1995) Stretch induced programmed myocyte cell death. J Clin Invest 96: 2247-2259
17. Cigola E, Kajstura J, Li B, Meggs LG, Anversa P (1997) Angiotensin II activates programmed myocyte cell death in vitro. Exp Cell Res 231: 363-371 (Pubitemid 27187989)
18. Danser AHJ, Van Kats JP, Admiraal PJJ, Derkx FHM, Lamers JMJ, Verdouw PD, Saxena PR, Schalekamp MADH (1994) Cardiac renin and angiotensins: Uptake from plasma versus in situ synthesis. Hypertension 24: 37-48 (Pubitemid 24195402)
19. Danser AHJ, Van Kesteren AM, Bax WA, Tavenier M, Derkx FHM, Saxena PR, Schalekamp MADH (1997) Prorenin, renin, angiotensinogen, and angiotensinconverting enzyme in normal and failing human hearts: evidence for renin binding. Circulation 96: 220-226 (Pubitemid 27298424)
20. Dell'Italia LJ, Meng QC, Balcells E, Wei CC, Palmer R, Hageman GR, Durand J, Hankes GH, Oparil S (1997) Compartimentalization of angiotensin II generation in the dog heart. J Clin Invest 100: 253-258
21. De Lannoy LM, Danser AHJ, Bouhuizen AMB, Saxena PR, Schalekamp ADH (1998) Localization and production of angiotensin II in the isolated perfused rat heart. Hypertension 31: 1111-1117 (Pubitemid 28191505)
22. Farrar DJ, Hill JD, Gray LA, Pennington DG, McBride LR, Pierce WS, Pae WE, Glenville B, Ross D, Galbraith TA, et al. (1988) Heterotopic prosthetic ventricles as a bridge to cardiac transplantation. Amulticenter study in 29 patients. N Engl J Med 318: 333-340 (Pubitemid 18044161)
23. Ferrario CM, Brosnihan KB, Diz DI, Jaiswal N, Khosla MC, Milsted A, Tallant EA (1991) Angiotensin-(1-7): A new hormone of the angiotensin system. Hypertension 8 (suppl III): 126-133
24. Fischer TA, Ungureanu-Longrois D, Singh K, De Zengotita J, De Ugarte D, Alali A, Gadbut AP, Lee M, Balligand JL, Kifor I, Smith TW, Kelly RA (1997) Regulation of bFGF expression and Ang II secretion in cardiac myocytes and microvascular endothelial cells. Am J Physiol 272: H958-H968
25. Ford WR, Clanachan AS, Jugdutt BI (1996) Opposite effects of angiotensin AT1 and AT2 receptor antagonists on recovery of mechanical function after ischemia-reperfusion in isolated working rat hearts. Circulation 94: 3087-308 (Pubitemid 26427471)
26. Gavras H, Gavras I (1991) Cardioprotective potential of angiotensin converting enzyme inhibitors. J Hypertens 9: 385-392
27. Gavras I, Manolis A, Gavras H (1995) Effects of ACE inhibition on the heart. J Hum Hypertens 9: 455-458
28. Gwathmey JK, Slawsky MT, Hajjar RJ, Briggs GM, Morgan JP (1987) Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circ Res 61: 70-76 (Pubitemid 17133480)
29. Hall KL, Venkateswaran S, Hanesworth JM, Schelling ME, Harding JW (1995) Characterization of a functional angiotensin IV receptor on coronary microvascular endothelial cells. Regul Pept 58: 107-115
30. Harada K, Komuro I, Hayashi D, Sugaya T, Murakami K, Yazaki Y (1998) Angiotensin II type 1a receptor is involved in the occurrence of reperfusion arrhythmias. Circulation 97: 315-3177 (Pubitemid 28074330)
31. Hasenfuss G, Reincke H, Studer R, Meyer M, Pieske B, Holtz J, Holubarsch CH, Posival H, Just H, Drexler H (1994) Relation between myocardial function and expression of sarcoplasmic reticulum Ca2+- ATPase in failing and nonfailing human myocardium. Circ Res 75: 434-442
32. Haywood GA, Gullestad L, Katsuya T, Hutchinson HG, Pratt RE, Horiuchi M, Fowler MB (1997) AT1 and AT2 angiotensin receptor gene expression in human heart failure. Circulation 95: 1201-1206 (Pubitemid 27097831)
33. Hibner U, Coutinho A (1994) Signal antonymy: A mechanism for apoptosis induction. Cell Death Diff 1: 33-37
34. Hill JD, Farrar DJ, Hershon JJ, Compton PG, Avery GJ, Levin BS, Brent BN (1986) Use of a prosthetic ventricle as a bridge to cardiac transplantation for postinfarction cardiogenic shock. N Engl J Med 314: 626-628 (Pubitemid 16132728)
35. Hokimoto S, Yasue H, Fujimoto K, Yamamoto H, Nakao K, Kaikita K, Sakata R, Miyamoto E (1996) Expression of angiotensin-converting enzyme in remaining viable myocytes of human ventricles after myocardial infarction. Circulation 94: 1513-1518 (Pubitemid 26320252)
36. Horiuchi M, Hayashida W, Kambe T, Yamada T, Dzau VJ (1997) Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. J Biol Chem 272: 19022-19026 (Pubitemid 27318258)
37. Horiuchi M, Yamada T, Hayashida W, Dzau VJ (1997) Interferon regulatory factor-1 upregulates angiotensin II type 2 receptor and induces apoptosis. J Biol Chem 272: 11952-11958 (Pubitemid 27202769)
38. Ito N, Kagaya Y, Weinberg EO, Barry WH, Lorell BH (1997) Endothelin and angiotensin II stimulation of Na-H exchange is impaired in cardiac hypertrophy. J Clin Invest 99: 125-135 (Pubitemid 27058303)
39. James TN (1997) Complex causes of fatal myocardial infarction. Circulation 96: 1696-1700 (Pubitemid 27375371)
40. James TN (1994) Normal and abnormal consequences of apoptosis in the human heart from postnatal morphogenesis to paroxysmal arrhythmias. Circulation 90: 556-573 (Pubitemid 24203723)
41. Kajstura J, Cigola E, Malhotra A, Li P, Cheng W, Meggs LG, Anversa P (1997) Angiotensin II induces apoptosis of adult ventricular myocytes in vitro. J Mol Cell Cardiol 29: 859-870 (Pubitemid 27196513)
42. Kerins DM, Hao Q, Vaughan DE (1995) Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV. J Clin Invest 96: 2515-2520
43. Kijima K, Matsubara H, Komuro I, Yasaki Y, Inada M (1996) Mechanical stretch induces enhanced expression of angiotensin II receptors in neonatal rat cardiac myocytes. Circ Res 79: 887-897 (Pubitemid 26317839)
44. Komuro I, Kaida T, Shibazaki Y, Kurabayashi M, Katoh Y, Hoh E, Takaku F, Yazaki Y (1990) Stretching cardiac myocyctes stimulates protooncogene expression. J Biol Chem 265: 3595-3598
45. Komuro I, Katoh Y, Kaida T, Shibazaki Y, Kurabayashi M, Hoh E, Takaku F, Yazaki Y (1991) Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes: possible role of protein kinase C activation. J Biol Chem 266: 1265-1268 (Pubitemid 21907253)
46. Komuro I, Yazaki Y (1993) Control of cardiac gene expression by mechanical stress. Ann Rev Physiol 55: 55-75 (Pubitemid 23102123)
47. Komuro I, Yazaki Y (1994) Intracellular signaling pathways in cardiac myocytes induced by mechanical stress. Trends Cardiovasc Med 4: 117-121 (Pubitemid 24206702)
48. Leri A, Claudio PP, Li Q, Wang X, Reiss K, Wang S, Malhotra A, Kajstura J, Anversa P (1998) Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the bcl-2-to-bax ratio in the cell. J Clin Invest 101: 1326-1342 (Pubitemid 28166830)
49. Li P, Chappell MC, Ferrario CM, Brosnihan KB (1997) Angiotensin-(1-7) augments bradykinin-induced vasodilatin by competing with ACE and releasing nitric oxide. Hypertension 29: 394-400 (Pubitemid 27074074)
50. Linz W, Schölkens BA (1992) Role of bradykinin in the cardiac effects of angiotensin-converting enzyme inhibition. J Cardiovasc Pharmacol 20 (suppl 9): S83-S90 (Pubitemid 23002818)
51. Linz W, Schölkens BA, Ganten D (1989) Converting enzyme inhibition specifically prevents the development and induces regression of cardiac hypertrophy in rats. Clin Exp Hypert 11: 1325-1350 (Pubitemid 19228218)
52. Liu YH, Yang XP, Sharov VG, Nass O, Sabbah HN, Peterson E, Carretero OA (1997) Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure: Role of kinins and angiotensin II type 2 receptors. J Clin Invest 99: 1926- 1935 (Pubitemid 27175940)
53. Lopez JJ, Lorell BH, Ingelfinger JR, Weinberg EO, Schunkert H, Diamant D, Tang SS (1994) Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts. Am J Physiol 267: H844-H85
54. MacLellan WR, Schneider MD (1997) Death by design: Programmed cell death in cardiovascular biology and disease. Circ Res 81: 137-144 (Pubitemid 27342480)
55. Maeso R, Navarro-Cid J, Munoz-Garcia R, Rodrigo E, Ruilope LM, Lahera V, Cachofeiro V (1996) Losartan reduces phenylephrine constrictor response in aortic rings from spontaneously hypertensive rats: Role of nitric oxide and angiotensin II type 2 receptors. Hypertension 28: 967-972 (Pubitemid 26415812)
56. Mann DL, Kent RL, Cooper G (1989) Load regulation of the properties of adult feline cardiocytes: Growth induction by cellular deformation. Circ Res 64: 1079-1090 (Pubitemid 19155778)
57. Masaki H, Kurihara T, Yamaki A, Inomata N, Nozawa Y, Mori Y, Murasawa S, Kizima K, Maruyama K, Horiuchi M, Dzau VJ, Takahashi H, Iwasaka T, Inada M, Matsubara H (1998) Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects. J Clin Invest 101: 527-535 (Pubitemid 28084234)
58. McKay RG, Pfeffer MA, Pasternak RC, Markis JE, Come PC, Nakao S, Alderman JD, Ferguson JJ, Safian RD, Grossman W (1986) Left ventricular remodeling after myocardial infarction: a corollary to infarct expansion. Circulation 74: 693-702 (Pubitemid 16007186)
59. Narula J, Haider N, Virmani R, DiSalvo T, Kolodgie FD, Hajjar RJ, Schmidt U, Semigran MJ, Dec W, Khaw BA (1996) Apoptosis in myocytes in end-stage heart failure. N Engl J Med 335: 1182-1189 (Pubitemid 26339772)
60. Narula J, Kharbanda S, Khaw BA (1997) Apoptosis and the heart. Chest 112: 1358- 1362 (Pubitemid 27497871)
61. Olivetti G, Abbi R, Quaini F, Kajstura J, Cheng W, Nitahara JA, Quaini E, DiLoreto C, Beltrami CA, Krajewski S, Reed JC, Anversa P (1997) Apoptosis in the failing human heart. N Engl J Med 336: 1131- 1141
62. Olivetti G, Caspasso JM, Sonnenblick EH, Anversa P (1990) Side-to-side slippage of myocytes participates in ventricular wall remodeling acutely after myocardial infarction in rats. Circ Res 67: 23-34 (Pubitemid 20223724)
63. Olivetti G, Quaini F, Sala R, Lagrasta C, Corradi D, Bonacina E, Gambert SR, Cigola E, Anversa P (1996) Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart. J Mol Cell Cardiol 28: 2005-201 (Pubitemid 26340560)
64. Pfeffer MA, Braunwald E (1990) Ventricular remodeling after myocardial infarction: Experimental observations and clinical implications. Circulation 81: 1161-1172 (Pubitemid 20119612)
65. Pfeffer MA, Braunwald E, Moye LA, Basta L, Brown EJ, Cuddy TE, Davis BR, Geltman EM, Goldman S, Flaker GC, Klein M, Lamas GA, Packer M, Rouleau J, Rouleau JL, Rutherford J, Wertheimer JH, Hawkins CM (1992) Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 327: 669-67
66. Pfeffer MA, Lamas GA, Vanghan DE, Parisi AF, Braunwald E (1988) Effect of captopril on progressive ventricular dilatation after myocardial infarction. N Engl J Med 319: 80-86
67. Pfeffer MA, Pfeffer JM, Steinberg C, Finn P (1985) Survival after an experimental myocardial infarction: beneficial effects of long-term therapy with captopril. Circulation 72: 406-412 (Pubitemid 15019891)
68. Pierzchalski P, Reiss K, Cheng W, Cirielli C, Kajstura J, Nitahara JA, Rizk M, Capogrossi MC, Anversa P (1997) P53 induces myocyte apoptosis via the activation of the renin-angiotensin system. Exp Cell Res 234: 57-65 (Pubitemid 27317902)
69. Pieske B, Kretschmann B, Meyer M, Holubarsch C, Weirich J, Posival H, Minami K, Just H, Hasenfuss G (1995) Alterations in intracellular calcium handling associated with the inverse froce-frequency relation in human dilated cardiomyopathy. Circulation 92: 1169-1178
70. Pitt B, Segal R, Martinez FA, Meurers G, Cowley AJ, Thomas I, Deedwania PC, Ney DE, Snavely DB, Chan PI (1997) Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of losartan in the elderly study, ELITE). Lancet 349: 747-752 (Pubitemid 27122456)
71. Pönicke K, Heinroth-Hoffmann I, Becker K, Brodde OE (1997) Trophic effect of angiotensin II in neonatal rat cardiomyocytes: Role of endothelin-1 and non-myocyte cells. Br J Pharmacol 121: 118-124 (Pubitemid 27192796)
72. Porsti I, Bara AT, Busse R, Hecker M (1994) Release of nitric oxide by angiotensin-( 1-7) from porcine coronary endothelium: implications for a novel angiotensin receptor. Br J Pharmacol 111: 652-654 (Pubitemid 24151646)
73. Püchler K, Nussberger J, Laeis P, Witte PU, Brunner HR (1997) Blood pressure and endocrine effects of single doses of CS- 866, a novel angiotensin II antagonist, in salt-estricted hypertensive patients. J Hypertens 15: 1809-1812 (Pubitemid 28029686)
74. Rossouw JE, Sullivan JM (1997) Does estrogen replacement prevent coronary heart disease? (letters). Circulation 96: 3789-379
75. Rumberger JA, Behrenbeck T, Breen JR, Reed JE, Gersh BJ (1993) Nonparallel changes in global left ventricular chamber volume and muscle mass during the first year after transmural myocardial infarction in human. J Am Coll Cardiol 21: 673-682 (Pubitemid 23076285)
76. Rutherford JD, Pfeffer MA, Flaker GC, Hakman BB, Kowey PR, Miller HS, Moye LA, Rouleau JL, Braunwald E (1993) The salutary effects of captopril on recurrent myocardial infarction: the SAVE trial experience. J Am Coll Cardiol 21: 44A-54A
77. Rutherford JD, Pfeffer MA, Moye LA, Davis BR, Flaker GC, Kowey PR, Lamas GA, Miller HS, Packer M, Rouleau JL, Braunwald E (1994) Effects of captopril on ischemic events after myocardial infarction. Circulation 90: 1731-1738
78. Sadoshima J, Izumo S (1993) Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: Potential involvement of an autocrine/ paracrine mechanism. EMBO J 12: 1681-1692 (Pubitemid 23112823)
79. Sadoshima J, Izumo S (1993) Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts: Acritical role of the AT1 receptor subtype. Circ Res 73: 413-423 (Pubitemid 23238726)
80. Sadoshima J, Izumo S (1993) Signal transduction pathways of angiotensin II induced c-fos gene expression in cardiac myocytes in vitro: roles of phospholipid-derived second messengers. Circ Res 73: 424-438 (Pubitemid 23238727)
81. Sadoshima J, Jahn L, Takahashi T, Kulik TJ, Izumo S (1992) Molecular characterization of the stretch-induced adaptation of cultured cardiac cells: An in vitro model of load-induced cardiac hypertrophy. J Biol Chem 267: 10551-10560
82. Sadoshima J, Takahashi T, Jahn L, Izumo S (1992) Roles of mechano-sensitive ion channels, cytoskeleton, and contractile activity in stretch-induced immediate-early gene expression and hypertrophy of cardiac myocytes. Proc Natl Acad Sci 89: 9905- 9909
83. Sadoshima J, Xu Y, Slayter HS, Izumo S (1993) Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 75: 977-984 (Pubitemid 24014554)
84. Sanbe A, Takeo S (1995) Long-term treatment with angiotensin I-converting enzyme inhibitors attenuate the loss of cardiac badrenoceptor responses in rats with chronic heart failure. Circulation 92: 2666-2675
85. Schieffer B, Wirger A, Meybrunn M, Seitz S, Holtz J, Riede UN, Drexler H (1994) Comparative effects of chronic angiotensin- converting enzyme inhibition and angiotensin type 1 receptor blockade on cardiac remodelin after myocardial infarction in the rat. Circulation 89: 2273-228 (Pubitemid 24142808)
86. Schumann H, Morawietz H, Hakim K, Zerkowski HR, Eschenhagen T, Holtz J, Darmer D (1997) Alternative splicing of the primary Fas transcript generating soluble Fas antagonists is suppressed in the failing human ventricular myocardium. Biochem Biophys Res Comm 239: 794- 798 (Pubitemid 27504181)
87. Seyedi N, Xu X, Nasjletti A, Hintze TH (1995) Coronary kinin generation mediates nitric oxide release after angiotensin receptor stimulation. Hypertension 26: 164-170
88. Siragy HM, Carey RM (1995) The subtype- 2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3',5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats. J Clin Invest 97: 1978-1982
89. Studer R, Reinecke H, Müller B, Holtz J, Just H, Drexler H (1994) Increased angiotensin-I converting enzyme gene expression in the failing human heart: quantification by competitive RNA polymerase chain reaction. J Clin Invest 94: 301-310
90. Tan LB, Jalil JE, Pick R, Janicki JS, Weber KT (1991) Cardiac myocyte necrosis induced by angiotensin II. Circulation 69: 1185-1195
91. Wada H, Zile MR, Ivester CT, Cooper G, McDermott PJ (1996) Comparative effects of contraction and angiotensin II on growth of adult feline cardiocytes in primary culture. Am J Physiol 271: H29-H37
92. Yamada T, Horiuchi M, Dzau VJ (1996) Angiotensin type-2 receptor mediates programmed cell death. Proc Natl Acad Sci 93: 156-160 (Pubitemid 26038119)
93. Yamazaki T, Kobe K, Hoh E, Maemura K, Kaida T, Komuro I, Tanemoto H, Kadowaki T, Nagai R, Yazaki Y(1993) Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes. J Biol Chem 268: 12069-12076 (Pubitemid 23168172)
94. Yamazaki T, Komuro I, Yazaki Y (1995) Molecular mechanism of cardiac cellular hypertrophy by mechanical stress. J Mol Cell Cardiol 27: 133-140
95. Yokoyama T, Nakano M, Bednarczyk JL, McIntyre BW, Entman M, Mann DL (1997) Tumor necrosis factor-a provokes a hypertrophic growth response in adult cardiac myocytes. Circulation 95: 1247-1252 (Pubitemid 27097837)
96. Yusuf S, Pepine CJ, Garces C, Pouleur H, Salem D, Kostis J, Benedict C, Rousseau M, Bourassa M, Pitt B (1992) Effect of enalapril on myocardial and unstable angina in patients with low ejection fraction. Lancet 340: 1173-1178
97. Zhang X, Dostal DE, Reiss K, Cheng W, Kajstura J, Li O, Huang H, Sonnenblick EH, Meggs LG, Baker KM, Anversa P (1995) Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes. Am J Physiol 269: H1791-H1802 (Pubitemid 3005975)
98. Zisman LS, Abraham WT, Meixel GE, Vamvakias BN, Quaife RA, Lowes BD, Roden RL, Peacock SJ, Groves BM, Raynolds MV, Bristow MR, Perryman MB (1995) Angiotensin II formation in the intact human heart: Predominance of the angiotensin converting enzyme pathway. J Clin Invest 95: 1490-1498