The influence of isoprostanes on ADP-induced platelet aggregation and cyclic AMP-generation in human platelets

Thrombosis Research

Volumn 86, Issue 4, 1997, Pages 337-342

  Leitinger, Norbert ^a   Blazek, Ingrid ^a   Sinzinger, Helmut ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cyclic AMP; Isoprostanes; Platelet aggregation

Indexed keywords

ADENOSINE DIPHOSPHATE; CYCLIC AMP; PHOSPHOLIPID; PROSTAGLANDIN F2 ALPHA DERIVATIVE; PROSTAGLANDIN H2; PROSTANOID; THROMBOXANE A2 RECEPTOR;

ADULT; ARTICLE; ATHEROSCLEROSIS; FEMALE; HEPATORENAL SYNDROME; HUMAN; HUMAN EXPERIMENT; INFLAMMATION; KIDNEY CIRCULATION; LIVER ISCHEMIA; LUNG VASOCONSTRICTION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION;

ADENOSINE DIPHOSPHATE; ADULT; BLOOD PLATELETS; CYCLIC AMP; DINOPROST; DINOPROSTONE; DRUG SYNERGISM; EICOSANOIDS; F2-ISOPROSTANES; FEMALE; HUMANS; ISOPROSTANES; MALE; PLATELET AGGREGATION;

EID: 0030742072     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(97)00077-7     Document Type: Article

References (18)

1. 2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical catalyzed mechanism. Proc Natl Acad Sci USA. 87:1990;9383-9387.
2. MORROW J.D., HARRIS T.M., ROBERTS L.J. Non-cyclooxygenase oxidative formation of a series of novel prostaglandins: analytical ramifications for the measurement of eicosanoids. Analyt Biochem. 184:1990;1-10.
3. 2α, in rabbit lung in situ. Am J Physiol. 263:1992;660-663.
4. 2 receptors. J Clin Invest. 90:1992;136-141.
5. 2-isoprostane receptors on rat vascular smooth muscle cells. Am J Physiol. 264:1993;C1619-C1624.
6. 2α, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist. Prostaglandins. 44:1992;155-163.
7. MORROW J.D., MINTON T.A., MUKUNDAN C.R., CAMPBELL M.D., ZACKERT W.E., DANIEL V.C., BADR K.F., BLAIR I.A., ROBERTS L.J. Free radical-induced generation of isoprostanes in vivo. J Biol Chem. 269:1994;4317-4326.
8. 2-isoprostane. Biochem Biophys Res Commun. 195:1993;507-515.
9. 2 on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor. Prostaglandins. 48:1994;247-257.
10. MATHEWS W.R., GUIDO D.M., FISHER M.A., JAESCHKE H. Lipid peroxidation as molecular mechanism of liver cell injury during reperfusion after ischemia. Free Rad Biol Med. 16:1994;763-770.
11. 2-isoprostanes) in the hepatorenal syndrome. J Lipid Mediat. 6:1993;417-420.
12. BORN G.C.R. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature (London). 194:1962;927-929.
13. 2 and aspirin on the secondary aggregation of human platelets. Nature New Biology. 236:1972;45-46.
14. VARGAFTIG B.B., CHIGNARD M. Substances that increase the cyclic AMP content prevent platelet aggregation and the concurrent release of pharmacologically active substances evoked by arachidonic acid. Agents Actions. 5:1975;137-144.
15. SALZMAN E.W., KENSLER P.C., LEVINE L. Cyclic 3′-5′-adenosine monophosphate in human blood platelets. Ann NY Acad Sci. 201:1972;61-71.
16. 2 in regulation of cyclic AMP and aggregation in human platelets: evidence for a common prostaglandin receptor. J Lab Clin Med. 84:1974;111-121.
17. 2-induced human platelet aggregation. Prostaglandins. 24:1982;195-206.
18. NEEDLEMAN P., RAZ A., MINKES M.S., FERRENDELLI J.A., SPRECHER H. Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties. Proc Natl Acad Sci USA. 76:1979;944-948.