Inhibition of human cytochrome P450 1A2 by flavones: A molecular modeling study

Journal of Protein Chemistry

Volumn 17, Issue 7, 1998, Pages 643-650

  Dai, Renke ^a   Zhai, Suoping ^b,c   Wei, Xiaoxiong ^b,c   Pincus, Matthew R ^d,e   Vestal, Robert E ^b,c,f   Friedman, Fred K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Boise VA Medical Center   (United States)

^c IDAHO STATE UNIVERSITY   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e SUNY DOWNSTATE MEDICAL CENTER   (United States)

^f UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Computational chemistry; Cytochrome P450; Flavones; Molecular modeling; Protein folding

Indexed keywords

3,5,7 TRIHYDROXYLFLAVONE; 3,5,7 TRIMETHOXYLFLAVONE; CYTOCHROME P450 ISOENZYME; FLAVONE; FLAVONE DERIVATIVE; METHOXYRESORUFIN; METHOXYRESORUFIN DEMETHYLASE; PHENACETIN O DEETHYLASE; RESORUFIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DEMETHYLATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; LYMPHOBLASTOID CELL; MICROSOME; MOLECULAR MODEL;

EID: 0031730172     PISSN: 02778033     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02780965     Document Type: Article

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