Adjuvant activity of iscoms; effect of ratio and co-incorporation of antigen and adjuvant

Vaccine

Volumn 14, Issue 8, 1996, Pages 753-760

  Bengtsson, Karin Lövgren ^a   Sjölander, Anders ^b  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b NATIONAL VETERINARY INSTITUTE   (Sweden)

Author keywords

Adjuvant formulation; Iscom; Iscom matrix

Indexed keywords

ADJUVANT; GAMMA INTERFERON; INFLUENZA VACCINE; INTERLEUKIN 2; ISCOM; QUIL A; VIRUS ANTIGEN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; INFLUENZA; INFLUENZA VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030175481     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0264-410X(95)00253-W     Document Type: Article

References (27)

1. 1 Morein, B., Sundquist, B., Höglund, S., Dalsgaard, K. and Osterhaus, A. Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses. Nature 1984, 308, 457-460
2. 2 Dalsgaard, K. A study on the isolation and characterization of the saponin Quil A. Evaluation of its adjuvant activity with special reference to the application in foot-and-mouth disease. Acta Vet. Scand. 1978, 69 (Suppl.), 1-40
3. 3 Kersten, G.F.A., Spiekstra, A., Beuvery, E.C. and Crommelin, D.J.A. On the structure of immune-stimulating saponin-lipid complexes (iscoms) BBA 1991, 1062, 165-171
4. 4 Lucy, J.A. and Glauert, A.M. Structure and assembly of macromolecular lipid complexes composed of globular micelles J. Mol. Biol. 1964, 8, 727-748
5. 5 Özel, M., Höglund, S., Gelderblom, H. and Morein, B. Quaternary structure of the immunostimulating complex (ISCOM). J. Ultrastructure Molec. Struct. Res. 1989, 102, 240-248
6. 6 Lövgren, K. and Morein, B. The requirement of lipids for the formation of immunostimulating complexes (iscoms). Biotechnol. Appl. Biochem. 1988, 10, 161-172
7. 7 Morein, B., Lövgren, K., Rönnberg, B., Sjölander, A. and Villacrés-Eriksson, M. Immunostimulating complexes. Clinical potential in vaccine development. Clin. Immunother. Adis International Ltd. 1995, 3, 409-448
8. 8 Bergström-Mollauglu, M., Lövgren, K., Åkerblom, L., Fossum, C. and Morein, B. Antigen-specific increases in the number of splenocytes expressing MHC Class II molecules following restimulation with antigen in various physical forms. Scand. J. Immunol. 1992, 36, 565-574
9. 9 Watson, D., Watson, N., Fossum, C., Lövgren, K. and Morein, B. Interactions between immune-stimulating complexes (ISCOMS) and peritoneal mononuclear leucocytes. Microbiol. Immunol. 1992, 36, 199-203
10. 10 Villacrés-Eriksson, M., Bergström-Mollauglu, M., Kåberg, H., Lövgren, K. and Morein, B. The induction of cell-associated and secreted interleukin-1 by iscoms, matrix or micelles in murine splenic cells. Clin. Exp. Immunol. 1993, 93, 120-125
11. 11 Valensi, J.P., Carlsson, J.R. and Van Nest, G.A. Systemic cytokine profiles in BALB/c mice immunized with trivalent influenza vaccine containing MF59 oil emulsion and other adjuvants. J. Immunol. 1994, 153, 4029-4039
12. 12 Fossum, C., Bergström, M., Lövgren, K., Watson, D.L. and Morein, B. Effect of iscom and/or their adjuvant moiety (matrix) on the initial proliferative and il-2 responses in vitro. Comparison of spleen cells from mice inoculated with iscoms and/or matrix. Cell. Immunol. 1990, 129, 414-425
13. 13 Villacrés-Eriksson, M., Bergström-Mollauglu, M., Kåberg, H. and Morein, B. Involvement of interleukin-2 and interferon-gamma in the immune response induced by influenza virus iscoms. Scand. J. Immunol. 1992, 36, 421-426
14. 14 Jones, P.D., Tha Hla, R., Morein, B., Lövgren, K. and Ada, G.L. Cellular immune responses in the murine lung to local immunization with influenza A virus glycoproteins in micelles and immunostimulating complexes (iscoms). Scand. J. Immunol. 1988, 27, 645-652
15. 15 Takahashi, H., Takeshita, T., Morein, B., Putney, S., Germain, R.N. and Berzofsky, J. Induction of CDS+ cytotoxic T cells by immunization with purified HIV-1 envelope proteins in iscoms. Nature 1990, 344, 873-875
16. 16 Höglund, S., Dalsgaard, K., Lövgren, K., Sundquist, B., Osterhaus, A., Morein, B. and Harris, R.J. Subcellular Biochemistry. 1989, 39-68. Plenum, New York
17. 17 Classen, I. and Osterhaus, A. The iscom structure as an immune enhancing moiety: experiences in viral systems. Res. Immunol. 1992, 143, 531-541
18. 18 Bradford, M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye-binding. Anal. Biochem. 1976, 72, 248-254
19. 19 Lövgren, K., Lindmark, J., Pipkorn, R. and Morein, B. Antigenic presentation of small molecules and synthetic peptides conjugated to a preformed iscom as carrier. J. Immunol. Meth. 1987, 98, 137-143
20. 20 Watson, D.L., Lövgren, K., Watson, N.A., Fossum, C., Morein, B. and Höglund, S. The inflammatory response and antigen localization following immunization with influenza virus iscoms. Inflammation 1989, 13, 641-649
21. 21 Villacrés-Eriksson, M. Induction of immune response by iscoms. Thesis. Swedish University of Agricultrural Sciences, Uppsala Sweden, Uppsala, 1993
22. 22 Verma, J.N., Rao, M., Amselem, S. et al. Adjuvant effects of liposomes containing lipid A: enhancement of liposomal antigen presentation and recruitment of macrophages. Infect. Immun. 1982, 60, 2438-2444
23. 23 Morgan, A., Finerty, S., Lövgren, K., Scullion, F.T. and Morein, B. Prevention of Epstein-Barr (EB) virus-induced lymphoma in cotton top tamarins by vaccination with EB virus envelope glycoprotein gp 340 incorporated into immune-stimulating complexes. J. Gen. Virol. 1988, 69, 2093-2096
24. 24 Vries de, P., Van Binnendijk, R.S., van der Marel, P. et al. Measles virus fusion protein presented in an immune-stimulating complex (iscom) induces haemolysis-inhibiting and fusion-inhibiting antibodies, virus-specific T cells and protection in mice. J. Gen. Virol. 1988, 69, 549-559
25. 25 Fekadu, M., Shaddock, J.H., Ekström, J. et al. An immune stimulating complex (ISCOM) subunit rabies vaccine protects dogs and mice against street rabies challenge. Vaccine 1992, 10, 192-197
26. 26 Lövgren, K. The serum antibody responses distributed in subclasses and isotypes following intranasal and subcutaneous immunization with influenza virus iscoms. Scand. J. Immunol. 1988, 2, 241-245
27. 27 Huang, R., Rott, R. and Klenk, H.-D. Influenza virus cause hemolysis and fusion of cells Virology 1982, 110, 243-247