Correlation between total homocysteine and cyclosporine concentrations in cardiac transplant recipients

Clinical Chemistry

Volumn 44, Issue 11, 1998, Pages 2307-2312

  Cole, David E G ^a,b,c,d   Ross, Heather J ^a,c   Evrovski, Jovan ^a   Langman, Loralie J ^a,c   Miner, Steven E S ^a,c   Daly, Paul A ^a,c   Wong, Pui Yuen ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d NONE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; COBALAMIN; CREATINE; CYCLOSPORIN; FOLIC ACID; HOMOCYSTEINE; METHIONINE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DRUG BLOOD LEVEL; FEMALE; FOLIC ACID BLOOD LEVEL; GLOMERULUS FILTRATION; HEART TRANSPLANTATION; HUMAN; HYPERHOMOCYSTEINEMIA; IMMUNOSUPPRESSIVE TREATMENT; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS;

GLOMERULUS;

EID: 0031729450     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/44.11.2307     Document Type: Article

References (38)

1. Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA 1995;274:1049-57.
2. Miner SES, Evrovski J, Cole DEC. Clinical chemistry and molecular biology of homocysteine metabolism: an update. Clin Biochem 1997;30:189-201.
3. Graham IM, Daly LE, Refsum HM, Robinson K, Brattstrom LE, Ueland PM, et al. Plasma homocysteine as a risk factor for vascular disease: the European concerted action project. JAMA 1997;277:1775-81.
4. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med 1998;338:1042-50.
5. Ubbink JB. The role of vitamins in the pathogenesis and treatment of hyperhomocyst(e)inaemia. J Inherit Metab Dis 1997;20:316-25.
6. Fyfe AI. Transplant atherosclerosis: the clinical syndrome, pathogenesis and possible model of spontaneous atherosclerosis. Can J Cardiovas Dis 1992;8:509-18.
7. Weis M, von Scheldt W. Cardiac allograft vasculopathy: a review. Circulation 1997;96:2069-77.
8. Ambrosi P, Barlatier A, Habib G, Garcon D, Kreitman B, Roland PH, et al. Hyperhomocysteinaemia in heart transplant recipients. Eur Heart J 1994;15:1191-5.
9. Berger PB, Jones JD, Olson LJ, Edwards BS, Frantz RP, Rodeheffer RJ, et al. Increase in total plasma homocysteine concentration after cardiac transplantation. Mayo Clin Proc 1995;70:125-31.
10. Gupta A, Moustapha A, Jacobsen DW, Goormastic M, Tuzcu EM, Hobbs R, et al. High homocysteine, low folate, and low vitamin B6 concentrations: prevalent risk factors for vascular disease in heart transplant recipients. Transplantation 1998;65:544-50.
11. Arnadottir M, Hultberg B, Vladov V, Nilsson-Ehle P, Thysell H. Hyperhomocysteinemia in cyclosporin-treated renal transplant recipients. Transplantation 1996;61:509-12.
12. Lussier-Cacan S, Xhignesse M, Piolot A, Selhub J, Davignon J. Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits. Am J Clin Nutr 1996;64:587-93.
13. Evrovski J, Callaghan M, Cole DEC. Determination of homocysteine by HPLC with pulsed integrated amperometry. Clin Chem 1995;41:757-8.
14. Cole DEC, Lehotay DC, Evrovski J. Simplified simultaneous assay of total homocysteine and methionine by HPLC and pulsed integrated amperometry. Clin Chem 1998;44:188-90.
15. 125I tracer. Clin Biochem 1991;24:43-8.
16. 125l-lncstar assays. Transplant Proc 1990;22:1166-70.
17. Ueland PM, Refsum H, Stabler SP, Malinow MR, Andersson A, Allen RH. Total homocysteine in plasma or serum: methods and clinical applications [Review]. Clin Chem 1993;39:1764-79.
18. Lewis CA, Pancharuniti N, Sauberlich HE. Plasma folate adequacy as determined by homocysteine level. Ann N Y Acad Sci 1992; 669:360-2.
19. Chadefaux B, Cooper BA, Gilfix BM, Lue-Shing H, Carson W, Gavsie A, Rosenblatt DS. Homocysteine: relationship to serum cobalamin, serum folate, erythrocyte folate, and lobation of neutrophils. Clin Investig Med 1994;17:540-50.
20. Tucker KL, Selhub J, Wilson PWF, Rosenberg IH. Dietary intake pattern relates to plasma folate and homocysteine concentrations in the Framingham heart study. J Nutr 1996;126:3025-31.
21. Malinow MR, Nieto FJ, Kruger WD, Szklo M, Chambless LE, Bond G. The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes. Arterioscler Thromb Vase Biol 1997;17:1157-62.
22. Gunter EW, Bowman BA, Caudill SP, Twite DB, Adams MJ, Sampson EJ. Results of an international round robin for serum and whole-blood folate. Clin Chem 1996;42:1689-94.
23. Bostom AG, Lathrop L. Hyperhomocysteinemia in end-stage renal disease: prevalence, etiology, and potential relationship to arteriosclerotic outcomes. Kidney Int 1997;52:10-20.
24. Miller LW. Long-term complications of cardiac transplantation. Prog Cardiovasc Dis 1991;33:229-82.
25. Hess ML, Hastillo A, Mohanokumar T, Cowley MJ, Vetrovac G, Szentpetery S, et al. Accelerated atherosclerosis in cardiac transplantation: role of cytotoxic B-cell antibodies and hyperlipidemia. Circulation 1983;68(Suppl 11):94-101.
26. Kobashigawa JA, Katznelson S, Laks H, Johnson JA, Yeatman L, Wang XM, et al. Effect of pravastatin on outcomes after cardiac transplantation. N Engl J Med 1995;333:621-7.
27. Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997;337:230-6.
28. Wilcken DEL, Gupta VJ, Betts AK. Homocysteine in the plasma of renal transplant recipients: effects of cofactors for methionine metabolism. Clin Sci 1981;61:743-9.
29. Massy ZA, Chadefaux-Vekemans B, Chevalier A, Bader CA, Drueke TB, Legendre C, et al. Hyperhomocysteinemia: a significant risk factor for cardiovascular disease in renal transplant recipients. Nephrol Dial Transplant 1994;9:1103-8.
30. Bostom AG, Goh RY, Tsai MY, Hopkins-Garcia BJ, Nadeau MR, Bianchi LA, et al. Excess prevalence of fasting and postmethionine-loading hyperhomocysteinemia in stable renal transplant recipients. Arterioscler Thromb Vase Biol 1997;17:1894-900.
31. Ducloux D, Fournier V, Rebibou JM, Bresson-Vautrin C, Gibey R, Chalopin JM. Hyperhomocyst(e)inemia in renal transplant recipients with and without cyclosporine. Clin Nephrol 1998;49:232-5.
32. Ueland PM, Refsum H. Plasma levels in health, disease, and drug therapy. J Lab Clin Med 1989;114:473-501.
33. McNally PG, Feehally J. Pathophysiology of cyclosporin A nephrotoxicity: experimental and clinical observations. Nephrol Dial Transplant 1992;7:791-804.
34. Chung G, Walker S, Vadher B, Murphy F, Leaver N, Banner N. Effect of Sandimmune cyclosporine on renal blood flow and function in heart transplant recipients. Transplant Proc 1998;30: 1147-8.
35. Bostom A, Brosnan JT, Hall B, Nadeau MR, Selhub J. Net uptake of plasma homocysteine by the rat kidney in vivo. Atherosclerosis 1995;116:59-62.
36. House JD, Brosnan ME, Brosnan JT. Characterization of homocysteine metabolism in the rat kidney. Biochem J 1997;328:287-92.
37. Guttormsen AB, Ueland PM, Svarstad E, Refsum H. Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure. Kidney Int 1997;52:495-502.
38. Miner SES, Ross HJ, Langman LJ, Verma A, Evrovski J, Wong BYL, et al. Total plasma homocysteine concentrations are strongly correlated with whole blood cyclosporine levels and angiographic coronary artery disease in heart transplant patients [Abstract]. Transplantation 1998;9(Suppl 1):103.