Transfer of PCBs via lactation simultaneously induces the expression of P450 isoenzymes and the protooncogenes c-Ha-ras and c-raf in neonates

Biochemical Pharmacology

Volumn 51, Issue 4, 1996, Pages 517-529

  Borlak, J T ^a,d   Scott, A ^b   Henderson, C J ^b   Jenke, H J ^c   Wolf, C R ^b  

^a UNIVERSITY OF READING   (United Kingdom)

^b NINEWELLS HOSPITAL   (United Kingdom)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d Solvay Pharmaceuticals GmbH   (Germany)

Author keywords

CYP450 induction; lactation; neonates; PCBs; protooncogenes; toxicity

Indexed keywords

AMINOPYRINE N DEMETHYLASE; AROCLOR 1254; CYTOCHROME B5; CYTOCHROME P450 ISOENZYME; DIMETHYLNITROSAMINE; DRUG METABOLIZING ENZYME; EPOXIDE HYDROLASE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; LIVER ENZYME; MESSENGER RNA; POLYCHLORINATED BIPHENYL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOT HYBRIDIZATION; DRUG METABOLISM; ENZYME INDUCTION; FEMALE; IMMUNOBLOTTING; LACTATION; LIVER; MOTHER; NEWBORN; NONHUMAN; NORTHERN BLOTTING; ONCOGENE C H RAS; PRIORITY JOURNAL; PROTO ONCOGENE; RAT; XENOBIOTIC METABOLISM;

EID: 0030030676     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)02228-7     Document Type: Article

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