Impact of mixed-backbone oligonucleotides on target binding affinity and target cleaving specificity and selectivity by Escherichia coli RNase H

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 10, 1998, Pages 1695-1705

  Shen, Ling X ^a,b   Kandimalla, Ekambar R ^b   Agrawal, Sudhir ^b  

^a Variagenics   (United States)

^b HYBRIDON INC   (United States)

Author keywords

2' O Me RNA; Antisense; Mixed backbone oligonucleotides; Point mutations; RNase H cleavage specificity

Indexed keywords

OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; RIBONUCLEASE H;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME SPECIFICITY; ESCHERICHIA COLI; NUCLEOTIDE METABOLISM; POINT MUTATION; PROTEIN DNA BINDING; ULTRAVIOLET SPECTROSCOPY;

BINDING SITES; DENSITOMETRY; DNA; ESCHERICHIA COLI; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; OLIGONUCLEOTIDES; RIBONUCLEASE H, CALF THYMUS; RNA; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIOPHOSPHORIC ACID ESTERS;

EID: 0031727487     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00131-X     Document Type: Article

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