메뉴 건너뛰기




Volumn 45, Issue 2, 1997, Pages 44-49

Effects of Meloxicam and Indomethacin on Cyclooxygenase Pathways in Healthy Volunteers

Author keywords

Cyclooxygenase isoenzymes; Indomethacin; Meloxicam; Platelet aggregation; Prostanoid formation

Indexed keywords

7 HYDROXY 5,11 DIOXOTETRANORPROSTANE 1,16 DIOIC ACID; 7-HYDROXY-5,11-DIOXOTETRANORPROSTANE-1,16-DIOIC ACID; INDOMETACIN; MELOXICAM; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; THIAZINE DERIVATIVE; THIAZOLE DERIVATIVE; THROMBOXANE B2;

EID: 0031063550     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (69)

References (33)
  • 1
    • 0025754779 scopus 로고
    • Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNa splicing
    • Xie W, Chipman JG, Robertson DL, Erikson RL, Simmons DL. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing Proc Natl Acad Sci USA 1991;88:2692-6.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 2692-2696
    • Xie, W.1    Chipman, J.G.2    Robertson, D.L.3    Erikson, R.L.4    Simmons, D.L.5
  • 2
    • 0025871150 scopus 로고
    • TIS10, a phorbol ester tumor promoter-inducible mRNa from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
    • Kujubu DA, Fletcher BS, Varnum CR, Lim W, Herschman H. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem 1991;266:12866-72.
    • (1991) J Biol Chem , vol.266 , pp. 12866-12872
    • Kujubu, D.A.1    Fletcher, B.S.2    Varnum, C.R.3    Lim, W.4    Herschman, H.5
  • 3
    • 0028926813 scopus 로고
    • New insights into the mode of action of anti-inflammatory drugs
    • Vane JR, Botting RM. New insights into the mode of action of anti-inflammatory drugs. Inflamm Res 1995;44:1-9.
    • (1995) Inflamm Res , vol.44 , pp. 1-9
    • Vane, J.R.1    Botting, R.M.2
  • 4
    • 0028791313 scopus 로고
    • Prostaglandin endoperoxide synthetase isoenzymes: The clinical relevance of selective inhibition
    • Frölich JC. Prostaglandin endoperoxide synthetase isoenzymes: the clinical relevance of selective inhibition. Ann Rheum Dis 1995;54:942-3.
    • (1995) Ann Rheum Dis , vol.54 , pp. 942-943
    • Frölich, J.C.1
  • 5
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
    • Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature: New Biology 1971;231:232-5.
    • (1971) Nature: New Biology , vol.231 , pp. 232-235
    • Vane, J.R.1
  • 6
    • 0015237275 scopus 로고
    • Aspirin selectively inhibits prostaglandin production in human platelets
    • Smith JB, Willis AL. Aspirin selectively inhibits prostaglandin production in human platelets. Nature: New Biology 1971;231:235-7.
    • (1971) Nature: New Biology , vol.231 , pp. 235-237
    • Smith, J.B.1    Willis, A.L.2
  • 7
    • 0028044609 scopus 로고
    • Towards a better aspirin
    • Vane JR. Towards a better aspirin. Nature 1994;367:215-6.
    • (1994) Nature , vol.367 , pp. 215-216
    • Vane, J.R.1
  • 8
    • 0027480087 scopus 로고
    • Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other nonsteroidal anti-inflammatory drugs
    • Meade EA, Smith WL, DeWitt DL. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other nonsteroidal anti-inflammatory drugs. J Biol Chem 1993;268:6610-4.
    • (1993) J Biol Chem , vol.268 , pp. 6610-6614
    • Meade, E.A.1    Smith, W.L.2    DeWitt, D.L.3
  • 9
    • 0002827472 scopus 로고    scopus 로고
    • Differential inhibition of COX-1 and COX-2 in vitro and pharmacological profile in vivo of NSAIDs
    • Vane JR, Botting JH, Botting RM, eds. Dordrecht: Kluwer Academic Publishers, William Harvey Press
    • Pairet M, Engelhardt G. Differential inhibition of COX-1 and COX-2 in vitro and pharmacological profile in vivo of NSAIDs. In: Vane JR, Botting JH, Botting RM, eds. Improved nonsteroid anti-inflammatory drugs: COX-2 enzyme inhibitors. Dordrecht: Kluwer Academic Publishers, William Harvey Press, 1996:103-19.
    • (1996) Improved Nonsteroid Anti-inflammatory Drugs: COX-2 Enzyme Inhibitors , pp. 103-119
    • Pairet, M.1    Engelhardt, G.2
  • 10
    • 0030030129 scopus 로고    scopus 로고
    • Meloxicam: Influence on arachidonic acid metabolism. in vitro and in vivo findings
    • Engelhardt G, Bögel R, Schnitzer C, Utzmann R. Meloxicam: influence on arachidonic acid metabolism. In vitro and in vivo findings. Biochem Pharmacol 1996;51(pt. 1):21-8.
    • (1996) Biochem Pharmacol , vol.51 , Issue.1 PT , pp. 21-28
    • Engelhardt, G.1    Bögel, R.2    Schnitzer, C.3    Utzmann, R.4
  • 11
    • 0030061289 scopus 로고    scopus 로고
    • Meloxicam: Influence on arachidonic metabolism. in vitro and in vivo findings
    • Engelhardt G, Bögel R, Schnitzer C, Utzmann R. Meloxicam: influence on arachidonic metabolism. In vitro and in vivo findings. Biochem Pharmacol 1996;51(pt. 2):29-38.
    • (1996) Biochem Pharmacol , vol.51 , Issue.2 PT , pp. 29-38
    • Engelhardt, G.1    Bögel, R.2    Schnitzer, C.3    Utzmann, R.4
  • 12
    • 0025909387 scopus 로고
    • Human platelet/erythroleukemia cell prostaglandin G/H synthase: CDNA cloning, expression, and gene chromosomal assignment
    • Funk CD, Funk LB, Kennedy ME, Pong AS, Fitzgerald GA. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J 1991;5:2304-12.
    • (1991) FASEB J , vol.5 , pp. 2304-2312
    • Funk, C.D.1    Funk, L.B.2    Kennedy, M.E.3    Pong, A.S.4    Fitzgerald, G.A.5
  • 14
    • 0016918043 scopus 로고
    • Quantification of the major urinary metabolite of the E-prostaglandins by mass spectrometry: Evaluation of the method's application to clinical studies
    • Seyberth HW, Sweetman BJ, Frölich JC, Oates JA. Quantification of the major urinary metabolite of the E-prostaglandins by mass spectrometry: evaluation of the method's application to clinical studies. Prostaglandins 1976;11:381-97.
    • (1976) Prostaglandins , vol.11 , pp. 381-397
    • Seyberth, H.W.1    Sweetman, B.J.2    Frölich, J.C.3    Oates, J.A.4
  • 16
    • 0023506180 scopus 로고
    • Stable isotope dilution assay for prostaglandin e metabolite: 24-hour urinary output in healthy male subjects
    • Ferretti A, Flanagan VP, Reeves VB. Stable isotope dilution assay for prostaglandin E metabolite: 24-hour urinary output in healthy male subjects. Anal Biochem 1987;167:174-80.
    • (1987) Anal Biochem , vol.167 , pp. 174-180
    • Ferretti, A.1    Flanagan, V.P.2    Reeves, V.B.3
  • 17
    • 0029868836 scopus 로고    scopus 로고
    • Meloxicam in osteoarthritis: A 6-month, double-blind comparison with diclofenac sodium
    • Hosie J, Distel M, Bluhmki E. Meloxicam in osteoarthritis: a 6-month, double-blind comparison with diclofenac sodium. Br J Rheumatol 1996;35(1 Suppl):39-43.
    • (1996) Br J Rheumatol , vol.35 , Issue.1 SUPPL. , pp. 39-43
    • Hosie, J.1    Distel, M.2    Bluhmki, E.3
  • 18
    • 0347932470 scopus 로고
    • A double-blind, randomised trial comparing meloxicam with diclofenac in osteoarthritis (OA)
    • Goei Thé H, Lund B, Bluhmki E. A double-blind, randomised trial comparing meloxicam with diclofenac in osteoarthritis (OA). Rheumatology in Europe 1995:24(3 Suppl):E51.
    • (1995) Rheumatology in Europe , vol.24 , Issue.3 SUPPL.
    • Goei Thé, H.1    Lund, B.2    Bluhmki, E.3
  • 21
    • 0027213379 scopus 로고
    • Rapid and selective inhibition of platelet aggregation and thromboxane formation by intravenous low-dose aspirin in man
    • Colch
    • Böger RH, Bode-Böger SM, Gutzki F-M, Tsikas D, Weskott H-P, Frölich JC. Rapid and selective inhibition of platelet aggregation and thromboxane formation by intravenous low-dose aspirin in man. Clin Sci (Colch) 1993;84:517-24.
    • (1993) Clin Sci , vol.84 , pp. 517-524
    • Böger, R.H.1    Bode-Böger, S.M.2    Gutzki, F.-M.3    Tsikas, D.4    Weskott, H.-P.5    Frölich, J.C.6
  • 22
    • 0027941447 scopus 로고
    • Impaired degradation of prostaglandins and thromboxane in Zellweger syndrome
    • Fauler J, Tsikas D, Mayatepek E, Keppler D, Frölich JC. Impaired degradation of prostaglandins and thromboxane in Zellweger syndrome. Pediatr Res 1994;36:449-55.
    • (1994) Pediatr Res , vol.36 , pp. 449-455
    • Fauler, J.1    Tsikas, D.2    Mayatepek, E.3    Keppler, D.4    Frölich, J.C.5
  • 23
    • 0028795025 scopus 로고
    • Nonsteroidal anti-inflammatory drugs and the gastrointestinal tract
    • Lichtenstein DR, Syngal S, Wolfe M. Nonsteroidal anti-inflammatory drugs and the gastrointestinal tract. Arthritis Rheum 1995;38:5-18.
    • (1995) Arthritis Rheum , vol.38 , pp. 5-18
    • Lichtenstein, D.R.1    Syngal, S.2    Wolfe, M.3
  • 24
    • 0029979358 scopus 로고    scopus 로고
    • Safety of meloxicam: A global analysis of clinical trials
    • Distel M, Mueller C, Bluhmki E, Fries J. Safety of meloxicam: a global analysis of clinical trials. Br J Rheumatol 1996;35(1 Suppl):68-77.
    • (1996) Br J Rheumatol , vol.35 , Issue.1 SUPPL. , pp. 68-77
    • Distel, M.1    Mueller, C.2    Bluhmki, E.3    Fries, J.4
  • 26
    • 0025319265 scopus 로고
    • Renal effects of ibuprofen, piroxicam, and sulindac in patients with asymptomatic renal failure
    • Whelton A, Stout RL, Spilman PS, Klassen DK. Renal effects of ibuprofen, piroxicam, and sulindac in patients with asymptomatic renal failure. Ann Intern Med 1990;112:568-76.
    • (1990) Ann Intern Med , vol.112 , pp. 568-576
    • Whelton, A.1    Stout, R.L.2    Spilman, P.S.3    Klassen, D.K.4
  • 27
    • 0019485592 scopus 로고
    • Participation of prostaglandins in the control of renal blood flow during acute reduction of cardiac output in the dog
    • Oliver JA, Sciacca RR, Pinto J, Cannon JA. Participation of prostaglandins in the control of renal blood flow during acute reduction of cardiac output in the dog. J Clin Invest 1981;67:229-37.
    • (1981) J Clin Invest , vol.67 , pp. 229-237
    • Oliver, J.A.1    Sciacca, R.R.2    Pinto, J.3    Cannon, J.A.4
  • 28
    • 0022526881 scopus 로고
    • Role of renal prostaglandins and the effects of non-steroidal anti-inflammatory drugs in patients with liver disease
    • Zipser RD. Role of renal prostaglandins and the effects of non-steroidal anti-inflammatory drugs in patients with liver disease. Am J Med 1986;81(26 Suppl):95-103.
    • (1986) Am J Med , vol.81 , Issue.26 SUPPL. , pp. 95-103
    • Zipser, R.D.1
  • 29
    • 0029932265 scopus 로고    scopus 로고
    • An open study to assess the safety and tolerability of meloxicam 15 mg in subjects with rheumatic disease and mild renal impairment
    • Bevis PJR, Bird HA, Lapham G. An open study to assess the safety and tolerability of meloxicam 15 mg in subjects with rheumatic disease and mild renal impairment. Br J Rheumatol 1996;35(1 Suppl):56-60.
    • (1996) Br J Rheumatol , vol.35 , Issue.1 SUPPL. , pp. 56-60
    • Bevis, P.J.R.1    Bird, H.A.2    Lapham, G.3
  • 30
    • 0027293391 scopus 로고
    • Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues
    • O'Neill GP, Ford-Hutchinson AW. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett 1993;330:156-60.
    • (1993) FEBS Lett , vol.330 , pp. 156-160
    • O'Neill, G.P.1    Ford-Hutchinson, A.W.2
  • 31
    • 0029870733 scopus 로고    scopus 로고
    • A double-blind, three-week study to compare the efficacy and safety of meloxicam 7.5 mg and meloxicam 15 mg in patients with rheumatoid arthritis
    • Reginster JY, Distel M, Bluhmki E. A double-blind, three-week study to compare the efficacy and safety of meloxicam 7.5 mg and meloxicam 15 mg in patients with rheumatoid arthritis. Br J Rheumatol 1996;35(1 Suppl):17-21.
    • (1996) Br J Rheumatol , vol.35 , Issue.1 SUPPL. , pp. 17-21
    • Reginster, J.Y.1    Distel, M.2    Bluhmki, E.3
  • 32
    • 0001692905 scopus 로고
    • Efficacy and tolerance of meloxicam, a new NSAID, in daily oral doses of 15, 30, and 60 mg in comparison to 20 mg piroxicam in patients with rheumatoid arthritis
    • Huskisson EC, Narjes H, Bluhmki E. Efficacy and tolerance of meloxicam, a new NSAID, in daily oral doses of 15, 30, and 60 mg in comparison to 20 mg piroxicam in patients with rheumatoid arthritis. Scand J Rheumatol 1994;98(Suppl):A115.
    • (1994) Scand J Rheumatol , vol.98 , Issue.SUPPL.
    • Huskisson, E.C.1    Narjes, H.2    Bluhmki, E.3
  • 33
    • 0029865433 scopus 로고    scopus 로고
    • A six-month, double-blind trial to compare the efficacy and safety of meloxicam 7.5 mg daily and naproxen 750 mg daily in patients with rheumatoid arthritis
    • Wojtulewski JA, Schattenkirchner M, Barceló P, Le Loet X, Bevis PJR, Bluhmki E, Distel M. A six-month, double-blind trial to compare the efficacy and safety of meloxicam 7.5 mg daily and naproxen 750 mg daily in patients with rheumatoid arthritis. Brit J Rheumatol 1996;35(1 Suppl):22-8.
    • (1996) Brit J Rheumatol , vol.35 , Issue.1 SUPPL. , pp. 22-28
    • Wojtulewski, J.A.1    Schattenkirchner, M.2    Barceló, P.3    Le Loet, X.4    Bevis, P.J.R.5    Bluhmki, E.6    Distel, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.