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Kakkanaiah VN, Shen GQ, Ojo-Amaize EA, Peter JB: Association of low concentrations of serum mannose-binding protein with recurrent infections in adults. Clin Diagnost Lab Immunol 1998, 5:319-321. Adults and children with recurrent infection were evaluated for low MBP levels. Low MBP serum levels were found in 22% of the pediatric patients and 38% of the adult patients compared with 4% of the controls.
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Clin Diagnost Lab Immunol
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Kakkanaiah, V.N.1
Shen, G.Q.2
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Peter, J.B.4
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40
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Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin
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Garred P, Madsen HO, Balslev U, Hofmann B, Pedersen C, Gerstoft J, Svejgaard A: Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin. Lancet 1997, 349:236-240.
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Lancet
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Garred, P.1
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Hofmann, B.4
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Gerstoft, J.6
Svejgaard, A.7
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41
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Requirement for the alternative pathway as well as C4 and C2 in complement-dependent hemolysis via the lectin pathway
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Suankratay C, Zhang X-H, Zhang Y, Lint TF, Gewurz H: Requirement for the alternative pathway as well as C4 and C2 in complement-dependent hemolysis via the lectin pathway. J Immunol 1998, 160:3006-3013.
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Suankratay, C.1
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Gewurz, H.5
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42
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0031008871
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Acquired C3 deficiency in patients with alcoholic cirrhosis predisposes to infection and increased mortality
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Homann C, Varming K, Hogasen K, Molines TE, Graudal N, Thomsen AC, Garred P: Acquired C3 deficiency in patients with alcoholic cirrhosis predisposes to infection and increased mortality. Gut 1997, 40:544-549.
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Gut
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Homann, C.1
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Thomsen, A.C.6
Garred, P.7
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43
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Antibodies to C1q in systemic lupus erythematosus: Characteristics and relation to Fc gamma RIIA alleles
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Hasely LA, Wisnieski JJ, Denburg MR, Michael-Frossman AR, Ginzler EM, Gourley MF, Hoffman JH, Kimberly RP, Salmon JE: Antibodies to C1q in systemic lupus erythematosus: characteristics and relation to Fc gamma RIIA alleles. Kidney Int 1997, 52:1375-1380. This important study evaluates antibodies to C1q as disease markers in SLE. Antibodies to C1q were highly associated with renal disease and titers correlated with treatment response. Inheritance of a low binding allele of FcγRIIAFN1AU: pls verify term; can it be spelled out? appeared to be a risk factor for developing antibodies to C1q.
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Kidney Int
, vol.52
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Hasely, L.A.1
Wisnieski, J.J.2
Denburg, M.R.3
Michael-Frossman, A.R.4
Ginzler, E.M.5
Gourley, M.F.6
Hoffman, J.H.7
Kimberly, R.P.8
Salmon, J.E.9
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44
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0030978867
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IgG autoantibodies to complement C1q in pediatric-onset systemic lupus erythematosus
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Ravelli A, Wisnieski JJ, Ramenghi B, Ballardini G, Zonta L, and Martini A: IgG autoantibodies to complement C1q in pediatric-onset systemic lupus erythematosus. Clin Exp Rheumatol 1997, 15:215-219.
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Clin Exp Rheumatol
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Ravelli, A.1
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Ramenghi, B.3
Ballardini, G.4
Zonta, L.5
Martini, A.6
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45
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In vitro stimulation of C1s proteolytic activities by C1s-presenting autoantibodies from patients with systemic lupus erythematosus
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He S, and Lin Y-L: In vitro stimulation of C1s proteolytic activities by C1s-presenting autoantibodies from patients with systemic lupus erythematosus. J Immunol 1998, 160:4641-4647. A new autoantibody in SLE is described, in which antibodies to C1s enhance cleavage of C4. The antibodies both stimulate C s activity and enhance conversion of latent C1s to active C1s. Overactivation of complement is hypothesized to induce tissue damage and lead to presentation of self antigens to B cells.
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J Immunol
, vol.160
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He, S.1
Lin, Y.-L.2
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46
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Hypocomplementemia caused by C3 nephritic factors (C3 NeF): Clinical findings and the coincidence of C3 NeF type II with anti-C1q antibodies
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Skattum L, Martensson U, Sjoholm AG: Hypocomplementemia caused by C3 nephritic factors (C3 NeF): clinical findings and the coincidence of C3 NeF type II with anti-C1q antibodies. J Int Med 1997, 242:455-464. This study emphasizes the heterogeneous clinical manifestations of C3 nephritic factors. Six of the patients with C3 nephritic factors also had antibodies to C1q. Membranoproliferative glomerulonephritis, partial lipodystrophy, Schönlein-Henoch purpura, SLE, and infection were seen in this population.
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(1997)
J Int Med
, vol.242
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Skattum, L.1
Martensson, U.2
Sjoholm, A.G.3
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47
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Homozygous C1q deficiency: A cause of systemic lupus erythematosus in humans and mice
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Botto M, Dell'Agnola C, Pandolfi PP, Bygrave A, Thompson M, Petry F, Loos M, Walport MJ: Homozygous C1q deficiency: a cause of systemic lupus erythematosus in humans and mice. Arthritis Rheum 1997, 40(suppl):S122.
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Arthritis Rheum
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Botto, M.1
Dell'Agnola, C.2
Pandolfi, P.P.3
Bygrave, A.4
Thompson, M.5
Petry, F.6
Loos, M.7
Walport, M.J.8
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48
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0031202759
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Mouse complement receptors type I (CR1;CD35) and type 2 (CR2;CD21)? expression on normal B cell populations and decreased levels during the development of autoimmunity in MRL/1 pr mice
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Takahashi K, Kozono Y, Waldschmidt TJ, Berthiaume D, Quigg RJ, Baron A, Holers VM: Mouse complement receptors type I (CR1;CD35) and type 2 (CR2;CD21)? expression on normal B cell populations and decreased levels during the development of autoimmunity in MRL/1 pr mice. J Immunol 1997, 159:1557-1569. Expression of CR1 and CR2 is decreased in human patients with SLE This study identified a similar phenomenon in a well-studied murine SLE model. The decrease in CR1/2 receptors preceeded clinical disease, suggesting that it may be part of the pathologic process.
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(1997)
J Immunol
, vol.159
, pp. 1557-1569
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Takahashi, K.1
Kozono, Y.2
Waldschmidt, T.J.3
Berthiaume, D.4
Quigg, R.J.5
Baron, A.6
Holers, V.M.7
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