In vitro stimulation of C1s proteolytic activities by C1s-presenting autoantibodies from patients with systemic lupus erythematosus

Journal of Immunology

Volumn 160, Issue 9, 1998, Pages 4641-4647

  He, Shiping ^a,c   Lin, Ya Ling ^b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN LIGHT CHAIN; MYOSIN HEAVY CHAIN;

ADULT; ANTIGEN PRESENTATION; ARTICLE; CATALYSIS; CLINICAL ARTICLE; DENSITOMETRY; ENZYME ACTIVITY; FEMALE; HUMAN; HYDROLYSIS; IMMUNOBLOTTING; IMMUNOSTIMULATION; MALE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SYSTEMIC LUPUS ERYTHEMATOSUS; TISSUE INJURY;

ANTIGEN-ANTIBODY COMPLEX; AUTOANTIBODIES; COMPLEMENT C1S; COMPLEMENT C4; COMPLEMENT INACTIVATOR PROTEINS; ENZYME ACTIVATION; HUMANS; IMMUNOGLOBULIN G; LUPUS ERYTHEMATOSUS, SYSTEMIC;

EID: 0032080624     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Budman, D. R., E. B. Merchant, A. D. Steinberg, B. Doft, M. E. Gershwin, E. Lizzio and J. P. Reeves. 1977. Increase spontaneous activity of antibody-forming cells in the peripheral blood of patients with active SLE. Arthritis Rheum. 20:829.
2. Fauci, A. S., A. D. Steinberg, B. F. Haynes and G. Whalen. 1987. Immuno-regulatory aberration in systemic lupus erythematosus. J. Immunol. 121:1473.
3. Bresnihan, B., and H. E. Jasin. 1977. Suppressor function of peripheral blood mononuclear cells in normal individuals and in patients with systemic lupus erythematosus. J. Clin. Invest. 59:106.
4. Steinberg, A. D., H. R. Smith, C. A. Laskin, B. J. Steinberg, and J. S. Smolen. 1983. Studies of immune abnormalities in systemic lupus erythematosus. In Advances in Systemic Lupus Erythematosus. J. P. Hayslet and J. A. Hardin, eds. Grune & Stratton, New York, pp. 5-14.
5. Tan, E. M., P. H. Schur, and R. I. Carr. 1966. Deoxyribonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus. J. Clin. Invest. 45:1732.
6. Schwartz, R. S., and B. D. Stollar. 1985. Origins of anti-DNA autoantibodies. J. Clin. Invest. 75:721.
7. Emlen, W., and M. Mannik. 1986. Clearance of circulating DNA-anti-DNA immune complexes in mice. J. Exp. Med. 155:1210.
8. Zouali, M., B. D. Stollar, and R. S. Schwartz. 1988. Origin and diversification of anti-DNA antibodies. Immunol. Rev. 105:137.
9. Robbins, W. C., H. R. Holman, H. R. Diecher, and H. G. Kunkel. 1957. Complement fixation with cell nuclei and DNA in lupus erythematosus. Proc. Soc. Exp. Biol. Med. 96:564.
10. Seligman, M. 1957. Mise en evidence dans le serum de malades atteints de lupus erythemateux dissemine d'une substance determinant une reaction de precipitation avec lacide desoxyribonucleique. C. R. Acad. Sci. 245:243.
11. Diecher, H. R., H. R. Holman, and H. G. Kunkel. 1959. The precipitating reaction between DNA and serum factor in systemic lupus erythematosus. J. Exp. Med. 109:97.
12. Barbu, E., M. Seligman, and M. Joly. 1960. Reactions entre des acides desoxyribonucleiques diversement denatures ou degrades et les anticorps antiacide desoxyribonucleique du serum de malades atteints de lupus erythemateux dissemine. Ann. Inst. Pasteur (Paris) 99:695.
13. Stollar, B. D., L. Levine, and J. Marmur. 1962. Antibodies to denatured DNA in lupus erythematosus serum. II. Characterization of antibodies in several sera. Biochem. Biophvs. Acta 61:7.
14. Schur, P. H., and N. Monroe. 1969. Antibodies to ribonucleic acid in systemic lupus erythematosus. Proc. Nat. Acad. Sci. USA 63:1108.
15. Koffler, D., R. I. Carr, V. Agnello, T. Feizi, and H. G. Kunkel. 1969. Antibodies to polynucleotides: distribution in human serums. Science 166:1648.
16. Steinberg, A. D., S. Baron, and N. Talal. 1969. The pathogenesis of autoimmunity in New Zealand mice. I. Induction of anti-nucleic acid autoantibodies by polyinosinic polycytidylic acid. Proc. Nat. Acad. Sci. USA 63:1102.
17. Lerner, M. R., and J. A. Steitz. 1979. Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus. Proc. Nat. Acad. Sci. USA 76:5405.
18. Lerner, M. R., J. A. Boyle, J. A. Hardin, and J. A. Steitz. 1981. Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus. Science 211:400.
19. Tan, E. M. 1967. Relationships of nuclear staining patterns with precipitating antibodies in systemic lupus erythematosus. J. Lab. Clin. Med. 70:800.
20. Holman, H. R. 1965. Partial purification and characterization of an extractible nuclear antigen which reacts with SLE sera. Ann. NY Acad. Sci. 124:800.
21. Clark, G., M. Reichlin, and T. B. Tomasi. 1968. Characterization of a soluble cytoplasmic antigen reactive with sera from patients with systemic lupus erythematosus. J. Immunol. 102:117.
22. Alspaugh, M., and P. Maddison. 1977. Resolution of the identity of certain antigen-antibody systems in systemic lupus erythematosus and Sjogren's syndrome: an interlaboratory collaboration. Arthritis Rheum. 22:796.
23. Mackworth-Young, C. G., S. Loizou, and M. J. Walport. 1989. Antiphospholipid antibodies and disease. Quart. J. Med. 72:767.
24. Lee, L. A., K. K. Gaither, S. N. Coulter, D. A Norris, and J. B. Harley. 1989. Pattern of cutaneous immunoglobulin G deposition in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro (SSA). J. Clin. Invest. 83:1556.
25. Senecal, J. L., and J. Rauch. 1988. Hybridoma lupus autoantibodies can bind major cytoskeletal filaments in the absence of DNA-binding activity. Arthritis Rheum. 31:864.
26. Minota, S., S. Koyasu, I. Yahara, and J. Winfield. 1988. Autoantibodies to the heat-shock protein hsp90 in systemic lupus erythematosus. J. Clin. Invest. 81:106.
27. Jazwinska, E. C., P. A. Gatenby, H. Dunckley, and S. W. Serjeantson. 1993. C1 inhibitor functional deficiency in systemic lupus erythematosus (SLE). Clin. Exp. Immunol. 92:268.
28. Jonsson, H., G. Sturfelt, U. Martensson, L. Truedsson, and A. G. Sjoholm. 1995. Prospective analysis of Cl dissociation and complement activation in patients with systemic lupus erythematosus. Clin. Exp. Rheumatol. 13:573.
29. Abramson, S. B., and J. P. Buyon. 1992. Activation of the complement pathway: comparison of normal pregnancy, preeclampsia and systemic lupus erythematosus during pregnancy. Am. J. Reprod. Immunol. 28:183.
30. Martensson, U., A. G. Sjoholm, G. Sturfelt, L. Truedsson, and A. B. Laurell. 1992. Western blot analysis of human IgG reactive with the collagenous portion of C1q: evidence of distinct binding specificities. Scand. J. Immunol. 35:735.
31. He, S., S. Tsang, J. North, N. Chohan, R. B. Sim, and K. Whaley. 1996. Epitope mapping of C1 inhibitor autoantibodies from patients with acquired C1 inhibitor deficiency. J. Immunol. 156:1009.
32. He, S., R. B. Sim, and K. Whaley. 1997. A secondary C1s interaction site on C1-inhibitor is essential for formation of a stable enzyme-inhibitor complex. FEBS Lett. 405:42.
33. Sim, R. B. 1981. The human complement system serine proteases C1r and C1s and their proenzymes. Methods Enzymol. 80:26.
34. Pilatte, Y., C. H. Hammer, M. M. Frank, and L. F. Fries. 1989. A new simplified procedure for C1 inhibitor purification: a novel use for jacalin-agarose. J. Immunol. Methods 120:37.
35. Ishizaki, E., Y. Yoshioka, Y. Mori, and J. Koyama. 1976. Isolation of two forms of activated C1s, a subcomponent of the first component of rabbit complement. J. Biochem. 80:1423.
36. Mori, Y., E. Ueda, T. Takenehi, S. Taniuchi, and J. Koyama. 1980. Proteolytic cleavage of an activated subcomponent of the first component of rabbit complement. J. Biochem. 87:1757.
37. Sim, R. B., and A. Reboul. 1981. Preparation and properties of human C1 inhibitor. Methods Enzymol. 80:43.
38. Hudson, L., and F. Hay. 1989. Practical Immunology, 3rd Ed. Blackwell Scientific Publications. Oxford, pp. 1-3.
39. Harrison, R. A. 1983. Human C1 inhibitor: improved isolation and preliminary structural charaterization. Biochemistry 22:5001.
40. Law, S. K. A., N. A. Lichtenberg, and R. P. Levine. 1979. Evidence for an ester linkage between the labile binding site of C3b and receptive surfaces. J. Immunol. 123:1388.
41. Warshel, A., and S. T. Russell. 1986. Theoretical correlation of structure and energetics in the catalytic reaction of trypsin. J. Am. Chem. Soc. 108:6569.
42. Schumaker, V. N., and M. L. Phillips. 1993. Electron microscope studies of C1s, C1s2, C1r2, C1r2C1s2 and C1-inhibitor. Behring Inst. Mitt. 93:17.