A phase 1 study to address the safety and efficacy of granulocyte colony-stimulating factor for the mobilization of hematopoietic progenitor cells in active rheumatoid arthritis

Arthritis and Rheumatism

Volumn 40, Issue 10, 1997, Pages 1838-1842

  McGonagle, Dennis ^a   Rawstron, Andrew ^b   Richards, Stephen ^b   Isaacs, John ^a   Bird, Howard ^a   Jack, Andrew ^b   Morgan, Gareth ^b   Emery, Paul ^a,c  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b LEEDS GENERAL INFIRMARY   (United Kingdom)

^c Department of Rheumatology ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CD34 ANTIGEN; CORTICOSTEROID; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ADULT; AGED; ARTICLE; CELL TRANSPLANTATION; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; DRUG SAFETY; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; PATIENT SELECTION; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SCORING SYSTEM; SUBCUTANEOUS DRUG ADMINISTRATION;

ADULT; AGED; ANTIGENS, CD34; ARTHRITIS, RHEUMATOID; C-REACTIVE PROTEIN; CELL COUNT; CELL MOVEMENT; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELLS; HUMANS; MIDDLE AGED; MONOCYTES; PAIN MEASUREMENT; RHEUMATOID FACTOR;

EID: 0030760621     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780401017     Document Type: Article

References (17)

1. Pincus T: Rheumatoid arthritis: disappointing long-term outcomes despite successful short-term clinical trials. J Clin Epidemiol 41:1037-1041, 1988
2. Waase I, Kayser C, Carlson PJ, Goronzy JJ, Weyand CM: Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings. Arthritis Rheum 39:904-913, 1996
3. Jendro MC, Ganten T, Matteson EL, Weyand CM, Goronzy JJ: Emergence of oligoclonal T cell populations following therapeutic T cell depletion in rheumatoid arthritis. Arthritis Rheum 38:1242-1251, 1995
4. McCune WJ, Vallance DK, Lynch JP III: Immunosuppressive drug therapy. Curr Opin Rheumatol 6:262-272, 1994
5. Marmont A, Tyndall A, Gratwohl A, Vischer T: Haemopoietic precursor cell transplants for autoimmune disease (abstract). Lancet 345:978, 1995
6. Gough A, Faint J, Salmon M, Hassell A, Wordsworth P, Pilling D, Birley A, Emery P: Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome. Arthritis Rheum 37:1766-1770, 1994
7. Grigg AP, Roberts AW, Raunow H, Houghton S, Layton JE, Boyd AW, McGrath KM, Maher D: Optimizing dose and scheduling of filgrastim (granulocyte colony-stimulating factor) for mobilization and collection of peripheral blood progenitor cells in normal volunteers. Blood 86:4437-4445, 1995
8. Scott DGL, Bacon PA, Tribe CR: Systemic rheumatoid vasculitis: a clinical and laboratory study of 50 cases. Medicine (Baltimore) 60:228-297, 1987
9. Yasuda M, Kihara T, Wada T, Shiokawa S, Furuta E, Suenagu Y, Nonaka S, Nobunaga M, Yoshioka K, Isayama T: Granulocyte colony-stimulating factor induction of improved leukocytopenia from inflammatory flare in a Felty's syndrome patient. Arthritis Rheum 37:145-146, 1994
10. De Haas M, Kerst JM, van dor Schoot CE, Calafat J, Hack CE, Nuijens JH, Roos D, van Oers RH, von dem Borne AE: Granulocyte colony-stimulating factor administration to healthy volunteers: analysis of the immediate activating effects on circulating neutrophils. Blood 84:3885-3894, 1994
11. Khwaja A, Carver JE, Linch DC: Interactions of granulocyte-macrophage colony-stimulating factor (CSF), granulocyte CSF, and tumor necrosis factor alpha in the priming of the neutrophil respiratory burst. Blood 79:745-753, 1992
12. Vidarsson B, Geirsson AJ, Onundarson PT: Reactivation of rheumatoid arthritis and development of leukocytoclastic vasculitis in a patient receiving granulocyte colony-stimulating factor for Felly's syndrome. Am J Med 98:589-591, 1995
13. Farhey YD, Herman JH: Vasculitis complicating granulocyte colony-stimulating factor treatment of leukopenia and infection in Felly's syndrome. J Rheumatol 22:1179-1182, 1995
14. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA Jr, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315-324, 1988
15. Steinbrocker O, Traeger CH, Batterman RC: Therapeutic criteria in rheumatoid arthritis. JAMA 140:659-662, 1949
16. Van Riel PLCM: Provisional guidelines for measuring disease activity in RA clinical trials. Br J Rheumatol 31:793-794, 1992
17. Emery P, Lopez A, Burns G, Vadas MA: Synovial fluid neutrophils of patients with rheumatoid arthritis have changes that reflect activation. Ann Rheum Dis 47:34-39, 1988