Immune ablation followed by stem cell transplantation (allogeneic) or support (autologous) for severe autoimmune diseases: Progress, controversies and suggested guidelines

Autologous Stem Cell Transplantation: Biological and Clinical Results in Malignancies

Volumn , Issue , 2020, Pages 441-450

  Marmont, A M ^a  

^a IRCSS San Martino Hospital National Cancer Research Institute   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 8544239753     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.4324/9781003077343-43     Document Type: Chapter

References (85)

1. Rose, N.R. and Bona, C. (1993) Defining criteria for autoimmune diseases (Witebsky’s postulates revisited) Immunol. Today, 14, 426-430.
2. Marmont, A.M. (1994) Defining criteria for autoimmune diseases. Immunol. Today, 15, 388 (letter).
3. Cash.J.M. and Wilder, R.M. (eds) (1995) Treatment-resistant rheumatic disease. Rheum. Dis. Clin. North America, 21, 1-270.
4. Burt, R.K, Burns, W. and Hess, A. (1995) Bone marrow transplantation for multiple sclerosis. Bone Marrow Transplant., 16, 1-6.
5. Hafler, D.A. and Weiner, H.L. (1995) Immunologic mechanisms and therapy in multiple sclerosis. Immunol. Reo., 144, 75-107.
6. Mackay, LR. and Rose, N.R. (1992) Autoimmunity: Horizons. In Rose, N.R. and Mackay, LR. (eds): The Autoimmune Diseases II; Academic Press, San Diego-Toronto, 409-430.
7. Shoenfeld, Y. and Isenberg, D. (1989) The mosaic of autoimmunity (the factors associated with autoimmune diseases). Amsterdam, Elsevier.
8. Kotb, M. (1995) Short analytical review. Infection and autoimmunity: a story of the host, the pathogen, and the copathogen. Clin. Immunol. Immunopathol, 74, 10-22.
9. Atkinson, J.P. (1995) Viewpoint. Some thoughts on autoimmunity. Arthr. Rheumatism, 38, 301-305.
10. Behar, S.M. and Porcelli, S.A. (1995) Mechanisms of autoimmune disease induction. The role of the immune response to microbial pathogens. Arthr. Rheumatism, 38, 458-476.
11. Fujnami, R.S. (1992) Molecular mimicry. In Rose, N.R. and Mckay, LR. (eds): The Autoimmune Diseases II; Academic Press, San Diego-Toronto, 153-171.
12. Mamula, M.J. (1995) Lupus autoimmunity: from peptides to particles. Immunological Rev., 144, 301-314.
13. Breedveld, EC, Struyk, L., van Lear, J.M. et al. (1995) Therapeutic regulation of T cells in rheumatoid arthritis. Immunological Rev., 144, 5-16.
14. Baixeras, E., Bosca, L., Stauber, C. et al. (1995) From apoptosis to autoimmunity: insights from the signaling pathways leading to proliferation or programmed cell death. Immunol. Rev., 142, 53-91.
15. Mountz, J.D., Jianguo, W., Jianhua, C. and Tong, Z. (1994) Autoimmune disease. A problem of defective apoptosis. Arthritis Rheumatism, 37, 1415-1420.
16. Elkon, KB. (1994) Apoptosis and SLE. Lupus, 3, 1-2.
17. Schur, RH. (1995) Genetics of systemic lupus erythematosus. Lupus, 4, 425-437.
18. Drake, G.G., Rozzo, J., Vyse, T.J. et al. (1995) Genetic contributions to lupus-like disease in (NZB X NZW) Fl mice. Immunol. Rev., 14, 51-74.
19. Talal, N. (1994) Oncogenes, autogenes, and rheumatic diseases. Arthr. Rheumatism, 37, 1421-1422.
20. Ikehara, S. (1994) Intractable diseases and bone marrow transplantation. Pathology Int., 44, 817-826.
21. Ikehara, S. (1996) The prospects for BMT-from mouse to human. In Ikehara, S. Takaku, F. and Good, R.A. (ed): Bone Marrow Transplantation. Basic and clinical studies. Springer, Tokyo-Singapore, 302-331.
22. Bach.J.F. (1994) Predictive medicine in autoimmune disease: from the identification of genetic predisposition and environmental influence to precocious immunotherapy. Clin. Immunopathol, 72, 156-161.
23. Klinman, D.M. and Steinberg, A.D. (1995) Inquiry into murine and human lupus. Immunol. Rev., 144, 157-193.
24. Mohan, C. and Datta, S.K. (1995) Short analytical review. Lupus: key pathogenic mechanisms and contributing factor. Clin. Immunol. Immunopathol, 77, 209-220.
25. Euler, H.H., Fastenrath, S., Dreger, P., Schmitz, N. and Marmont, A. (1996) Knochenmarktransplantation - eine neue Option bei schweren SLE? Akt. Rheumatol, 21, 114-122.
26. Izui, S., Merino, R., Iwamoto, M. and Fossati, L. (1995) Mechanisms of genetic control of murine systemic lupus erythematosus. In Miescher, P. (ed): Systemic Lupus Erythematosus. Berlin-Heidelberg-New York, Springer, 3-22.
27. Drake, GG., Rozzo, S.J., Vyse, T.J. et al. (1995) Genetic contributions to lupus-like disease in (NZB X NZW) Fl mice. Immunol. Rev., 144, 51-74.
28. Theophilopoulos, A.N. (1995) The basis of autoimmunity: Part I Mechanisms of aberrant self recognition. Immunol. Today, 16, 90-98.
29. Theophilopoulos, A.N. (1995) The basis of autoimmunity: Part II. Genetic predisposition. Immunol. Today, 16, 150-159.
30. Reininger, L., Radszkiewicz, T. and Kosco, M. (1992) Development of autoimmune disease in SCID mice populated with long-term “in vitro” proliferating (NZBxNZW) Fl pre-B cells. J. Exper. Med., 176, 1343-1353.
31. Ikuta, K., Uchida, N., Friedman, J. et al. (1992) Lymphocyte development from stem cells. Ann. Rev. Immunol., 10, 759-783.
32. Roitt, I.M. (1994) The nature of the antigens driving autoimmune disease. In Lydyard, RM. and Brostoff, J. (eds): Autoimmune disease. Aetiopathogenesis, diagnosis and treatment. Blackwell Science Ltd., 1-256.
33. Tan, E.M. (1989) Antinuclear antibodies. Diagnostic markers for autoimmune diseases and probes for cell biology. Adv. Immunol., 44, 93-151.
34. Adorini, L. (ed) (1995) Selective immunosuppression: basic concepts and clinical applications. Basel-Sydney, Karger.
35. Bach, J.F. (ed) (1993) T-cell directed immune interventions. London-Vienna, Blackwell Scientific Publications.
36. Maini, R.N. Elliott, M.J., Brennan, RM. et al. (1995) Immunol. Rev., 144, 195-223.
37. Cush, J.J. and Kavanaugh, A.F. (1995) Biologic interventions in rheumatoid arthritis. Rheum. Dis. Clin. North Amer., 21, 797-816.
38. Elliott, M.G., Maini, R.N., Feldman, M. et al. (1994) Randomized double blind comparison of chimeric monoclonal antibody to tumor necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis. Lancet, 334, 1105-1110.
39. Marmont, A.M. (1994) Immune ablation followed by allogeneic or autologous bone marrow transplantation: a new treatment for severe autoimmune diseases? Stem Cells, 12, 125-135.
40. Marmont, A.M. (1992) Autoimmunity and allogeneic bone marrow transplantation. Bone Marrow Transplant., 9, 1-3.
41. Van Bekkum, D.W. (1993) Review: BMT in experimental autoimmune diseases. Bone Marrow Transplant., 11, 183-187.
42. Marmont, A.M. and van Bekkum, D.W. (1995) Stem cell transplantation for severe autoimmune diseases: new proposals but still unanswered questions. Bone Marrow Transplant, 16, 497-498.
43. Brooks, P.M., Atkinson, K. and Hamilton, J.A. (1995) Stem cell transplantation in autoimmune disease. J. Rheumatol, 221, 1809-1811.
44. Van Bekkum, D.W., Tyndall, A., Vriesendorp, F.J. et al. (1996) Severe autoimmune diseases: a new target for bone marrow transplantation. Stem Cells, 14, 460-472.
45. Morton, J.L. and Siegel, B.V. (1974) Transplantation of autoimmune potential. Development of antinuclear antibodies in H-2 histocompatible recipients of bone marrow from New Zealand Black mice. Proc. Natl. Acad. Set. USA, 71, 2162-2166.
46. Denman, A.M., Russel, A.S. and Denman, E.J. (1969) Adoptive transfer of the disease of New Zeland Black mice to normal mouse strains. Clin. Exp. Immunol, 5, 567-570.
47. Van Gelder, M. (1995) Bone marrow transplantation for treatment of experimental autoimmune encephalomyelitis in rats. Prospects for therapy of severe multiple sclerosis. Thesis. Leiden University, 11, 161-163.
48. Nishimura, M., Toki, J., Sugiura, K. et al. (1994) Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder. J. Exp. Med., 179, 1053-1058.
49. Ikehara, S., Mizutani, H., Kurata, Y. (1995) Autoimmune thrombocytopenic purpura. Crit. Rev. Oncology /Hematology, 19, 33-45.
50. Adachi, Y, Inaba, M., Amoh, Y. et al. (1995) Effect of bone marrow transplantation on antiphos-pholipid antibody syndrome in murine lupus mice. Immunobiol, 192, 218-230.
51. Ende, N., Czarneski, J. and Reveche, E. (1995) Effect of human cord blood transfer on survival and disease activity in MLR - lpr mice. Clin. Immunol. Immunopathol, 75, 190-195.
52. Levite, M., Zinger, H., Mozes, E. and Reisner, Y. (1993) Systemic lupus erythematosus-related autoantibody production in mice is determined by bone marrow derived cells. Bone Marrow Transplant, 12, 79-183.
53. Blank, M., Krause, J., Lanir, N. et al. (1995) Transfer of experimental antiphospholipid syndrome by bone marrow cell transplantation. The importance of T cell. Arthr. Rheumatism, 38, 115-122.
54. Van Gelder, M. and van Bekkum, D.W. (1995) Treatment of relapsing experimental autoimmune encephalomyelitis in rats with allogeneic bone marrow transplantation from a resistant strain. Bone Marrow Transplant, 16, 343-351.
55. Knaan-Shanzer, S., Houben, P., Kinwel-Bohré, E.P.M. and van Bekkum, D.W. (1992) Remission induction of adjuvant arthritis in rats by total body irradiation and autologous bone marrow transplantation. Bone Marrow Transplant, 8, 333-338.
56. Karussis, D.M., Slavin, S., Ben Nun, A. et al. (1992) Chronic relapsing autoimmune encephalomyelitis (CR-EAR): treatment and induction of tolerance with high-dose cyclophosphamide followed by syngeneic bone marrow transplantation. J. Neuroimmunol, 39, 200-201.
57. Slavin, S. (1993) Treatment of life-threatening autoimmune diseases with myeloablative doses of immunosuppressive agents: experimental background and rationale for ABMT. Bone Marrow Transpl, 12, 201-210.
58. Grau, J.M., Casademont, J., Monforte, R. et al. (1990) Myasthenia gravis after allogeneic bone marrow transplantation: report of a new case and pathogenetic considerations. Bone Marrow Transplant., 5, 435-437.
59. Melms, A., Faul, G, Sommer, N. et al. (1992) Myasthenia gravis after BMT: identification of patient at risk? Bone Marrow Transpl, 9, 78-79.
60. Aldoury, M.A., Ruggier, R., Epstein, O. et al. (1990) Adoptive transfer of hyperthyroidism and autoimmune thyroiditis following allogeneic bone marrow transplantation for chronic myeloid leukaemia. Br. J. Haematol, 74, 118-119.
61. Thomson, J.A., Wilson, R.M. and Franklin, I.M. (1995) Transmission of thyrotoxicosis of autoimmune type by sibling allogeneic transplant. Eur. J. Endocrinol, 133, 564-566.
62. Lampeter, E.F., Hornberg, M., Quebeck, K. et al. (1993) Transfer of insulin dependent diabetes between HLA identical siblings by bone marrow transplantation. Lancet, 341, 1243-1244.
63. Storb, R. Personal communication.
64. De Witte, Th. Personal communication.
65. McKendry, R.J.R., Huebsch, L. and Le Clair, B. (1996) Progression of rheumatoid arthritis following bone marrow transplantation: a case report with a 13-year follow-up. Arthritis Rheum., 39, 1246-1253.
66. Lohse, A.W., Oho, G., Hermann, E. et al. (1993) Remission of severe rheumatoid arthritis following liver transplantation. Br. J. Rheumatol, 32, 827-828.
67. Roychowdhury, D.F. and Linker, C.A. (1995) Pure red cell aplasia complicating an ABO-compatible allogeneic bone marrow transplantation, treated successfully with antithymocyte globulin. Bone Marrow Transplant, 16, 471-473.
68. Liu Yin, J.A. and Jowitt, S.N. (1992) Resolution of immune-mediated diseases following allogeneic bone marrow transplantation for leukaemia. Bone Marrow Transplant, 9, 31-33.
69. Eedy, D.J., Burrows, D., Bridges, J.M. and Jones, F.G. (1990) Clearance of severe psoriasis after allogeneic bone marrow transplantation. Br. Med. J., 300, 908-909.
70. Snowden, J.A., Hannah, E.E., O’Donnell, J. et al. (1996) Resolution of longstanding systemic lupus erythematosus after autologous bone marrow transplant for non-Hodgkin’s lymphoma. Bone Marrow Transplantation, 17(suppl. 1), 6 (abst).
71. Euler, H.H., Marmont, A.M., Bacigalupo, A. et al. (1996) Early recurrence or persistence of autoimmune diseases after unmanipulated autologous stem cell transplantation. Blood, in press.
72. Salzman, D., Tami, J., Jackson, C. et al. (1994) Clinical remission of myasthenia gravis (MG) in a patient (PT) after high dose therapy and autologous transplantation with CD34+ stem cells (SC). Blood, 84, 206a (abstr.).
73. Fassas, A, Anagnostopoulos, A., Kazis, A. et al. Peripheral blood progenitor cell transplantation (PBSC-T) for the treatment of multiple sclerosis. Bone Marrow Transplant, 17(suppl. 1), 69a (abst).
74. Kolb, H.J., Achattemberg, A., Goldman, J.M. et al. Graft Versus Leukemia Effect of donor lymphocyte Transfusions in Marrow Grafted Patients et al. Blood, 86, 2041-2050.
75. Mackinnon, S., Papadopoulos, E.B., Carabasi, M.H. et al. (1995) Adoptive Immunotherapy Evaluating escalating doses of donor leukocytes for relapse of chronic myeloid leukemia after bone marrow transplantation: separation of Graft-versus-leukemia responses from Graft-versus-host disease. Blood, 86, 1261-1268.
76. Van Rhee, F. and Kolb, H.J. (1995) Donor leukocyte transfusion for leukemic relapse. Curr. Opin. Hematol, 2, 423-457.
77. Marmont, A.M., Tyndall, A., Gratwohl, A. and Vischer, T. (1995) Haematopoietic precursor-cell transplants for autoimmune diseases. Lancet, 345, 978.
78. Tyndall, A. and Gratwohl, A. (1996) Haematopoietic stem and progenitor cells in the treatment of severe autoimmune diseases. Ann. Rheum. Dis., 35, 149-151.
79. Meloni, G. personal communication.
80. Euler, H.H., Schroeder, J.O., Harten, P. et al. (1994) Treatment-free remission in severe systemic lupus erythematosus following synchronization of plasmapheresis with subsequent pulse cyclophosphamide. Arthritis Rheumatism, 37, 1784-1794.
81. Silberstein, L. and Jefferie, L.C. (1996) Placental blood banking: a new frontier in transfusion medicine. New Engl. J. Med., 335, 199-202.
82. Kurtzberg, J., Laughlin, M., Graham, M.L. et al. (1996) Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. New Engl. J. Med., 335, 157-166.
83. Laporte, J.P., Gorin, N.L., Rubinstein, P. et al. (1996) Brief report: cord blood transplantation from an unrelated donor in an adult with chronic myelogenous leukemia. New Engl. J. Med., 335, 167-170.
84. Emerson, S.G. (1996) Ex vivo expansion of hemopoietic precursors, progenitors and stem cells: the next generation of cellular therapeutics. Blood, 87, 3082-3088.
85. Marmont, A.M. (1993) Perspective. Immune Ablation with Stem Cell Rescue: A possible Cure for Systemic Lupus Erythematosus? Lupus, 2, 151-156.