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Volumn 4, Issue 10, 1998, Pages 2337-2347

Signal transduction abnormalities in T lymphocytes from patients with advanced renal carcinoma: Clinical relevance and effects of cytokine therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CD3 ANTIGEN; CYTOKINE; FLUOROURACIL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IONOMYCIN; MONOCLONAL ANTIBODY; PHORBOL 13 ACETATE 12 MYRISTATE; RECOMBINANT ALPHA2B INTERFERON; RECOMBINANT INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR;

EID: 0031722032     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (58)

References (41)
  • 1
    • 0027056895 scopus 로고
    • Alterations in signal transaction molecules in T lymphocytes from tumor bearing mice
    • Washington DC
    • Mizoguchi, H., O'Shea, J. J., Longo, D. L., Loeffler, C. M., McVicar, D. W., and Ochoa, A. C. Alterations in signal transaction molecules in T lymphocytes from tumor bearing mice. Science (Washington DC), 258: 1795-1798, 1992.
    • (1992) Science , vol.258 , pp. 1795-1798
    • Mizoguchi, H.1    O'Shea, J.J.2    Longo, D.L.3    Loeffler, C.M.4    McVicar, D.W.5    Ochoa, A.C.6
  • 3
    • 0029737843 scopus 로고    scopus 로고
    • Expression and activity of signaling molecules in T lymphocytes obtained from patients with metastatic melanoma before and after interleukin 2 therapy
    • Rabinowich, H., Banks, M., Reichert, T. E., Logan, T. F., Kirkwood, J. M., and Whiteside, T. L. Expression and activity of signaling molecules in T lymphocytes obtained from patients with metastatic melanoma before and after interleukin 2 therapy. Clin. Cancer Res., 2: 1263-1274, 1996.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 1263-1274
    • Rabinowich, H.1    Banks, M.2    Reichert, T.E.3    Logan, T.F.4    Kirkwood, J.M.5    Whiteside, T.L.6
  • 5
    • 0028884202 scopus 로고
    • Variable expression of CD3-ζ chain in tumor infiltrating lymphocytes (TIL) derived from renal-cell carcinoma: Relationship with TIL phenotype and function
    • Tartour, E., Latour, S., Mathiot, C., Thiounn, N., Mosseri, V., Joyeux, I., D'Enghien, C. D., Lee, R., Debre, B., and Fridman, W. H. Variable expression of CD3-ζ chain in tumor infiltrating lymphocytes (TIL) derived from renal-cell carcinoma: relationship with TIL phenotype and function. Int. J. Cancer, 63: 205-212, 1995.
    • (1995) Int. J. Cancer , vol.63 , pp. 205-212
    • Tartour, E.1    Latour, S.2    Mathiot, C.3    Thiounn, N.4    Mosseri, V.5    Joyeux, I.6    D'Enghien, C.D.7    Lee, R.8    Debre, B.9    Fridman, W.H.10
  • 6
    • 0030035046 scopus 로고    scopus 로고
    • Alterations in expression and function of signal-transducing proteins in tumor-associated T and natural killer cells in patients with ovarian carcinoma
    • Lai, P., Rabinowich, H., Crowley-Nowick, P. A., Bell, M. C., Mantovani, G., and Whiteside, T. L. Alterations in expression and function of signal-transducing proteins in tumor-associated T and natural killer cells in patients with ovarian carcinoma. Clin. Cancer Res., 2: 161-173, 1996.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 161-173
    • Lai, P.1    Rabinowich, H.2    Crowley-Nowick, P.A.3    Bell, M.C.4    Mantovani, G.5    Whiteside, T.L.6
  • 7
    • 0029902054 scopus 로고    scopus 로고
    • T-cells from patients with Hodgkin's disease have a defective T-cell receptor C chain expression that is reversible by T-cell stimulation with CD3 and CD28
    • Renner, C., Ohnesorge, S., Held, G., Bauer, S., Jung, W., Pfitzenmeier, J., and Pfreundschuh, M. T-cells from patients with Hodgkin's disease have a defective T-cell receptor C chain expression that is reversible by T-cell stimulation with CD3 and CD28. Blood, 88: 236-241, 1996.
    • (1996) Blood , vol.88 , pp. 236-241
    • Renner, C.1    Ohnesorge, S.2    Held, G.3    Bauer, S.4    Jung, W.5    Pfitzenmeier, J.6    Pfreundschuh, M.7
  • 9
    • 0029042847 scopus 로고
    • Alterations in the signal-transducing molecules of T-cells and NK cells in colorectal tumor-infiltrating, gut mucosal and peripheral lymphocytes: Correlation with the stage of the disease
    • Matsuda, M., Peterson, M., Lenkei, R., Taupin, J. L., Magnusson, I., and Mellstedt, H. Alterations in the signal-transducing molecules of T-cells and NK cells in colorectal tumor-infiltrating, gut mucosal and peripheral lymphocytes: correlation with the stage of the disease. Int. J. Cancer, 61: 765-772, 1995.
    • (1995) Int. J. Cancer , vol.61 , pp. 765-772
    • Matsuda, M.1    Peterson, M.2    Lenkei, R.3    Taupin, J.L.4    Magnusson, I.5    Mellstedt, H.6
  • 10
    • 0028176728 scopus 로고
    • Alterations in NFκB/rel family proteins in splenic T-cells from tumor bearing mice and reversal following therapy
    • Ghosh, P., Sica, A., Young, H. A., Ye, J., Franco, J. L., Wiltrout, R. H., Longo, D. L., Rice, N. R., and Komschlies, K. L. Alterations in NFκB/rel family proteins in splenic T-cells from tumor bearing mice and reversal following therapy. Cancer Res., 54: 2969-2972, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 2969-2972
    • Ghosh, P.1    Sica, A.2    Young, H.A.3    Ye, J.4    Franco, J.L.5    Wiltrout, R.H.6    Longo, D.L.7    Rice, N.R.8    Komschlies, K.L.9
  • 11
    • 0028172067 scopus 로고
    • T-cells from renal cell carcinoma patients exhibit an abnormal pattern of κB-specific DNA binding activity: A preliminary report
    • Li, X., Liu, J., Park, J. K., Hamilton, T. A., Rayman, P., Klein, E., Edinger, M., Tubbs, R., Bukowski, R., and Finke, J. T-cells from renal cell carcinoma patients exhibit an abnormal pattern of κB-specific DNA binding activity: a preliminary report. Cancer Res., 54: 5424-5429, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 5424-5429
    • Li, X.1    Liu, J.2    Park, J.K.3    Hamilton, T.A.4    Rayman, P.5    Klein, E.6    Edinger, M.7    Tubbs, R.8    Bukowski, R.9    Finke, J.10
  • 12
    • 0024245729 scopus 로고
    • Proliferative and cytolytic potentials of purified human tumor-infiltrating T-lymphocytes. Impaired response to mitogen-driven stimulation despite T-cell receptor expression
    • Miescher, S., Stoeck, M., Qiao, L., Barros, C., Barrelet, L., and von Fliedner, V. Proliferative and cytolytic potentials of purified human tumor-infiltrating T-lymphocytes. Impaired response to mitogen-driven stimulation despite T-cell receptor expression. Int. J. Cancer, 42: 659-666, 1988.
    • (1988) Int. J. Cancer , vol.42 , pp. 659-666
    • Miescher, S.1    Stoeck, M.2    Qiao, L.3    Barros, C.4    Barrelet, L.5    Von Fliedner, V.6
  • 13
    • 0027406425 scopus 로고
    • T-cells infiltrating renal cell carcinoma display a poor proliferative response even though they can produce interleukin-2 and express interleukin-2 receptors
    • Alexander, J. P., Kudoh, S., Melsop, K. A., Hamilton, T. A., Edinger, M. G., Tubbs, R. R., and Sica, D. T-cells infiltrating renal cell carcinoma display a poor proliferative response even though they can produce interleukin-2 and express interleukin-2 receptors. Cancer Res., 53: 1380-1387, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 1380-1387
    • Alexander, J.P.1    Kudoh, S.2    Melsop, K.A.3    Hamilton, T.A.4    Edinger, M.G.5    Tubbs, R.R.6    Sica, D.7
  • 14
    • 0026689890 scopus 로고
    • Expression of mRNA for cytokines in tumor-infiltrating mononuclear cells in ovarian adenocarcinoma and invasive breast cancer
    • Vitolo, D., Zerbe, T., Kanbour, A., Dahl, C., Herberman, R. B., and Whiteside, T. L. Expression of mRNA for cytokines in tumor-infiltrating mononuclear cells in ovarian adenocarcinoma and invasive breast cancer. Int. J. Cancer, 51: 573-580, 1992.
    • (1992) Int. J. Cancer , vol.51 , pp. 573-580
    • Vitolo, D.1    Zerbe, T.2    Kanbour, A.3    Dahl, C.4    Herberman, R.B.5    Whiteside, T.L.6
  • 16
    • 0024380087 scopus 로고
    • Rapid detection of octamer binding proteins with Amini-extracts prepared from a small number of cells
    • Schreiber, E., Matthias, E., Muller, M. M., and Schaffner, W. Rapid detection of octamer binding proteins with Amini-extracts prepared from a small number of cells. Nucleic Acids Res, 17: 6419, 1989.
    • (1989) Nucleic Acids Res , vol.17 , pp. 6419
    • Schreiber, E.1    Matthias, E.2    Muller, M.M.3    Schaffner, W.4
  • 17
    • 0342742310 scopus 로고
    • Tumor necrosis factor a and interleukin-1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor KB
    • Osborn, L., Kunkel, S., and Nabel, G. J. Tumor necrosis factor a and interleukin-1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor KB. Proc. Natl. Acad. Sci. USA, 86: 2336-2340, 1989.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 2336-2340
    • Osborn, L.1    Kunkel, S.2    Nabel, G.J.3
  • 18
    • 0001884644 scopus 로고
    • Individual comparisons by ranking methods
    • Wilcoxon, F. Individual comparisons by ranking methods. Biometrics, 1: 80-83, 1945.
    • (1945) Biometrics , vol.1 , pp. 80-83
    • Wilcoxon, F.1
  • 22
    • 0013886333 scopus 로고
    • Evaluation of survival data and two new rank order statistics arising in its consideration
    • Mantel, N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chem. Rep., 50: 163-170, 1966.
    • (1966) Cancer Chem. Rep. , vol.50 , pp. 163-170
    • Mantel, N.1
  • 23
    • 0031463916 scopus 로고    scopus 로고
    • Phase II trial of interleukin-2 and interferon-α in patients with renal cell carcinoma: Clinical results and immunologic correlates of response
    • Bukowski, R. M., Olencki, T., Wang, Q., Peereboom, D., Budd, G. T., Elson, P., Sandstrom, K., Tuason, L., Rayman, P., and Tubbs, R. Phase II trial of interleukin-2 and interferon-α in patients with renal cell carcinoma: clinical results and immunologic correlates of response. J. Immunother., 20: 301-311, 1997.
    • (1997) J. Immunother. , vol.20 , pp. 301-311
    • Bukowski, R.M.1    Olencki, T.2    Wang, Q.3    Peereboom, D.4    Budd, G.T.5    Elson, P.6    Sandstrom, K.7    Tuason, L.8    Rayman, P.9    Tubbs, R.10
  • 24
    • 0000389858 scopus 로고    scopus 로고
    • Phase I/II trial of simultaneously administered rIL-2/rHuIFNα2a and 5-FU in patients (PTS) with metastatic renal cell carcinoma (RCC)
    • Olencki, T., Bukowski, R. M., Budd, G. T., Peereboom, D., McLain, D., Sandstrom, K., Finke, J., and Elson, P. Phase I/II trial of simultaneously administered rIL-2/rHuIFNα2a and 5-FU in patients (PTS) with metastatic renal cell carcinoma (RCC). Proc. Am. Soc. Clin. Oncol., 15: 263, 1996.
    • (1996) Proc. Am. Soc. Clin. Oncol. , vol.15 , pp. 263
    • Olencki, T.1    Bukowski, R.M.2    Budd, G.T.3    Peereboom, D.4    McLain, D.5    Sandstrom, K.6    Finke, J.7    Elson, P.8
  • 25
    • 0028045991 scopus 로고
    • Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2 secreting tumors
    • Salvadori, S., Gansbacher, B., Pizzimenti, A. M., and Zier, K. S. Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2 secreting tumors. J. Immunol., 153: 5176-5182, 1994.
    • (1994) J. Immunol. , vol.153 , pp. 5176-5182
    • Salvadori, S.1    Gansbacher, B.2    Pizzimenti, A.M.3    Zier, K.S.4
  • 26
    • 0029902054 scopus 로고    scopus 로고
    • T cells from patients with Hodgkin's disease have a defective T-cell receptor ζ chain expression that is reversible by T-cell stimulation with CD3 and CD28
    • Renner, C., Ohnesorge, S., Held, G., Bauer, S., Jung, W., Pfitzenmeier, J. P., and Pfreundschuh, M. T cells from patients with Hodgkin's disease have a defective T-cell receptor ζ chain expression that is reversible by T-cell stimulation with CD3 and CD28. Blood, 88: 236-241, 1996.
    • (1996) Blood , vol.88 , pp. 236-241
    • Renner, C.1    Ohnesorge, S.2    Held, G.3    Bauer, S.4    Jung, W.5    Pfitzenmeier, J.P.6    Pfreundschuh, M.7
  • 28
    • 0030816213 scopus 로고    scopus 로고
    • T-cell receptor S-chain expression or tumor infiltrating lymphocytes from renal cell carcinoma
    • Cardi, G., Heaney, J. A., Schnol, A. L., Phillip, D. M., Branda, M. T., and Ernstoff, M. S. T-cell receptor S-chain expression or tumor infiltrating lymphocytes from renal cell carcinoma. Cancer Res., 57: 3517-3519, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 3517-3519
    • Cardi, G.1    Heaney, J.A.2    Schnol, A.L.3    Phillip, D.M.4    Branda, M.T.5    Ernstoff, M.S.6
  • 29
    • 0028568628 scopus 로고
    • The decreased expression of CD3ζ chains in cancer patients is not reversed by IL-2 administration
    • Farace, F., Angevin, E., Vanderplancke, J., Escudier, B., and Triebel, F. The decreased expression of CD3ζ chains in cancer patients is not reversed by IL-2 administration. Int. J. Cancer, 59: 752-755, 1994.
    • (1994) Int. J. Cancer , vol.59 , pp. 752-755
    • Farace, F.1    Angevin, E.2    Vanderplancke, J.3    Escudier, B.4    Triebel, F.5
  • 30
    • 0030271387 scopus 로고    scopus 로고
    • NFκB: Ten years after
    • Baeuerle, P. A., and Baltimore, D. NFκB: ten years after. Cell, 87: 13-20, 1996.
    • (1996) Cell , vol.87 , pp. 13-20
    • Baeuerle, P.A.1    Baltimore, D.2
  • 32
    • 0026452286 scopus 로고
    • Loss of transcription factor AP-1 DNA binding activity during lymphocyte aging in vitro
    • Sikora, E., Kaminska, B., Radziszewska, E., and Kaczmarek, L. Loss of transcription factor AP-1 DNA binding activity during lymphocyte aging in vitro. FEBS Lett., 312: 179-182, 1992.
    • (1992) FEBS Lett. , vol.312 , pp. 179-182
    • Sikora, E.1    Kaminska, B.2    Radziszewska, E.3    Kaczmarek, L.4
  • 33
    • 0029935914 scopus 로고    scopus 로고
    • Age-related decreases in IL-2 production by human T cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT
    • Whisler, R. L., Beiqing, L., and Chen, M. Age-related decreases in IL-2 production by human T cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT. Cell Immunol., 169: 185-195, 1996.
    • (1996) Cell Immunol. , vol.169 , pp. 185-195
    • Whisler, R.L.1    Beiqing, L.2    Chen, M.3
  • 34
  • 35
    • 0031157453 scopus 로고    scopus 로고
    • Sequential development of structural and functional alterations on T-cells from tumor-bearing mice
    • Correa, M. R., Ochoa, A. C., Ghosh, P., Mizoguchi, H., Harvey, L., and Longo, D. L. Sequential development of structural and functional alterations on T-cells from tumor-bearing mice. J. Immunol., 158: 5292-5296, 1997.
    • (1997) J. Immunol. , vol.158 , pp. 5292-5296
    • Correa, M.R.1    Ochoa, A.C.2    Ghosh, P.3    Mizoguchi, H.4    Harvey, L.5    Longo, D.L.6
  • 36
    • 0022597562 scopus 로고
    • Functional properties of tumor-infiltrating and blood lymphocytes in patients with solid tumors: Effects of tumor cells and their supernatants on proliferative responses of lymphocytes
    • Miescher, S., Whiteside, T. L., Carrel, S., and Von Fliedner, V. Functional properties of tumor-infiltrating and blood lymphocytes in patients with solid tumors: effects of tumor cells and their supernatants on proliferative responses of lymphocytes. J. Immunol., 136: 1899-1907, 1986.
    • (1986) J. Immunol. , vol.136 , pp. 1899-1907
    • Miescher, S.1    Whiteside, T.L.2    Carrel, S.3    Von Fliedner, V.4
  • 37
    • 0027364351 scopus 로고
    • An immune suppressive factor derived from esophageal squamous carcinoma induces apoptosis in normal and transformed cells of lymphoid lineage
    • O'Mahony, A. M., O'Sullivan, G. C., O'Connell, J., Cotter, T. G., and Collins, J. K. An immune suppressive factor derived from esophageal squamous carcinoma induces apoptosis in normal and transformed cells of lymphoid lineage. J. Immunol., 151: 4847-4856, 1993.
    • (1993) J. Immunol. , vol.151 , pp. 4847-4856
    • O'Mahony, A.M.1    O'Sullivan, G.C.2    O'Connell, J.3    Cotter, T.G.4    Collins, J.K.5
  • 38
    • 0030048536 scopus 로고    scopus 로고
    • Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing ζ molecules and inhibits tumor-specific T-cell and natural killer cell-mediated cytotoxicity
    • Kono, K., Salazar-Onfray, F., Petersson, M., Hansson, J., Masucci, G., and Wasserman, K. Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing ζ molecules and inhibits tumor-specific T-cell and natural killer cell-mediated cytotoxicity. Eur. J. Immunol., 26: 1308-1313, 1996.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1308-1313
    • Kono, K.1    Salazar-Onfray, F.2    Petersson, M.3    Hansson, J.4    Masucci, G.5    Wasserman, K.6
  • 39
    • 0029841427 scopus 로고    scopus 로고
    • Oxidative stress by tumor-derived macrophages suppresses the expression of CD3ζ chain of T-cell receptor complex and antigen-specific T-cell responses
    • Otsuji, M., Kimura, Y., Aoe, T., Okamoto, Y., and Saito, T. Oxidative stress by tumor-derived macrophages suppresses the expression of CD3ζ chain of T-cell receptor complex and antigen-specific T-cell responses. Proc. Natl. Acad. Sci. USA, 93: 13119-13124, 1996.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13119-13124
    • Otsuji, M.1    Kimura, Y.2    Aoe, T.3    Okamoto, Y.4    Saito, T.5
  • 40
    • 0031026259 scopus 로고    scopus 로고
    • Transfer of the interleukin-2 gene into human cancer cells induces specific antitumor recognition and restores the expression of CD3/T-cell receptor associated signal transduction molecules
    • Guarini, A., Riera, L., Cignetti, A., Montacchini, L., Massaia, M., and Foa, R. Transfer of the interleukin-2 gene into human cancer cells induces specific antitumor recognition and restores the expression of CD3/T-cell receptor associated signal transduction molecules. Blood, 89: 212-218, 1997.
    • (1997) Blood , vol.89 , pp. 212-218
    • Guarini, A.1    Riera, L.2    Cignetti, A.3    Montacchini, L.4    Massaia, M.5    Foa, R.6
  • 41
    • 0032528628 scopus 로고    scopus 로고
    • Impaired activation of NFκB in T cells from a subset of renal cell carcinoma patients is mediated by inhibition of phosphorylation and degradation of the inhibitor, IκBa
    • Ling, W., Rayman, P., Uzzo, R., Clark, P., Kim, H. J., Tubbs, R., Novick, A., Bukowski, R., Hamilton, T., and Finke, J. Impaired activation of NFκB in T cells from a subset of renal cell carcinoma patients is mediated by inhibition of phosphorylation and degradation of the inhibitor, IκBa. Blood, 92: 1334-1341, 1998.
    • (1998) Blood , vol.92 , pp. 1334-1341
    • Ling, W.1    Rayman, P.2    Uzzo, R.3    Clark, P.4    Kim, H.J.5    Tubbs, R.6    Novick, A.7    Bukowski, R.8    Hamilton, T.9    Finke, J.10


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