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Volumn 92, Issue 4, 1998, Pages 1334-1341

Impaired activation of NFκB in T cells from a subset of renal cell carcinoma patients is mediated by inhibition of phosphorylation and degradation of the inhibitor, IκBα

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ONCOPROTEIN; RELB PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RELB;

EID: 0032528628     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.4.1334     Document Type: Article
Times cited : (61)

References (65)
  • 1
  • 2
    • 0025255387 scopus 로고
    • Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: The missing link
    • Ullman KS, Northrop JP, Verweij CL, Crabtree GR: Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: The missing link. Annu Rev Immunol 8:421, 1990
    • (1990) Annu Rev Immunol , vol.8 , pp. 421
    • Ullman, K.S.1    Northrop, J.P.2    Verweij, C.L.3    Crabtree, G.R.4
  • 3
    • 0022481133 scopus 로고
    • Multiple nuclear factors interact with the immunoglobulin enhancer sequences
    • Sen R, Baltimore D: Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46:705, 1986
    • (1986) Cell , vol.46 , pp. 705
    • Sen, R.1    Baltimore, D.2
  • 4
    • 0026842287 scopus 로고
    • The inhibitory ankyrin and activator Rel proteins
    • Nolan GP, Baltimore D: The inhibitory ankyrin and activator Rel proteins. Curr Opin Genet Dev 2:211, 1992
    • (1992) Curr Opin Genet Dev , vol.2 , pp. 211
    • Nolan, G.P.1    Baltimore, D.2
  • 8
    • 0025975795 scopus 로고
    • DNA binding and IκB inhibition of the cloned p65 subunit of NFκB, a rel-related polypeptide
    • Noland GP, Ghosh S, Liou HC, Tfempst P, Baltimore D: DNA binding and IκB inhibition of the cloned p65 subunit of NFκB, a rel-related polypeptide. Cell 64:961, 1991
    • (1991) Cell , vol.64 , pp. 961
    • Noland, G.P.1    Ghosh, S.2    Liou, H.C.3    Tfempst, P.4    Baltimore, D.5
  • 9
    • 0024360163 scopus 로고
    • A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon
    • Brownell E, Mittereder N, Rice NR: A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon. Oncogene 4:935, 1989
    • (1989) Oncogene , vol.4 , pp. 935
    • Brownell, E.1    Mittereder, N.2    Rice, N.R.3
  • 11
    • 0025738076 scopus 로고
    • Cloning of an NFκB subunit which stimulates HIV transcription in synergy with p65
    • Schmid RM, Perkins ND, Duckett CS, Andrews PC, Nabel GJ: Cloning of an NFκB subunit which stimulates HIV transcription in synergy with p65. Nature 352:733, 1991
    • (1991) Nature , vol.352 , pp. 733
    • Schmid, R.M.1    Perkins, N.D.2    Duckett, C.S.3    Andrews, P.C.4    Nabel, G.J.5
  • 14
    • 0026592340 scopus 로고
    • A novel complex between the p65 subunit of NF-κB and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene
    • Hansen SK, Nerlov C, Zabel U, Verde P, Johnsen M, Baeuerle PA, Blasi F: A novel complex between the p65 subunit of NF-κB and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene. EMBO J 11:205, 1992
    • (1992) EMBO J , vol.11 , pp. 205
    • Hansen, S.K.1    Nerlov, C.2    Zabel, U.3    Verde, P.4    Johnsen, M.5    Baeuerle, P.A.6    Blasi, F.7
  • 15
    • 0025782658 scopus 로고
    • NF-κB contacts DNA by a heterodimer of the p50 and p65 subunit
    • Urban MB, Schreck R, Baeuerle PA: NF-κB contacts DNA by a heterodimer of the p50 and p65 subunit. EMBO J 10:1817, 1991
    • (1991) EMBO J , vol.10 , pp. 1817
    • Urban, M.B.1    Schreck, R.2    Baeuerle, P.A.3
  • 17
    • 0027333044 scopus 로고
    • The IκB proteins: Members of a multifunctional family
    • Gilmore TD, Morin PJ: The IκB proteins: Members of a multifunctional family. Trends Genet 9:427, 1993
    • (1993) Trends Genet , vol.9 , pp. 427
    • Gilmore, T.D.1    Morin, P.J.2
  • 19
    • 0027332498 scopus 로고
    • The I kappa B proteins: Multifunctional regulators of Rel/NF-kappa B transcription factors
    • Beg AA, Baldwin AS Jr: The I kappa B proteins: Multifunctional regulators of Rel/NF-kappa B transcription factors. Genes Dev 7:2064, 1993
    • (1993) Genes Dev , vol.7 , pp. 2064
    • Beg, A.A.1    Baldwin Jr., A.S.2
  • 20
    • 0028986193 scopus 로고
    • NFκB: A lesson in family values
    • Thanos D, Maniatis T: NFκB: A lesson in family values. Cell 80:529, 1995
    • (1995) Cell , vol.80 , pp. 529
    • Thanos, D.1    Maniatis, T.2
  • 23
    • 0028978032 scopus 로고
    • Phosphorylation of human IκBα on serines 32 and 36 controls IκBα proteolysis and NFκB activation in response to diverse stimuli
    • Traenckner, EB-M, Pahl HL, Henkel T, Schmidt KN, Wilk S, Baeuerle PA: Phosphorylation of human IκBα on serines 32 and 36 controls IκBα proteolysis and NFκB activation in response to diverse stimuli. EMBO J 14:2876, 1995
    • (1995) EMBO J , vol.14 , pp. 2876
    • Traenckner, E.B.-M.1    Pahl, H.L.2    Henkel, T.3    Schmidt, K.N.4    Wilk, S.5    Baeuerle, P.A.6
  • 24
    • 0013842807 scopus 로고
    • Impaired in vitro lymphocyte transformation in Hodgkin's disease
    • Hersh EM, Oppenheim JJ: Impaired in vitro lymphocyte transformation in Hodgkin's disease. N Engl J Med 273:1006, 1965
    • (1965) N Engl J Med , vol.273 , pp. 1006
    • Hersh, E.M.1    Oppenheim, J.J.2
  • 25
  • 26
    • 0022597562 scopus 로고
    • Functional properties of tumor-infiltrating and blood lymphocytes in patients with solid tumors: Effects of tumor cells and their supernatants on proliferative responses of lymphocytes
    • Miescher S, Whiteside TL, Carrel S, Von Fliedner V: Functional properties of tumor-infiltrating and blood lymphocytes in patients with solid tumors: Effects of tumor cells and their supernatants on proliferative responses of lymphocytes. J Immunol 136:1899, 1986
    • (1986) J Immunol , vol.136 , pp. 1899
    • Miescher, S.1    Whiteside, T.L.2    Carrel, S.3    Von Fliedner, V.4
  • 28
    • 0026552282 scopus 로고
    • Tumor-reactive T-cells accumulate in lung cancer tissues but fail to respond due to tumor cell-derived factor
    • Yoshino I, Yano T, Murata M, Ishida T, Sugimachi K, Kimura G, Nomoto K: Tumor-reactive T-cells accumulate in lung cancer tissues but fail to respond due to tumor cell-derived factor. Cancer Res 52:775, 1992
    • (1992) Cancer Res , vol.52 , pp. 775
    • Yoshino, I.1    Yano, T.2    Murata, M.3    Ishida, T.4    Sugimachi, K.5    Kimura, G.6    Nomoto, K.7
  • 30
    • 0024245729 scopus 로고
    • Proliferative and cytolytic potentials of purified human tumor-in filtrating T lymphocytes. Impaired response to mitogen-driven stimulation despite T-cell receptor expression
    • Miescher S, Stoeck M, Qiao L, Barras C, Barrelet L, Von Fliedner V: Proliferative and cytolytic potentials of purified human tumor-in filtrating T lymphocytes. Impaired response to mitogen-driven stimulation despite T-cell receptor expression. Int J Cancer 42:659, 1988
    • (1988) Int J Cancer , vol.42 , pp. 659
    • Miescher, S.1    Stoeck, M.2    Qiao, L.3    Barras, C.4    Barrelet, L.5    Von Fliedner, V.6
  • 32
    • 0028045991 scopus 로고
    • Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL2 secreting tumors
    • Salvadori S, Gansbacher B, Pizzimenti AM, Zier KS: Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL2 secreting tumors. J Immunol 153:5176, 1994
    • (1994) J Immunol , vol.153 , pp. 5176
    • Salvadori, S.1    Gansbacher, B.2    Pizzimenti, A.M.3    Zier, K.S.4
  • 36
    • 0029828089 scopus 로고    scopus 로고
    • Decreased expression of signal-transducing Ζ chain in peripheral T cells and natural killer cells in patients with cervical cancer
    • Kono K, Ressing ME, Brandt RMP, Melief CJM, Potkul RK, Anderson B, Petersson M, Kast WM, Kiessling R: Decreased expression of signal-transducing Ζ chain in peripheral T cells and natural killer cells in patients with cervical cancer. Clin Cancer Res 2:1825, 1996
    • (1996) Clin Cancer Res , vol.2 , pp. 1825
    • Kono, K.1    Ressing, M.E.2    Rmp, B.3    Cjm, M.4    Potkul, R.K.5    Anderson, B.6    Petersson, M.7    Kast, W.M.8    Kiessling, R.9
  • 37
    • 0028884202 scopus 로고
    • Variable expression of CD3-Ζ chain in tumor-infiltrating lymphocytes (TIL) derived from renal-cell carcinoma: Relationship with TIL phenotype and function
    • Tartour E, Latour S, Mathiot C, Thiounn N, Mosseri V, Joyeux I, D'Enghien CD, Lee R, Debre B, Fridman WH: Variable expression of CD3-Ζ chain in tumor-infiltrating lymphocytes (TIL) derived from renal-cell carcinoma: Relationship with TIL phenotype and function. Int J Cancer 63:205, 1995
    • (1995) Int J Cancer , vol.63 , pp. 205
    • Tartour, E.1    Latour, S.2    Mathiot, C.3    Thiounn, N.4    Mosseri, V.5    Joyeux, I.6    D'Enghien, C.D.7    Lee, R.8    Debre, B.9    Fridman, W.H.10
  • 38
    • 0029737843 scopus 로고    scopus 로고
    • Expression and activity of signaling molecules in T lymphocytes obtained from patients with metastatic melanoma before and after interleukin 2 therapy
    • Rabinowich H, Banks M, Reichert TE, Logan TF, Kirkwood JM, Whiteside TL: Expression and activity of signaling molecules in T lymphocytes obtained from patients with metastatic melanoma before and after interleukin 2 therapy. Clin Cancer Res 2:1263, 1996
    • (1996) Clin Cancer Res , vol.2 , pp. 1263
    • Rabinowich, H.1    Banks, M.2    Reichert, T.E.3    Logan, T.F.4    Kirkwood, J.M.5    Whiteside, T.L.6
  • 42
    • 0029147649 scopus 로고
    • T Cells infiltrating non-Hodgkin's B cell lymphomas show altered tyrosine phosphorylation pattern even though T cell receptor/CD3-associated kinases are present
    • Wang Q, Stanley J, Kudoh S, Myles J, Kolenko V, Yi T, Tubbs R, Bukowski R, Finke J: T Cells infiltrating non-Hodgkin's B cell lymphomas show altered tyrosine phosphorylation pattern even though T cell receptor/CD3-associated kinases are present. J Immunol 155: 1382, 1995
    • (1995) J Immunol , vol.155 , pp. 1382
    • Wang, Q.1    Stanley, J.2    Kudoh, S.3    Myles, J.4    Kolenko, V.5    Yi, T.6    Tubbs, R.7    Bukowski, R.8    Finke, J.9
  • 43
    • 0024380087 scopus 로고
    • Rapid detection of octamer binding proteins with "mini-extracts" prepared from a small number of cells
    • Schreiber E, Matthias P, Muller MM, Schaffner W: Rapid detection of octamer binding proteins with "mini-extracts" prepared from a small number of cells. Nucleic Acids Res 7:6419, 1989
    • (1989) Nucleic Acids Res , vol.7 , pp. 6419
    • Schreiber, E.1    Matthias, P.2    Muller, M.M.3    Schaffner, W.4
  • 44
    • 0027451924 scopus 로고
    • In vivo control of NF-κB activation by IκBα
    • Rice NR, Ernst MK: In vivo control of NF-κB activation by IκBα.EMBOJ 12:4685, 1993
    • (1993) EMBOJ , vol.12 , pp. 4685
    • Rice, N.R.1    Ernst, M.K.2
  • 45
    • 0028170265 scopus 로고
    • Activation of NF-κB in vivo is regulated by multiple phosphorylations
    • Naumann M, Scheidereit C: Activation of NF-κB in vivo is regulated by multiple phosphorylations. EMBO J 13:4597, 1994
    • (1994) EMBO J , vol.13 , pp. 4597
    • Naumann, M.1    Scheidereit, C.2
  • 46
    • 0027462682 scopus 로고
    • Mutual regulation of the transcriptional activator NFκB and its inhibitor, IκBα
    • Brown K, Park S, Kanno T, Franzoso T, Siebenlist U: Mutual regulation of the transcriptional activator NFκB and its inhibitor, IκBα. Proc Natl Acad Sci USA 90:2532, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2532
    • Brown, K.1    Park, S.2    Kanno, T.3    Franzoso, T.4    Siebenlist, U.5
  • 48
    • 0028557348 scopus 로고
    • Tumor necrosis factor α-induced phosphorylation of IκBα is a signal for its degradation but not dissociation from NFκB
    • Miyamoto S, Maki M, Schmitt MJ, Hatanaka M, Verma IM: Tumor necrosis factor α-induced phosphorylation of IκBα is a signal for its degradation but not dissociation from NFκB. Proc Natl Acad Sci USA 91:12740, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12740
    • Miyamoto, S.1    Maki, M.2    Schmitt, M.J.3    Hatanaka, M.4    Verma, I.M.5
  • 49
    • 0027207242 scopus 로고
    • Tumor necrosis factor and interleukin 1 lead to phosphorylation and loss of IκBα: A mechanism for NFκB activation
    • Beg AA, Finco TS, Nantermet PV, Baldwin AS Jr: Tumor necrosis factor and interleukin 1 lead to phosphorylation and loss of IκBα: A mechanism for NFκB activation. Mol Cell Biol 13:3301, 1993
    • (1993) Mol Cell Biol , vol.13 , pp. 3301
    • Beg, A.A.1    Finco, T.S.2    Nantermet, P.V.3    Baldwin Jr., A.S.4
  • 50
    • 0025599439 scopus 로고
    • NF-κB: A family of inducible and differentially expressed enhancer-binding proteins in human T cells
    • Molitor JA, Walker WH, Doerre D, Ballard DW, Greene WC: NF-κB: A family of inducible and differentially expressed enhancer-binding proteins in human T cells. Proc Natl Acad Sci USA 87:10028, 1990
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 10028
    • Molitor, J.A.1    Walker, W.H.2    Doerre, D.3    Ballard, D.W.4    Greene, W.C.5
  • 51
    • 0026717450 scopus 로고
    • IL-2-induced signal transduction involves the activation of nuclear NF-κB expression
    • Arima N, Kuziel WA. Grdina TA, Greene WC: IL-2-induced signal transduction involves the activation of nuclear NF-κB expression. J Immunol 149:83, 1992
    • (1992) J Immunol , vol.149 , pp. 83
    • Arima, N.1    Kuziel, W.A.2    Grdina, T.A.3    Greene, W.C.4
  • 53
    • 0027581634 scopus 로고
    • Activation of primary human T-lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NFκB
    • Costello R, Lipcey C, Algarte M, Cerdan C, Baeuerle PA, Olive D, Imbert J: Activation of primary human T-lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NFκB. Cell Growth Differ 4:329, 1993
    • (1993) Cell Growth Differ , vol.4 , pp. 329
    • Costello, R.1    Lipcey, C.2    Algarte, M.3    Cerdan, C.4    Baeuerle, P.A.5    Olive, D.6    Imbert, J.7
  • 54
    • 0011152741 scopus 로고
    • Tumor necrosis factor α induces proteins that bind specifically to κB-like enhancer elements and regulate interleukin-2 receptor α-chain gene expression in primary human T lymphocytes
    • Lowenthal JW, Ballard DW, Bohnlein E, Greene WC: Tumor necrosis factor α induces proteins that bind specifically to κB-like enhancer elements and regulate interleukin-2 receptor α-chain gene expression in primary human T lymphocytes. Proc Natl Acad Sci USA 86:2331, 1989
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 2331
    • Lowenthal, J.W.1    Ballard, D.W.2    Bohnlein, E.3    Greene, W.C.4
  • 55
    • 0025266685 scopus 로고
    • Activation in vitro of NFκB by phosphorylation of its inhibitor IκB
    • Ghosh S, Baltimore D: Activation in vitro of NFκB by phosphorylation of its inhibitor IκB. Nature 344:678, 1990
    • (1990) Nature , vol.344 , pp. 678
    • Ghosh, S.1    Baltimore, D.2
  • 57
    • 0027219329 scopus 로고
    • KB site-dependent induction of gene expression by diverse inducers of nuclear factor kB requires Raf-1
    • Finco TS, Baldwin AS Jr: KB site-dependent induction of gene expression by diverse inducers of nuclear factor kB requires Raf-1. J Biol Chem 268:17676, 1993
    • (1993) J Biol Chem , vol.268 , pp. 17676
    • Finco, T.S.1    Baldwin Jr., A.S.2
  • 59
    • 0031285250 scopus 로고    scopus 로고
    • Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway
    • Lee FS, Hagler J, Chen ZJ, Maniatis T: Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88:213, 1997
    • (1997) Cell , vol.88 , pp. 213
    • Lee, F.S.1    Hagler, J.2    Chen, Z.J.3    Maniatis, T.4
  • 60
    • 0030610362 scopus 로고    scopus 로고
    • A cytokine-responsive IκB kinase that activates the transcription factor NFκB
    • DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M: A cytokine-responsive IκB kinase that activates the transcription factor NFκB. Nature 388:548, 1997
    • (1997) Nature , vol.388 , pp. 548
    • DiDonato, J.A.1    Hayakawa, M.2    Rothwarf, D.M.3    Zandi, E.4    Karin, M.5
  • 61
    • 0028965830 scopus 로고
    • Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex
    • Aoe T, Okamoto Y, Saito T: Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex. J Exp Med 181:1881, 1995
    • (1995) J Exp Med , vol.181 , pp. 1881
    • Aoe, T.1    Okamoto, Y.2    Saito, T.3
  • 62
    • 0030048536 scopus 로고    scopus 로고
    • Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing zeta molecules and inhibits tumor-specific T cell and NK-mediated cytotoxicity
    • Kono K, Salazar-Onfray F, Petersson M, Hansson J, Masucci G, Wasserman K, Nakazawa T, Anderson P, Kiessling R: Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing zeta molecules and inhibits tumor-specific T cell and NK-mediated cytotoxicity. Eur J Immunol 26:1308, 1996
    • (1996) Eur J Immunol , vol.26 , pp. 1308
    • Kono, K.1    Salazar-Onfray, F.2    Petersson, M.3    Hansson, J.4    Masucci, G.5    Wasserman, K.6    Nakazawa, T.7    Anderson, P.8    Kiessling, R.9
  • 63
    • 0031026259 scopus 로고    scopus 로고
    • Transfer of the interleukin-2 gene into human cancer cells induces specific antitumor recognition and restores the expression of CD3/T-cell receptor associated signal transduction molecules
    • Guarini A, Riera L, Cignetti A, Montacchini L, Massaia M, Foa R: Transfer of the interleukin-2 gene into human cancer cells induces specific antitumor recognition and restores the expression of CD3/T-cell receptor associated signal transduction molecules. Blood 89:212, 1997
    • (1997) Blood , vol.89 , pp. 212
    • Guarini, A.1    Riera, L.2    Cignetti, A.3    Montacchini, L.4    Massaia, M.5    Foa, R.6
  • 64
    • 0031571785 scopus 로고    scopus 로고
    • Tumor-induced suppression of T lymphocyte proliferation coincides with inhibition of Jak3 expression and IL2 receptor signaling: Role of soluble products from human renal cell carcinomas
    • Kolenko V, Wang Q, Riedy MC, O'Shea J, Ritz J, Cathcart MK, Rayman P, Tubbs R, Edinger M, Novick A, Bukowski R, Finke J: Tumor-induced suppression of T lymphocyte proliferation coincides with inhibition of Jak3 expression and IL2 receptor signaling: Role of soluble products from human renal cell carcinomas. J Immunol 159:3057, 1997
    • (1997) J Immunol , vol.159 , pp. 3057
    • Kolenko, V.1    Wang, Q.2    Riedy, M.C.3    O'Shea, J.4    Ritz, J.5    Cathcart, M.K.6    Rayman, P.7    Tubbs, R.8    Edinger, M.9    Novick, A.10    Bukowski, R.11    Finke, J.12


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