Protection against lethal encephalomyocarditis virus infection in the absence of serum-neutralizing antibodies

Journal of Virology

Volumn 72, Issue 10, 1998, Pages 8052-8060

  Neal, Zane C ^a   Splitter, Gary A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENCEPHALOMYOCARDITIS VIRUS; LYMPHOCYTE COUNT; MAJOR HISTOCOMPATIBILITY COMPLEX; MENGO VIRUS; MOUSE; NONHUMAN; PICORNAVIRUS INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE SUBPOPULATION; TARGET CELL; VIRUS STRAIN;

EID: 0031719016     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.10.8052-8060.1998     Document Type: Article

References (50)

1. b gene become resistant to persistent infection by Theiler's virus. J. Virol. 68:4049-4052.
2. Bogaerts, W. J., and D. van der Oord. 1972. Immunization of mice against encephalomyocarditis virus. II. Intraperitoneal and respiratory immunization with ultraviolet-inactivated vaccine: effect of Bordetella pertussis extract on the immune response. Infect. Immun. 6:513-517.
3. Caruso, A., S. Licenziati, M. Corulli, A. D. Canaris, M. A. De Francesco, S. Fiorenrini, L. Peroni, F. Fallacara, F. Dima, A. Balsari, and A. Turano. 1997. Flow cytometric analysis of activation markers on stimulated T cells and their correlation with cell proliferation. Cytometry 27:71-76.
4. Christensen, J. P., O. Marker, and A. R. Thomsen. 1994. The role of CD4+ T cells in cell-mediated immunity to LCMV: studies in MHC class I and class II deficient mice. Scand. J. Immunol. 40:373-382.
5. Dethlefs, S., N. Escriou, M. Brahic, S. van der Werf, and E. Larsson-Sciard. 1997. Theiler's virus and Mengo virus induce cross-reactive cytotoxic T lymphocytes restricted to the same immunodominant VP2 epitope in C57BL/6 mice. J. Virol. 71:5361-5365.
6. Dethlefs, S., M. Brahic, and E. Larsson-Sciard. 1997. An early, abundant cytotoxic T-lymphocyte response against Theiler's virus is critical for preventing viral persistence. J. Virol. 71:8875-8878.
7. Dick, G. W. A. 1948. Mengoencephalomyelitis virus: pathogenicity for animals and physical properties. Br. J. Exp. Pathol. 29:559-577.
8. Doherty, P. C., S. Hou, and R. A. Tripp. 1994. CD8+ T-cell memory to viruses. Curr. Opin. Immunol. 6:545-552.
9. Duke, G. M., J. E. Osorio, and A. C. Palmenberg. 1990. Attenuation of Mengo virus through genetic engineering of 5' noncoding poly(C) tract. Nature 343:474-476.
10. Duke, G. M., and A. C. Palmenberg. 1989. Cloning and synthesis of infectious cardiovirus RNAs containing short, discrete poly(C) tracts. J. Virol. 63:1822-1826.
11. Escriou, N., C. Leclerc, S. Gerbaud, M. Girard, and S. van der Werf. 1995. Cytotoxic T cell response to Mengo virus in mice: effector cell phenotype and target proteins. J. Gen. Virol. 76:1999-2007.
12. Fiette, L., M. Brahic, and C. Pena-Rossi. 1996. Infection of class II-deficient mice by the DA strain of Theiler's virus. J. Virol. 70:4811-4815.
13. Fiette, L., C. Aubert, M. Brahic, and C. Pena-Rossi. 1993. Theiler's virus infection of β2-microglobulin-deficient mice. J. Virol. 67:589-592.
14. Fujinami, R. S., A. Rosenthal, P. W. Lampert, A. Zurbriggen, and M. Yamada. 1989. Survival of athymic (nu/nu) mice after Theiler's murine encephalomyelitis virus infection by passive administration of neutralizing monoclonal antibody. J. Virol. 63:2081-2087.
15. Grusby, M. J., and L. H. Glimcher. 1995. Immune responses in MHC class II-deficient mice. Annu. Rev. Immunol. 13:417-435.
16. Guthke, R., A. Veckenstedt, J. Guttner, R. Stracke, and F. Bergter. 1987. Dynamic model of the pathogenesis of Mengo virus infection in mice. Acta Virol. (Praha) 31:307-320.
17. Hassin, D., R. Fixier, H. Bank, A. S. Klein, and Y. Hasin. 1985. Cytotoxic T lymphocytes and natural killer cell activity in the course of mengo virus infection of mice. Immunology 56:701-705.
18. Hou, S., L. Hyland, and P. C. Doherty. 1995. Host responses to Sendai virus in mice lacking class II major histocompatibility complex glycoproteins. J. Virol. 69:1429-1434.
19. Johannisson, A., A. Thuvander, and I. L. Gadhasson. 1995. Activation markers and cell proliferation as indicators of toxicity: a flow cytometric approach. Cell Biol. Toxicol. 11:355-366.
20. Kagi, D., and H. Hengartner. 1996. Different roles for cytotoxic T cells in the control of infections with cytopathic versus noncytopathic viruses. Curr. Opin. Immunol. 8:472-177.
21. Kimura, T., K. Nakayama, J. Penninger, M. Kitagawa, H. Harada, T. Matsuyama, N. Tanaka, R. Kamijo, J. Vilcek, and T. W. Mak. 1994. Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science 264:1921-1924.
22. Larsson-Sciard, E., S. Dethlefs, and M. Brahic. 1997. In vivo administration on interleukin-2 protects susceptible mice from Theiler's virus persistence. J. Virol. 71:797-799.
23. Minor, P. D. 1987. Structure of picornavirus coat proteins and their antigenicity, p. 259-280. In D. J. Rowlands, M. A. Mayo, and B. W. J. Mahy (ed.), The molecular biology of the positive strand RNA viruses. Academic Press Inc., Orlando, Fla.
24. Mosmann, T. R., and S. Sad. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17:138-146.
25. Mosser, A. G., D. M. Leippe, and R. R. Rueckert. 1989. Neutralization of picornaviruses; support for the pentamer bridging hypothesis, p. 155-168. In B. L. Semler and E. Ehrenfeld (ed.), Molecular aspects of picornavirus infection and detection. American Society for Microbiology, Washington, D.C.
26. Muir, S., J. P. Weintraub, J. Hogle, and J. L. Bittle. 1991. Neutralizing antibody to Mengo virus, induced by synthetic peptides. J. Gen. Virol. 72: 1087-1092.
27. Murdin, A. D., M. G. Murry, and E. Wimmer. 1990. Novel approaches to picornavirus vaccines, p. 301-323. In A. Mizrahi (ed.), Viral vaccines. WileyLiss, Inc., New York, N.Y.
28. Murphy, B. R., and R. M. Chanock, 1996. Immunization against viruses, p. 467-498. In B. N. Fields, D. M. Knipe, P. M. Howley, R. M. Chanock, J. L. Melnick, T. P. Monath, B. Roizman, and S. E. Straus (ed.), Fields virology, 3rd ed. Lippincott-Raven Press, Philadelphia, Pa.
29. + T lymphocytes possessing cytolytic activity confer protection in the absence of prophylactic antibodies. J. Virol. 69:4914-4923.
30. + T lymphocytes provide protection against TMEV-induced demyelinating disease in BALB/c mice. J. lmmunol. 156: 1276-1283.
31. Njenga, M. K., K. D. Pavelko, J. Baisch, X. Lin, C. David, J. Leibowitz, and M. Rodriguez. 1996. Theiler's virus persistence and demyelination in major histocompatibility complex II-deficient mice. J. Virol. 70:1729-1737.
32. Nomoto, A., N. lizuka, M. Kohara, and M. Arita. 1988. Strategy for construction of live picornavirus vaccines. Vaccine 6:134-137.
33. O'Gorman, M. R., V. Corrochano, and R. Y. Poon. 1996. Beyond tritiated thymidine: flow cytometric assays for the evaluation of lymphocyte activation/proliferation. Clin. lmmunol. News 16:164-172.
34. Ozmen, L., M. Aguet, G. Trinchiieri, and G. Garotta. 1995. The in vivo antiviral activity of interleukin-12 is mediated by gamma Interferon. J. Virol. 69:8147-8150.
35. Palmenberg, A. C. 1989. Sequence alignments of picornaviral capsid proteins, p. 211-242. In B. L. Semler and E. Ehrenfeld (ed.), Molecular aspects of picornavirus infection and detection. American Society for Microbiology, Washington, D.C.
36. Palmenberg, A. C. Personal communication.
37. Pihlgren, M., P. M. Dubois, M. Tomkowiak, T. Sjogren, and J. Marvel. 1996. Resting memory CD8+ T cells are hyperreactive to antigenic challenge in vitro. J. Exp. Med. 184:2141-2151.
38. Rock, K. L., and K. Clark, 1996. Analysis of the role of MHC class II presentation in the stimulation of cytotoxic T lymphocytes by antigens targeted into the exogenous antigen-MHC class I pathway. J. Immunol. 156: 3721-3726.
39. Rodriguez, M., and C. S. David. 1985. Demyelination induced by Theiler's virus: influence of the H-2 haplotype. J. Immunol. 135:2145-2148.
40. b mice deficient in β2-microglobulin. J. Immunol. 151: 266-276.
41. Rossi, C. P., E. Cash, C. Aubert, and A. Coutinho. 1991. Role of the humoral immune response in resistance to Theiler's vims infection. J. Virol. 65:3895-3899.
42. Rueckert, R. R. 1996. Picornaviridae: the viruses and their replication, p. 609-654. In B. N. Fields, D. M. Knipe, P. M. Howley, R. M. Chanock, J. L. Melnick, T. P. Monath, B. Roizman, and S. E. Straus (ed.), Fields virology, 3rd ed. Lippincott-Raven Press, Philadelphia, Pa.
43. Smith, D. M., F. P. Stuart, G. A. Wemhoff, J. Quintans, and F. W. Fitch. 1987. Cellular pathways for rejection of class-I-MHC-disparate skin and tumor allografts. Transplantation 45:168-175.
44. Sriram, S., D. J. Topham, S. K. Huang, and M. Rodriguez. 1989. Treatment of encephalomyocarditis virus-induced central nervous system demyelination with monoclonal anti-T-cell antibodies. J. Virol. 63:4242-4248.
45. Thomsen, A. R., J. Johansen, O. Marker, and J. P. Christensen. 1996. Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B celldeficient mice. J. Immunol. 157:3074-3080.
46. b gene. J. Immunol. 155:2955-2959.
47. Veckenstedt, A. 1974. Pathogenicity of Mengo virus to mice. I. Virological studies. Acta Virol. (Praha) 18:501-507.
48. von Herrath, M. G., M. Yokoyama, J. Dockter, M. B. A. Oldstone, and J. L. Whitton. 1996. CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge. J. Virol. 70:1072-1079.
49. Welsh, C. J., P. Tonks, A. A. Nash, and W. F. Blakemore. 1987. The effect of L3T4 T cell depletion on the pathogenesis of Theiler's murine encephalomyelitis virus infection in CBA mice. J. Gen. Virol. 68:1659-1667.
50. Zinkernagel, R. M. 1996. Immunology taught by viruses. Science 271:173-178.