The zebrafish organizer

Current Opinion in Genetics and Development

Volumn 8, Issue 4, 1998, Pages 464-471

  Schier, Alexander F ^a   Talbot, William S ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; OSTEOGENIC PROTEIN 1;

ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME MUTATION; EMBRYO; EMBRYO AXIS; ENDODERM; GASTRULA; GENETIC MARKER; GERM LAYER; NERVOUS SYSTEM DEVELOPMENT; NEUROECTODERM; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPINAL NERVE; VERTEBRATE; ZEBRA FISH;

DANIO RERIO; VERTEBRATA;

EID: 0031712745     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(98)80119-6     Document Type: Article

References (89)

1. Spemann H, Mangold H: Ueber die Induktion von Embryonalanlagen durch Implantation artfremder Organisatoren. Wilhelm Roux Arch Entw Mech 1924, 100:599-638 [Title translation: On the induction of embryonic structures by implantation of organizers of different species.].
2. Harland R, Gerhart J: Formation and function of Spemann's organizer. Annu Rev Cell Dev Biol 1997, 13:611-667.
3. Beddington RSP: Induction of a second neural axis by the mouse node. Development 1994, 120:613-620.
4. Waddington CH: Experiments on the development of the chick and the duck embryo cultivated in vitro. Proc Trans R Soc Lond (B) 1932, 211:179-230.
5. Oppenheimer J: Transplantation experiments on developing teleosts (Fundulus and Perca). J Exp Zool 1936, 72:409-437.
6. Shih J, Fraser SE: Characterizing the zebrafish organizer: microsurgical analysis at the early-shield stage. Development 1996, 122:1313-1322.
7. ••].
8. ••] also show that removal of the vegetal region of the yolk disrupts shield formation in the zebrafish embryo.
9. Heasman J: Patterning the Xenopus blastula. Development 1997, 124:4179-4191.
10. Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF: Stages of embryonic development of the zebrafish. Dev Dyn 1995, 203:253-310.
11. Mizuno T, Yamaha E, Wakahara M, Kuroiwa A, Takeda H: Mesoderm induction in zebrafish. Nature 1996, 383:131-132.
12. Long WL: The role of the yolk syncytial layer in determination of the plane of bilateral symmetry in rainbow trout, Salmo gairdneri Richardson. J Exp Zool 1983, 228:91-97.
13. Solnica-Krezel L, Stemple DL, Driever W: Transparent things: cell fates and cell movements during early embryogenesis of zebrafish. Bioessays 1995, 17:931-939.
14. Schneider S, Steinbeisser H, Warga RM, Hausen P: Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos. Mech Dev 1996, 57:191-198.
15. •].
16. •] report that disruption of microtubule arrays that form in the early embryo also interferes with establishment of the organizer, suggesting a role for these arrays in the translocation of ofdorsal determinants initially located at the vegetal pole.
17. Kelly GM, Erezyilmaz DF, Moon RT: Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of β-catenin. Mech Dev 1995, 53:261-273.
18. Wittbrodt J, Rosa FM: Disruption of mesoderm and axis formation in fish by ectopic expression of activin variants: the role of maternal activin. Genes Dev 1994, 8:1448-1462.
19. Heide KA, Grunwald DJ: The DVR-1 (Vg1) transcript of zebrafish is maternally supplied and distributed throughout the embryo. Dev Biol 1993, 159:418-426.
20. Keller RE: Vital dye mapping of the gastrula and neurula of Xenopus laevis Part II. Prospective areas and morphogenetic mnovements of the deep region. Dev Biol 1976, 51:118-137.
21. Hemmati-Brivanlou A, Melton D: Vertebrate neural induction. Annu Rev Neurosci 1997, 20:43-60.
22. De Robertis EM, Sasai Y: A common plan for dorsoventral patterning in Bilateria. Nature 1996, 380:37-40.
23. Dosch R, Gawantka V, Delius H, Blumenstock C, Niehrs C: Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus. Development 1997, 124:2325-2334.
24. Jones CM, Smith JC: Establishment of a BMP-4 morphogen gradient by long-range inhibition. Dev Biol 1998, 194:12-17.
25. Wilson PA, Lagna G, Suzuki A, Hemmati-Brivanlou A: Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1. Development 1997, 124:3177-3184.
26. Hammerschmidt M, Pelegri F, Mullins MC, Kane DA, van Eeden FJ, Granato M, Brand M, Furutani SM, Haffter P, Heisenberg CP et al.: dino and mercedes, two genes regulating dorsal development in the zebrafish embryo. Development 1996, 123:95-102.
27. Solnica-Krezel L, Stemple DL, Mountcastle-Shah E, Rangini Z, Neuhauss SCF, Malicki J, Schier AF, Stainier DYR, Zwartkruis F Abdelilah S, Driever W: Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish. Development 1996, 123:67-80.
28. Mullins MC, Hammerschmidt M, Kane DA, Odenthal J, Brand M, van Eeeden FJ, Furutani SM, Granato M, Haffter P, Heisenberg CP et al.: Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes. Development 1996, 123:81-93.
29. ••].
30. ••] establishes the essential role of these factors in patterning the dorsal-ventral axis in mesoderm and ectoderm. The observation that the mutants can be rescued by widespread expression of injected RNA underscores the role of other factors in specifying positional values along the dorsal-ventral axis.
31. Martinez-Barbera JP, Toresson H, Da Rocha S, Krauss S: Cloning and expression of three members of the zebrafish Bmp family: Bmp2a, Bmp2b and Bmp4. Gene 1997, 198:53-59.
32. Nikaido M, Tada M, Saji T, Ueno N: Conservation of BMP signaling in zebrafish mesoderm patterning. Mech Dev 1997, 61:75-88.
33. Hammerschmidt M, Serbedzija GN, McMahon AP: Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor. Genes Dev 1996, 10:2452-2461.
34. Winnier G, Blessing M, Labosky PA, Hogan BL: Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 1995, 9:2105-2116.
35. Hawley SH, Wunnenberg SK, Hashimoto C, Laurent MN, Watabe T, Blumberg BW, Cho KW: Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction. Genes Dev 1995, 9:2923-2935.
36. Steinbeisser H, Fainsod A, Niehrs C, Sasai Y, De RE: The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss-of-function study using antisense RNA. EMBO J 1995, 14:5230-5243.
37. Chin AJ, Chen J-N, Weinberg ES: Bone morphogenetic protein-4 expression characterizes inductive boundaries in organs of developing zebrafish. Dev Genes Evol 1997, 207:107-114.
38. Ekker M, Wegner J, Akimenko MA, Westerfield M: Coordinate embryonic expression of three zebrafish engrailed genes. Development 1992, 116:1001-1010.
39. Ekker SC, Ungar AR, Greenstein P, von KD, Porter JA, Moon RT, Beachy PA: Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. Curr Biol 1995, 5:944-955.
40. Currie PD, Ingham PW: Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish. Nature 1996, 382:452-455.
41. Krauss S, Concordet JP, Ingham PW: A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell 1993, 75:1431-1444.
42. Postlethwait JH, Van Y-L, Gates MA, Home S, Amores A, Brownlie A, Donovan A, Egan ES, Force A, Gong Z et al.: Vertebrate genome evolution and the zebrafish gene map. Nat Genet 1998, 18:345-349. This gene-mapping study identifies chromosomal segments where synteny is conserved between zebrafish and human. Analysis of the conserved segments suggests that two genomic duplications occurred in vertebrate evolution prior to the divergence of zebrafish and human ancestors, and that a third whole-genome duplication occurred in the zebrafish lineage after divergence. The observation that some linkage relationships have been preserved since the divergence of zebrafish and human raises the possibility that the locations of zebrafish genes can be predicted by comparison with human maps.
43. Hanks M, Wurst W, Anson-Cartwright L, Auerbach AB, Joyner AL: Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science 1995, 269:679-682.
44. Schwarz M, Alvarez-Bolado G, Urbanek P, Busslinger M, Gruss P: Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: evidence from targeted mutations. Proc Natl Acad Sci USA 1997, 94:14518-14523.
45. Piccolo S, Sasai Y, Lu B, De Robertis EM: Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. Cell 1996, 86:589-598.
46. Miller-Bertoglio VE, Fisher S, Sanchez A, Mullins MC, Halpern ME: Differential regulation of chordin expression domains in mutant zebrafish. Dev Biol 1997, 192:537-550.
47. Furthauer M, Thisse C, Thisse B: A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula. Development 1997, 124:4253-4564. These authors report the identification of a zebrafish FGF-8 homolog that is expressed in the dorsal marginal region of the early gastrula. Ectopic expression studies show that FGF-8 can expand lateral fates at the expense of ventral, supporting a role in dorsal-ventral patterning.
48. Ferguson EL: Conservation of dorsal-ventral patterning in arthropods and chordates. Curr Opin Genet Dev 1996, 6:424-431.
49. ••].
50. ••] show that vertebrate homologs of the Drosophila protease tolloid cleave the BMP-antagonist chordin. These results suggest that tolloid homologues have a role in establishing, refining or maintaining graded BMP signaling in the embryo.
51. Sasai Y, De Robertis EM: Ectodermal patterning in vertebrate embryos. Dev Biol 1997, 182:5-20.
52. Wilson PA, Hemmati-Brivanlou A: Induction of epidermis and inhibition of neural fate by Bmp-4. Nature 1995, 376:331-333.
53. Fisher S, Amacher SL, Halpern ME: Loss of cerebum function ventralizes the zebrafish embryo. Development 1997, 124:1301-1311.
54. Bouwmeester T, Leyns L: Vertebrate head induction by anterior primitive endoderm. Bioessays 1997, 19:855-863.
55. Doniach T: Induction of anteroposterior neural pattern in Xenopus by planar signals. Development 1992, Suppl.:183-1 93.
56. Ruiz i Altaba A: Induction and axial patterning of the neural plate: planar and vertical signals. J Neurobiol 1993, 24:1276-1304.
57. Schier AF, Neuhauss SC, Harvey M, Malicki J, Solnica-Krezel L, Stainier DY, Zwartkruis F, Abdelilah S, Stemple DL, Rangini Z et al.: Mutations affecting the development of the embryonic zebrafish brain. Development 1996, 123:165-178.
58. Brand M, Heisenberg CP, Warga RM, Pelegri F, Karlstrom RO, Beuchle D, Picker A, Jiang YJ, Furutani SM, van Eeden FJ et al.: Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. Development 1996, 123:129-142.
59. Heisenberg CP, Nüsslein-Volhard C: The function of silberblick in the positioning of the eye anlage in the zebrafish embryo. Dev Biol 1997, 184:85-94.
60. Hatta K, Kimmel CB, Ho RK, Walker C: The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system. Nature 1991, 350:339-341.
61. Talbot WS, Trevarrow B, Halpern ME, Melby AE, Farr G, Postlethwait JH, Jowett T, Kimmel CB, Kimelman D: A homeobox gene essential for zebrafish notochord development. Nature 1995, 378:150-157.
62. Odenthal J, Haffter P, Vogelsang E, Brand M, van Eeden FJM, Furutani-Seiki M, Granato M, Hammerschmidt M, Heisenberg C-P, Jiang Y-J et al.: Mutations affecting the formation of the notochord in the zebrafish, Danio rerio. Development 1996, 123:103-115.
63. •].
64. ••] that a secreted form of OEP protein can rescue oep mutants.
65. ••].
66. ••].
67. ••] identify new signaling centers that pattern the anterior-posterior neural axis in the vertebrate embryo. These centers, rather than the organizer, may instruct anterior-posterior neural patterning.
68. Heisenberg CP, Brand M, Jiang YJ, Warga RM, Beuchle D, van Eeden FJ, Furutani-Seiki M, Granato M, Haffter P, Hammerschmidt M et al.: Genes involved in forebrain development in the zebrafish, Danio rerio. Development 1996, 123:191-203.
69. Melby AE, Warga RM, Kimmel CB: Specification of cell fates at the dorsal margin of the zebrafish gastrula. Development 1996, 122:2225-2237.
70. Gont LK, Fainsod A, Kim SH, De Robertis EM: Overexpression of the homeobox gene Xnot-2 leads to notochord formation in Xenopus. Dev Biol 1996, 174:174-178.
71. Amacher S, Kimmel C: Promoting notochord fate and repressing muscle development in zebrafish axial mesoderm. Development 1998, 125:1397-1406. Analysis of flh;spt double mutants provides genetic evdience that the notochord-specific flh gene functions to repress spt, which is required for development of trunk muscle. Transplantation studies show that cells mutant for flh, which encodes a homeodomain protein, can acquire a notochord fate in response to signals present in a wild-type environment.
72. Kimmel CB, Kane DA, Walker C, Warga RM, Rothman MB: A mutation that changes cell movement and cell fate in the zebrafish embryo. Nature 1989, 337:358-362.
73. Hammerschmidt M, Pelegri F, Mullins MC, Kane DA, Brand M, van Eeden FJ, Furutani SM, Granato M, Haffter P, Heisenberg CP et al.: Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. Development 1996, 123:143-151.
74. Zhang J, Talbot WS, Schier AF: Positional cloning identifies zebrafish one-eyedpinheadas a permissive EGF-related ligand required during gastrulation. Cell 1998, 92:241-251. These authors employ a positional cloning approach to identifiy a new gene with essential function in prechordal plate and endoderm development. The oep gene product might be a previously unrecognized component of a known signalling pathway, or it might define a novel pathway operating in the early embryo.
75. Ciccodicola A, Dono R, Obici S, Simeone A, Zollo M, Persico MG: Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells. EMBO J 1989, 8:1987-1991.
76. Shen MM, Wang H, Leder P: A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation. Development 1997, 124:429-442.
77. Kinoshita N, Minshull J, Kirschner MW: The identification of two novel ligands of the FGF receptor by a yeast screening method and their activity in Xenopus development. Cell 1995, 83:621-630.
78. Kannan S, De SM, Lohmeyer M, Riese DF, Smith GH, Hynes N, Seno M, Brandt R, Bianco C, Persico G et al.: Cripto enhances the tyrosine phosphorylation of She and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells. J Biol Chem 1997, 272:3330-3335.
79. Parkin NT, Kitajewski J, Varmus HE: Activity of wnt1 as a transmembrane protein. Genes Dev 1993, 7:2181-2193.
80. Talbot WS, Schier AF: Positional cloning of mutated genes in zebrafish. Methods Cell Biol 1998, 60:in press.
81. Postlethwait JH, Talbot WS: Zebrafish genomics: from mutants to genes. Trends Genet 1997, 13:183-190.
82. Gaiano N, Amsterdam A, Kawakami K, Allende M, Becker T, Hopkins N: Insertional mutagenesis and rapid cloning of essential genes in zebrafish. Nature 1996, 383:829-832.
83. Schier AF, Joyner AL, Lehmann R, Talbot WS: From screens to genes: prospects for insertional mutagenesis in zebrafish. Genes Dev 1996, 10:3077-3080.
84. •].
85. •] have constructed a Tc1-class transposon by correcting inactivating mutations from salmonid transposon- like sequences and showed that this synthetic element, Sleeping Beauty, is active in fish and mammalian cells. These reports lay the foundation for transposon-mediated gene transfer and, if transposition efficiency can be improved, mutagenesis in zebrafish.
86. Knapik EW, Goodman A, Ekker M, Chevrette M, Delgado J, Neuhauss S, Shimoda N, Driever W, Fishman MC, Jacob HJ: A microsatellite genetic linkage map for zebrafish. Nat Genet 1998, 18:338-343. The construction of a genetic map with 705 simple sequence-length polymorphisms is an important advance for genetic and genomic analysis in zebrafish.
87. Postlethwait JH, Johnson SL, Midson CN, Talbot WS, Gates M, Ballinger EW, Africa D, Andrews R, Carl T, Eisen JS et al.: A genetic linkage map for the zebrafish. Science 1994, 264:699-703.
88. Serbedzija G, Chen JN, Fishman M: Regulation in the heart field of zebrafish. Development 1998, 125:1095-1101. The authors use laser-activated caged-fluorescein fate mapping to define the locations of cardiac progenitors in the embryo and to identfiy the source of cells that can divert to a cardiac fate when the normal progenitors are ablated. This paper represents an important advance in the utility of caged compunds in the transparent zebrafish embryo.
89. Long Q, Meng A, Wang H, Jessen JR, Farrell MJ, Lin S: GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development 1997, 124:4105-4111. These authors report a GATA-1-GFP transgene that serves as an in vivo reporter of promoter activity, paving the way for the identification of control elements and controlled mis-expression studies in zebrafish.