Infrequent genetic alterations of the PTEN* gene in Japanese patients with sporadic prostate cancer

Journal of Human Genetics

Volumn 43, Issue 4, 1998, Pages 228-230

  Orikasa, Kazuhiko ^a   Fukushige, Shin Ichi ^a   Hoshi, Senji ^a   Orikasa, Seiichi ^a   Kondo, Keiichi ^b   Miyoshi, Yasuhide ^b   Kubota, Yoshinobu ^b   Horii, Akira ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Chromosome 10q; Loss of heterozygosity (LOH); Prostate cancer; PTEN gene; Tumor suppressor gene

Indexed keywords

DNA;

ADULT; AGED; ARTICLE; CHROMOSOME 10Q; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; JAPAN; MALE; POLYMERASE CHAIN REACTION; PROSTATE CANCER; TUMOR SUPPRESSOR GENE;

EID: 0031702230     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380050078     Document Type: Article

References (12)

1. Cairns P, Okami K, Halachmi S, Halachmi N, Esteller M, Herman JG, Jen J, Isaacs WB, Bova GS, Sidransky D (1997) Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res 57: 4997-5000
2. Carter BS, Ewing CM, Ward WS, Treiger BF, Aalders TW, Schalken JA, Epstein JI, Isaacs WB (1990) Allelic loss of chromosome 16q and 10q in human prostate cancer. Proc Natl Acad Sci USA 87: 8751-8755
3. Eagle LR, Yin X, Brothman AR, Williams BJ, Atkin NB, Prochownik EV (1995) Mutation of the MXI1 gene in prostate cancer. Nat Genet 9: 249-255
4. Kong D, Suzuki A, Zou T-T, Sakurada A, Kemp LW, Wakatsuki S, Yokoyama T, Yamakawa H, Furukawa T, Sato M, Ohuchi N, Sato S, Yin J, Wang S, Abraham JM, Souza RF, Smolinski KN, Meltzer SJ, Horii A (1997) PTEN1 is frequently mutated in primary endometrial carcinomas. Nat Genet 17: 143-144
5. Li D-M, Sun H (1997) TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor β. Cancer Res 57: 2124-2129
6. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Hibshoosh H, Wigler MH, Parsons R (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943-1947
7. Prout GR (1973) Diagnosis and staging of prostate carcinoma. Cancer 32: 1096-1103
8. Risinger JI, Hayes AK, Berchuck A, Barrett JC (1997) PTEN/MMAC1 mutations in endometrial cancers. Cancer Res 57: 4736-4738
9. Sakurada A, Suzuki A, Sato M, Yamakawa H, Orikasa K, Uyeno S, Ono T, Ohuchi N, Fujimura S, Horii A (1997) Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary. Jpn J Cancer Res 88: 1025-1028
10. Steck PA, Pershouse MA, Jasser SA, Yang WKA, Lin H, Ligon AH, Langford LA, Baumgard ML, Harrier T, Davis T, Frye C, Hu R, Swedlund B, Teng DHF, Tavtigian SV (1997) Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15: 356-362
11. Suzuki H, Freije D, Nusskern D, Okami K, Cairns P, Sidransky D, Issacs W, Bova G (1998) Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues. Cancer Res 58, 204-209
12. Tashiro H, Blazes MS, Wu R, Cho KR, Bose S, Wang SI, Li J, Parsons R, Ellenson LH (1997) Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res 57: 3935-3940