Comparison of D0870, a new triazole antifungal agent, to fluconazole for inhibition of Candida albicans cytochrome P-450 by using in vitro assays

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 6, 1996, Pages 1382-1386

  Venkateswarlu, K ^a   Denning, D W ^c   Manning, N J ^b   Kelly, S L ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,4 DIFLUOROPHENYL) 1 [3 [2 [4 (2,2,3,3 TETRAFLUOROPROPOXY)PHENYL]VINYL] 1,2,4 TRIAZOL 1 YL] 3 (1,2,4 TRIAZOL 1 YL) 2 PROPANOL; ANTIFUNGAL AGENT; CARBON MONOXIDE; CYTOCHROME P450; ERGOSTEROL; FLUCONAZOLE; MEVALONIC ACID; OXIDOREDUCTASE; STEROL; STEROL 14ALPHA DEMETHYLASE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; BINDING AFFINITY; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME INHIBITION; FUNGUS GROWTH; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STEROL SYNTHESIS;

EID: 0030028176     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.6.1382     Document Type: Article

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