Functional and nonfunctional mutations distinguished by random recombination of homologous genes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 15, 1997, Pages 7997-8000

  Zhao, Huimin ^a   Arnold, Frances H ^a  

^a California Institute of Technology   (United States)

Author keywords

Adaptive evolution; DNA shuffling; In vitro evolution; Neutral mutations

Indexed keywords

DNA; SUBTILISIN;

ADAPTATION; ARTICLE; DNA LIBRARY; ENZYME STABILITY; ESCHERICHIA COLI; EVOLUTION; GENE MUTATION; GENETIC RECOMBINATION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SURVIVAL;

CALORIMETRY, DIFFERENTIAL SCANNING; ENZYME STABILITY; MUTAGENESIS, SITE-DIRECTED; MUTATION; RECOMBINATION, GENETIC; SUBTILISINS;

ESCHERICHIA COLI;

EID: 0030858562     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.15.7997     Document Type: Article

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