Signal transduction revisited: Recent developments in angiotensin II signaling in the cardiovascular system

Cardiovascular Research

Volumn 36, Issue 3, 1997, Pages 310-322

  Van Bilsen, Marc ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Angiotensin II; Cytokine; MAP kinase; Protein kinase C; Signal transduction; Tyrosine kinase

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; CYTOKINE; ENDOTHELIN 1; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C; PROTEIN KINASE C; PROTEIN P21; PROTEIN TYROSINE KINASE; RAF PROTEIN; RAS PROTEIN; RECEPTOR SUBTYPE; SOMATOMEDIN C; STAT1 PROTEIN;

CARDIOVASCULAR SYSTEM; CELL COMMUNICATION; EXTRACELLULAR MATRIX; MECHANORECEPTOR; PRIORITY JOURNAL; REVIEW; SHEAR STRESS; SIGNAL TRANSDUCTION;

ANGIOTENSIN II; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARDIOVASCULAR SYSTEM; ENZYME ACTIVATION; GENES, RAS; HUMANS; MYOCARDIUM; PROTEIN KINASES; RECEPTORS, ANGIOTENSIN; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION;

EID: 0031454594     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(97)00239-3     Document Type: Review

References (144)

1. Duff J.L., Marrero M.B., Paxton W.G., Schieffer B., Bernstein K.E., Berk B.C. Angiotensin II signal transduction and the mitogen-activated protein kinase pathway. Cardiovasc Res. 30:1995;511-517.
2. Marrero M.B., Schieffer B., Paxton W.G., Duff J.L., Berk B.C., Bernstein K.E. The role of tyrosine phosphorylation in angiotensin II-mediated intracellular signalling. Cardiovasc Res. 30:1995;530-536.
3. Booz G.W., Baker K.M. Molecular signalling mechanisms controlling growth and function of cardiac fibroblasts. Cardiovasc Res. 30:1995;537-543.
4. Watson P. Mechanical activation of signaling pathways in the cardiovascular system. Trends Cardiovasc Med. 6:1996;73-79.
5. Yamazaki T., Komuro I., Yazaki Y. Molecular mechanism of cardiac cellular hypertrophy by mechanical stress. J Mol Cell Cardiol. 27:1995;133-140.
6. Sigurdson W., Ruknudin A., Sachs F. Calcium imaging of mechanically induced fluxes in tissue-cultured chick heart: role of stretch-activated ion channels. Am J Physiol. 262:1992;H1110-1115.
7. Sadoshima J., Takahashi T., Jahn L., Izumo S. Roles of mechano-sensitive ion channels, cytoskeleton, and contractile activity in stretch-induced immediate-early gene expression and hypertrophy of cardiac myocytes. Proc Natl Acad Sci USA. 89:1992;9905-9909.
8. Juliano R.L., Haskill S. Signal transduction from the extracellular matrix. J Cell Biol. 120:1993;577-585.
9. Hamasaki K., Mimura T., Furuya H.et al. Stretching mesangial cells stimulates tyrosine phosphorylation of focal adhesion kinase pp125FAK. Biochem Biophys Res Commun. 212:1995;544-549.
10. Richardson A., Parsons J.T. Signal transduction through integrins: a central role for focal adhesion kinase? Bioessays. 17:1995;229-236.
11. Schaller M.D., Hildebrand J.D., Shannon J.D., Fox J.W., Vines R.R., Parsons J.T. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol. 14:1994;1680-1688.
12. Malek A.M., Greene A.L., Izumo S. Regulation of endothelin 1 gene by fluid shear stress is transcriptionally mediated and independent of protein kinase C and cAMP. Proc Natl Acad Sci USA. 90:1993;5999-6003.
13. Noris M., Morigi M., Donadelli R.et al. Nitric oxide synthesis by cultured endothelial cells is modulated by flow conditions. Circ Res. 76:1995;536-543.
14. Sadoshima J., Xu Y., Slayter H.S., Izumo S. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell. 75:1993;977-984.
15. Ito H., Hirata Y., Adachi S.et al. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest. 92:1993;398-403.
16. Shubeita H.E., McDonough P.M., Harris A.N. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly and cardiac gene expression in ventricular myocytes: a paracrine mechanism for myocardial cell hypertrophy. J Biol Chem. 265:1990;20555-20562.
17. Sadoshima J., Izumo S. Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Circ Res. 73:1993;413-423.
18. Baker K.M., Booz G.W., Dostal D.E. Cardiac actions of angiotensin II: Role of an intracardiac renin-angiotensin system. Ann Rev Physiol. 54:1992;227-241.
19. Passier R.C., Smits J.F., Verluyten M.J., Daemen M.J. Expression and localization of renin and angiotensinogen in rat heart after myocardial infarction. Am J Physiol. 271:1996;H1040-1048.
20. Shyu K.G., Chen J.J., Shih N.L.et al. Angiotensinogen gene expression is induced by cyclical mechanical stretch in cultured rat cardiomyocytes. Biochem Biophys Res Commun. 211:1995;241-248.
21. Kijima K., Matsubara H., Murasawa S.et al. Mechanical stretch induces enhanced expression of angiotensin II receptor subtypes in neonatal rat cardiac myocytes. Circ Res. 79:1996;887-897.
22. Brink M., Wellen J., Delafontaine P. Angiotensin II causes weight loss and decreases circulating insulin-like growth factor I in rats through a pressor-independent mechanism. J Clin Invest. 97:1996;2509-2516.
23. Delafontaine P., Brink M., Du J. Angiotensin II Modulation of Insulin Like Growth Factor I Expression in the Cardiovascular System. Trends Cardiovasc Med. 6:1996;187-193.
24. Neuss M., Regitz Zagrosek V., Hildebrandt A., Fleck E. Human cardiac fibroblasts express an angiotensin receptor with unusual binding characteristics which is coupled to cellular proliferation. Biochem Biophys Res Commun. 204:1994;1334-1339.
25. Nio Y., Matsubara H., Murasawa S., Kanasaki M., Inada M. Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarction. J Clin Invest. 95:1995;46-54.
26. Berk B.C., Corson M.A. Angiotensin II Signal Transduction in Vascular Smooth Muscle: Role of Tyrosine Kinases. Circ Res. 80:1997;607-616.
27. Regitz Zagrosek V., Neuss M., Warnecke C., Holzmeister J., Hildebrandt A.G., Fleck E. Subtype 2 and atypical angiotensin receptors in the human heart. Basic Res Cardiol. 91:1996;73-77.
28. Regitz Zagrosek V., Friedel N., Heymann A.et al. Regulation, chamber localization, and subtype distribution of angiotensin II receptors in human hearts. Circulation. 91:1995;1461-1471.
29. Everett A.D., Heller F., Fisher A. AT1 receptor gene regulation in cardiac myocytes and fibroblasts. J Mol Cell Cardiol. 28:1996;1727-1736.
30. Lee Y.A., Liang C.S., Lee M.A., Lindpaintner K. Local stress, not systemic factors, regulate gene expression of the cardiac renin-angiotensin system in vivo: a comprehensive study of all its components in the dog. Proc Natl Acad Sci USA. 93:1996;11035-11040.
31. Iwai N., Shimoike H., Kinoshita M. Cardiac renin-angiotensin system in the hypertrophied heart. Circulation. 92:1995;2690-2696.
32. Wolf K., Della Bruna R., Bruckschlegel G., Schunkert H., Riegger G.A., Kurtz A. Angiotensin II receptor gene expression in hypertrophied left ventricles of rat hearts. J Hypertens. 14:1996;349-354.
33. Lopez J.J., Lorell B.H., Ingelfinger J.R.et al. Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts. Am J Physiol. 267:1994;H844-852.
34. Fujii N., Tanaka M., Ohnishi J.et al. Alterations of angiotensin II receptor contents in hypertrophied hearts. Biochem Biophys Res Commun. 212:1995;326-333.
35. Haywood G.A., Gullestad L., Katsuya T.et al. AT(1) and AT(2) angiotensin receptor gene expression in human heart failure. Circulation. 95:1997;1201-1206.
36. Abdellatif M.M., Neubauer C.F., Lederer W.J., Rogers T.B. Angiotensin-induced desensitization of the phosphoinositide pathway in cardiac cells occurs at the level of the receptor. Circ Res. 69:1991;800-809.
37. Nahmias C., Strosberg A.D. The angiotensin AT2 receptor: searching for signal-transduction pathways and physiological function. Trends Pharmacol Sci. 16:1995;223-225.
38. Mukoyama M., Horiuchi M., Nakajima M., Pratt R.E., Dzau V.J. Characterization of a rat type 2 angiotensin II receptor stably expressed in 293 cells. Mol Cell Endocrinol. 112:1995;61-68.
39. Zhang J., Pratt R.E. The AT2 receptor selectively associates with Giα2 and Giα3 in the rat fetus. J Biol Chem. 271:1996;15026-15033.
40. 2) receptor is linked to protein kinase C but not cAMP dependent pathways in the cardiomyocyte. Can J Physiol Pharmacol. 74:1996;125-131.
41. - symport through a phosphoinositide-independent mechanism in cardiac cells. J Biol Chem. 270:1995;20432-20438.
42. Booz G.W., Baker K.M. Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy. Hypertension. 28:1996;635-640.
43. Nakajima M., Hutchinson H.G., Fujinaga M.et al. The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer. Proc Natl Acad Sci USA. 92:1995;10663-10667.
44. Liu Y.H., Yang X.P., Sharov V.G.et al. Effects of angiotensin converting enzyme inhibitors and Angiotensin II Type 1 receptor antagonists in rats with heart failure: Role of kinins and Angiotensin II Type 2 receptors. J Clin Invest. 99:1997;1926-1935.
45. Lee S.B., Rhee S.G. Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes. Curr Opin Cell Biol. 7:1995;183-189.
46. Lee C.H., Park D., Wu D., Rhee S.G., Simon M.I. Members of the Gq alpha subunit gene family activate phospholipase C beta isozymes. J Biol Chem. 267:1992;16044-16047.
47. Pawson T., Gish G. SH2 and SH3 domains: from structure to function. Cell. 71:1992;359-362.
48. Ji Q.S., Winnier G.E., Niswender K.D.et al. Essential role of the tyrosine kinase substrate phospholipase C γ1 in mammalian growth and development. Proc Natl Acad Sci USA. 94:1997;2999-3003.
49. Brodde O.E., Michel M.C., Zerkowski H.R. Signal transduction mechanisms controlling cardiac contractility and their alterations in chronic heart failure. Cardiovasc Res. 30:1995;570-584.
50. Neer E.J. Heterotrimeric G proteins: organizers of transmembrane signals. Cell. 80:1995;249-257.
51. LaMorte V.J., Thorburn J., Absher D.et al. Gq- and Ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following α1-adrenergic stimulation. J Biol Chem. 269:1994;13490-13496.
52. Sugden P.H., Bogoyevitch M.A. Intracellular signalling through protein kinases in the heart. Cardiovasc Res. 30:1995;478-492.
53. Marrero M.B., Paxton W.G., Duff J.L., Berk B.C., Bernstein K.E. Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma 1 in vascular smooth muscle cells. J Biol Chem. 269:1994;10935-10939.
54. Liao F., Shin H.S., Rhee S.G. In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by src-family protein tyrosine kinases. Biochem Biophys Res Commun. 191:1993;1028-1033.
55. Ishida M., Marrero M.B., Schieffer B., Ishida T., Bernstein K.E., Berk B.C. Angiotensin II activates pp60c-src in vascular smooth muscle cells. Circ Res. 77:1995;1053-1059.
56. Marrero M.B., Schieffer B., Paxton W.G., Schieffer E., Bernstein K.E. Electroporation of pp60c-src antibodies inhibits the angiotensin II activation of phospholipase C-γ1 in rat aortic smooth muscle cells. J Biol Chem. 270:1995;15734-15738.
57. Schelling J.R., Nkemere N., Konieczkowski M., Martin K.A., Dubyak G.R. Angiotensin II activates the β1 isoform of phospholipase C in vascular smooth muscle cells. Am J Physiol. 272:1997;C1558-C1566.
58. Newton A.C. Protein kinase C: structure, function, and regulation. J Biol Chem. 270:1995;28495-28498.
59. Van Bilsen M., Van der Vusse G.J. Phospholipase-A2-dependent signalling in the heart. Cardiovasc Res. 30:1995;518-529.
60. Kasahara K., Kikkawa U. Distinct effects of saturated fatty acids on protein kinase C subspecies. J Biochem Tokyo. 117:1995;648-653.
61. Schachter J.B., Lester D.S., Alkon D.L. Synergistic activation of protein kinase C by arachidonic acid and diacylglycerols in vitro: Generation of a stable membrane bound, cofactor independent state of protein kinase C activity. Biochim Biophys Acta. 1291:1996;167-176.
62. Musial A., Mandal A., Coroneos E., Kester M. Interleukin-1 and endothelin stimulate distinct species of diglycerides that differentially regulate protein kinase C in mesangial cells. J Biol Chem. 270:1995;21632-21638.
63. Harrington E.O., Ware A.O. Diversity of the protein kinase C gene family. Implication for cardiovascular disease. Trends Cardiovasc Med. 5:1995;193-199.
64. Steinberg S.F., Goldberg M., Rybin V.O. Protein kinase C isoform diversity in the heart. J Mol Cell Cardiol. 27:1995;141-153.
65. + antiport activity and gene expression in cultured vascular smooth muscle cells. Role of protein kinase C. J Clin Invest. 93:1994;2623-2631.
66. Ishii H., Jirousek M.R., Koya D.et al. Amelioration of vascular dysfunctions in diabetic rats by an oral PKCβ inhibitor. Science. 272:1996;728-731.
67. Pucéat M., Hilal-Dandan R., Strulovici B., Brunton L.L., Brown J.H. Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes. J Biol Chem. 269:1994;16938-16944.
68. Disatnik M.H., Buraggi G., Mochly-Rosen D. Localization of protein kinase C isozymes in cardiac myocytes. Exp Cell Res. 210:1994;287-297.
69. Klauck T.M., Faux M.C., Labudda K., Langeberg L.K., Jaken S., Scott J.D. Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein. Science. 271:1996;1589-1592.
70. Rybin V., Steinberg S.F. Do adult rat ventricular myocytes express protein kinase Cα Am J Physiol. 41:1997;H2485-H2491.
71. Rybin V.O., Buttrick P.M., Steinberg S.F. PKCλ Is the atypical protein kinase C isoform expressed by immature ventricle. Am J Physiol. 272:1997;H1636-H1642.
72. Clerk A., Bogoyevitch M.A., Fuller S.J., Lazou A., Parker P.J., Sugden P.H. Expression of protein kinase C isoforms during cardiac ventricular development. Am J Physiol. 269:1995;H1087-1097.
73. McGill C.J., Brooks G. Expression and regulation of 80K/MARCKS, a major substrate of protein kinase C, in the developing rat heart. Cardiovasc Res. 34:1997;368-376.
74. Rouetbenzineb P., Mohammadi K., Perennec J., Poyard M., Bouanani N.E., Crozatier B. Protein kinase C isoform expression in normal and failing rabbit hearts. Circ Res. 79:1996;153-161.
75. Clerk A., Bogoyevitch M.A., Anderson M.B., Sugden P.H. Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts. J Biol Chem. 269:1994;32848-32857.
76. Decock J.B., Gillespie Brown J., Parker P.J., Sugden P.H., Fuller S.J. Classical, novel and atypical isoforms of PKC stimulate ANF- and TRE/AP-1-regulated-promoter activity in ventricular cardiomyocytes. FEBS Lett. 356:1994;275-278.
77. De Jonge H.W., Van Heugten H.A., Lamers J.M. Signal transduction by the phosphatidylinositol cycle in myocardium. J Mol Cell Cardiol. 27:1995;93-106.
78. Arai H., Escobedo J.A. Angiotensin II type 1 receptor signals through Raf-1 by a protein kinase C-dependent, Ras-independent mechanism. Mol Pharmacol. 50:1996;522-528.
79. Liao D.F., Monia B., Dean N., Berk B.C. Protein kinase C ζ mediates Angiotensin II activation of Erk1/2 in vascular smooth muscle cells. J Biol Chem. 272:1997;6146-6150.
80. Kolch W., Heidecker G., Kochs G.et al. Protein kinase C α activates RAF-1 by direct phosphorylation. Nature. 364:1993;249-252.
81. Cacace A.M., Ueffing M., Philipp A., Han E.K., Kolch W., Weinstein I.B. PKC ε functions as an oncogene by enhancing activation of the Raf kinase. Oncogene. 13:1996;2517-2526.
82. Yamazaki T., Komuro I., Kudoh S.et al. Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes. J Clin Invest. 96:1995;438-446.
83. Bogoyevitch M.A., Marshall C.J., Sugden P.H. Hypertrophic agonists stimulate the activities of the protein kinases c-Raf and A-Raf in cultured ventricular myocytes. J Biol Chem. 270:1995;26303-26310.
84. 1 and β adrenoceptors. Circulation. 95:1997;1260-1268.
85. Glennon P.E., Kaddoura S., Sale E.M., Sale G.J., Fuller S.J., Sugden P.H. Depletion of mitogen-activated protein kinase using an antisense oligodeoxynucleotide approach downregulates the phenylephrine-induced hypertrophic response in rat cardiac myocytes. Circ Res. 78:1996;954-961.
86. Thorburn J., Frost J.A., Thorburn A. Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy. J Cell Biol. 126:1994;1565-1572.
87. Thorburn J., McMahon M., Thorburn A. Raf-1 kinase activity is necessary and sufficient for gene expression changes but not sufficient for cellular morphology changes associated with cardiac myocyte hypertrophy. J Biol Chem. 269:1994;30580-30586.
88. Post G.R., Goldstein D., Thuerauf D.J., Glembotski C.C., Brown J.H. Dissociation of p44 and p42 mitogen-activated protein kinase activation from receptor-induced hypertrophy in neonatal rat ventricular myocytes. J Biol Chem. 271:1996;8452-8457.
89. Thorburn J., Xu S., Thorburn A. MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells. EMBO J. 16:1997;1888-1900.
90. Aronson D., Violan M.A., Dufresne S.D., Zangen D., Fielding R.A., Goodyear L.J. Exercise Stimulates the Mitogen Activated Protein Kinase Pathway in Human Skeletal Muscle. J Clin Invest. 99:1997;1251-1257.
91. Lin L.L., Wartmann M., Lin A.Y., Knopf J.L., Seth A., Davis R.J. cPLA2 is phosphorylated and activated by MAP kinase. Cell. 72:1993;269-278.
92. Sturgill T.W., Ray L.B., Erikson E., Maller J.L. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Nature. 334:1988;715-718.
93. Haystead T.A., Haystead C.M., Hu C., Lin T.A., Lawrence J.C. Jr. Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes. J Biol Chem. 269:1994;23185-23191.
94. Peraldi P., Zhao Z., Filloux C., Fischer E.H., Van Obberghen E. Protein-tyrosine-phosphatase 2C is phosphorylated and inhibited by 44-kDa mitogen-activated protein kinase. Proc Natl Acad Sci USA. 91:1994;5002-5006.
95. Pulverer B.J., Kyriakis J.M., Avruch J., Nikolakaki E., Woodgett J.R. Phosphorylation of c-jun mediated by MAP kinases. Nature. 353:1991;670-674.
96. Marais R., Wynne J., Treisman R. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell. 73:1993;381-393.
97. Thorburn A., Thorburn J., Chen S.Y.et al. H-Ras dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy. J Biol Chem. 268:1993;2244-2249.
98. Sadoshima J., Izumo S. The heterotrimeric Gq protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. EMBO J. 15:1996;775-787.
99. Schorb W., Peeler T.C., Madigan N.N., Conrad K.M., Baker K.M. Angiotensin II-induced protein tyrosine phosphorylation in neonatal rat cardiac fibroblasts. J Biol Chem. 269:1994;19626-19632.
100. Linseman D.A., Benjamin C.W., Jones D.A. Convergence of angiotensin II and platelet-derived growth factor receptor signaling cascades in vascular smooth muscle cells. J Biol Chem. 270:1995;12563-12568.
101. Hunter J.J., Tanaka N., Rockman H.A., Ross J., Chien K.R. Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice. J Biol Chem. 270:1995;23173-23178.
102. Abdellatif M., MacLellan W.R., Schneider M.D. p21 Ras as a governor of global gene expression. J Biol Chem. 269:1994;15423-15426.
103. Zou Y., Komuro I., Yamazaki T.et al. Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes. J Biol Chem. 271:1996;33592-33597.
104. Stokoe D., McCormick F. Activation of c-Raf1 by Ras and Src through different mechanisms: Activation in vivo and in vitro. EMBO J. 16:1997;2384-2396.
105. Darnell J.E. Jr., Kerr I.M., Stark G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 264:1994;1415-1421.
106. Marrero M.B., Schieffer B., Paxton W.G.et al. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature. 375:1995;247-250.
107. Ihle J.N. STATs: signal transducers and activators of transcription. Cell. 84:1996;331-334.
108. Bhat G.J., Thekkumkara T.J., Thomas W.G., Conrad K.M., Baker K.M. Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein. J Biol Chem. 269:1994;31443-31449.
109. Bhat G.J., Thekkumkara T.J., Thomas W.G., Conrad K.M., Baker K.M. Activation of the STAT pathway by angiotensin II in T3CHO/AT1A cells. Cross-talk between angiotensin II and interleukin-6 nuclear signaling. J Biol Chem. 270:1995;19059-19065.
110. Bhat G.J., Abraham S.T., Baker K.M. Angiotensin II interferes with interleukin 6-induced Stat3 signaling by a pathway involving mitogen-activated protein kinase kinase 1. J Biol Chem. 271:1996;22447-22452.
111. Hirota H., Yoshida K., Taga T., Kishimoto T. Gp130 signaling pathways: recent advances and implications for cardiovascular disease. Trends Cardiovasc Med. 6:1996;109-115.
112. Seino Y., Ikeda U., Sekiguchi H.et al. Expression of leukocyte chemotactic cytokines in myocardial tissue. Cytokine. 7:1995;301-304.
113. Munger M.A., Johnson B., Amber I.J., Callahan K.S., Gilbert E.M. Circulating concentrations of proinflammatory cytokines in mild or moderate heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 77:1996;723-727.
114. Finkel M.S., Oddis C.V., Jacob T.D., Watkins S.C., Hattler B.G., Simmons R.L. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science. 257:1992;387-389.
115. Pennica D., King K.L., Shaw K.J.et al. Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc Natl Acad Sci USA. 92:1995;1142-1146.
116. Kunisada K., Hirota H., Fujio Y.et al. Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes. Circulation. 94:1996;2626-2632.
117. Sheng Z.L., Knowlton K., Chen J., Hoshijima M., Brown J.H., Chien K.R. Cardiotrophin 1 (CT1) inhibition of cardiac myocyte apoptosis via a mitogen activated protein kinase dependent pathway: Divergence from downstream CT1 signals for myocardial cell hypertrophy. J Biol Chem. 272:1997;5783-5791.
118. Yoshida K., Taga T., Saito M.et al. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci USA. 93:1996;407-411.
119. Hirota H., Yoshida K., Kishimoto T., Taga T. Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice. Proc Natl Acad Sci USA. 92:1995;4862-4866.
120. Palmer J.N., Hartogensis W.E., Patten M., Fortuin F.D., Long C.S. Interleukin-1 beta induces cardiac myocyte growth but inhibits cardiac fibroblast proliferation in culture. J Clin Invest. 95:1995;2555-2564.
121. Wollert K.C., Taga T., Saito M.et al. Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series via gp130/leukemia inhibitory factor receptor-dependent pathways. J Biol Chem. 271:1996;9535-9545.
122. Matsui H., Fujio Y., Kunisada K., Hirota H., Yamauchi Takihara K. Leukemia inhibitory factor induces a hypertrophic response mediated by gp130 in murine cardiac myocytes. Res Commun Mol Pathol Pharmacol. 93:1996;149-162.
123. Patten M., Hartogensis W.E., Long C.S. Interleukin-1beta is a negative transcriptional regulator of alpha1-adrenergic induced gene expression in cultured cardiac myocytes. J Biol Chem. 271:1996;21134-21141.
124. Robledo O., Fourcin M., Chevalier S.et al. Signaling of the cardiotrophin 1 receptor: Evidence for a third receptor component. J Biol Chem. 272:1997;4855-4863.
125. Kyriakis J.M., Banerjee P., Nikolakaki E.et al. The stress-activated protein kinase subfamily of c-Jun kinases. Nature. 369:1994;156-160.
126. Force T., Pombo C.M., Avruch J.A., Bonventre J.V., Kyriakis J.M. Stress-activated protein kinases in cardiovascular disease. Circ Res. 78:1996;947-953.
127. Sanchez I., Hughes R.T., Mayer B.J.et al. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature. 372:1994;794-798.
128. Coso O.A., Teramoto H., Simonds W.F., Gutkind J.S. Signaling from G protein-coupled receptors to c-Jun kinase involves βγ subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway. J Biol Chem. 271:1996;3963-3966.
129. Laderoute K.R., Webster K.A. Hypoxia/reoxygenation stimulates Jun kinase activity through redox signaling in cardiac myocytes. Circ Res. 80:1997;336-344.
130. Bogoyevitch M.A., Gillespie Brown J., Ketterman A.J.et al. Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion. Circ Res. 79:1996;162-173.
131. Bogoyevitch M.A., Ketterman A.J., Sugden P.H. Cellular stresses differentially activate c-Jun N-terminal protein kinases and extracellular signal-regulated protein kinases in cultured ventricular myocytes. J Biol Chem. 270:1995;29710-29717.
132. Kudoh S., Komuro I., Mizuno T.et al. Angiotensin II stimulates c-Jun NH2-terminal kinase in cultured cardiac myocytes of neonatal rats. Circ Res. 80:1997;139-146.
133. Komuro I., Kudo S., Yamazaki T., Zou Y., Shiojima I., Yazaki Y. Mechanical stretch activates the stress-activated protein kinases in cardiac myocytes. FASEB J. 10:1996;631-663.
134. 1 adrenergic receptor and Ras activation and is associated with in vitro and in vivo cardiac hypertrophy. J Biol Chem. 272:1997;14057-14061.
135. Shirakabe K., Yamaguchi K., Shibuya H.et al. Tak1 mediates the ceramide signaling to stress activated protein kinase Jun-N terminal kinase. J Biol Chem. 272:1997;8141-8144.
136. Jarvis W.D., Kolesnick R.N., Fornari F.A., Traylor R.S., Gewirtz D.A., Grant S. Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway. Proc Natl Acad Sci USA. 91:1994;73-77.
137. Perry D.K., Obeid L.M., Hannun Y.A. Ceramide and the Regulation of Apoptosis and the Stress Response. Trends Cardiovasc Med. 6:1996;158-162.
138. Sugden P.H., Bogoyevitch M.A. Endothelin-1 dependent signaling pathways in the myocardium. Trends Cardiovasc Med. 6:1996;87-94.
139. Duerr R.L., Huang S., Miraliakbar H.R., Clark R., Chien K.R., Ross J. Jr. Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure. J Clin Invest. 95:1995;619-627.
140. Yazaki Y., Yamazaki T. Reversing congestive heart failure with Endothelin receptor antagonists. Circulation. 95:1997;1752-1754.
141. Fukunaga R., Hunter T. Mnk1, a new MAP Kinase activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J. 16:1997;1921-1933.
142. Berger H.J., Prasad S.K., Davidoff A.J.et al. Continual electric field stimulation preserves contractile function of adult ventricular myocytes in primary culture. Am J Physiol. 266:1994;H341-H349.
143. Millar B.C., Schluter K.D., Zhou X.J., McDermott B.J., Piper H.M. Neuropeptide Y stimulates hypertrophy of adult ventricular cardiomyocytes. Am J Physiol. 266:1994;C1271-1277.
144. Kirshenbaum L.A., MacLellan W.R., Mazur W., French B.A., Schneider M.D. Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus. J Clin Invest. 92:1993;381-387.