Coincidental changes in behavior and plasma cortisol in unrestrained pigs after intracerebroventricular injection of tumor necrosis factor-α

Endocrinology

Volumn 138, Issue 6, 1997, Pages 2365-2371

  Warren, E J ^a   Finck, B N ^a   Arkins, S ^b   Kelley, K W ^a   Scamurra, R W ^c   Murtaugh, M P ^c   Johnson, R W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b ILLINOIS STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PHASE RESPONSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; BEHAVIOR; BODY TEMPERATURE; CASTRATION; CONTROLLED STUDY; FEVER; FOOD INTAKE; HYDROCORTISONE BLOOD LEVEL; HYPERSOMNIA; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; ILLNESS BEHAVIOR; INFLAMMATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL; SWINE;

EID: 0030962171     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.6.5180     Document Type: Article

References (45)

1. McGeehan GM, Becherer JD, Bast RC, Boyer CM, Champion B, Conolly KM, Conway JG, Furdon P, Karp S, Kidao S, McElroy AB, Nichols J, Pryzwansky KM, Schoenen F, Sekut L, Truesdale A, Verghese M, Warner J, Ways JP 1994 Regulation of tumor necrosis factor-α processing by a metalloproteinase inhibitor. Nature 370:558-561
2. Adams F, Quesada JR, Gutterman JU 1984 Neuropsychiatric manifestations of human leukocyte interferon therapy in patients with cancer. J Am Med Assoc 252:938-941
3. Fent K, Zbinden G 1987 Toxicity of interferon and interleukin. Trends Pharmacol Sci 8:100-105
4. Kent S, Bluthé RM, Kelley KW, Dantzer R 1992 Sickness behavior as a new target for drug development. Trends Pharmacol Sci 131:24-28
5. Johnson RW, Arkins S, Dantzer R, Kelley KW, Hormones lymphohemopoietic cytokines and the neuroimmune axis. Comp Biochem Physiol, in press
6. Dantzer R 1994 How do cytokines say hello to the brain? Neural vs. humoral mediation. Eur Cytokine Netw 5:271-273
7. Renno T, Krakowski M, Piccirillo C, Lin J, Owens T 1995 TNF-α expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis. J Immunol 154:944-953
8. Tchelingerian J-L, Quinonero J, Booss J, Jacque C 1993 Localization of TNFα and IL-1α immunoreactivities in striatal neurons after surgical injury to the hippocampus. Neuron 10:219-224
9. Breder CD, Hazuka C, Ghayur T, Klug C, Huginin M, Yasuda K, Teng M, Saper CB 1994 Regional induction of tumor necrosis factor α expression in the mouse brain after systemic lipopolysaccharide administration. Proc Natl Acad Sci USA 91:11393-11397
10. Layé S, Parnet P, Goujon E, Dantzer R 1994 Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice. Mol Brain Res 27:157-162
11. Perry VH 1994 Macrophages and the Nervous System. R. G. Landes Co., Austin TX
12. Dinarello CA 1988 Biology of interleukin-1. FASEB J 2:108-115
13. Plata-Salamán CR, Oomura Y, Kai Y 1988 Tumor necrosis factor and interleukin-1β: suppression of food intake by direct action in the central nervous system. Brain Res 448:106-114
14. McCann SM, Rettori V, Milenkovic L, Jurcovicova J, Snyder G, Beutler B 1988 Role of interleukin-1 and cachectin in control of anterior pituitary hormone release. In: Perez-Polo JR (ed) Natural Control of Reproductive Function, Liss, New York
15. Perlstein RS, Whitnall MH, Abrams JS, Mougey EH, Neta R 1993 Synergistic roles of interleukin-6, interleukin-1, and tumor necrosis factor in the adrenocorticotropin response to bacterial lipopolysaccharide in vivo. Endocrinology 132:946-952
16. Kinouchi K, Brown G, Pasternak G, Donner DB 1991 Identification and characterization of receptors for tumor necrosis factor-α in the brain. Biochem Biophys Res Comm 181:1532-1538
17. MolitorTW, Morilla A, Risdahl JM, Murtaugh MP, Chao C, Peterson PK 1992 Chronic morphine administration impairs cell-mediated immune responses in swine. J Pharmacol Exp Ther 260:581-586
18. Olson NC, Dodam JR, Kruse-Elliot KT 1992 Endotoxemia and gram-negative bacteremia in swine: chemical mediators and therapeutic considerations. JAVMA 200:1884-1893
19. Sachs DH 1995 The immunological response to xenografts. ILAR J 37:16-22
20. Nam MJ, Thore C, Busija D 1995 Rapid induction of prostaglandin synthesis in piglet astroglial cells by interleukin-1α. Brain Res Bull 36:215-218
21. Megyeri P, Abraham CS, Temesvari P, Kovacs J, Vas T, Speer CP 1992 Recombinant human tumor necrosis factor α constricts pial arterioles and increases blood-brain barrier permeability in newborn piglets. Neurosci Lett 148:137-140
22. Murtaugh MP, Baarsch MJ, Zhou Y, Scamurra RW, Lin G 1996 Inflammatory cytokines in animal health and disease. Vet Immunol Immunopathol 54:45-55
23. Zhou Y, Lin G, Baarsch MJ, Scamurra RW, Murtaugh MP 1994 Interleukin-4 suppresses inflammatory cytokine gene transcription in porcine macrophages. J Leukoc Biol 56:507-513
24. Johnson RW, Propes M, Shavit Y 1996 Corticosterone modulates the behavioral and metabolic effects of lipopolysaccharide. Am J Physiol 270:R192-R198
25. Propes MJ, Johnson RW 1997 Role of corticosterone in the behavioral effects of central interleukin-1β. Physiol Behav 61:7-13
26. Goujon E, Parnet P, Aubert A, Goodall G, Dantzer R 1995 Corticosterone regulates behavioral effects of lipopolysaccharide and interleukin-1β in mice. Am J Physiol 269:R154-R159
27. Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching, 1988 Consortium for Developing A Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching, Champaign IL, pp 1-74
28. Johnson RW, von Borell E, Anderson LL, Kojic LD, Cunnick JE 1994 Intracerebroventricular injection of corticotropin releasing hormone in the pig: acute effects on behavior, adrenocorticotropin secretion, and immune suppression. Endocrinology 135:642-648
29. Baarsch MJ, Wannemuehler MJ, Molitor TW, Murtaugh MP 1991 Detection of tumor necrosis factor-alpha from porcine alveolar macrophages using an L929 fibroblast bioassay. J Immunol Methods 140:15-22
30. Johnson RW, von Borell E 1994 Lipopolysaccharide-induced sickness behavior in pigs is inhibited by pretreatment with indomethacin. J Anim Sci 72:309-314
31. Webel D, Finck BN, Baker D, Johnson RW, Tumor necrosis factor-α, interleukin-6 and several blood metabolites in swine following intraperitoneal injection of lipopolysaccharide. J Anim Sci, in press
32. SAS Institute Inc 1992 SAS/STAT User's Guide, ed. 4, Cary, NC
33. Blalock JE 1994 The immune system. Our sixth sense. The Immunologist 2:8-15
34. Besedovsky HO, delRey A, Sorkin E, Dinarello CA 1987 Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233:652-654
35. Munck A, Guyre PM, Holbrook NJ 1984 Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr Rev 5:25-44
36. Dantzer R, Bluthe RM, Kent S, Goodall G 1993 Behavioral Effects of cytokines: an insight into mechanisms of sickness behavior. Methods Neurosci 17:130-150
37. Tilders FJH, DeRijk RH, Van Dam AM, Vincent VAM, Schotanus K, Persoons JHA 1994 Activation of the hypothalamus-pituitary-adrenal axis by bacterial endotoxins: routes and intermediate signals. Psychoneuroendocrinology 19:209-232
38. Pezeshki G, Pohl T, Schöbitz B 1996 Corticosterone controls interleukin-1β expression and sickness behavior in the rat. J Neuroendocrinol 8:129-135
39. Coelho MM, Souza G, Pelá I 1992 Endotoxin-induced fever is modulated by endogenous glucocorticoids in rats. Am J Physiol 263:R423-R427
40. Morrow LE, McClellan JL, Conn CA, Kluger MJ 1993 Glucocorticoids alter fever and IL-6 responses to psychological stress and to lipopolysaccharide. Am J Physiol 264:R1010-R1017
41. Mózes T, Ben-Efraim S, Tak CJAM, Heiligers JPC, Saxena PR, Bonta IL 1991 Serum levels of tumor necrosis factor determine the fatal or non-fatal course of endotoxic shock. Immunol Lett 27:157-162
42. Grunfeld C, Palladino MA 1990 Tumor necrosis factor: immunologic, anti-tumor, metabolic, and cardiovascular activities. Adv Intern Med 35:45-72
43. Layé S, Bluthé R, Kent S, Combe C, Médina C, Parnet P, Kelley K, Dantzer R 1995 Subdiaphragmatic vagotomy blocks induction of IL-1β mRNA in mice brain in response to peripheral LPS. Am J Physiol 268:R1327-R1331
44. Bret-Dibat JL, Bluthé RM, Kent S, Kelley KW, Dantzer R 1995 Lipopolysaccharide and interleukin-1 depress food-motivated behavior in mice by a vagal-mediated mechanism. Brain Behav Immun 9:242-246
45. Sonti G, Ilyin SE, Plata-Salamán CR 1996 Anorexia induced by cytokine interactions at pathophysiological concentrations. Am J Physiol 270:R1394-R1402